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Efficacy of short-term multidisciplinary intensive rehabilitation in patients with different Parkinson's disease motor subtypes: a prospective pilot study with 3-month follow-up

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Neural Regeneration Research 2021年第7期16卷 1336-1343页

作者： ke-ke Chen Zhao-hui jin Lei Gao lin Qi Qiao-xia Zhen Cui liu Ping wang Yong-hong liu Rui-Dan wang Yan-Jun liu jin-Ping Fang Yuan Su xiao-Yan Yan Ai-xian liu Bo-Yan Fang Beijing Rehabilitation Medical College Capital Medical UniversityBeijingChina Parkinson Medical Center Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina Peking University Clinical Research Institute BeijingChina

Parkinson's disease(PD) can be classified into three motor-based subtypes: postural instability/gait difficulty(PIGD), tremor dominant(TD), and *** neuropathophysiological mechanisms of the three motor subtypes are different, which may lead to different responses to ***-nine patients with idiopathic Parkinson's disease(Hoehn–Yahr stage ≤ 3) were screened from 436 patients with Parkinsonism recruited through outpatient services and the *** to the Movement Disorder Society Unified Parkinson's Disease Rating Scale(MDS-UPDRS) TD/PIGD ratio, the patients were divided into PIGD(TD/PIGD ≤ 0.09;n = 36), TD(TD/PIGD ≥1.15;n = 19), and indeterminate(TD/PIGD = 0.90–1.15;n = 14) *** patients received 2 weeks of multidisciplinary intensive rehabilitation treatment(MIRT) during hospitalization, as well as a remote home rehabilitation health education *** with the scores at admission, all patients showed significant improvements in their MDS-UPDRS III score, walking ability, balance, and posture control at ***, the MDS-UPDRS III score improvement was greater in the PIGD group than in the TD *** follow-up data, collected for 3 months after discharge, showed that overall symptom improvement in each group was maintained for 1–3 ***, there were no significant differences in the duration or grade effects of symptom improvement among the three *** findings suggest that 2 weeks of MIRT is effective for improving motor performance in all three motor *** in the PIGD group had a better response after hospitalization than those in the TD *** study was approved by the Institutional Ethics Committee of Beijing Rehabilitation Hospital of Capital Medical University of China(approval No.2018 bkky022) on May 7, 2018 and registered with the Chinese Clinical Trial Registry(registration *** CTR1900020771) on January 19, 2019.

关键词： balance gait motor neurodegeneration Parkinson's disease posture rehabilitation tremor

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Bufalin-induced cardiotoxicity: new findings into mechanisms

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Chinese Journal of Natural Medicines 2020年第7期18卷 550-560页

作者： li Min wang Xi-Jie ZHAO Qi wang Jia-xian XING hong-Yan ZHANG Yi-Zhe ZHANG Xue-xia ZHI Yang-Yang li hua MA jing China State Institutes of Pharmaceutical Industry National Shanghai Center for New Drug Safety Evaluation and Research Shanghai 201203China Shanghai InnoStar Bio-Tech Co. Ltd.Shanghai 201203China Department of Cardiology the First Affiliated Hospital of Nanjing Medical UniversityNanjing Medical UniversityNanjing 211100China Department of Research and Development HELP Stem Cell TherapeuticsNanjing 211100China

Bufalin is one of the main pharmacological and toxicological components of Venenum Bufonis and many traditional Chinese medicine *** cardiotoxicity clearly limits its application to patients living in ***,an investigation of its toxicological mechanism is helpful for new drug development and treatment of the related clinical adverse *** investigate the cardiotoxicity of bufalin using human induced pluripotent stem cells-derived cardiomyocytes(hiPSC-CMs)(0.003–0.1μmol·L–1),human induced pluripotent stem cells-derived cardiomyocytes(hiPSC-CMs)(0.03–0.3μmol·L–1)and eight human cardiac ion channel currents(0.01–100μmol·L–1)combined with an impedance-based bioanalytical and patch clamp *** effect of bufalin on the contractility in hiPSC-CMs,which has been shown to strengthen myocardial contractility,accelerate conduction,and increase beating rate at the earlier stage of administration,whereas weakened myocardial contractility,abolished conduction,and ceased beating rate at the later stage of *** decreased the action potential duration(Action potential duration at 30%,50%and 90%repolarization),cardiac action potential amplitude,and maximal depolarization rate and depolarized the resting membrane potential of *** beating rates of hiPSC-CMs were markedly increased at 0.03μmol·L–1,while were weakened at 0.3μmol·L–1 after *** blocks INav1.5 in a concentration-dependent manner with half maximal inhibitory concentration of 74.5μmol·L–*** respectively increased the late sodium current and Na+-Ca2+exchange current with a concentration for 50%of maximal effect of 2.48 and 66.06μmol·L–1 in ***,bufalin showed no significant effects on other cardiac ion channel *** enhancement of the late sodium current is one of the main mechanism for cardiotoxicity of bufalin.

