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Physical Prediction Model of Compound Hydrodynamic Unload-Load Response Ratio and Its Application in Reservoir Colluvium Landslide

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Journal of Earth Science 2024年第4期35卷 1304-1315页

作者： Lu Guo Keqiang He Honghua Liu Fandi Meng xuchun wang School of Civil Engineering Qingdao University of TechnologyQingdao266520China Key Laboratory of Geological Safety of Coastal Urban Underground Space Ministry of Natural ResourcesQingdao266071China

It is well known that the deformation and damage of reservoir colluvium landslides are often determined by the combined dynamics of reservoir water level change and *** on the systematic analysis of the change law of reservoir water level,rainfall and displacements of reservoir colluvium landslide,this paper proposes the compound hydrodynamic action of rainfall and reservoir water as the unload-load parameter,and the landslide displacement as the unload-load response *** on this,a physical prediction model of the compound hydrodynamic unload-load response ratio of reservoir colluvium landslide was established,and the quantitative relationship between the compound hydrodynamic unload-load response ratio and its stability evolution was in-depth analyzed and *** the basis of the above research,taking Shuping landslide,a typical hydrodynamic pressure landslide as an example,the unload-load response ratio model is used to systematically evaluate and predict the stability evolution law and the change trend of the landslide under compound hydrodynamic *** prediction result shows that the variation law of the compound hydrodynamic unload-load response ratio is consistent with the dynamic evolution law of its ***,the above studies show that the compound hydrodynamic unload-load response ratio parameter is an effective displacement dynamic evaluation parameter for reservoir colluvium landslides,so it can be used in the prediction of the reservoir colluvium landslides.

关键词： landslides reservoir colluvium landslide compound hydrodynamics unload-load response ratio Shuping landslide stability evaluation

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p53 exerts anticancer effects by regulating enhancer formation and activity

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Journal of Biomedical Research 2024年第4期38卷 334-347页

作者： Shuhan Chen xuchun wang Nan Yang Yuechi Song He Cheng Yujie Sun Key Laboratory of Human Functional Genomics of Jiangsu Province School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Department of Cell Biology School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical UniversityNanjingJiangsu 211166China

The abnormality of the p53 tumor suppressor is crucial in lung cancer development,because p53 regulates target gene promoters to combat *** studies have shown extensive p53 binding to enhancer ***,whether p53 exerts a tumor suppressor role by shaping the enhancer landscape remains poorly *** the current study,we employed several functional genomics approaches to assess the enhancer activity at p53 binding sites throughout the genome based on our established TP53 knockout(KO)human bronchial epithelial cells(BEAS-2B).A total of 943 active regular enhancers and 370 super-enhancers(SEs)disappeared upon the deletion of p53,indicating that p53 modulates the activity of hundreds of enhancer *** found that one p53-dependent SE,located on chromosome 9 and designated as KLF4-SE,regulated the expression of the Krüppel-like factor 4(KLF4)***,the deletion of p53 significantly decreased the KLF4-SE enhancer activity and the KLF4 expression,but increased colony formation ability in the nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced cell transformation ***,in TP53 KO cells,the overexpression of KLF4 partially reversed the increased clonogenic capacity caused by p53 ***,KLF4 expression also decreased in lung cancer tissues and cell *** appeared that overexpression of KLF4 significantly suppressed the proliferation and migration of lung cancer ***,our results suggest that the regulation of enhancer formation and activity by p53 is an integral component of the p53 tumor suppressor ***,our findings offer some novel insights into the regulation mechanism of p53 in lung oncogenesis and introduce a new strategy for screening therapeutic targets.

关键词： p53 enhancer tumor malignant transformation

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p53 exerts anticancer effects by regulating enhancer formation and activity

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The Journal of Biomedical Research 2024年第04期 334-347页

作者： Shuhan Chen xuchun wang Nan Yang Yuechi Song He Cheng Yujie Sun Key Laboratory of Human Functional Genomics of Jiangsu Province School of Basic Medical Sciences Nanjing Medical University Department of Cell Biology School of Basic Medical Sciences Nanjing Medical University Jiangsu Key Lab of Cancer Biomarkers Prevention and Treatment Collaborative Innovation Center for Personalized Cancer Medicine Nanjing Medical University

