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Naringin ameliorates H_(2)O_(2)-induced oxidative damage in cells and prolongs the lifespan of female Drosophila melanogaster via the insulin signaling pathway

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Food Science and Human Wellness 2024年第3期13卷 1231-1245页

作者： Xiaomei Du Kexin wang Xiaoyan Sang Xiangxing Meng Jiao Xie Tianxin wang Xiaozhi Liu qun Huang Nan Zhang Hao wang State Key Laboratory of Food Nutrition and Safety Tianjin University of Science and TechnologyTianjin 300457China The key Laboratory of Environmental Pollution Monitoring and Disease Control Ministry of EducationGuizhou Medical UniversityGuizhou 550025China Department of neurosurgery the Fifth Central Hospital of TianjinTianjin 300450China Tianjin Key Laboratory of Epigenetics for Organ Department in Preterm Infants the Fifth Central Hospital of TianjinTianjin 300450China

Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological *** this study,PC12,HepG2 cells,and female Drosophila melanogaster were used to investigate the antioxidative and anti-aging effects of naringin and explore the underlying *** results showed that naringin inhibited H_(2)O_(2)-induced decline in cell viability and decreased,the content of reactive oxygen species in ***,naringin prolonged the lifespan of flies,enhanced the abilities of climbing and the resistance to stress,improved the activities of antioxidant enzymes,and decreased malondialdehyde *** also improved intestinal barrier dysfunction and reduced abnormal proliferation of intestinal stem ***,naringin down-regulated the mRNA expressions of inr,chico,pi 3k,and akt-1,and up-regulated the mRNA expressions of dilp2,dilp3,dilp5,and foxo,thereby activating autophagy-related genes and increasing the number of ***,the mutant stocks assays and computer molecular simulation results further indicated that naringin delayed aging by inhibiting the insulin signaling(IIS)pathway and activating the autophagy pathway,which was consistent with the result of network pharmacological predictions.

关键词： Drosophila melanogaster Insulin signaling(IIS)pathway Naringin PC12 cell HepG2 cell

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Parent-offspring relationship recognition based on SSR and mtDNA confirmed resource supplement effect of Fenneropenaeus chinensis release

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Acta Oceanologica Sinica 2024年第2期43卷 156-160页

作者： Song Sun Ding Lyu Xianshi Jin Xiujuan shan Weiji wang Key Laboratory of Sustainable Development of Marine Fisheries Ministry of Agriculture and Rural AffairsYellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdao 266071China Function Laboratory for Marine Fisheries Science and Food Production Processes Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

The resource of Fenneropenaeus chinensis has declined sharply due to excessive fishing intensity,ecological changes and *** order to supplement the fishing yield and restore resources of ***,the relevant authorities have carried out the activities of stock enhancement and *** can increase biomass and recover ***,compared with increasing biomass,there were still few reports on its effect on the recovery of *** recovery is a process related to whether the released individuals can form a reproductive *** to now,there has been a lack of evidence whether the released *** can complete the entire life history,and form reproduction *** this study,gravid female shrimp after spawning migration were captured from coastal waters of Haiyang,Qingdao,and Yellow *** identifying parentage relationships using simple sequence repeat(SSR)and mtDNA haplotype,it was finally confirmed that there were eight released individuals in the recapture *** was confirmed for the first time that at least part of the released *** can complete overwintering and reproductive migration,and maintain the migration habits as their wild ***,we infered that the released shrimp can reproduce under natural conditions,these *** can form reproductive populations theoretically if without human *** results indicated that enhancenment and release activities have a positive effect on resource recovery.

关键词： Fenneropenaeus chinensis release simple sequence repeat(SSR) mtDNA resource supplement

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Oleuropein alleviates sepsis-induced acute lung injury via the AMPK/Nrf-2/HO-1 signaling

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Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 187-198页

作者： shan-Hu wang Yang-Yang Wu Xiao-Jiao Xia Department of Pediatrics The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325027China

Objective:To explore the effect of oleuropein on sepsis-induced acute lung injury(ALI)in vitro and in vivo and investigate the underlying ***:In an lipopolysaccharide(LPS)-mediated cell model of sepsis-induced ALI and a cecal ligation and puncture-induced mouse model of septic ALI,CCK-8 assay and flow cytometry analysis were used to detect cell activity and *** and relevant assay kits were used to measure the levels of inflammatory cytokines and oxidative stress,*** blot was applied to determine the expression of apoptosis-and AMP-activated protein kinase(AMPK)/nuclear factor erythroid 2-related factor-2(Nrf-2)/heme oxygenase-1(HO-1)signaling-associated ***-1 staining,adenosine triphosphate(ATP)assay kit,and MitoSOX Red assays were performed to detect mitochondrial membrane potential,ATP content,and mitochondrial ROS formation,***,lung injury was evaluated by measuring lung morphological alternations,lung wet-to-dry ratio,myeloperoxidase content,and total protein ***:Oleuropein reduced inflammatory reaction,oxidative damage,and apoptosis,and ameliorated mitochondrial dysfunction in LPS-exposed BEAS-2B cells and mice with septic ***,oleuropein activated the AMPK/Nrf-2/HO-1 signaling ***,these effects of oleuropein were abrogated by an AMPK inhibitor compound ***:Oleuropein can protect against sepsis-induced ALI in vitro and in vivo by activating the AMPK/Nrf-2/HO-1 signaling,which might be a potential therapeutic agent for the treatment of sepsis-induced ALI.

