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Genetic mutations associated with sensitivity to neoadjuvant chemotherapy in metastatic colon cancer:A case report and review of literature

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World Journal of Clinical Cases 2021年第24期9卷 7099-7109页

作者： Long Zhao quan wang Shi-dong Zhao Jing Zhou Ke-Wei Jiang Ying-Jiang Ye shan wang Zhan-Long Shen Department of Gastroenterological Surgery Laboratory of Surgical OncologyBeijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment ResearchPeking University People's HospitalBeijing 100044China

BACKGROUND Colorectal liver metastases(CLM)occur in 15%-30%of patients with colorectal cancer(CRC).Advancements in next generation sequencing(NGS)can provide more precise prognoses for cancer patients and help guide clinical ***,the genetic variants that predict high sensitivity to neoadjuvant chemotherapy remain unclear,especially in patients with *** aim of this study was to identify the relevant genetic variants in a single CLM patient and to summarize the current evidence on mutations and single nucleotide polymorphisms(SNPs)that objectively predict sensitivity to neoadjuvant *** SUMMARY A 76-year-old male patient,who was diagnosed as stage IV colon cancer with liver metastases,was found to have APC/TP53/KRAS *** showed a good therapeutic response to 12 courses of oxaliplatin regimens combined with *** analysis of the patient identified 5 genes with 7 detected SNPs that may be related to a better response to chemotherapy *** addition,a critical literature review was performed based on a standardized appraisal form after selecting the ***,21 eligible studies were appraised to assess the association between gene mutations and good *** in KRAS,TP53,SMAD4,and APC were identified as being associated with a poor response to chemotherapy drugs,whereas mutations of CREBBP and POLD1 were associated with longer overall *** NGS can identify precise predictors of response to neoadjuvant chemotherapy,leading to improved outcomes for CRC patients.

关键词： Colorectal liver metastases Next generation sequencing Neoadjuvant chemotherapy Genetic variants Case report

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Improvement on AMS Measurement of ^(236)U at CIAE

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Chinese Physics Letters 2012年第8期29卷 60-64页

作者： wang Xiang-Gao HE Ming dong Ke-Jun JIANG shan China Institute of Atomic Energy Beijing 102413 College of Physics Science and Technology Guangxi UniversityNanning 530004

In order to improve the detection efficiency and sensitivity for ^(236)U measurement at China Institute of Atomic Energy(CIAE)accelerator mass spectrometry(AMS)system to meet the requirement of some applications,we present some new improvements of the measurement method for AMS measurement of ^(236) at CIAE *** main features of the method include:(i)measurement optimization;(ii)improvement of the TOF time resolution~500 *** on these improvements,the sensitivity is~10^(-11) for ^(236)/^(238) in the present work,higher than before(^(236)/^(238)~5×10^(-10)).

关键词： method system optimization

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C-X-C chemokine receptor type 7 antibody enhances neural plasticity after ischemic stroke

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Neural Regeneration Research 2023年第9期18卷 1976-1982页

作者： Xiao-Qian Zhang Xiao-Yin wang bing-Chao dong Mei-Xuan Li Yu wang Ting Xiao shan-shan Zhao Department of Neurology The First Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Key Laboratory of Immunodermatology Ministry of HealthMinistry of EducationShenyangLiaoning ProvinceChina

Stromal cell-derived factor-1 and its receptor C-X-C chemokine receptor 4(CXCR4) have been shown to regulate neural regeneration after *** r,whether stromal cell-derived factor-1 receptor CXCR7,which is widely distributed in the develo ping and adult central nervous system,participates in neural regeneration remains poorly unde *** this study,we established rat models of focal cerebral ischemia by injecting endothelin-1 into the cerebral co rtex and *** on day 7 after injury,CXCR7-neutralizing antibody was injected into the lateral ventricle using a micro drug delivery system for 6 consecutive *** results showed that CXCR7-neutralizing antibody increased the total length and number of sprouting co rticospinal tra ct fibers in rats with cerebral ischemia,increased the expression of vesicular glutamate transporter 1 and growth-related protein 43,marke rs of the denervated spinal cord synapses,and promoted the differentiation and maturation of oligodendrocyte progenitor cells in the *** addition,CXCR7 antibody increased the expression of CXCR4 in the striatum,increased the protein expression of RAS and ERK1/2 associated with the RAS/ERK signaling pathway,and im proved rat motor *** findings suggest that CXCR7 improved neural functional recovery after ischemic stroke by promoting axonal regeneration,synaptogenesis,and myelin regeneration,which may be achieved by activation of CXCR4 and the RAS/ERK1/2 signaling pathway.

