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Construction and validation of a neovascular glaucoma nomogram in patients with diabetic retinopathy after pars plana vitrectomy

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World Journal of Diabetes 2024年第4期15卷 654-663页

作者： Yi Shi Yan-Xin Zhang Ming-fei Jiao Xin-Jun Ren Bo-Jie Hu ai-Hua Liu Xiao-Rong Li Surgical Retina Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China Glaucoma Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China Ocular Trauma Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China

BACKGROUND Neovascular glaucoma(NVG)is likely to occur after pars plana vitrectomy(PPV)for diabetic retinopathy(DR)in some patients,thus reducing the expected *** the risk factors for NVG occurrence and building effective risk prediction models are currently required for clinical *** To develop a visual risk profile model to explore factors influencing DR after *** We retrospectively selected 151 patients with DR undergoing *** patients were divided into the NVG(NVG occurrence)and No-NVG(No NVG occurrence)groups according to the occurrence of NVG within 6 months after *** risk factors for postoperative NVG were screened by logistic regression.A nomogram prediction model was established using R software,and the model’s prediction accuracy was verified internally and externally,involving the receiver operator characteristic curve and correction *** After importing the data into a logistic regression model,we concluded that a posterior capsular defect,preoperative vascular endothelial growth factor≥302.90 pg/mL,glycosylated hemoglobin≥9.05%,aqueous fluid interleukin 6(IL-6)≥53.27 pg/mL,and aqueous fluid IL-10≥9.11 pg/mL were independent risk factors for postoperative NVG in patients with DR(P<0.05).A nomogram model was established based on the aforementioned independent risk factors,and a computer simulation repeated sampling method was used to internally and externally verify the nomogram *** area under the curve(AUC),sensitivity,and specificity of the model were 0.962[95%confidence interval(95%CI):0.932-0.991],91.5%,and 82.3%,*** AUC,sensitivity,and specificity of the external validation were 0.878(95%CI:0.746-0.982),66.7%,and 95.7%,*** A nomogram constructed based on the risk factors for postoperative NVG in patients with DR has a high prediction *** study can help formulate relevant preventive and treatment measures.

关键词： Diabetic retinopathy Retinopathy Neovascular Glaucoma Risk factors Nomogram

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Ovarian-adnexal reporting and data system ultrasound evaluation and pathological characteristics of ovarian collision tumor

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World Journal of Clinical Cases 2024年第22期12卷 4932-4939页

作者： Chan Yin Yong wang Zhi-Hui fei Li-Hong Sun Wei-ai Zhou Heng Li Department of Ultrasound Hunan University of Arts and Sciences Affiliated Changde Maternal and Child Health HospitalChangde 415000Hunan ProvinceChina Department of Ultrasound People's Hospital of Shimen CountyChangde 415300Hunan ProvinceChina Department of Ultrasound Medicine The Maternal and Child Health Hospital of ChangdeChangde 415000Hunan ProvinceChina Department of Psychology The Maternal and Child Health Hospital of ChangdeChangde 415000Hunan ProvinceChina Department of Gynaecology Hunan University of Arts and Sciences Affiliated Changde Maternal and Child Health HospitalChangde 415000Hunan ProvinceChina Department of Ultrasound The First People's Hospital of ChangdeChangde 415000Hunan ProvinceChina