关键词： AMPK/Nrf-2/HO-1 signaling Inflammatory response Lung damage Mitochondrial dysfunction Oleuropein Oxidative stress Sepsis

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Design and synthesis of polyoxovanadate-based framework for efficient dye degradation

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Tungsten 2024年第2期6卷 447-453页

作者： Qing Lan Su-Juan Jin Zheng wang Xu-Yang Li Yan Xiong Zhuo-Cheng wang shan-shan Liu Zhi-Ming Zhang Qiang Zhao Engineering Technology Research Center of Henan Province for Solar Catalysis School of Chemical and Pharmaceutical EngineeringNanyang Normal UniversityNanyang 473061China Institute of New Energy Materials&Low Carbon Technology Tianjin University of TechnologyTianjin 300384China

A new polyoxovanadate-based framework material[Cu(en)_(2)]_(4)V_(18)O_(42)(H_(2)O)·6H_(2)O(1)was designed and synthesized by hydrothermal reaction of NaVO_(3),Cu(NO_(3))_(2)·6H_(2)O and 1,2-diaminoethane(en)via carefully adjusting the pH value of the reaction *** structure of the title compound has been determined by single-crystal X-ray diff raction analysis,thermogravimetric analysis,infrared spectra and elemental *** structural analysis demonstrate the three-dimensional(3D)framework structure of compound 1,which was composed of the[V_(18)O_(42)(H_(2)O)]_(8)−({V_(18)O_(42)(H_(2)O)})anions linked by the Cu^(2+)*** 1 represents the fi rst 3D framework based on{V_(18)O_(42)(H_(2)O)}polyoxoanions and copper ***-driven degradation of residual organic pollutants in industrial wastewater is still a major problem for human *** experiments reveal that compound 1 possesses of excellent photocatalytic activity for the degradation of methylene blue and rhodamine B.

关键词： Polyoxovanadate Framework Polyoxovanadate-based framework Photocatalytic Organic pollutants

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Research on Bast Fiber Extracted from the White Bark of Three Species in the Genus Broussonetia

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Chinese Journal of Polymer Science 2024年第6期42卷 729-738页

作者： shan-shan Jin Si-Nong wang Yan-Yan Huang Jing-Yu Zhang Peng Liu Hui Yu Hong-Dong Zhang Yu-Liang Yang Institute for Preservation and Conservation of Chinese Ancient Books Fudan University LibraryFudan UniversityShanghai200433China State key laboratory of Molecular Engineering of polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China

Against the backdrop of a global paper resource shortage,there is a growing need to identify fast-growing tree species capable of producing long-lasting *** plant species namely Broussonetia kazinoki,Broussonetia papyrifera and hybrid paper mulberry,belong to the Broussonetia genus,were collected from China to study their white bark suitability for pulp and *** chemical composition revealed that the holocellulose content in Broussonetia kazinoki and Broussonetia papyrifera was more than 80%.The molecular weight distribution of several holocellulose/α-cellulose is observed by GPC,which allows us to better observe the changes of various components on the molecular *** yield,lignin,whiteness,and molecular weight of the pulps obtained by NaOH treatment were *** microscope was used to characterize the fiber length-width ratio and ***,the improvement of the fiber rigidity method based on the Kratky-Porod chain model makes it more theoretical and further reveals the influencing factors of fiber *** study demonstrates the high potentiality of these three species for papermaking applications.

关键词： Broussonetia genus Cellulose Alkaline pulping Kratky-Porod chain model Fiber rigidity

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Development of wet adhesion of honeybee arolium incorporated polygonal structure with three-phase composite interfaces

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Friction 2024年第2期12卷 215-230页

作者： Lulu LIANG Jieliang ZHAO qun NIU Li YU Xiangbing WU Wenzhong wang Shaoze YAN Zhenglei YU School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China Division of Intelligent and Biomechanical Systems State Key Laboratory of TribologyDepartment of Mechanical EngineeringTsinghua UniversityBeijing 100084China Key of Bionic Engineering Ministry of EducationJilin UniversityChangchun 130022China

Inspired by the dynamic wet adhesive systems in nature,various artificial adhesive surfaces have been developed but still face different ***,the theoretical mechanics of wet adhesives has never been sufficiently ***,we develop a novel adhesive mechanism for governing wet adhesion and investigate the biological models of honeybee arolium for reproducing the natural wet adhesive ***-nano structures of honeybee arolium and arolium-prints were observed by Cryogenic scanning electron microscopy(Cryo-SEM),and the air pockets were found in the contact interface ***,the adhesive models with a three-phase composite interface(including air pockets,liquid secretion,and hexagonal frames of arolium),were formed to analyze the wet adhesion of honeybee *** results of theoretical calculations and experiments indicated an enhanced adhesive mechanism of the honeybee by liquid self-sucking effects and air-embolism *** these effects,normal and shear adhesion can be adjusted by controlling the proportion of liquid secretion and air pockets in the contact ***,the air-embolism effects contribute to the optimal coupling of smaller normal adhesion with greater shear adhesion,which is beneficial for the high stride frequency of *** works can provide a fresh perspective on the development of bio-inspired wet adhesive surfaces.