关键词： axonal regeneration cerebral ischemia C-X-C chemokine receptor 4 CXCR7 antibody neural plasticity RAS/ERK pathway remyelination stroke stromal cell-derived factor-1 synaptogenesis

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半夏厚朴汤加减治疗甲状腺结节的临床疗效分析

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系统医学 2024年第6期9卷 33-36页

作者：单昌飞郭松胥栋徐州市贾汪区人民医院普外二科江苏徐州221011

目的分析半夏厚朴汤加减治疗甲状腺结节的临床疗效。方法选取2021年1月—2022年12月徐州市贾汪区人民医院治疗的64例甲状腺结节患者为研究对象,按照随机数表法分成两组,对照组(32例)采用左旋甲状腺素治疗,观察组(32例)在此基础上加用半... 详细信息

目的分析半夏厚朴汤加减治疗甲状腺结节的临床疗效。方法选取2021年1月—2022年12月徐州市贾汪区人民医院治疗的64例甲状腺结节患者为研究对象,按照随机数表法分成两组,对照组(32例)采用左旋甲状腺素治疗,观察组(32例)在此基础上加用半夏厚朴汤加减治疗,比较两组临床疗效、中医证候评分、甲状腺结节最大直径、血清促甲状腺素(Thyroid Stimulating Hormone,TSH)。结果观察组治疗总有效率为90.63%,高于对照组的65.63%,差异有统计学意义(χ^(2)=4.480,P0.05)。结论半夏厚朴汤加减治疗甲状腺结节的疗效好,可减小甲状腺结节直径、改善临床症状,且安全性高。

关键词：半夏厚朴汤甲状腺结节左旋甲状腺素

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Uncertainty in illness and coping styles:Moderating and mediating effects of resilience in stroke patients

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World Journal of Clinical Cases 2021年第30期9卷 8999-9010页

作者： Zi-Ting Han Hui-Min Zhang Yi-Ming wang shan-shan Zhu dong-Yang wang School of Nursing Xinxiang Medical UniversityXinxiang 453000Henan ProvinceChina School of International Education Xinxiang Medical UniversityXinxiang 453000Henan ProvinceChina Department of Nursing School of PharmacyChangzhou UniversityChangzhou 213000Jiangsu ProvinceChina Faculty of Nursing Mahidol UniversityNakhon Pathom 73170Thailand

BACKGROUND Stroke has a great influence on the patient’s mental health,and reasonable psychological adjustment and disease perception can promote the recovery of mental *** To explore the relationships among resilience,coping style,and uncertainty in illness of stroke *** A retrospective study was used to investigate 154 stroke patients who were diagnosed and treated at eight medical institutes in Henan province,China from October to December *** used the Mishel Uncertainty in Illness Scale,the Connor-Davidson Resilience Scale,and the Medical Coping Modes Questionnaire to test the uncertainty in illness,resilience,and coping style,*** Resilience had a significant moderating role in the correlation between coping style and unpredictability and information deficiency for uncertainty in illness(P<0.05).Further,the tenacity and strength dimensions of resilience mediated the correlation between the confrontation coping style and complexity,respectively(P<0.05).The strength dimension of resilience mediated the correlation between an avoidance coping style and the unpredictability of uncertainty in illness(P<0.05),as well as correlated with resignation,complexity,and unpredictability(P<0.05).CONCLUSION Resilience has moderating and mediating roles in the associations between coping style and uncertainty in illness,indicating that it is vital to improve resilience and consider positive coping styles for stroke patients in the prevention and control of uncertainty in illness.

关键词： Stroke Resilience,Psychological Coping styles Uncertainty in illness

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Discovery of a new Proterozoic paleo-reservoir and its oil source in the Jianchang Sag,Yanliao Faulted-Depression Zone,North China

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Petroleum Science 2022年第5期19卷 1927-1938页

作者： Hong Xiao Mei-Jun Li Tie-Guan wang dong-Xia Chen Wu-Jiang Kang Yan-shan wang State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China College of Geosciences China University of PetroleumBeijing102249China Research Institute of Petroleum Exploration and Development Liaohe Oilfield CompanyPetroChinaPanjinLiaoning 124010China