BACKGROUND Collision tumor are neoplasms,including two histologically distinct tumors that coexist in the same mass without histological *** incidence of collision tumor is low and is rare *** To investigate ultrasound images and application of ovarian-adnexal reporting and data system(O-RADS)to evaluate the risk and pathological characteristics of ovarian collision *** This study retrospectively analyzed 17 cases of ovarian collision tumor diagnosed pathologically from January 2020 to December *** clinical features,ultrasound images and histopathological features were collected and *** O-RADS score was used for *** O-RADS score was determined by two senior doctors in the gynecological ultrasound *** with O-RADS score of 1-3 were classified as benign tumors,and lesions with O-RADS score of 4 or 5 were classified as malignant *** There were 17 collision tumors detected in 16 of 6274 patients who underwent gynecological *** average age of 17 women with ovarian collision tumor was 36.7 years(range 20-68 years),in whom,one occurred bilaterally and the rest occurred *** average tumor diameter was 10 cm,of which three were 2-5 cm,11 were 5-10 cm,and three were>10 ***(29.4%)tumors with O-RADS score 3 were endometriotic cysts with fibroma/serous cystadenoma,and unilocular or multilocular cysts contained a small number of parenchymal ***(64.7%)tumors had an O-RADS score of 4,including two in category 4A,six in category 4B,and three in category 4C;all of which were multilocular cystic tumors with solid components or multiple papillary ***(5.9%)tumor had an O-RADS score of *** case was a solid mass,and a small amount of pelvic effusion was detected under *** pathology was high-grade serous cystic cancer combined with cystic mature *** were nine(52.9%)tumors with elevated serum carbohydrate antigen(CA)125 and two(11.8%)with

关键词： Ovarian collision tumor Ovarian-adnexal reporting and data system Epithelial tumor Serous cystadenoma Ultrasound images

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When Does Sora Show:The Beginning of TAO to Imaginative Intelligence and Scenarios Engineering

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 809-815页

作者： fei-Yue wang Qinghai Miao Lingxi Li Qinghua Ni Xuan Li Juanjuan Li Lili Fan Yonglin Tian Qing-Long Han School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190China Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China Department of Electrical and Computer Engineering Indiana University-Purdue University IndianapolisIndianapolisIN 46202USA Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China Virtual Reality Fundamental Research Laboratory Department of Mathematics and TheoriesPeng Cheng LaboratoryShenzhen 518000China State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourneVIC 3122Australia

DURING our discussion at workshops for writing“What Does ChatGPT Say:The DAO from Algorithmic Intelligence to Linguistic Intelligence”[1],we had expected the next milestone for Artificial Intelligence(ai)would be in the direction of Imaginative Intelligence(II),i.e.,something similar to automatic wordsto-videos generation or intelligent digital movies/theater technology that could be used for conducting new“Artificiofactual Experiments”[2]to replace conventional“Counterfactual Experiments”in scientific research and technical development for both natural and social studies[2]-[6].Now we have Openai’s Sora,so soon,but this is not the final,actually far away,and it is just the beginning.

关键词： something Intelligence replace

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颗粒蛋白前体与骨关节疾病的相关性

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中华骨质疏松和骨矿盐疾病杂志 2022年第3期15卷 304-310页

作者：李光飞王爱飞蔚建鲁徐又佳苏州大学附属第二医院骨科骨质疏松症临床中心苏州大学骨质疏松诊疗技术研究所江苏苏州215004 山东大学齐鲁医院骨科济南250012

颗粒蛋白前体(progranulin,PGRN)作为体内的自分泌性生长因子,近些年研究发现其除了与神经系统等密切相关外,还与临床骨关节疾病密切相关。在类风湿关节炎,PGRN可通过与肿瘤坏死因子α(tumor necrosis factorsα,TNF-α)竞争性结合肿瘤... 详细信息

颗粒蛋白前体(progranulin,PGRN)作为体内的自分泌性生长因子,近些年研究发现其除了与神经系统等密切相关外,还与临床骨关节疾病密切相关。在类风湿关节炎,PGRN可通过与肿瘤坏死因子α(tumor necrosis factorsα,TNF-α)竞争性结合肿瘤坏死因子受体(tumor necrosis factor receptor,TNFR)抑制类风湿关节炎的进展;在骨性关节炎(osteoarthritis,OA),PGRN可抑制白细胞介素1b(interleukin-1b,IL-1b)介导的软骨细胞分解,并通过TNFR2/14-3-3ε信号通路促进软骨形成;在腰椎间盘突出症,目前报道较少,尚待进一步研究认识其相互关系;在绝经后骨质疏松症,结合相关文献报道,推测绝经后骨质疏松症可能是由于绝经后雌激素缺乏,体内PGRN表达下降,雌激素受体α(estrogen receptorα,ERα)泛素化增加而表达减少,进而通过影响前成骨细胞和破骨细胞导致骨质疏松。本文对相关文献进行综述,为PGRN在骨关节疾病的临床研究和应用提供参考。

