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The theory of helix-based RNA folding kinetics and its application

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Chinese Physics B 2020年第10期29卷 9-16页

作者： Sha Gong Taigang Liu yanli wang Wenbing Zhang Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization Hubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie MountainsHuanggang Normal UniversityHuanggang 438000China Department of Physics Wuhan UniversityWuhan 430072China

RNAs carry out diverse biological functions, partly because different conformations of the same RNA sequence can play different roles in cellular activities. To fully understand the biological functions of RNAs requires a conceptual framework to investigate the folding kinetics of RNA molecules, instead of native structures alone. Over the past several decades, many experimental and theoretical methods have been developed to address RNA folding. The helix-based RNA folding theory is the one which uses helices as building blocks, to calculate folding kinetics of secondary structures with pseudoknots of long RNA in two different folding scenarios. Here, we will briefly review the helix-based RNA folding theory and its application in exploring regulation mechanisms of several riboswitches and self-cleavage activities of the hepatitis delta virus (HDV) ribozyme.

关键词： RNA folding kinetics RNA structure Riboswitch HDV ribozyme

老年人群睡眠障碍与阿尔茨海默病相关性研究进展

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中华老年多器官疾病杂志 2024年第1期23卷 68-71页

作者：张源姜季委王艳丽徐俊首都医科大学附属北京天坛医院神经病学中心认知障碍性疾病科北京100070

睡眠模式随衰老而变化,老年人群易合并入睡困难、睡眠碎片化、白日嗜睡、早醒等睡眠障碍。阿尔茨海默病(AD)是衰老背景下的神经系统退行性疾病,也是老年人最常见的痴呆原因。目前,越来越多的研究发现,睡眠障碍与AD之间存在显著的相关性... 详细信息

睡眠模式随衰老而变化,老年人群易合并入睡困难、睡眠碎片化、白日嗜睡、早醒等睡眠障碍。阿尔茨海默病(AD)是衰老背景下的神经系统退行性疾病,也是老年人最常见的痴呆原因。目前,越来越多的研究发现,睡眠障碍与AD之间存在显著的相关性,尤其是睡眠觉醒障碍,可通过影响脑内淋巴循环代谢,导致β-淀粉样蛋白清除率降低,进而影响AD发生发展。尽管有一定的研究基础,但是睡眠障碍究竟是AD发生发展的因还是果仍未可知,睡眠障碍影响AD发生发展的潜在机制仍不明确,AD相关认知障碍患者的睡眠干预及调节策略仍缺乏统一的指导意见。因此,本文综述了衰老与睡眠生理变化、睡眠障碍与AD相关性及睡眠障碍干预与认知改善的最新研究证据,旨在提高人们对睡眠障碍及睡眠调节重要性的认识,以期达到疾病的早期预防。

关键词：老年人睡眠障碍阿尔茨海默病昼夜节律

Numerical Validation for High Order Hyperbolic Moment System of Wigner Equation

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Communications in Computational Physics 2014年第3期15卷 569-595页

作者： Ruo Li Tiao Lu yanli wang Wenqi Yao School of Mathematical Sciences Peking UniversityBeijing 100871P.R.China HEDPS and LMAM Peking UniversityBeijing 100871P.R.China BICMR Peking UniversityBeijing 100871P.R.China CAPT Peking UniversityBeijing 100871P.R.China

A globally hyperbolic moment system upto arbitrary order for the Wigner equation was derived in[6].For numerically solving the high order hyperbolic moment system therein,we in this paper develop a preliminary numerical method for this system following the NRxx method recently proposed in[8],to validate the moment system of the Wigner *** method developed can keep both mass and momentum conserved,and the variation of the total energy under control though it is not strictly *** systematically study the numerical convergence of the solution to the moment system both in the size of spatial mesh and in the order of the moment expansion,and the convergence of the numerical solution of the moment system to the numerical solution of the Wigner equation using the discrete velocity *** numerical results indicate that the high order moment system in[6]is a valid model for the Wigner equation,and the proposed numerical method for the moment system is quite promising to carry out the simulation of the Wigner equation.

关键词： Wigner equation NRxx method moment method

2021-2022年张家口市高血压性视网膜病变患病率调查及危险因素分析

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眼科 2024年第1期33卷 57-60页

作者：张佳王艳丽宋晓丛王淑珍张家口市第一医院眼科河北张家口075000

目的了解张家口市高血压视网膜病变的患病情况及其危险因素。设计横断面研究。研究对象2021年5月至2022年12月张家口市19个县区的居民。方法对居民进行高血压病和高血压视网膜病变筛查,所有受检人员均进行血压测量、眼科检查以及静脉血... 详细信息