The discovery of many Proterozoic primary oil and gas reservoirs around the world testifies that the Meso-Neoproterozoic petroleum is an energy resources realm worthy of *** paper firstly reports the occurrence of hydrocarbon accumulations in the Neoproterozoic Luotuoling Formation in the Jianchang Sag,the Yanliao Faulted-Depression *** observation shows that the lower sandstone member of the Luotuoling Formation contains yellow fluorescent liquid hydrocarbons,while the upper sandstone member is rich in solid *** analysis of the biomarkers and isotopic compositions reveals that the upper and lower reservoirs have different oil *** bitumen in the lower reservoir is rich in C_(19)-C_(20)tricyclic terpanes(TTs),13α(n-alkyl)-tricyclic terpanes and rearranged hopanes,but lacks gammacerane and steranes and depletes ^(13)C isotope(-33.4‰to-30.6‰).This is consistent with the properties of the Hongshuizhuang Formation source *** upper reservoir bitumen has C_(23)TT as the major peak among C_(19)-C_(23)TTs,lacks 13α(n-alkyl)-tricyclic terpanes,has a low abundance of rearranged hopanes,obvious distribution of gammacerane and steranes,and depletion of the^(13)C isotope;essentially the same as the Gaoyuzhuang Formation source *** discovery of oil seepage in the Luotuoling Formation of the Han-1 well is a promising indicator of the Precambrian oil and gas exploration potential of the Jianchang Sag.

关键词： Proterozoic paleo-reservoir Biomarkers Carbon isotope Oil-source correlation Jianchang sag

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大型乙烯裂解炉用低NO_(x)燃烧器的结构优选

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化工机械 2024年第1期51卷 37-45,83页

作者：李宁李金科董金善南京工业大学机械与动力工程学院天华化工机械及自动化研究设计院有限公司

随着大能力大型化裂解炉的不断发展,国内首台单炉膛20万吨/年产能乙烯裂解炉对燃烧器提出了更高的设计要求,在稳定燃烧的同时还要满足特定的工艺要求和严苛的环保要求。采用CFD技术和热态试验方法优选新型乙烯裂解炉用低NO_(x)燃烧器,... 详细信息

随着大能力大型化裂解炉的不断发展,国内首台单炉膛20万吨/年产能乙烯裂解炉对燃烧器提出了更高的设计要求,在稳定燃烧的同时还要满足特定的工艺要求和严苛的环保要求。采用CFD技术和热态试验方法优选新型乙烯裂解炉用低NO_(x)燃烧器,通过数值分析方法研究不同底部与侧壁供热比(底侧比)下裂解炉内的燃烧状态(火焰形状、火焰长度、炉内温度分布及NO_(x)排放量等),结果表明:在底侧比为70:30时燃烧状态最优,炉膛内温度分布均匀且满足工艺要求和环保要求。在热态试验炉上对最终设计工况(底侧比72:28)进行热态试验,结果显示:炉内燃烧状态良好,温度分布均匀且满足热通量曲线,NO_(x)排放量也较低。

关键词：裂解炉燃烧器低NO_(x) 数值分析热态试验底侧比

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功能化 MgFe-LDH吸附环丙沙星的研究

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环境科学与技术 2024年第5期47卷 18-36页

作者：萧珊滕月吴懂孔雯静刘志英徐炎华南京工业大学环境科学与工程学院江苏南京211800 南京工业大学土木工程学院江苏南京211800

该文采用水热法将镁铁层状双金属氢氧化物(MgFe-LDH)负载到活性炭纤维(ACF)上,制得MgFe-LDH/ACF(MFLA),并将ACF和MFLA作为吸附剂用于考察溶液初始pH、吸附时间、反应温度等对环丙沙星(CIP)吸附效果的影响。结果表明,MgFe-LDH已被固定在... 详细信息

该文采用水热法将镁铁层状双金属氢氧化物(MgFe-LDH)负载到活性炭纤维(ACF)上,制得MgFe-LDH/ACF(MFLA),并将ACF和MFLA作为吸附剂用于考察溶液初始pH、吸附时间、反应温度等对环丙沙星(CIP)吸附效果的影响。结果表明,MgFe-LDH已被固定在ACF上,且在Mg^(2+)和Fe^(3+)摩尔比为3∶1时制备的最佳MFLA(3-MFLA)晶型更完整。当CIP的初始浓度为20 mg/L时,ACF和3-MFLA分别在360、60 min时达到吸附平衡,其吸附量分别为3.00 mg/g和19.31 mg/g。拟二级动力学模型和Langmuir等温线模型均可准确地描述ACF和3-MFLA对CIP的吸附行为。CIP主要通过静电引力、氢键、离子交换、π-π相互作用和金属-碳π相互作用被3-MFLA吸附。此外,抗干扰实验、循环再生实验及固定床动态吸附实验结果均表明3-MFLA具有较高的实际应用潜力。