关键词：颗粒蛋白前体类风湿关节炎骨性关节炎腰椎间盘突出症骨质疏松症

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河北孟村方言的比较句及其百年演变--以戴遂良汉语教材和现代河北方言为基础

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沧州师范学院学报 2021年第3期37卷 39-44,74页

作者：董淑慧王爱菲南开大学汉语言文化学院天津300071

根据语义功能,河北孟村方言的比较句分等比句、差比句、极比句和递比句四种,具体句式有“A+跟/会+B+一样+AP/VP”“A+比+B+AP/VP”“A+赶上+B+AP”“A+没/不如/不跟/不像+B+AP/VP”“A+不如/不跟/比不得/伴不得/赶不上+B”等。这些句式... 详细信息

根据语义功能,河北孟村方言的比较句分等比句、差比句、极比句和递比句四种,具体句式有“A+跟/会+B+一样+AP/VP”“A+比+B+AP/VP”“A+赶上+B+AP”“A+没/不如/不跟/不像+B+AP/VP”“A+不如/不跟/比不得/伴不得/赶不上+B”等。这些句式在句法条件、语义功能或语用倾向上存在差异。比较基准在谓词后的比较句在孟村方言仅有少量保留。此外,通过比较戴遂良汉语教材和现代方言,可看出河间府方言百年的演变。

关键词：孟村方言比较句戴遂良

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支承机匣磨抛参数建模与稳健优化研究

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航空动力学报 2024年第6期39卷 20-28页

作者：曾爱黄飞王玉泉杨滨涛张玉中国航发贵州黎阳航空动力有限公司贵阳550014

针对支承机匣内孔磨抛表面质量难以保证及磨抛效率低问题,开展了磨抛工艺参数对表面质量影响研究。基于Preston理论建立了螺旋式磨抛材料去除量方程,理论上揭示了螺旋式磨抛工艺参数对表面质量的影响规律。通过正交实验进行方差灵敏度分... 详细信息

针对支承机匣内孔磨抛表面质量难以保证及磨抛效率低问题,开展了磨抛工艺参数对表面质量影响研究。基于Preston理论建立了螺旋式磨抛材料去除量方程,理论上揭示了螺旋式磨抛工艺参数对表面质量的影响规律。通过正交实验进行方差灵敏度分析,探寻出打磨轮目粒度、打磨轮进给速度、打磨轮转速和抛光时间等影响因子对材料去除率和表面粗糙度影响规律及贡献率,在此基础上以材料去除率和表面粗糙度为优化研究目标,构建了基于Kriging响应面近似模型的稳健优化设计数学模型,采用粒子群算法进行计算求解,计算出2611组优化解。结合实际工程要求,最佳的工艺参数为目粒度1400目、进给速度3 mm/s、转速3600 r/min、抛光时间9 min,为磨抛工程领域的工艺质量改善提供技术支撑。

关键词：支承机匣螺旋式磨抛材料去除率正交实验稳健优化粒子群算法

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Analysis of data for γp → f1(1285)p photoproduction

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Chinese Physics C 2024年第2期48卷 141-152页

作者：王爱超韦能昌黄飞 College of Science China University of Petroleum(East China)Qingdao 266580China School of Physics Henan Normal UniversityXinxiang 453007China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 101408China

