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Tracking the Confiscated Green Sea Turtles in the South China Sea:Where Did They Come From?Where Will They Go?

Asian Herpetological Research 2024年第3期15卷 173-182页

作者： min CHEN Tong HUANG Dayi NIE Liu LIN Fang CHEN Jing wang Jinyan YANG Jing ZHANG Tong LIU Yiqiong CUI School of Life Sciences Institute of Eco-ChongmingShanghai Institute of Wildlife EpidemicsEast China Normal UniversityShanghai 200241China Hainan Institute of East China Normal University Sanya 572025HainanChina ministry of Education Key Laboratory for Ecology of Tropical Islands Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikou 571158HainanChina Aquatic Wildlife Conservation Branch of China Wildlife Conservation Association Beijing 100013China Society of Entrepreneurs and Ecology Beijing 100012China Commonwealth Scientific and Industrial Research Organisation Canberra ACT 2601Australia

The population of the green sea turtle(Chelonia mydas)is under decline,threatened by bycatch and illegal acquisition despite worldwide protection ***,the confiscation of illegally acquired sea turtles could aid in tracking their origin and movement patterns,crucial for effective conservation *** satellite tracking and genetic analysis offers an opportunity to investigate the relationship between the origins and migration directions of green sea turtles in the western ***,we applied two methods to investigate the spatial ecology of 18 green turtles caught as bycatch in the South China *** results revealed the genetic origins and diverse movements of the *** Mixed Stock Analysis(MSA)suggested that these turtles originated from the rookery of the Xisha Islands(49.6%),central Ryukyu(24.6%),NE Borneo(8%),and the Sulu Sea(5.2%),with other rookeries in meagre proportions(ming *** results indicate that the South China Sea is likely an important transportation hub and mating spot for green *** findings provided evidence for the rehabilitation of these green turtles in the wild and illustrated the complexity of movement during the green turtle’s life history,and the“mixed backgrounds”of the green turtles also highlight the need for joint conservation efforts of neighbouring countries in the South China Sea.

关键词： conservation genetics green sea turtle(Chelonia mydas) movement rookery satellite tracking

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Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence

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Journal of Pharmaceutical Analysis 2021年第3期11卷 340-350页

作者： Huizhen Zhang Yongtao wang Lihuan Guan Yixin Chen Panpan Chen Jiahong Sun Frank J.Gonzalez min Huang Huichang Bi Guangdong Provincial Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical SciencesSun Yat-Sen UniversityGuangzhou510006China Laboratory of Metabolism Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD20892USA

Lipotoxicity, caused by intracellular lipid accumulation, accelerates the degenerative process of cellular senescence, which has implications in cancer development and therapy. Previously, carnitine palmitoyltransferase 1C(CPT1C), a mitochondrial enzyme that catalyzes carnitinylation of fatty acids, was found to be a critical regulator of cancer cell senescence. However, whether loss of CPT1C could induce senescence as a result of lipotoxicity remains unknown. An LC/MS-based lipidomic analysis of PANC-1,MDA-MB-231, HCT-116 and A549 cancer cells was conducted after siRNA depletion of CPT1C. Cellular lipotoxicity was further confirmed by lipotoxicity assays. Significant changes were found in the lipidome of CPT1C-depleted cells, including major alterations in fatty acid, diacylglycerol, triacylglycerol, oxidative lipids, cardiolipin, phosphatidylglycerol, phosphatidylcholine/phosphatidylethanolamine ratio and sphingomyelin. This was coincident with changes in expressions of mRNAs involved in *** and biochemical analyses revealed higher lipid accumulation and increased malondialdehyde and reactive oxygen species, signatures of lipid peroxidation and oxidative stress. Reduction of ATP synthesis, loss of mitochondrial transmembrane potential and down-regulation of expression of mitochondriogenesis gene m RNAs indicated mitochondrial dysfunction induced by lipotoxicity, which could further result in cellular senescence. Taken together, this study demonstrated CPT1C plays a critical role in the regulation of cancer cell lipotoxicity and cell senescence, suggesting that inhibition of CPT1C may serve as a new therapeutic strategy through induction of tumor lipotoxicity and senescence.