目的了解张家口市高血压视网膜病变的患病情况及其危险因素。设计横断面研究。研究对象2021年5月至2022年12月张家口市19个县区的居民。方法对居民进行高血压病和高血压视网膜病变筛查,所有受检人员均进行血压测量、眼科检查以及静脉血实验室检测,采用问卷调查形式收集患者年龄、性别、病程、体质量指数、并发症等,统计高血压视网膜病变的患病率,分析影响患病率的危险因素。主要指标患病率、危险因素。结果实际接受检查居民8056例,高血压患病率为16.39%(1320例);1320例高血压患者中检出视网膜病变患者212例(13.06%),占受检居民的2.63%;高血压视网膜病变患病在不同性别无差异,年龄≥60岁者的患病率高于<60岁者(P<0.05);多因素分析显示,病程长(OR=1.747)、高收缩压(OR=2.340)、高舒张压(OR=1.424)、有糖尿病史(OR=13.481)是发生高血压视网膜病变的危险因素(P均<0.05)。结论张家口市19个县区的居民高血压患者中高血压视网膜病变患病率约13%,年龄≥60岁、病程长、高收缩压、高舒张压、有糖尿病史是其危险因素。(眼科,2024,33:57-60)

关键词：高血压性视网膜病变危险因素

张家口市高血压视网膜病变患者情况调查及危险因素分析

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基础医学与临床 2024年第6期44卷 853-857页

作者：张佳王艳丽宋晓丛王淑珍张家口市第一医院眼科河北张家口075000

目的探讨张家口市高血压视网膜病变患者情况调查及危险因素。方法2021年5月至2022年12月对张家口市19个县区的居民进行高血压病和高血压视网膜病变筛查,所有受检人员均测量血压、眼科检查以及血糖检测,采用问卷调查形式收集患者年龄、... 详细信息

目的探讨张家口市高血压视网膜病变患者情况调查及危险因素。方法2021年5月至2022年12月对张家口市19个县区的居民进行高血压病和高血压视网膜病变筛查,所有受检人员均测量血压、眼科检查以及血糖检测,采用问卷调查形式收集患者年龄、性别、病程、体质量指数(BMI)、并发症等,统计张家口市居民高血压视网膜病变的患病率,分析影响患者的危险因素。结果实际接受检查居民8056例,共检出高血压患者1320例,高血压患病率为16.39%(1320/8056);调查出的1320例高血压患者中检查出视网膜病变患者212例,在高血压患者中患病率为13.06%(212/1320),在所有受检居民中患病率为2.63%;年龄≥60岁占比高于<60岁占比,无高血压治疗史患者占比高于有治疗史患者(P<0.05);病患组病程、收缩压、舒张压、糖尿病占比及吸烟史占比均高于对照组(P<0.05);高血压病程长、高收缩压、高舒张压、有糖尿病史是发生高血压视网膜病变发生的危险因素(P<0.05)。结论张家口市19个县区的居民高血压视网膜病变发生率较低,且在年龄≥60岁中发病率较高,病程长、高收缩压、高舒张压及糖尿病史是其危险因素。

关键词：高血压视网膜病变危险因素患病率

Gravimetric analysis for PM_(2.5) mass concentration based on year-round monitoring at an urban site in Beijing

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Journal of Environmental Sciences 2016年第2期28卷 154-160页

作者： yanli wang Wen Yang Bin Han Wenjie Zhang Mindong Chen Zhipeng Bai State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science & Technology

Daily PM_（2.5）（particulate matter with an aerodynamic diameter of below 2.5 μm） mass concentrations were measured by gravimetric analysis in Chinese Research Academy of Environmental Sciences（CRAES）, in the northern part of the Beijing urban area, from December 2013 to April 2015. Two pairs of Teflon（T1/T2） and Quartz（Q1/Q2） samples were obtained, for a total number of 1352 valid filters. Results showed elevated pollution in Beijing,with an annual mean PM_（2.5）mass concentration of 102 μg/m^3. According to the calculated PM_（2.5）mass concentration, 50% of our sampling days were acceptable（PM_（2.5）〈 75 μg/m^3）, 30% had slight/medium pollution（75–150 μg/m^3）, and 7% had severe pollution（〉 250 μg/m^3）. Sampling interruption occurred frequently for the Teflon filter group（75%） in severe pollution periods,resulting in important data being missing. Further analysis showed that high PM_（2.5）combined with high relative humidity（RH） gave rise to the interruptions. The seasonal variation of PM_（2.5）was presented, with higher monthly average mass concentrations in winter（peak value in February, 422 μg/m^3）, and lower in summer（7 μg/m^3 in June）. From May to August, the typical summer period, least severe pollution events were observed, with high precipitation levels accelerating the process of wet deposition to remove PM_（2.5）. The case of February presented the most serious pollution, with monthly averaged PM_（2.5）of 181 μg/m^3 and 32% of days with severe pollution. The abundance of PM_（2.5）in winter could be related to increased coal consumption for heating needs.