The abnormality of the p53 tumor suppressor is crucial in lung cancer development, because p53 regulates target gene promoters to combat cancer. Recent studies have shown extensive p53 binding to enhancer ***, whether p53 exerts a tumor suppressor role by shaping the enhancer landscape remains poorly understood. In the current study, we employed several functional genomics approaches to assess the enhancer activity at p53 binding sites throughout the genome based on our established TP53 knockout(KO) human bronchial epithelial cells(BEAS-2B). A total of 943 active regular enhancers and 370 super-enhancers(SEs)disappeared upon the deletion of p53, indicating that p53 modulates the activity of hundreds of enhancer *** found that one p53-dependent SE, located on chromosome 9 and designated as KLF4-SE, regulated the expression of the Krüppel-like factor 4(KLF4) gene. Furthermore, the deletion of p53 significantly decreased the KLF4-SE enhancer activity and the KLF4 expression, but increased colony formation ability in the nitrosamines4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced cell transformation model. Subsequently, in TP53 KO cells, the overexpression of KLF4 partially reversed the increased clonogenic capacity caused by p53 ***, KLF4 expression also decreased in lung cancer tissues and cell lines. It appeared that overexpression of KLF4 significantly suppressed the proliferation and migration of lung cancer cells. Collectively, our results suggest that the regulation of enhancer formation and activity by p53 is an integral component of the p53 tumor suppressor function. Therefore, our findings offer some novel insights into the regulation mechanism of p53 in lung oncogenesis and introduce a new strategy for screening therapeutic targets.

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Enhancing the crystallinity and stability of perovskite solar cells with 4-tert-butylpyridine induction for efficiency exceeding 24%

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Journal of Energy Chemistry 2024年第6期93卷 1-7,I0001页

作者： You Liu Lishuang Zheng Kuanxiang Zhang Kun Xu Weicheng Xie Jue Zhang Yulu Tian Tianyuan Liu Hanzhong Xu Ruoming Ma Wei Huang Jiahui Chen Jusheng Bao Chen Chen Yongsheng Zhou xuchun wang Junming Chen Jungan wang College of Chemistry and Materials Engineering Anhui Science and Technology UniversityBengbu 233000AnhuiChina Anhui Province Quartz Sand Purification and Photovoltaic Glass Engineering Research Center Chuzhou 233100AnhuiChina Triumph Photovoltaic Materials Co.Ltd BengbuAnhuiChina National Laboratory of Solid State Microstructures School of PhysicsNanjing UniversityNanjing 210009JiangsuChina JinkoSolar Holding Co.Ltd HainingZhejiangChina

Perovskite solar cells(PSCs)have emerged as a promising photovoltaic technology because of their high light absorption coefficient,long carrier diffusion distance,and tunable ***,PSCs face challenges such as hysteresis effects and stability *** this study,we introduced a novel approach to improve film crystallization by leveraging 4-tert-butylpyridine(TBP)molecules,thereby enhancing the performance and stability of *** findings demonstrate the effective removal of PbI_(2)from the perovskite surface through strong coordination with TBP ***,by carefully adjusting the concentration of the TBP solution,we achieved enhanced film crystallinity without disrupting the perovskite *** TBP-treated perovskite films exhibit a low defect density,improved crystallinity,and improved carrier *** a result,the PSCs manufactured with TBP treatment achieve power conversion efficiency(PCE)exceeding 24%.Moreover,we obtained the PCE of 21.39%for the 12.25 cm^(2)module.

关键词： 4-tert-butylpyridine Film crystallization Perovskite solar cells Power conversion efficiency Stability improvement

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The secret of the magic gourd(I): biomass from various organizations of ourds as a sustainable source for high-performance supercapacitors

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Science China Chemistry 2024年

作者： Shaoqing Zhang xuchun wang Tianming Lv Baixue Dong Jiqi Zheng Yang Mu Miao Cui Ting Zhang Changgong Meng College of Chemistry and Materials Engineering Anhui Science and Technology University Anhui Province Quartz Sand Purification and Photovoltaic Glass Engineering Research Center Anhui Science and Technology University Instrumental Analysis Center Dalian University of Technology School of Chemical Engineering Zhejiang University of Technology College of Environment and Chemical Engineering Dalian University School of Chemical Engineering Dalian University of Technology

