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Peroxisome proliferator-activated receptor gamma coactivator-1(PGC-1)family in physiological and pathophysiological process and diseases

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1249-1292页

作者： Lu Qian Yanli Zhu Chao Deng Zhenxing Liang Junmin chen ying chen Xue wang Yanqing Liu Ye Tian Yang Yang Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases Xi'an No.3 HospitalThe Affiliated Hospital of Northwest UniversityNorthwest UniversityXi'an 710021China Xi'an Key Laboratory of Innovative Drug Research for Heart Failure Faculty of Life Sciences and MedicineNorthwest University229 Taibai North RoadXi'an 710069China Department of Cardiovascular Surgery The First Affiliated Hospital of Xi'an Jiaotong University277 Yanta West RoadXi'an 710061China Department of Cardiothoracic Surgery The First Affiliated Hospital of Zhengzhou University1 Jianshe EastZhengzhou 450052China Department of Hematology The First Affiliated Hospital of Xi'an JiaotongUniversity277 Yanta West RoadXi'an 710061China

Peroxisome proliferator-activated receptor gamma coactivator-1(PGC-1)family(PGC-1s),consisting of three members encompassing PGC-1a,PGC-1β,and PGC-1-related coactivator(PRC),was discovered more than a quarter-century ***-1s are essential coordinators of many vital cellular events,including mitochondrial functions,oxidative stress,endoplasmic reticulum homeostasis,and *** evidence has shown that PGC-1s are implicated in many diseases,such as cancers,cardiac diseases and cardiovascular diseases,neurological disorders,kidney diseases,motor system diseases,and metabolic *** the upstream modulators and co-activated partners of PGC-1s and identifying critical biological events modulated by downstream effectors of PGC-1s contribute to the presentation of the elaborate network of ***,discussing the correlation between PGC-1s and diseases as well as summarizing the therapy targeting PGC-1s helps make individualized and precise intervention *** this review,we summarize basic knowledge regarding the PGC-1s family as well as the molecular regulatory network,discuss the physio-pathological roles of PGc-1s in human diseases,review the application of PGC-1s,including the diagnostic and prognostic value of PGC-1s and several therapies in pre-clinical studies,and suggest several directions for future *** review presents the immense potential of targeting PGC-1s in the treatment of diseases and hopefully facilitates the promotion of PGC-1s as new therapeutic targets.

关键词： diseases life precise

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Bromocriptine protects perilesional spinal cord neurons from lipotoxicity after spinal cord injury

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Neural Regeneration Research 2024年第5期19卷 1142-1149页

作者： ying Peng Zhuoxuan Li Zhiyang Zhang yinglun chen Renyuan wang Nixi Xu Yuanwu Cao Chang Jiang Zixian chen Haodong Lin Trauma Center Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Orthopedics Zhongshan HospitalFudan UniversityShanghaiChina Department of Rehabilitation Medicine Shanghai Geriatric Medical CenterShanghaiChina

Recent studies have revealed that lipid droplets accumulate in neurons after brain injury and evoke lipotoxicity,damaging the ***,how lipids are metabolized by spinal cord neurons after spinal cord injury remains ***,we investigated lipid metabolism by spinal cord neurons after spinal cord injury and identified lipid-lowering compounds to treat spinal cord *** found that lipid droplets accumulated in perilesional spinal cord neurons after spinal cord injury in *** droplet accumulation could be induced by myelin debris in HT22 *** debris degradation by phospholipase led to massive free fatty acid production,which increased lipid droplet synthesis,β-oxidation,and oxidative *** oxidative phosphorylation increased reactive oxygen species generation,which led to increased lipid peroxidation and HT22 cell *** was identified as a lipid-lowering compound that inhibited phosphorylation of cytosolic phospholipase A2 by reducing the phosphorylation of extracellular signal-regulated kinases 1/2 in the mitogen-activated protein kinase pathway,thereby inhibiting myelin debris degradation by cytosolic phospholipase A2 and alleviating lipid droplet accumulation in myelin debris-treated HT22 *** function,lipid droplet accumulation in spinal cord neurons and neuronal survival were all improved in bromocriptine-treated mice after spinal cord *** results suggest that bromocriptine can protect neurons from lipotoxic damage after spinal cord injury via the extracellular signal-regulated kinases 1/2-cytosolic phospholipase A2 pathway.