关键词： PM_(2.5) Gravimetric analysis Sampling interruption Pollution level Relative humidity(RH) Seasonal variation

血清基质金属蛋白酶-9、可溶性尿激酶型纤溶酶原激活物受体及纤溶酶原激活物抑制因子-1联合检测预测老年慢性心力衰竭患者预后的价值

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实用临床医药杂志 2024年第3期28卷 34-38页

作者：杨博王艳丽崔晓敬河北省廊坊市中医医院心血管病科河北廊坊065000 河北省廊坊市人民医院急诊重症医学科河北廊坊065000

目的探讨血清基质金属蛋白酶-9(MMP-9)、可溶性尿激酶型纤溶酶原激活物受体(suPAR)及纤溶酶原激活物抑制因子-1(PAI-1)表达与老年慢性心力衰竭(CHF)患者心功能分级及预后的关系。方法选取廊坊市中医医院收治的108例CHF患者及同期50例... 详细信息

目的探讨血清基质金属蛋白酶-9(MMP-9)、可溶性尿激酶型纤溶酶原激活物受体(suPAR)及纤溶酶原激活物抑制因子-1(PAI-1)表达与老年慢性心力衰竭(CHF)患者心功能分级及预后的关系。方法选取廊坊市中医医院收治的108例CHF患者及同期50例健康体检者分别作为研究组和对照组。采集受试者血液标本,测定血清MMP-9、suPAR及PAI-1水平。比较不同纽约心脏病协会(NYHA)心功能分级患者及不同预后患者的血清指标差异,并分析各血清指标对不良预后的预测价值。结果与对照组相比,研究组血清MMP-9、suPAR、PAI-1水平更高,差异有统计学意义(P<0.05)。NYHA分级Ⅱ级、Ⅲ级、Ⅳ级CHF患者的血清MMP-9、suPAR、PAI-1水平呈逐渐升高趋势,差异均有统计学意义(P<0.05)。随访1年的结果显示,预后良好65例,预后不良43例,预后不良率为39.81%(43/108)。与预后良好患者相比,预后不良患者的年龄更大,合并高血压率更高,左室射血分数(LVEF)更低,左室舒张末期内径(LVEDD)、MMP-9、suPAR及PAI-1水平更高,差异有统计学意义(P<0.05)。Logistic回归分析显示,年龄、MMP-9、suPAR、PAI-1均是老年CHF患者预后不良的危险因素,LVEF是老年CHF患者预后不良的保护因素(P<0.05)。血清MMP-9、suPAR、PAI-1单独检测及3项联合检测的曲线下面积(AUC)分别为0.711、0.829、0.768和0.840,3项联合检测的敏感度为88.21%,特异度为79.46%。结论老年慢性CHF患者的血清MMP-9、suPAR、PAI-1表达水平与心功能分级及预后不良密切相关。

关键词：慢性心力衰竭基质金属蛋白酶-9 可溶性尿激酶型纤溶酶原激活物受体纤溶酶原激活物抑制因子-1 预后

Web search and data mining of natural products and their bioactivities in PubChem

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Science China Chemistry 2013年第10期56卷 1424-1435页

作者： HAO Ming CHENG Tiejun wang yanli BRYANT H. Stephen National Center for Biotechnology Information National Library of Medicine National Institutes of HealthBethesda MD 20894 USA

Natural products,as major resources for drug discovery historically,are gaining more attentions recently due to the advancement in genomic sequencing and other technologies,which makes them attractive and amenable to drug candidate *** and mining the bioactivity information of natural products are extremely important for accelerating drug development process by reducing ***,a number of publicly accessible databases have been established to facilitate the access to the chemical biology data for small molecules including natural ***,it is imperative for scientists in related fields to exploit these resources in order to expedite their researches on natural products as drug leads/candidates for disease ***,as a public database,contains large amounts of natural products associated with bioactivity *** this review,we introduce the information system provided at PubChem,and systematically describe the applications for a set of PubChem web services for rapid data retrieval,analysis,and downloading of natural *** hope this work can serve as a starting point for the researchers to perform data mining on natural products using PubChem.

关键词： natural products drug discovery PubChem public database data mining

基于风险因子理论的辅仁药业财务舞弊及防范分析

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财务管理研究 2024年第6期 78-83页

作者：王艳丽刘杨杨郑美琪新疆财经大学乌鲁木齐830012

当前,随着证券市场的快速发展,拥有一个健全的证券市场环境是所有企业和投资者的共同心愿。然而,近年来因为披露的财务报告信息不规范而被调查的上市公司越来越多。这种混乱的局面使投资者对自身的投资行为失去了准确判断,同时也影响了... 详细信息

当前,随着证券市场的快速发展,拥有一个健全的证券市场环境是所有企业和投资者的共同心愿。然而,近年来因为披露的财务报告信息不规范而被调查的上市公司越来越多。这种混乱的局面使投资者对自身的投资行为失去了准确判断,同时也影响了市场经济的正常运转。准确识别上市公司的各种财务造假手段并针对性地采取应对措施至关重要。以辅仁药业为例,基于舞弊风险因子理论,通过对辅仁药业财务舞弊手段的分析,得出如下结论:风险因子理论在分析企业财务舞弊时具有明显的优势。要预防和控制公司产生财务舞弊,则要从内部和外部两个方面入手采取有效对策,建立起一套科学完善的制度。

关键词：财务舞弊风险因子理论辅仁药业