关键词： Lipidomics Lipid accumulation Lipid peroxidation Oxidative stress Mitochondrial dysfunction Anticancer target

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Lycium ruthenicum Murr. treatment attenuates APP_(SWE)/PS1ΔE9 mouse model-like mitochondrial dysfunction in Slc25a46 knockout mouse model

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Food Science and Human Wellness 2023年第5期12卷 1618-1625页

作者： min wang Tianxiong Xu Li Gao Chujun Huang Piao Xu Congcong Gong William Kwame Amakye Linfeng Liao Maojin Yao Jiaoyan Ren School of Food Science and Engineering South China University of TechnologyGuangzhou 510641China Guangzhou Institute of Respiratory Disease&China State Key Laboratory of Respiratory Disease The First Affi liated Hospital of Guangzhou Medical UniversityGuangzhou 510182China

Mitochondrial dysfunction is proposed to be substantially associated with ageing and ageing-related diseases like Alzheimer's disease(AD). However, it is unclear whether different mouse models with mitochondrialrelated diseases have similar changes in mitochondrial morphology of the same tissues. Moreover, whether similarities in mitochondrial morphology can be a suitable marker for screening and/or discovering mitochondrial-protective substances remains unknown. Mitochondria morphology in different tissues of a novel mitochondrial outer membrane protein Slc25a46 knockout mouse and a traditional APP_(SWE)/PS1ΔE9 transgenic mouse were examined using transmission electron microscope(TEM). Both young Slc25a46 knockout mice and aged APP_(SWE)/PS1ΔE9 mice models showed similar mitochondrial damage in cerebellum tissues. The results indicated that different mitochondrial-related diseases shared similar alteration and defects in mitochondrial morphology. Furthermore, Lycium ruthenicum Murr. extract, a bioactive food substance with cognition-improving property, could effectively improve muscle strength and increase body weight in the Slc25a46 knockout mice. These findings suggest that mitochondrial morphology defects in mice models, particularly in the mitochondrial compartment, represent a unified and effective marker for screening and validating natural product-derived functional substances with mitochondrial protective properties. It also holds potential application in mitochondrial-impaired senile neurodegenerative diseases, especially in AD.

关键词： Mitochondria dysfunction Ageing Slc25a46 knockout mouse Alzheimer’s disease Lycium ruthenicum Murr.

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Chitosan hydrogel encapsulated with LL-37 peptide promotes deep tissue injury healing in a mouse model

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Military Medical Research 2020年第4期7卷 409-417页

作者： Xu Yang Jing-Lin Guo Jing Han rui-Juan Si Pan-Pan Liu Zi-rui Zhang Ai-min wang Ju Zhang School of Nursing Qingdao UniversityQingdao 266021China

Background:LL-37 peptide is a member of the human cathelicidin family,and has been shown to promote the healing of pressure ***,the low stability of this peptide within the wound environment limits its clinical ***(CS)hydrogel is commonly used as a base material for wound dressing ***:CS hydrogel(2.5%w/v)was encapsulated with *** of the product was examined in cultured NIH3 T3 *** on immune response was examined by measuring tumor necrosis factor-α(TNF-α)release from RAW 264.7 macrophages upon exposure to *** activity was assessed using Staphylococcus *** effect on pressure ulcers was examined using a mouse ***,adult male C57 BL/6 mice were subjected to skin pressure using magnets under a 12/12 h schedule for 21 *** were randomized to receive naked LL-37(20μg),chitosan gel containing 20μg LL-37(LL-37/CS hydrogel)or hydrogel alone under the ulcer bed(n=6).A group of mice receiving no intervention was also included as a ***:LL-37/CS hydrogel did not affect NIH3 T3 cell *** a concentration of 1–5μg/ml,LL-37/CS inhibited TNF-αrelease from *** 5μg/ml,LL-37/CS inhibited the growth of Staphylococcus *** area of the pressure ulcers was significantly lower in mice receiving LL-37/CS hydrogel in comparison to all other 3 groups on days 11(84.24%±0.25%),13(56.22%±3.91%)and 15(48.12%±0.28%).Histological examination on days 15 and 21 showed increased epithelial thickness and density of newly-formed capillary with naked LL-37 and more so with LL-37/*** expression of key macromolecules in the process of angiogenesis(i.e.,hypoxia inducible factor-1α(HIF-1α)and vascular endothelial growth factor-A(VEGF-A))in wound tissue was increased at both the mRNA and protein ***:Chitosan hydrogel encapsulated with LL-37 is biocompatible and could promote the healing of pressure ulcers.