The classic cartoon “Calabash Brothers” describes a story of seven brothers born from a magic gourd uniting to defeat powerful enemies. In order to explore the secret of the magic gourd, several transition metals were used to synthesize metal silicates（CMSi） by planted gourd leaves（GLs） and then the C-MSi materials were used to fabricate supercapacitor electrodes and devices with superior electrochemical performance. By integrating theoretical calculations and experimental results, the supercapacitor electrodes and devices obtained from the combination of transition metals with amorphous carbon exhibit superior electrochemical performance. In detail, in the three-electrode system, the NaOH etched materials（C-MSi） exhibited better electrochemical performance(for instance, as for C-CdSi, 607 F g-1at 0.5 A g-1and the capacitance retention of 98.2% after 10,000cycles) than the unetched ones（i-C-MSi）. Hybrid supercapacitor（HSC） devices also achieve very excellent electrochemical properties. Take C-CdSi//AC as an example, the areal specific capacitance with 691 m F cm-2at 2 mA cm-2, the energy density with 5.04 Wh m-2at the power density of 22.2 W m-2and the cycle stability with 87.3% after 6,000 cycles. This approach is very versatile and was also applied to produce many hierarchically structured metal-silicate materials of other biomass precursors,including roots, vines, flowers, fruits and seeds of the planted gourds. Thus, it is a potential way to prepare transition metal silicates using biomaterials for the enhancement of electrochemical performance and improvement of energy storage and conversion. Also, this paper preliminarily reveals the secret of the magic gourd.

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高强高韧锚杆钢能量吸收特性研究

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岩石力学与工程学报 2024年第S01期43卷 3204-3216页

作者：王鼎何满潮周辉王琦王旭春中国矿业大学(北京)机械与电气工程学院北京100083 中国矿业大学(北京)深部岩土力学与地下工程国家重点实验室北京100083 中国科学院武汉岩土力学研究所岩土力学与工程国家重点实验室湖北武汉430071 青岛理工大学土木工程学院山东青岛266033

在深部地下工程中,研发和应用新型金属支护材料越发引起人们的关注与重视,然而关于其在预应力和围岩加载过程中的能量吸收规律和特性尚不清楚,亟待进行相关研究。因此,基于晶体塑性方法,以新型高强高韧锚杆钢为例,比较分析不同金属支护... 详细信息

在深部地下工程中,研发和应用新型金属支护材料越发引起人们的关注与重视,然而关于其在预应力和围岩加载过程中的能量吸收规律和特性尚不清楚,亟待进行相关研究。因此,基于晶体塑性方法,以新型高强高韧锚杆钢为例,比较分析不同金属支护材料的力学和能量吸收特性。同时采用以物理机制为基础的晶体塑性模型,研究不同预应力和围岩加载速率对高强高韧锚杆钢能量吸收特性的影响。研究结果表明,传统金属支护材料在能量吸收密度方面存在发展瓶颈。与传统金属支护材料的能量吸收密度与极限抗拉强度存在倒置关系不同,新型高强高韧锚杆钢在保持高强度(>940 MPa)和较大延伸率(>0.4)的同时,具有极高的能量吸收密度(>3.5×10^(8)J/m^(3)),是现有金属支护材料的3~7倍。晶体塑性模拟结果表明,通过调整预应力和控制围岩加载速率,可以进一步提高锚杆钢的能量吸收能力。例如,通过提高预应力可以快速提高材料的有效能量吸收速率,并能抵抗围岩加载速率的影响。当预应力增加至接近材料的屈服应力且围岩加载速率控制在10-2MPa/s以下时,可以使高强高韧锚杆钢获得最大的有效应变量(>0.54)和最高的有效能量吸收密度(>4.5×10^(8)J/m^(3)),充分发挥高强高韧锚杆钢的能量吸收特性。研究结果为高强高韧锚杆钢在高地应力支护工程上的应用提供理论依据和技术指导。

关键词：岩石力学能量吸收高强高韧锚杆钢围岩大变形预应力加载速率晶体塑性

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山西省2010—2018年20岁及以上成年居民超重和肥胖的流行趋势研究

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中国全科医学 2024年第10期27卷 1245-1251页