The photoproduction of the f1(1285)meson off the proton target is investigated within an effective Lagrangian *** t-channelρ-andω-exchange diagrams,u-channel nucleon-exchange diagram,generalized contact term,and s-channel pole diagrams of the nucleon and a minimal number of nucleon resonances are taken into account in constructing the reaction amplitudes to describe the experimental *** different models,that is,the Feynman,Regge,and interpolated Regge models,are employed,where the t-channel reaction amplitudes are constructed in Feynman,Regge,and interpolated Regge types,*** results show that neither the Feynman model with two nucleon resonances nor the interpolated Regge model with one nucleon resonance can satisfactorily reproduce the available data forγp→f1(1285)***,in the Regge model,when any one of the N(1990)7/2^(+),N(2000)5/2^(+),N(2040)3/2^(+),N(2060)5/2^(-),N(2100)1/2^(+),N(2120)3/2^(-),N(2190)7/2^(-),N(2300)1/2^(+),and N(2570)5/2^(-)resonances is considered,the data can be well *** resulting resonance parameters are consistent with those advocated in the Particle Data Group(PDG)*** analysis shows that,in the high-energy region,the peaks of γp→f1(1285)p differential cross sections at forward angles are dominated by the contributions from t-channelρ-andω-exchange diagrams,while in low-energy region,the s-channel pole diagrams of resonances also provide significant contributions to theγp→f1(1285)p cross sections.

关键词： photoproduction reactions effective Lagrangian approach nucleon resonances

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面向新能源波动平抑的储能多参数等价折算配置方法

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电网技术 2024年第4期48卷 1498-1509,I0037页

作者：王睿琪薛熙臻黄阮明艾小猛方家琨文劲宇王晓晖费斐强电磁技术全国重点实验室(华中科技大学) 湖北省武汉市430074 国网上海市电力公司经济技术研究院上海市浦东新区200233

基于储能在参与调节新能源出力随机性和波动性的重要作用,针对由储能种类多样性和参数复杂性导致的储能选型和配置困难问题,提出了一种面向新能源波动平抑的储能快速选型与配置方法。首先,从储能的物理模型本质出发,综合考虑储能的多类... 详细信息

基于储能在参与调节新能源出力随机性和波动性的重要作用,针对由储能种类多样性和参数复杂性导致的储能选型和配置困难问题,提出了一种面向新能源波动平抑的储能快速选型与配置方法。首先,从储能的物理模型本质出发,综合考虑储能的多类型参数,提出了一种储能多参数等价折算的方法;该方法将储能的荷电状态(state of charge,SOC)、寿命、效率和初始投资成本等多参数对比等价折算为功率和容量的配置成本对比,对复杂参数关系进行综合量化表征,实现对储能价值的快速准确评估。然后,为保证新能源出力平滑,建立了不同时间尺度下的新能源波动平抑指标,提出了新能源波动平抑的储能优化配置模型。该模型以储能成本、限电损失费用和新能源波动越限惩罚费用最小化为目标,考虑系统的运行约束与储能约束,实现系统技术和经济性能的最优化。最后,根据某实际算例的波动平抑需求调研了多种应用广泛的储能系统,基于所提储能多参数等价折算方法对不同储能的技术经济参数进行分析与比较,验证了所提的储能选型配置方法和新能源波动平抑模型的有效性和适用性。

关键词：储能参数折算净配置成本储能选型与优化配置新能源波动平抑

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酪酸梭菌活菌散联合四磨汤对厌食症患儿神经肽Y和胃动素水平的影响及疗效观察

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中国微生态学杂志 2015年第12期27卷 1427-1430页

作者：季燕王爱飞台州市妇幼保健院儿科浙江台州318000 仙居县妇幼保健院儿科浙江仙居317300

目的探讨酪酸梭菌活菌散联合四磨汤对厌食症患儿神经肽Y（NPY）和胃动素（MTL）水平的影响及疗效观察。方法选取儿童厌食症患者82例,随机分为观察组和对照组各41例。两组纠正以往不良饮食习惯及予以健胃消食药等常规治疗。观察组加用酪... 详细信息