关键词： LL-37 Chitosan hydrogel Deep tissue injury Pressure ulcer Cathelicidin

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Improving the second-tier classification of methylmalonic acidemia patients using a machine learning ensemble method

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World Journal of Pediatrics 2024年第10期20卷 1090-1101页

作者： Zhi-Xing Zhu Georgi ZGenchev Yan-min wang Wei Ji Yong-Yong Ren Guo-Li Tian Sira Sriswasdi Hui Lu Shanghai Engineering Research Center for Big Datain Pediatric Precision Medicine Center for BiomedicalInformaticsShanghai Children’s HospitalSchoolof MedicineShanghai Jiao Tong UniversityShanghaiChina Center of Excellence in Computational Molecular Biology Faculty of MedicineChulalongkorn UniversityBangkokThailand Newborn Screening Center Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina SJTU-Yale Joint Center for Biostatistics and Data Science National Center for Translational MedicineShanghai JiaoTong UniversityShanghaiChina Center for Artifcial Intelligence in Medicine ResearchAfairsFaculty of MedicineChulalongkorn UniversityBangkokThailand State Key Laboratory of Microbial Metabolism JointInternational Research Laboratory of Metabolic&Developmental SciencesDepartment of Bioinformaticsand BiostatisticsSchool of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina

Introduction Methylmalonic acidemia(MMA)is a disorder of autosomal recessive inheritance,with an estimated prevalence of 1:50,***-tier clinical diagnostic tests often return many false positives[fve false positive(FP):one true positive(TP)].In this work,our goal was to refne a classifcation model that can minimize the number of false positives,currently an unmet need in the upstream diagnostics of *** We developed machine learning multivariable screening models for MMA with utility as a secondary-tier tool for false positives *** utilized mass spectrometry-based features consisting of 11 amino acids and 31 carnitines derived from dried blood samples of neonatal patients,followed by additional ratio feature *** selection strategies(selection by flter,recursive feature elimination,and learned vector quantization)were used to determine the input set for evaluating the performance of 14 classifcation models to identify a candidate model set for an ensemble model *** Our work identifed computational models that explore metabolic analytes to reduce the number of false positives without compromising *** best results[area under the receiver operating characteristic curve(AUROC)of 97%,sensitivity of 92%,and specifcity of 95%]were obtained utilizing an ensemble of the algorithms random forest,C5.0,sparse linear discriminant analysis,and autoencoder deep neural network stacked with the algorithm stochastic gradient boosting as the *** model achieved a good performance trade-of for a screening application with 6%false-positive rate(FPR)at 95%sensitivity,35%FPR at 99%sensitivity,and 39%FPR at 100%*** The classifcation results and approach of this research can be utilized by clinicians globally,to improve the overall discovery of MMA in pediatric *** improved method,when adjusted to 100%precision,can be used to further inform the diagnostic process journey of MMA and help r

关键词： Machine learning Methylmalonic acidemia Second-tier test Stacking

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Surveying on two-zone height of sublevel strip mining

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Journal of Coal Science & Engineering(China) 2010年第2期16卷 129-134页

作者： WU Chao-fan WU Wen-jin YANG Wei-min wang Han-jun School of Resource Engineering Lonyan College Longyan 364012 China Beijing Polytechinc College Beijing 100042 China Institute of Geomechanics Chinese Academy of Geological Sciences Beijing 100081 China