关键词：活性炭纤维层状双金属氢氧化物吸附环丙沙星改性

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大跨度三塔自锚式悬索桥横向减震体系的研究

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公路 2024年第8期69卷 49-53页

作者：李盘山陈张伟周宁欧光鲲刘春香王冬山东易方达建设项目管理有限公司济南市250000 上海市政工程设计研究总院(集团)有限公司上海市200092 济南城市建设集团有限公司济南市250000

以在建某悬索桥为工程背景,采用大型有限元软件SAP2000建立全桥三维有限元杆系模型,研究滑动支座+钢阻尼器的横向组合减震体系的减震特性,通过分析优化选取恰当的钢阻尼器参数进行数值模拟分析。与横向固定约束体系对比,本研究给出的横... 详细信息

以在建某悬索桥为工程背景,采用大型有限元软件SAP2000建立全桥三维有限元杆系模型,研究滑动支座+钢阻尼器的横向组合减震体系的减震特性,通过分析优化选取恰当的钢阻尼器参数进行数值模拟分析。与横向固定约束体系对比,本研究给出的横向组合减震体系能显著减小各桥墩和桥塔基础的地震需求,同时能不同程度地减小各桥墩和桥塔关键截面的剪力和弯矩,并能够有效地控制墩、梁的相对位移。因此,本研究提出的横向组合约束体系是较为合理的,可为同类型桥梁的减震提供借鉴参考。

关键词：悬索桥钢阻尼器横向组合减震体系有限元分析

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Mn^(2+)促进Bacillus altitudinis LZP02生物膜形成

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生物技术通报 2024年第3期40卷 251-260页

作者：单馨黄东慧徐伟慧王志刚陈文晶胡云龙齐齐哈尔大学生命科学与农林学院齐齐哈尔161006 黑龙江省农业微生物制剂产业化技术创新中心齐齐哈尔161006 黑龙江省农用生物制剂产业化协同创新中心齐齐哈尔161006

【目的】Bacillus altitudinis LZP02是一株水稻根际促生菌(PGPR),能定殖于水稻根部,形成生物膜,且Mn^(2+)对LZP02菌株生物膜形成具有促进作用,但调控机制尚不明确,旨在探究Mn^(2+)对LZP02菌株生物膜形成的促进机制。【方法】采用结晶... 详细信息

【目的】Bacillus altitudinis LZP02是一株水稻根际促生菌(PGPR),能定殖于水稻根部,形成生物膜,且Mn^(2+)对LZP02菌株生物膜形成具有促进作用,但调控机制尚不明确,旨在探究Mn^(2+)对LZP02菌株生物膜形成的促进机制。【方法】采用结晶紫染色法进行生物膜定量分析、蒽酮-硫酸法测定胞外多糖产量、扫描电镜(SEM)观察LZP02菌株在水稻根际定殖情况、转录组学测序技术分析差异表达基因(DEGs)。【结果】添加4 mmol/L Mn^(2+)和8 mmol/L Mn^(2+)显著提高了LZP02菌株的成膜能力和胞外多糖产量,扫描电镜发现4 mmol/L Mn^(2+)和8 mmol/L Mn^(2+)提高了LZP02菌株在水稻根际的定殖能力,随着Mn^(2+)浓度的增加,DEGs数量显著增多,其主要富集在芽孢形成、毒素代谢途径和双组分系统中。1 mmol/L Mn^(2+)和4 mmol/L Mn^(2+)处理组发现skf操纵子中基因的表达均上调。扫描电镜观察发现在1 mmol/L Mn^(2+)和4 mmol/L Mn^(2+)处理组中LZP02菌体存在损伤。4 mmol/L Mn^(2+)处理组双组分系统中KinE和Spo0A基因均显著上调。【结论】Mn^(2+)通过“嗜食同类”和双组分系统中KinE基因激活Spo0A~P提高了菌株LZP02的成膜能力。

关键词： Bacillus altitudinis LZP02 生物膜 Mn^(2+)

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