关键词： Bufalin Cardiomyocytes Cardiotoxicity Ion channels Stem cell

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Study on PCR rapid molecular detection technique of Meloidogyne vitis

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Journal of Integrative Agriculture 2022年第11期21卷 3408-3416页

作者： YANG Yan-mei liU Pei li hong-mei PENG huan DU xia DONG Ye hu xian-qi College of Plant Protection Yunnan Agricultural UniversityKunming 650201.P.R.China State key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan Agricultural UniversityKunming 650201P.R.China Institute of Agricultural Environment&Resources Yunnan Academy of Agricultural SciencesKunming 650205P.R.China International College Yunnan Agricultural UniversityKunming 650201P.R.China State key Laboratory for Biology of Plant Disease and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China

Meloidogyne vitis is a new root-knot nematode parasitic on grape root in Yunnan Province,*** order to establish a rapid,reliable and specific molecular detection method for ***,the species-specific primers were designed with rDNA-ITS(ribosomal DNA internal transcribed spacer)gene fragment as the *** reaction system was optimized and the reliability,specificity and sensitivity of primer were testified,therefore,a rapid PCR detection method for *** was *** result showed that the optimal annealing temperature of the primers was 53℃,which was suitable for the detection of different life stages of *** test showed that the specific fragment size of 174 bp was obtained from ***,but other five non-target nematodes did not have any amplification bands,thus effectively distinguish *** and the other five species,and could specifically detect the *** from mixed *** test showed that this PCR technique could detect the DNA of a single second-stage juvenile(J_(2))and 10^(-4)***,this PCR technique could be used to detect directly *** from soil *** rapid,sensitive and specific PCR molecular detection technique could be used for the direct identification of a single J_(2)of *** and the detection of *** in mixed nematode populations and the detection of two J_(2)s or one male in 0.5 g soil samples,which will provide technical support for the investigation of the occurrence and damage of *** and the formulation of efficient green co ntrol strategies.

关键词： Meloidogyne vitis PCR rapid detection reliability specificity sensitivity

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面向DAG任务的分布式智能计算卸载和服务缓存联合优化

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中山大学学报（自然科学版）（中英文） 2025年第1期64卷 71-82页

作者：李云南子煜姚枝秀夏士超鲜永菊重庆邮电大学通信与信息工程学院重庆400065 重庆邮电大学软件工程学院重庆400065

建立了一种有向无环图(DAG,directed acyclic graph)任务卸载和资源优化问题,旨在应用最大可容忍时延等约束实现系统能耗最小化。考虑到网络中计算请求高度动态、完整的系统状态信息难以获取等因素,最后使用多智能体深度确定性策略梯度(... 详细信息

建立了一种有向无环图(DAG,directed acyclic graph)任务卸载和资源优化问题,旨在应用最大可容忍时延等约束实现系统能耗最小化。考虑到网络中计算请求高度动态、完整的系统状态信息难以获取等因素,最后使用多智能体深度确定性策略梯度(MADDPG,multi-agent deep deterministic policy gradient)算法来探寻最优的策略。相比于现有的任务卸载算法,MADDPG算法能够降低14.2%至40.8%的系统平均能耗,并且本地缓存命中率提高3.7%至4.1%。

关键词：移动边缘计算多智能体深度强化学习计算卸载资源分配服务缓存

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Ecological operation for Three Gorges Reservoir

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Water Science and Engineering 2011年第2期4卷 143-156页

作者： Wen-xian GUO hong-xiang wang Jian-xin XU Zi-qiang xia North China University of Water Conservancy and Electric Power Zhengzhou 450011 P. R. China State key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai Univerxity Nanjing 210098 R R. China

The traditional operation of the Three Gorges Reservoir has mainly focused on water for flood control, power generation, navigation, water supply, and recreation, and given less attention to the negative impacts of reservoir operation on the river ecosystem. In order to reduce the negative influence of reservoir operation, ecological operation of the reservoir should be studied with a focus on maintaining a healthy river ecosystem. This study considered ecological operation targets, including maintaining the river environmental flow and protecting the spawning and reproduction of the Chinese sturgeon and four major Chinese carps. Using flow data from 1900 to 2006 at the Yichang gauging station as the control station data for the Yangtze River, the minimal and optimal river environmental flows were analyzed, and eco-hydrological targets for the Chinese sturgeon and four major Chinese carps in the Yangtze River were calculated. This paper proposes a reservoir ecological operation model, which comprehensively considers flood control, power generation, navigation, and the ecological environment. Three typical periods, wet, normal, and dry years, were selected, and the particle swarm optimization algorithm was used to analyze the model. The results show that ecological operation modes have different effects on the economic benefit of the hydropower station, and the reservoir ecological operation model can simulate the flood pulse for the requirements of spawning of the Chinese sturgeon and four major Chinese carps. According to the results, by adopting a suitable re-operation scheme, the hydropower benefit of the reservoir will not decrease dramatically while the ecological demand is met. The results provide a reference for designing reasonable operation schemes for the Three Gorges Reservoir.