目的探讨酪酸梭菌活菌散联合四磨汤对厌食症患儿神经肽Y（NPY）和胃动素（MTL）水平的影响及疗效观察。方法选取儿童厌食症患者82例,随机分为观察组和对照组各41例。两组纠正以往不良饮食习惯及予以健胃消食药等常规治疗。观察组加用酪酸梭菌活菌散联合四磨汤治疗,连用6周。其中酪酸梭菌活菌散1.0g/次,2次/d,温开水冲服;四磨汤口服液10mL/次,2-3次/d。对照组患儿加用单用四磨汤治疗,其用法及疗程与观察组相同。分析与检测两组患儿治疗前及治疗6周后血清NPY及MTL指标变化,并评估其临床疗效及随访半年内的复发情况。结果治疗6周后,两组血清NPY和MTL水平较前明显上升（P〈0.05或P〈0.01）,且观察组上升值明显大于对照组（P〈0.05）;同时观察组临床总有效率（95.12%）明显高于对照组（78.05%）（χ^2=5.14,P〈0.05）。对治疗有效者随访半年,观察组39例中复发8例,对照组32例中复发14例。观察组复发率（20.51%）明显低于对照组（43.75%）（χ^2=4.44,P〈0.05）。结论酪酸梭菌活菌散联合四磨汤治疗儿童厌食症的近期疗效显著,增强患儿食欲,提高患儿体重,且其中远期疗效亦较佳,可减少其复发率,作用机制与其能提高血清NPY和MTL指标水平密切相关。

关键词：厌食症儿童酪酸梭菌活菌散四磨汤神经肽Y 胃动素

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铁调素上调活性氧水平促进破骨样细胞分化机制

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中华骨质疏松和骨矿盐疾病杂志 2022年第3期15卷 252-256页

作者：王啸孙婧悦钱晨月王爱飞华俊徐又佳苏州大学附属第二医院骨科骨质疏松症临床中心苏州大学骨质疏松诊疗技术研究所江苏苏州215004 苏州大学附属第一医院肿瘤科江苏苏州215006 苏州大学附属第二医院药剂科江苏苏州215004

目的探讨铁调素对小鼠单核细胞株RAW264.7向破骨样细胞分化过程的影响及活性氧(reactive oxygen species,ROS)在其中的作用。方法常规培养两组RAW264.7,一组作为对照,另一组以1.6μmol/L铁调素(hepcidin,Hepc)干预,以巨噬细胞集落刺激... 详细信息

目的探讨铁调素对小鼠单核细胞株RAW264.7向破骨样细胞分化过程的影响及活性氧(reactive oxygen species,ROS)在其中的作用。方法常规培养两组RAW264.7,一组作为对照,另一组以1.6μmol/L铁调素(hepcidin,Hepc)干预,以巨噬细胞集落刺激因子、核因子-κB受体活化因子配体诱导向破骨样细胞分化,分化能力采用抗酒石酸酸性磷酸酶(tartrate resistant acid phosphatase,TRAP)染色检测。采用免疫荧光(immunofluorescence,IF)检测膜铁转运蛋白(ferroportin,FPN)表达水平,同时检测细胞内铁离子水平差异。二氯二氢荧光素(dichlorodihydrofluorescein,DCFH)荧光探针标记并检测细胞ROS水平差异。抗氧化剂吡咯烷二硫代甲酸铵(pyrrolidine dithiocarbamate ammonium,PDTC)干预后采用TRAP染色检测破骨样细胞分化水平。结果铁调素干预后小鼠破骨样细胞分化能力增强,TRAP阳性染色细胞增多(P<0.001)。IF结果示铁调素干预后,破骨样细胞FPN表达下调。铁含量检测试剂盒检测结果表明铁调素可升高破骨样细胞内铁水平。进一步检测DCFH荧光示铁调素使细胞ROS水平升高。进一步使用抗氧化剂PDTC干预可抑制破骨样细胞分化(P<0.001),降低铁调素对破骨样细胞分化的促进作用。结论铁调素可封闭破骨样细胞胞膜FPN,造成胞内高铁状态,上调ROS水平,最终促进破骨样细胞分化。

关键词：骨质疏松症活性氧铁调素破骨样细胞

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