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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan wang bin wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Controlled cationic ring-opening polymerization of L-lactide by organic ion pair: novel approach to isotactic-rich and crystalline polylactide

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Science China Chemistry 2025年第01期 394-402页

作者： Zhiqiang Ding Mingqian wang Zijing Zhou bin wang Yuesheng Li Tianjin Key Laboratory of Composite & Functional Materials School of Materials Science and Engineering Tianjin University

Living/controlled cationic ring-opening polymerization （ROP） of L-lactide is a promising approach to isotactic-rich and crystalline poly（L-lactide）.In contrast with the unsubstituted lactones,L-LA can not be polymerized by organic Lewis acids or carbenium ions,and the state of the art in this field is the cationic ROP of L-LA catalyzed by Br?nsted acid/alcohol system via activated monomer ***,we reported the first example of controlled cationic ROP of L-LA by using Meerweintype ion pair[Me3O]+[B（C6F5）4]-as the catalyst.[Me3O]+[B（C6F5）4]-promoted rapid L-LA cationic polymerization in the absence of alcohol,producing isotactic-rich and crystalline PLLA without transesterification and epimerization side *** activated chain end mechanism,involving twice SN2 substitution and configuration-inversion （S→R→S） with the assistance of released Me2O,was proposed and further verified by density functional theory and control *** work expands the catalytic toolbox of isotactic-rich and crystalline polylactide *** represents a unique example of cationic-controlled polymerization of L-LA catalyzed by an organic ion pair.

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AN EXPLICIT MULTI-CONSERVATION FINITE-DIFFERENCE SCHEME FOR SHALLOW-WATER-WAVE EQUATION

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Journal of Computational Mathematics 2008年第3期26卷 404-409页

作者： bin wang LASG Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China

An explicit multi-conservation finite-difference scheme for solving the spherical shallow-water-wave equation set of barotropic atmosphere has been proposed. The numerical scheme is based on a special semi-discrete form of the equations that conserves four basic physical integrals including the total energy, total mass, total potential vorticity and total enstrophy. Numerical tests show that the new scheme performs closely like but is much more time-saving than the implicit multi-conservation scheme.

关键词： Explicit finite difference scheme Multi-conservation Shallow-water-wave Physical integral

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Nonlinear Random Motion Analysis of A Tension Leg Platform Consider- ing the Set-down Motion of A Floating Body

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China Ocean Engineering 2017年第2期31卷 210-219页

作者： wang bin School of Civil Engineering Tianjin University Tianjin 300072 China State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin University Tianjin 300072 China

The dynamic analysis of a Tension Leg Platform （TLP） in random wave is investigated by considering the set-down of a floating body. The nonlinear restoring stiffness is derived with the set-down motion of a floating body and the coupled motion of the tension leg and platform and the differential equations of the motion are established. The study focuses on the influence of the set-down motion on the nonlinear response of the platform. By considering different significant wave heights and currents, motion responses of the platform are calculated and compared. The analysis shows that the set-down motion significantly increases the heave motion with low frequency and the equilibrium position of the heave motion with the set-down motion is much lower than that without set-down motion. The results in this paper indicate that the set-down motion has a major impact on the safety of the platform inproduction operation, and it is also a threat to the strength of tension legs and risers.

关键词： Tension Leg Platform (TLP) set-down nonlinear restoring stiffness random wave coupled motion

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A Protection Method for Inverter-based Microgrid Using Current-only Polarity Comparison

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Journal of Modern Power Systems and Clean Energy 2020年第3期8卷 446-453页

作者： bin wang Liuming Jing State Key Laboratory of Power System Department of Electrical EngineeringTsinghua UniversityBeijing 100084China

The design of an effective protection system for inverter-based microgrids is a complicated engineering *** is due to the fact that inverters have limited fault current capabilities, and that the conventional overcurrent protection is not suitable for inverter-based microgrids. This paper introduces a novel protection method for inverter-based microgrid using a current-only polarity comparison. The proposed method is based on the phase difference between the pre-fault and fault current components. The method responds to faults in both grid-connected and autonomous operation modes and provides a new way to identify faulted sections. Simulations of an inverter-based microgrid with a relay model are conducted using PSCAD/EMTDC software. The results show that the proposed method can detect faults in inverter-based microgrids.

关键词： Distributed energy resources inverter microgrid protection fault current

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Relationship Between General MP and DPP for the Stochastic Recursive Optimal Control Problem with Jumps

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系统科学与复杂性学报（英文版） 2024年第6期37卷 2466-2486页

作者： wang bin SHI Jingtao School of Mathematics Shandong UniversityJinan 250100China

This paper is concerned with the relationship between general maximum principle and dynamic programming principle for the stochastic recursive optimal control problem with jumps,where the control domain is not necessarily *** among the adjoint processes,the generalized Hamiltonian function and the value function are proven,under the assumption of a smooth value function and within the framework of viscosity solutions,*** examples are given to illustrate the theoretical results.