关键词： ecological operation environmental flow Three Gorges Reservoir particle swarm optimization algorithm

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Mechanical properties of nanocrystalline nanoporous gold complicated by variation of grain and ligament: A molecular dynamics simulation

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Science China(Technological Sciences) 2018年第9期61卷 1353-1363页

作者： li JieJie xian Yuehui ZHOU hongJian WU RunNi hu GuoMing xia Re key Laboratory of Hydraulic Machinery Transients Ministry of Education Wuhan University hubei key Laboratory of Waterjet Theory and New Technology Wuhan University

A series of large-scale molecular dynamics(MD) simulations has been performed to study the effects of grain size and ligament diameter on the mechanical properties of nanocrystalline nanoporous gold. Such simulations indicate that the principal deformation mechanism is a combination of grain boundary sliding, grain rotation and dislocation movement. The results of uniaxial tensile tests reveal the presence of a reverse Hall-Petch relation between strength and nominal grain size, rather than the conventional Hall-Petch relationship in the present range of nominal grain size(7.9–52.7 nm). An increase of flow stress may possibly attribute to the lower total proportion of grain boundary sliding and grain rotation in the deformation of samples with larger grain size. The Young's modulus shows a linear relation with the reciprocal of nominal grain size, which depends largely on the volume fraction of grain boundaries and thus decreasing grain size leads to relatively lower Young's modulus. MD simulations on samples with ligament diameter ranging from 4.07 to 8.10 nm are also carried out and results show that the increasing ligament diameter resulted in decreased flow stress and increased Young's modulus.

关键词： nanocrystalline nanoporous gold grain-size effect ligament-size effect mechanical properties molecular dynamics

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LDL-C levels,lipid-lowering treatment and recurrent stroke in minor ischaemic stroke or TIA

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Stroke & Vascular Neurology 2022年第4期7卷 276-284页

作者： Yuesong Pan Runqi wangqin Hao li Aoming jin Jiejie li jinxi lin xia Meng Ying xian Daniel T Laskowitz Yongjun wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Neurology Duke University Medical CenterDurhamNCUSA Department of Neurology UT Southwestern Medical CenterDallasTexasUSA Duke Clinical Research Institute DurhamNorth CarolinaUSA Advanced Innovation Center for human Brain Protection Capital Medical UniversityBeijingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina

Background and purpose Dyslipidaemia is a major risk factor for ischaemic stroke and transient ischaemic attack(TIA).This study aimed to investigate the association between baseline low-density lipoprotein cholesterol(LDL-C)level,lipid-lowering treatment and short-term risk of new stroke in patients with a minor ischaemic stroke or *** We derived data from the Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events *** with a minor stroke or TIA were categorised by LDL-C level at baseline(lipid-lowering treatment after symptom *** primary outcome was a new ischaemic stroke at 3 *** association of baseline LDL-C level,lowering treatment and outcomes were *** Among 3027 patients,2154(71.2%)patients had an initial LDL-C≥2.6 mmol/L,of which 1267(41.9%)received lipid-lowering *** LDL-C level was associated with a higher risk of new ischaemic stroke at 3 months in patients without lipid-lowering treatment(***=1.35,95%CI:1.19 to 1.53),but not in those with lipid-lowering treatment(***=0.99,95%CI:0.82 to 1.19)(p for interaction=0.007).Patients with LDL-C≥2.6 mmol/L had a numerically higher risk of ischaemic stroke(11.8%vs 8.0%,***=1.37,95%CI:0.96 to 1.96)in those without lipid-lowering *** patients with LDL-C≥2.6 mmol/L,lipid-lowering treatment was associated with reduced risk of ischaemic stroke at 3 months(7.9%vs 11.8%;***=0.54,95%CI:0.39 to 0.75).Conclusions Elevated untreated baseline LDL-C level was associated with an increased short-term risk of ischaemic stroke among patients presenting with minor ischaemic stroke or *** was potential benefit of lipid-lowering treatment in minor stroke or TIA patients with LDL-C≥2.6 mmol/*** registration number NCT00979589.