关键词： bromocriptine central nervous system cytosolic phospholipase A2 high-content screening lipid droplet lipid metabolism lipotoxicity mitogen-activated protein kinase spinal cord injury spinal cord neurons

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Continuous synthesis of N,N-dicyanoethylaniline in microreactors:Reaction kinetics and process intensification

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Chinese Journal of Chemical Engineering 2024年第8期72卷 95-105页

作者： Pengcheng Lu Yaoyao Li Jianjun Zhang Yuchao Zhao Qingqiang wang ying chen Nan Jin Xiugang Yu Shandong Provincial Key Laboratory of Chemical Engineering and Process College of Chemistry and Chemical EngineeringYantai UniversityYantai 264005China Shandong ANOKY Chemical Technology Research Co. Ltd.Yantai 265601China Yantai Guobang Chemical Machinery Technology Co. Ltd.Yantai 264000China

Cyanoethylation of phenylamine is one of the important steps for the production of dicyanoethyl-based disperse ***,the exothermic nature of this reaction and the inherent instability of intermittent dynamic operation pose challenges in achieving both high safety and reaction *** this study,a continuous cyanoethylation of phenylamine for synthesizing N,N-dicyanoethylaniline in a microreactor system has been *** optimizing the reaction conditions,the reaction time was significantly reduced from over 2 h in batch operation to approximately 14 min in the microreactor,while high conversion and selectivity were *** on the reaction network constructed,the reaction kinetics was established,and the kinetic parameters were then *** findings provide valuable insights into a controllable cyanoethylation reaction,which would be helpful for the design of efficient processes and optimization of reactors.

关键词： Cyanoethylation Microreactor Kinetics N,N-dicyanoethylaniline Optimization Safety

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Characteristics and main controlling factors of helium resources in the main petroliferous basins of the North China Craton

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Acta Oceanologica Sinica 2024年第2期43卷 23-33页

作者： Zihan Gao Zhi chen Hongyi He Zhaofei Liu Chang Lu Hanyu wang Yili Luo ying Li Institute of Earthquake Forecasting China Earthquake AdministrationBeijing 100036China College of Geosciences China University of Petroleum-BeijingBeijing 102249China School of Earth Science and Resources China University of Geosciences(Beijing)Beijing 100083China

At present, the main controlling factors of helium accumulation is one of the key scientific problems restricting the exploration and development of helium reservoir. In this paper, based on the calculation results of He generation rate and the geochemical characteristics of the produced gas, both the similarities and differences between natural gas and He resources in the Bohai Bay, Ordos and the surrounding Songliao Basin are compared and analyzed, discussing the main controlling factors of helium resources in the three main petroliferous basins of the North China Craton. It is found that the three basins of Bohai Bay, Ordos and Songliao have similar characteristics of source rocks, reservoirs and cap rocks, that's why their methane resource characteristics are essentially the same. The calculated ~4He generation per cubic metamorphic crystalline basement in the three basins is roughly equivalent, which is consistent with the measured He resources, and it is believed that the ~4He of radiogenic from the crust is the main factor controlling the overall He accumulation in the three basins;there is almost no contribution of the mantle-derived CH_4, which suggests that the transport and uplift of mantle-derived ~3He carried by the present-day magmatic activities along the deep-large faults is not the main reason for the mantle-derived ~3He mixing in the basins. Combined with the results of regional volcanic and geophysical studies,it is concluded that under the background of the destruction of North China Craton, magma intrusion carried a large amount of mantle-derived material and formed basic volcanic rocks in the Bohai Bay Basin and Songliao Basin, which replenished mantle-derived ~3He for the interior of the basins, and that strong seismic activities in and around the basins also promoted the upward migration of mantle source ~3He. This study suggests that the tectonic zone with dense volcanic rocks in the Cenozoic era and a high incidence of historical strong ear