关键词： Backward stochastic differential equation with jumps dynamic programming principle maximum principle recursive optimal control viscosity solution

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Innovative Thin-Walled Structure with Transverse Negative Poisson’s Ratio for High-Performance Crashworthiness

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Acta Mechanica Solida Sinica 2023年第1期36卷 34-44页

作者： bin wang Yongtao Sun Tianjin Key Laboratory of Soft Soils and Engineering Environment Tianjin Chengjian UniversityTianjin 300384China Department of Mechanics and Tianjin Key Laboratory of Nonlinear Dynamics and Control Tianjin UniversityTianjin 300350China

In this paper,an innovative type of thin-walled structures,the convex-concave honeycomb columns(CCHCs)with transverse negative Poisson’s ratio(NPR),is proposed for energy absorbers by replacing the cell walls of square honeycomb lattice columns with sine-shaped or zigzag-shaped walls of equal *** simulations show that,under axial impact,contrary to the conventional square honeycomb columns of equal mass,the transverse cross section of NPR CCHC shrinks inward,making the cell walls of CCHC contact and interact sufficiently with each other and thus dissipate the impact energy much more *** suitably adjusting the transverse NPR,the CCHC can have the combined advantages of effective total energy absorption,high specific energy absorption and low maximum peak crushing *** research of this paper provides a new strategy for the design of high-performance energy absorbers widely used in the engineering fields of vehicle engineering,aerospace engineering etc.

关键词： Energy absorbers Convex-concave honeycomb columns(CCHC) Transverse negative Poisson’s ratio Axial impact High-performance crashworthiness

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binder-and conductive additive-free Ga2O3 nanowires as a self-healing anode for lithium storage

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Progress in Natural Science:Materials International 2023年第2期33卷 203-210页

作者： Yang Gao bin wang CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology

High-capacity anode materials have stimulated much attention to developing high-performance lithium-ion batteries. However, high-capacity anode materials commonly suffer from the pulverization matter that greatly hinders their practical applications, especially in terms of the high proportion of active materials. In this work, a Ga2O3nanowire electrode is synthesized by thermal evaporation and immediately used as an anode without the aid of binders and conductive additives. The 3D interconnected architecture of the Ga2O3nanowire electrode shortens lithium diffusion lengths and expedites reaction kinetics. The Ga2O3nanowires exhibit high elasticity and a self-healing ability which is inherited from metallic Ga formed during the electrochemical transition process, thus circumventing the formidable pulverization issue to a certain extent. Benefiting from the unique structural, mechanical, and chemical attributes, the as-grown Ga2O3nanowire electrode gives a high initial lithiation capacity of 1462 m Ah g-1under a current density of 0.1 A g-1. It delivers good cyclic stability with a reversible capacity of 445 m Ah g-1after 200 cycles at 0.5 A g-1. Furthermore, the investigation of lithium storage behaviors indicates the high rate capability of Ga2O3nanowires. This paper contributes to understanding binderand conductive additive-free electrodes consisting of high-capacity active materials from various viewpoints.

关键词： Lithium-ion battery Gallium oxide Nanowires binder-free Mechanical testing

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Sub-Nyquist sampling-based wideband spectrum sensing:a compressed power spectrum estimation approach

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Frontiers of Computer Science 2024年第2期18卷 139-145页

作者： Jilin wang Yinsen HUANG bin wang National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of ChinaChengdu 611731China

In this paper,we introduce a sub-Nyquist sampling-based receiver architecture and method for wideband spectrum *** of recovering the original wideband analog signal,the proposed method aims to directly reconstruct the power spectrum of the wideband analog signal from sub-Nyquist *** that power spectrum alone is sufficient for wideband spectrum *** only the covariance matrix of the wideband signal is needed,the proposed method,unlike compressed sensing-based methods,does not need to impose any sparsity requirement on the frequency *** proposed method is based on a multi-coset sampling *** exploiting the inherent sampling structure,a fast compressed power spectrum estimation method whose primary computational task consists of fast Fourier transform(FFT)is *** results are presented to show the effectiveness of the proposed method.

关键词： wideband spectrum sensing sub-Nyquist multicoset sampling FCPSE

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Emerging contaminant control:From science to action

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Frontiers of Environmental Science & Engineering 2022年第6期16卷 171-174页

作者： bin wang Gang Yu Beijing Laboratory of Environmental Frontier Technology Beijing Key Laboratory of Emerging Organic Contaminants ControlSchool of EnvironmentTsinghua UniversityBeijing 100084China Research Institute for Environmental Innovation(Suzhou) TsinghuaSuzhou 215163China

Since the concept of emerging contaminants(ECs)was first proposed in 2001,the global scientific research of ECs has developed *** the past decades,great progress has been achieved in the scientific research of ECs in China,including the establishment of EC analysis method system,the evaluation of the pollution status,pollution characteristics and environmental risk of ECs in typical regions of China,and establishment of EC control technology *** progress in scientific research of ECs promoted China’s action on EC *** is planned that the environmental risk of ECs will be generally controlled by 2035 in *** ECs should be screened for environmental *** great efforts have been made,the EC control in China still faces tremendous *** is necessary to bridge the gap between scientific research and decision-making *** on the science and technology study,various measures such as engineering,policy management and public participation should be combinedly adopted for EC control.

关键词： Emerging contaminants Priority pollutants PPCPs POPs Control policy

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