The site drilling packer permeability test and TEM to the 2100 workface in Gucheng coalmine determined the two-zone height under sublevel strip *** conclusion considers that the lying strata deterioration law of the strip mining is similar to that of the sublevel ***, against that the actually measured data lacked, it is feasible to refer to the reservation of the waterproof coal pillar in the neighbor coalmine under sublevel ***, it is necessary to further launch the research on lying strata deterioration law under sublevel striping mining for the purpose of providing the right foundation for the layout of the workface not mined so far and the reservation of the waterproof coal pillar in the mining area.

关键词： sublevel strip mining water conducted zone collapsed zone pressure water test

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A comparative analysis of differentially expressed genes in rostral and caudal regions after spinal cord injury in rats

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Neural Regeneration Research 2022年第10期17卷 2267-2271页

作者： Xue-min Cao Sheng-Long Li Yu-Qi Cao Ye-Hua Lv Ya-Xian wang Bin Yu Chun Yao Key Laboratory of Neuroregeneration of Jiangsu and ministry of Education NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsCo-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina

The initial mechanical damage of a spinal cord injury(SCI)triggers a progressive secondary injury cascade,which is a complicated process integrating multiple systems and *** is crucial to explore the molecular and biological process alterations that occur after SCI for therapy *** differences between the rostral and caudal regions around an SCI lesion have received little ***,we analyzed the differentially expressed genes between rostral and caudal sites after injury to determine the biological processes in these two segments after *** identified a set of differentially expressed genes,including Col3a1,Col1a1,Dcn,Fn1,Kcnk3,and Nrg1,between rostral and caudal regions at different time points following *** enrichment analysis indicated that these genes were involved in response to mechanical stimulus,blood vessel development,and brain *** then chose Col3a1,Col1a1,Dcn,Fn1,Kcnk3,and Nrg1 for quantitative real-time PCR and Fn1 for immunostaining *** results indicate alterations in different biological events enriched in the rostral and caudal lesion areas,providing new insights into the pathology of SCI.

关键词： biological process caudal differentially expressed genes Gene Ontology hemisection immunostaining Rattus norvegicus RNA-sequencing rostral spinal cord injury

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CuFe2O4@GO nanocomposite as an effective and recoverable catalyst of peroxymonosulfate activation for degradation of aqueous dye pollutants

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Chinese Chemical Letters 2019年第12期30卷 2216-2220页

作者： Xiaoman Lei Menghan You Fei Pan min Liu Peng Yang Dongsheng Xia Qiang Li Yanting wang Jie Fu School of Environmental Engineering Wuhan Textile UniversityEngineering Research Centre for Clean Production of Textile Dyeing and PrintingMinistry of EducationWuhan 430073China Department of Environmental Science&Engineering Fudan UniversityShanghai 200438China

Recently,heterogeneous activation of peroxymonosulfate(PMS) to oxidatively degrade organic pollutants has been a *** the present work,copper ferrite-graphite oxide hybrid(CuFe2 O4@GO)was prepared and used as catalyst to activate PMS for degradation of methylene blue(MB) in aqueous solution.A high degradation efficiency(93.3%) was achieved at the experimental conditions of20 mg/L MB,200 mg/L CuFe2 O4@GO,0.8 mmol/L PMS,and 25℃***,CuFe2 O4@GO showed an excellent reusability and *** effects of various operational parameters including pollutant type,solution pH,catalyst dosage,PMS dosage,pollutant concentration,temperature,natural organic matter(NOM),and inorganic anions on the catalytic degradation process were comprehensively investigated and *** further mechanistic study revealed the Cu(Ⅱ)/Cu(Ⅰ) redox couple on CuFe2 O4@GO played the dominant role in PMS activation,where both hydroxyl and sulfate radicals were generated and proceeded the degradation of *** general,CuFe2 O4@GO is a promising heterocatalyst for PMS-based advanced oxidation processes(AOPs) in wastewater treatment.