关键词： Helium Bohai Bay Basin destruction of the North China Craton fault Cenozoic volcanic rocks strong earthquake activity

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Anti-vascular endothelial growth factor drugs combined with laser photocoagulation maintain retinal ganglion cell integrity in patients with diabetic macular edema: study protocol for a prospective, non-randomized, controlled clinical trial

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Neural Regeneration Research 2024年第4期19卷 923-928页

作者： Xiangjun Li Chunyan Li Hai Huang Dan Bai Jingyi wang Anqi chen Yu Gong ying Leng Department of Ophthalmology Affiliated Hospital of Beihua University Department of Endocrinology Affiliated Hospital of Beihua University

The integrity of retinal ganglion cells is tightly associated with diabetic macular degeneration that leads to damage and death of retinal ganglion cells,affecting *** major clinical treatments for diabetic macular edema are anti-vascular endothelial growth factor drugs and laser ***,although the macular thickness can be normalized with each of these two therapies used alone,the vision does not improve in many *** might result from the incomplete recovery of retinal ganglion cell ***,a prospective,non-randomized,controlled clinical trial was designed to investigate the effect of anti-vascular endothelial growth factor drugs combined with laser photocoagulation on the integrity of retinal ganglion cells in patients with diabetic macular edema and its relationship with vision *** this trial,150 patients with diabetic macular edema will be equally divided into three groups according to therapeutic methods,followed by treatment with anti-vascular endothelial growth factor drugs,laser photocoagulation therapy,and their *** patients will be followed up for 12 *** primary outcome measure is retinal ganglion cell-inner plexiform layer thickness at 12 months after *** secondary outcome measures include retinal ganglion cell-inner plexiform layer thickness before and 1,3,6,and 9 months after treatment,retinal nerve fiber layer thickness,best-corrected visual acuity,macular area thickness,and choroidal thickness before and 1,3,6,9,and 12 months after *** measure is the incidence of adverse events at 1,3,6,9,and 12 months after *** study protocol hopes to validate the better efficacy and safety of the combined treatment in patients with diabetic macula compared with the other two monotherapies alone during the 12-month follow-up *** trial is designed to focus on clarifying the time-effect relationship between imaging measures related to the integrity of retinal

关键词： choroidal thickness diabetic macular edema laser photocoagulation retinal ganglion cell-inner plexiform layer thickness retinal ganglion cells retinal nerve fiber layer thickness thickness of the macular area vascular endothelial growth factor visual acuity

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Track correlation algorithm based on CNN-LSTM for swarm targets

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Journal of Systems Engineering and Electronics 2024年第2期35卷 417-429页

作者： chen Jinyang wang Xuhua chen Xian Research Institute for National Defense Engineering Academy of Military SciencesLuoyang 471023China Information Engineering University Zhengzhou 450001China School of Computer Science and Technology Xidian UniversityXi’an 710071China

The rapid development of unmanned aerial vehicle(UAV) swarm, a new type of aerial threat target, has brought great pressure to the air defense early warning system. At present, most of the track correlation algorithms only use part of the target location, speed, and other information for *** this paper, the artificial neural network method is used to establish the corresponding intelligent track correlation model and method according to the characteristics of swarm ***, a route correlation method based on convolutional neural networks (CNN) and long short-term memory (LSTM)Neural network is designed. In this model, the CNN is used to extract the formation characteristics of UAV swarm and the spatial position characteristics of single UAV track in the formation,while the LSTM is used to extract the time characteristics of UAV swarm. Experimental results show that compared with the traditional algorithms, the algorithm based on CNN-LSTM neural network can make full use of multiple feature information of the target, and has better robustness and accuracy for swarm targets.