作者：宋伟梅王旭春任浩赵英陈利民仇丽霞山西医科大学公共卫生学院卫生统计学教研室山西省太原市030001 山西省太原市疾病预防控制中心慢病科 030001 山西省疾病预防控制中心慢病科山西省太原市030012 山西省人民医院党委办公室山西省太原市030012

背景超重、肥胖和中心性肥胖现已成为全球范围内影响居民生命健康的严重公共卫生问题。分析山西省居民超重、肥胖和中心性肥胖的流行趋势,可为相关疾病防治提供一定的科学价值。目的分析2010—2018年山西省20岁及以上成年人超重、肥胖... 详细信息

背景超重、肥胖和中心性肥胖现已成为全球范围内影响居民生命健康的严重公共卫生问题。分析山西省居民超重、肥胖和中心性肥胖的流行趋势,可为相关疾病防治提供一定的科学价值。目的分析2010—2018年山西省20岁及以上成年人超重、肥胖及中心性肥胖情况,分析其流行趋势。方法选取2010年8月—2018年11月(2010、2013、2015和2018年)中国慢病监测项目中山西省部分20岁及以上成年人的调查数据,计算不同年份、性别、年龄和地区20岁及以上成年人的超重率、肥胖率和中心性肥胖率,分析不同特征成年人的超重、肥胖和中心性肥胖的流行趋势。结果本研究2010、2013、2015、2018年分别获得有效人数3527、4066、4545、4788人,年龄20~108岁。调查对象以40~59岁年龄段人群较多,女性居民较男性居民多,农村居民较城市居民多。山西省2010—2018年20岁及以上成年人整体超重粗率和经年龄、性别标化后的标化超重率分别为37.7%~40.1%、36.1%~39.6%,无明显上升趋势(Z=0.005、2.413,P=0.942、0.120);整体标化肥胖率和整体中心性肥胖粗率、标化中心性肥胖率分别由2010年的17.2%、53.8%、52.4%增长至2018年的20.0%、61.6%、60.2%(Z=8.100、10.994、12.218,P0.05)。2013年男性标化超重率高于女性(χ^(2)=4.259,P=0.039)、男性标化肥胖率低于女性(χ^(2)=13.724,P0.05)。20~39岁年龄组的整体肥胖率、男性肥胖率以及男、女性中心性肥胖率均呈现上升趋势(P0.05),不同性别和地区之间的变化趋势也无明显差异(P>0.05)。结论2010—2018年山西省20岁及以上成年居民超重率趋于稳定,肥胖率和中心性肥胖率整体呈现上升趋势。肥胖、中心性肥胖防治方面应以20~39岁青壮年为重点干预人群,减缓增长速度,以40岁以上人群为重点防治人群,采取相应预防干预措施,以控制超重、肥胖和中心性肥胖的流行。

关键词：超重肥胖中心性肥胖 Joinpoint回归流行趋势山西省

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Deformation-softening behaviors of high-strength and high-toughness steels used for rock bolts

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第6期14卷 1872-1884页

作者： Ding wang Manchao He Zhigang Tao Aipeng Guo xuchun wang State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining&TechnologyBeijing100083China Research Institute for Deep Underground Science and Engineering China University of Mining&TechnologyBeijing100083China School of Civil Engineering Qingdao University of TechnologyQingdao266033China

In deep ground engineering,the use of high-strength and high-toughness steels for rock bolt can significantly improve its energy absorption ***,the mechanisms and effects of rock loading conditions on this kind of high energy-absorbing steel for rock bolt remain *** this study,taking Muzhailing highway tunnel as the background,physically based crystal plasticity simulations were performed to understand the effect of rock loading rate and pretension on the deformation behaviors of twinning induced plasticity(TWIP)steel used for rock *** material physical connecting to the underlying microscopic mechanisms of dislocation glide and deformation twinning were incorporated in numerical *** rock loading conditions were mimicked by the real-time field monitoring data of the NPR bolt/cable equipment installed on the tunnel surrounding rock *** results indicate that the bolt rod exhibits pronounced deformation-softening behavior with decrease of the loading *** is also a sound deformation-relaxation phenomenon induced by the dramatic decrease of loading rate after *** high pretension(>600 MPa or 224 k N)can help bolt rod steel resist deformation-softening behavior,especially at low loading rate(<10~(-1)MPa/s or 10~(-2)kN/s).The loading rate was found to be a significant factor affecting deformation-softening behavior while the pretension was found to be the major parameter accounting for the deformation-relaxation *** results provide the theoretical basis and technical support for practical applications.