关键词： CuFe2O4@GO Peroxymonosulfate Methylene blue Sulfate radical Advanced oxidation processes

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Inductive and synergistic interactions between plant allelochemical flavone and Bt toxin Cry1 Ac in Helicoverpa armigera

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Insect Science 2021年第6期28卷 1756-1765页

作者： Shan wang min Zhang Jinyong Huang Leyao Li Kaiyuan Huang Yuting Zhang Yalu Li Zhongyuan Deng Xinzhi Ni Xianchun Li School of Agricultural Sciences Zhengzhou UniversityZhengzhouChina School of Life Sciences Zhengzhou UniversityZhengzhouChina USDA-ARS Crop Genetics and Breeding Research UnitUniversity of Georgia-Tifton CampusTiftonGAUSA Department of Entomology and BI05 Institute University of ArizonaTucsonAZUSA

Genetically engineered crops simultaneously produce defensive allelochemi-cals and Bacillus thuringiensis(Bt)toxin proteins to kill some of the world's most devastating insect *** the two types of toxins,when ingested sequentially or simultaneously,interact at both lethal and sublethal doses in these pests remains ***,we examined the toxicological interactions between the Bt toxin Cry 1 Ac and the flavonoid allelochemical flavone in Helicoverpa *** exposure of *** neonates to lethal doses(LC25)of Cry 1 Ac and flavone caused a mortality significantly higher than that of either toxin alone and their expected additive *** for 24 h to a sublethal dose(LC10)of Cry 1 Ac followed by 6-d simultaneous exposure to the same dose of Cry 1 Ac plus a lethal dose(1.6 mg/g diets,LC50)of flavone resulted in a mortality significantly higher than that of the LC50 dose of flavone alone and the expected additive mortality of the LC50 dose of flavone plus the LC10 dose of Cry 1 ***-day preexposure to the sublethal dose(LC10)of flavone followed by 6-d simultaneous exposure to the LC50 dose(6 ng/cm2)of Cry 1 Ac plus the LC25 dose of flavone yielded a mortality significantly higher than that of the LC50 dose of Cry 1 Ac but similar to the expected additive mortality of the LC50 dose of Cry 1 Ac plus the LC50 dose of *** results suggest that Cry 1 Ac induces and synergizes the toxicity of flavone against *** larvae.

关键词： allelochemicals Bt crops combination toxicity induced toxicity resistance toxicological interactions

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Synergistic effect between Er-doped MoS_(2)nanosheets and interfacial Mo-N coupling phases for enhanced electrocatalytic hydrogen evolution

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Rare Metals 2024年第3期43卷 1301-1308页

作者： Nian-Peng Li Lei Zhang Hua Zhang Fan-Fei min Lei wang Sam Toan Xi-Jun Liu Guang-Zhi Hu State Key Laboratory of mining Response and Disaster Prevention and Control in Deep Coal mines School of Materials Science and EngineeringAnhui University of Science and TechnologyHuainan232001China Donghai Laboratory Zhoushan316021China Department of Chemical Engineering University of Minnesota-DuluthDuluthMN55812USA School of Ecology and Environmental Science Institute for Ecological Research and Pollution Control of Plateau LakesYunnan UniversityKunming650504China MOE Key Laboratory of New Processing Technology for Non-Ferrous Metals and Materials Guangxi Key Laboratory of Processing for Non-Ferrous Metals and Featured MaterialsGuangxi UniversityNanning530004China

Hydrogen production via electrochemical water splitting is a promising and green *** one of the most representative transition metal sulfides layered materials,Molybdenum disulfide(MoS_(2))has immense potential for the hydrogen evolution reaction(HER).We successfully prepared a nitrogen-doped carbon(NC)in situ-grown erbium-doped MoS_(2)polyhedral structure(Er-MoS_(2)/NC)that incorporates an interfacial Mo-N coupling phase.

关键词： hydrogen interfacial coupling

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