关键词： track correlation correlation accuracy rate swarm target convolutional neural network(CNN) long short-term memory(LSTM)neural network

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MiR-4465-modified mesenchymal stem cell-derived small extracellular vesicles inhibit liver fibrosis development via targeting LOXL2 expression

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 594-604页

作者： Yanjin wang Yifei chen Fuji YANG Xiaolong YU ying CHU Jing ZHOU Yongmin YAN Jianbo XI Department of Laboratory Medicine Wujin Hospital Affiliated with Jiangsu UniversityJiangsu UniversityChangzhou 213017China Department of Laboratory Medicine School of MedicineJiangsu UniversityZhenjiang 212013China Changzhou Key Laboratory of Molecular Diagnostics and Precision Cancer Medicine Wujin Clinical College of Xuzhou Medical UniversityChangzhou 213017China

Liver fibrosis is a significant health burden,marked by the consistent deposition of ***,the currently available treatment approaches for this condition are far from *** oxidase-like protein 2(LOXL2)secreted by hepatic stellate cells(HSCs)is a crucial player in the cross-linking of matrix collagen and is a significant target for treating liver *** stem cell-derived small extracellular vesicles(MSC-sEVs)have been proposed as a potential treatment option for chronic liver *** studies have found that MSC-sEV can be used for microRNA delivery into target cells or *** is currently unclear whether microRNA-4465(miR-4465)can target LOXL2 and inhibit HSC ***,it is uncertain whether MSC-sEV can be utilized as a gene therapy vector to carry miR-4465 and effectively inhibit the progression of liver *** study explored the effect of miR-4465-modified MSC-sEV(MSC-sEVmiR-4465)on LOXL2 expression and liver fibrosis *** results showed that miR-4465 can bind specifically to the promoter of the LOXL2 gene in ***,MSC-sEVmiR-4465 inhibited HSC activation and collagen expression by downregulating LOXL2 expression in ***-sEVmiR-4465 injection could reduce HSC activation and collagen deposition in the CCl4-induced mouse ***-sEVmiR-4465 mediating via LOXL2 also hindered the migration and invasion of HepG2 *** conclusion,we found that MSC-sEV can deliver miR-4465 into HSC to alleviate liver fibrosis via altering LOXL2,which might provide a promising therapeutic strategy for liver diseases.

关键词： Mesenchymal stem cell(MSC) Small extracellular vesicle(sEV) MicroRNA-4465(miR-4465) Hepatic stellate cell(HSC) Liver fibrosis

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Formation environment and hydrocarbon potential of the Paleogene Enping Formation coal measures in the ZhuⅠDepression of northern South China Sea

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Acta Oceanologica Sinica 2024年第4期43卷 119-135页

作者： Yuting Yin Lei Lan Dongdong wang ying chen Yan Liu Youchuan Li Zengxue Li Jiamin Liu College of Earth Science and Engineering Shandong University of Science and TechnologyQingdaoShandong 266590China China National Offshore Oil Corporation Research Institute Co. Ltd.Beijing 100028China School of Geography Earth and Environmental SciencesUniversity of BirminghamBirminghamB152TTUK

The coal-measure source rock in the Chinese sea area plays a significant role as a hydrocarbon source rock,with its genetic environment,development and distribution,and hydrocarbon generation potential serving as essential factors for the exploration of coal-type oil and gas *** study focuses on the coal-measure source rock of the Paleogene Enping Formation in the ZhuⅠDepression,located in the northern South China *** main geological insights obtained are as *** coal measures of the Enping Formation are developed in a warm and wet tropical-subtropical *** development environment of the coal-measure source rock in the Enping Formation includes the braided river delta upper plain peat swamp,characterized by dry forest swamp coal facies with relatively thick coal seams and a small number of *** braided river delta lower plain swamp-interdistributary bay of braided river delta front represents a forest edge-wetland herbaceous swamp coal facies with numerous layers of thin coal seams and poor *** shore swamp corresponds to an open water swamp coal facies with multiple layers of thin coal seams and poor *** organic matter abundance in the braided river delta upper plain is the highest,followed by the braided river delta lower plain-braided river delta front,and the shore-shallow *** organic matter type is predominantly typeⅡ*** evolution analysis suggests that the organic matter has progressed into a substantial oil generation *** hydrocarbon generation potential of the coal-measure source rock in the Enping Formation is the highest in the braided river delta upper plain,followed by the braided river delta lower plain-braided river delta front and the shore-shallow ***,this study proposes three organic facies in the coal-measure source rock of the Enping Formation:upper-plain swamp-dry forest swamp facies,lower plain-interdistributary bay-forest-herbaceous swamp facies,and lake swamp-herbaceo