关键词： Rock bolt High-strength and high-toughness steels Loading rate Pretension Deformation-softening Crystal plasticity

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Energy absorption characteristics of novel high-strength and hightoughness steels used for rock support

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第6期15卷 1441-1456页

作者： Ding wang Manchao He Liangjiu Jia Xiaoming Sun Min Xia xuchun wang State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyBeijing100083China Research Institute for Deep Underground Science and Engineering China University of Mining and TechnologyBeijing100083China Department of Disaster Mitigation for Structures School of Civil EngineeringTongji UniversityShanghai200092China State Key Laboratory of Disaster Reduction in Civil Engineering Tongji UniversityShanghai200092China Department of Geotechnical Engineering School of Civil EngineeringTongji UniversityShanghai200092China School of Civil Engineering Qingdao University of TechnologyQingdao266033China

Nowadays,the development of novel metallic materials for rock support have attracted research interests since they can significantly improve the deformation and energy absorption capacities of rock *** previous studies proved the importance and mechanical advantages of utilizing high-strength and high-toughness(HSHT)steels in rock support,there is no systematic analysis to reveal the essential energy absorption parameter and the guidelines for further development of metallic rock support *** paper analyzes the energy absorption characteristics of novel HSHT steels(negative Poisson’s ratio(NPR)and twinning-induced plasticity(TWIP)steels)in comparison with conventional rock support materials.A physically based crystal plasticity(CP)model was set up and calibrated to study the effect of strain hardening rate(SHR).Meanwhile,the roles of underlying physical mechanisms,*** dislocation density and twin volume fraction,were *** results show that the improvement of energy absorption density(EAD)is essential for further development of rock support materials,besides the increase of energy absorption rate(EAR)for previous development of conventional rock support *** increase of EAD requires increases of both strength and deformation capacity of *** HSHT steels,the decrease of SHR has a positive effect on the improvement of *** addition,the increase of EAD is followed by the increase of twin volume fraction and the decrease of plastic Poisson’s ratio which can promote deformation plasticity of ***,the increase of EAR is correlated with the accumulation of dislocation density,which can increase the strength of *** paper provides the theoretical basis and guidelines for developing rock support materials in deep underground engineering and other related fields.

关键词： Rock support Steel Energy absorption Strain hardening rate(SHR) Crystal plasticity(CP)

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In situ surface-confined fabrication of single atomic Fe-N_(4) on N-doped carbon nanoleaves for oxygen reduction reaction

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Journal of Energy Chemistry 2021年第8期30卷 482-491,I0011页

作者： Xiaojing Jiang Jianian Chen Fenglei Lyu Chen Cheng Qixuan Zhong xuchun wang Ayaz Mahsud Liang Zhang Qiao Zhang Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China

Controllable fabrication of Fe-N-C based single-atom catalysts(SACs)for enhanced electrocatalytic performance is highly desirable but still ***,an in situ surface-confined strategy was demonstrated for the synthesis of single atomic Fe-N_(4))on N-doped carbon nanoleaves(L-FeNC).The in situ generated Zn3[Fe(CN)6]2 could not only serve as a protection layer against collapse of nanoleaves but also provide abundant Fe source for the formation of Fe-N moieties during pyrolysis,leading to high surface area and high graphitization degree of L-FeNC *** from abundant Fe-N_(4))active sites,enhanced mass and charge transfer,the as-prepared L-FeNC manifested a half-wave potential of 0.89 V for oxygen reduction reaction(ORR)in 0.1 M KOH.A maximum power density of 140 m W cm^(-2)and stable discharge voltage even after operation for 50,000 s have been demonstrated when the L-FeNC was used as air cathode for Zn-air *** work not only provided a unique surfaceconfined strategy for the synthesis of two-dimensional nanocarbons,but also demonstrated the significant benefit from rational design and engineering of Fe-N-C SACs,thus offering great opportunities for fabrication of efficient energy conversion and storage devices.

关键词： Single atom catalyst Iron-nitrogen-carbon Surface confine Oxygen reduction reaction Metal-organic frameworks

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