关键词： ischaemic treatment Acute

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DNA-binding Studies of Two Silver(I)-sulfonate Complexes Constructed by In Situ Reaction

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Chinese Journal of Structural Chemistry 2016年第2期35卷 219-226页

作者： wang Gui-xian xia Yan wang xiao-Juan FENG Yun-Long Department of Chemistry and Chemical Engineering Lishui University key Laboratory of the Ministry of Education for Advanced Catalysis Material Institute of Physical ChemistryZhejiang Normal University

Two silver（I）-sulfonate complexes,[Ag（NO3）（4,4＇-bipy）][Ag（HL）（4,4＇-bipy）]·2H2O（1） and[Ag（H2O）（4,4＇-bipy）][AgL（4,4＇-bipy）]·2H2O（2）,have been synthesized by in situ reaction（H2L = 2-formylbenzenesulfonic acid,4,4-bipy = 4,4-bipyridine）.1 displays two parallel 1D chains expending to a 3D supramolecule by n—n interactions and O-H…O hydrogen bonds,in which the[Ag（NO3）]or[Ag（HL）]units are joined by bridging 4,4＇-bipy molecules,*** interactions between the complexes and DNA were studied by means of fluorescence spectra and surface-enhanced Raman scattering（SERS） *** special configuration and intercalation effects between 1 and DNA are stronger than that between 2 and DNA.

关键词： in situ synthesis Ag(I) complex DNA-binding

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Molecular structure and phylogenetic analyses of the complete chloroplast genomes of three original species of Pyrrosiae Folium

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Chinese Journal of Natural Medicines 2020年第8期18卷 573-581页

作者： YANG Chu-hong liU xia CUI Ying-xian NIE li-Ping liN Yu-lin WEI Xue-Ping wang Yu YAO hui key Lab of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People’s Republic of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China School of Chemistry Chemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070China Engineering Research Center of Chinese Medicine Resources Ministry of EducationBeijing 100193China

Pyrrosia petiolosa,Pyrrosia lingua and Pyrrosia sheareri are recorded as original plants of Pyrrosiae Folium(PF)and commonly used as Chinese herbal *** to the similar morphological features of PF and its adulterants,common DNA barcodes cannot accurately distinguish PF *** of the chloroplast(cp)genome is widely used in species identification,molecular marker and phylogenetic ***,we determined the complete cp genomes of three original species of PF via highthroughput sequencing *** three cp genomes exhibited a typical quadripartite structure with sizes ranging from 158165 to 163026 *** cp genomes of *** and *** encoded 130 genes,whilst that of *** encoded 131 *** complete cp genomes were compared,and five highly divergent regions of pet A-psb J,mat K-rps16,ndh C-trn M,psb M-pet N and psa Cndh E were screened as potential DNA barcodes for identification of Pyrrosia genus *** phylogenetic tree we obtained indicated that *** and *** are clustered in a single clade and,thus,share a close *** study provides invaluable information for further studies on the species identification,taxonomy and phylogeny of Pyrrosia genus species.

关键词： Complete chloroplast genome Pyrrosia petiolosa Pyrrosia lingua Pyrrosia sheareri Identification Phylogenetic relationship

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Performance improvement of Ethylene-Vinyl Acetate Copolymer Pour Point Depressant(EVA PPD)by adding small dosages of Laurylamine(LA)

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Petroleum Science 2022年第5期19卷 2472-2482页

作者： Xue xia Chuan-xian li Guang-Yu Sun ke-ke Zhao Jie Zhang Bo Yao Fei Yang College of Pipeline and Civil Engineering China University of PetroleumQingdaoShandong266580PR China Shandong Provincial key Laboratory of Oil&Gas Storage and Transportation Safety QingdaoShandong266580PR China China Petroleum Engineering&Construction Corp.Beijing Company PR China

Lauramine is widely considered to be an asphaltene flocculant,but its effect on the modification of crude oil by PPDs has been little *** this paper,the effect of LA dosage on the rheology improvement of EVA PPDs(100 ppm)on Qinghai waxy crude oil was investigated through rheological measurement,wax precipitating analysis,granularity test and resins/asphaltenes FTIR *** with pure EVA,the compounding of LA and EVA obviously enhances the agglomeration degree and reduces the number of fine wax crystals,thus further enhancing the rheology of the oil samples,and the best performance is at the LA dosage of 200 *** relatively small LA dosages,the LA facilitates the adsorption of EVA molecules on the asphaltene surfaces,which favors the becoming of EVA/asphaltenes composite particles;but at relatively high LA dosages,the LA makes the asphaltenes more aggregated and disturbs the EVA adsorption on the asphaltenes,which is adverse for the formation of EVA/asphaltenes compound *** compound particles can serve as wax precipitating templates and significantly influence its morphology,thus further improving the crude oil *** consequence,the rheology improvement of EVA PPDs on Qinghai waxy crude oil first increases and then decreases with increasing the LA dosage.

关键词： Waxy crude oil EVA PPD Laurylamine Asphaltenes Synergistic effect

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