关键词： coal-measure source rock Paleogene genetic environment hydrocarbon generation characteristic ZhuⅠDepression

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MoO_(x) nanoclusters on Mo-doped TiO_(2) nanosheets with enhanced singlet oxygen generation and sulfide conversion abilities for photocatalytic aerobic oxidative desulfurization

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Science China Chemistry 2024年第1期67卷 408-414页

作者： Suting Xie Xinyu Zhao Dongxiao wang Huawei Yang Lixia Yang Liangjiu Bai Donglei Wei Wenxiang wang ying Liang Hou chen Shaojun Guo College of Chemistry and Materials Science Ludong UniversityYantai 264025China College of Materials Science and Engineering Peking UniversityBeijing 100871China

Photocatalytic aerobic oxidation desulfurization(PAODS)is a promising and sustainable alternative to conventional,energyintensive desulfurization techniques for petroleum ***,its development is greatly plagued by the low capability in generating highly reactive oxygen species and sluggish kinetics of sulfide oxidation of reported *** we report a class of MoO_(x)nanocluster decorated on ultrathin Mo-doped TiO_(2)nanosheet(MoO_(x)/MoTiO)catalyst for efficiently facilitating the photocatalytic aerobic oxidation of *** demonstrate that MoO_(x)/MoTiO can not only promote the generation of highly reactive singlet oxygen(^(1)O_(2))but also enhance the aerobic conversion of sulfides,which leads to a record dibenzothiophene oxidation activity of 3.90 mmol g^(-1)h^(-1).The multiple experimental characterizations and density functional theory calculations collectively reveal that the doped-Mo sites can interact with the photogenerated excitons,enabling directly energy transfer generation of^(1)O_(2)through a new exciton modulation mechanism,and the coordination unsaturated MoO_(x)clusters play the role of co-catalyst to enhance the separation of charge carriers,and effectively catalyze the reaction between sulfides and1O_(2)to form sulfones.

关键词： titanium dioxide photocatalytic aerobic oxidation desulfurization dibenzothiophene singlet oxygen

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Moisture‑Electric–Moisture‑Sensitive Heterostructure Triggered Proton Hopping for Quality‑Enhancing Moist‑Electric Generator

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Nano-Micro Letters 2024年第3期16卷 351-366页

作者： Ya’nan Yang Jiaqi wang Zhe wang Changxiang Shao Yuyang Han ying wang Xiaoting Liu Xiaotong Sun Liru wang Yuanyuan Li Qiang Guo Wenpeng Wu Nan chen Liangti Qu Key Laboratory of Cluster Science Ministry of Education of ChinaKey Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081People’s Republic of China Yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing 314019People’s Republic of China Department of Chemistry Key Laboratory of Organic Optoelectronics&Molecular EngineeringMinistry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Moisture-enabled electricity(ME)is a method of converting the potential energy of water in the external environment into electrical energy through the interaction of functional materials with water molecules and can be directly applied to energy harvesting and signal ***,ME can be unreliable in numerous applications due to its sluggish response to moisture,thus sacrificing the value of fast energy harvesting and highly accurate information ***,by constructing a moisture-electric-moisture-sensitive(ME-MS)heterostructure,we develop an efficient ME generator with ultra-fast electric response to moisture achieved by triggering Grotthuss protons hopping in the sensitized ZnO,which modulates the heterostructure built-in interfacial potential,enables quick response(0.435 s),an unprecedented ultra-fast response rate of 972.4 mV s^(−1),and a durable electrical signal output for 8 h without any *** research provides an efficient way to generate electricity and important insight for a deeper understanding of the mechanisms of moisture-generated carrier migration in ME generator,which has a more comprehensive working scene and can serve as a typical model for human health monitoring and smart medical electronics design.

关键词： Moist-electric generators Grotthuss proton hopping Fast response Durable electrical output Personal health monitoring

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