关键词： honeybee arolium air pockets wet adhesion a three-phase interface self-sucking effects air-embolism effects

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Propagation form of internal cracks induced by continuous casting soft reduction and control strategy for internal quality

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Journal of Iron and Steel Research(International) 2024年第3期31卷 622-633页

作者： Pu wang Liang Chen qun-wei Tang Wei-tao Li Shao-xiang Li Jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Weifang Special Steel Group Co..Ltd. Weifang 262400ShandongChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

The propagation form of internal cracks induced by continuous casting soft reduction and the control strategy for enhancing the internal quality of 45 steel through industrial trials and a three-dimensional flow-heat transfer-solidification coupling model were *** results showed that the internal cracks induced by soft reduction exhibited a characteristic of being"coarse in the middle and fine at both ends",and displayed an elliptical arc distribution on the loose side of the strand cross *** cracks originated within the brittle temperature range and propagated inward to the liquid impenetrable temperature and outward to the zero ductility temperature or *** control strategy for enhancing the internal quality of the 45 steel strand through soft reduction is to adjust the casting speed or the reduction zone appropriately,ensuring that the central solid fraction of the reduction zone falls within the range of *** this point,a reasonable reduction amount is allocated to eliminate the center shrinkage cavities and center segregation,even if it results in minor reduction-induced cracks.

关键词： Continuous casting Soft reduction Crack propagation Internal quality Control strategy

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Pressure stimulated current in progressive failure process of combined coal-rock under uniaxial compression:Response and mechanism

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International Journal of Mining Science and Technology 2024年第2期34卷 227-243页

作者： Tiancheng shan Zhonghui Li Xin Zhang Haishan Jia Xiaoran wang Enyuan wang Yue Niu Dong Chen Weichen Sun Dongming wang State Key Laboratory of Coal Mine Disaster Prevention and Control China University of Mining and TechnologyXuzhou 221116China National Engineering Research Center for Coal Gas Control China University of Mining and TechnologyXuzhou 221116China School of Safety Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory for Fine Exploration and Intelligent Development of Coal Resources China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China

Effective monitoring of the structural health of combined coal-rock under complex geological conditions by pressure stimulated currents(PSCs)has great potential for the understanding of dynamic disasters in underground *** reveal the effect of this way,the uniaxial compression experiments with PSC monitoring were conducted on three types of coal-rock combination samples with different strength *** mechanism explanation of PSCs are investigated by resistivity test,atomic force microscopy(AFM)and computed tomography(CT)methods,and a PSC flow model based on progressive failure process is *** influence of strength combinations on PSCs in the progressive failure process are *** results show the PSC responses between rock part,coal part and the two components are different,which are affected by multi-scale fracture characteristics and electrical *** the rock strength decreases,the progressive failure process changes obviously with the influence range of interface constraint effect decreasing,resulting in the different responses of PSC strength and direction in different parts to fracture *** PSC flow model is initially validated by the relationship between the accumulated charges of different *** results are expected to provide a new reference and method for mining design and roadway quality assessment.

关键词： Combined coal-rock Pressure stimulated current Progressive failure process Mechanism Flow model

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n-octyl acrylate is a candidate sex pheromone component involved in courtship in parasitoid wasp Microplitis mediator

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Insect Science 2024年第4期31卷 1200-1210页

作者： Yu-Xiao Tao Shuang shan Youssef Dewer shan-Ning wang Adel Khashaveh Rui-Jun Li Yong-Jun Zhang State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijingChina College of Plant Protection Agricultural University of HebeiBaodingHebei ProvinceChina Bioassay Research Department Central Agricultural Pesticide LaboratorySabahia Plant Protection Research StationAgricultural Research CenterAlexandriaEgypt Beijing Key Laboratory of Environment Friendly Management on Fruit Diseases and Pests in North China Institute of Plant ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijingChina

Sex pheromones are considered to play critical roles in partner communication of most parasitic ***,the identification of sex pheromone components remains limited to a few families of parasitoid *** this study,we functionally characterized a candidate sex pheromone component in Microplitis mediator(Hymenoptera:Braconidae),a solitary parasitoid of Noctuidae *** found that the body surface extract from female wasps could significantly stimulate courtship behavior of *** chromatography-electroantennographic detection(GC-EAD)analysis revealed that a candidate semiochemical from extract triggered significant electrophysiological response of antennae of *** performing gas chromatography-mass spectrometer(GC-MS)measurement,GC-EAD active compound was identified as n-octyl acrylate,a candidate sex pheromone component in female *** electroantennogram(EAG)tests,antennae of male wasps showed significantly higher electrophysiological responses to n-octyl acrylate than those of females.Y-tube olfactometer assays indicated that male wasps significantly chose n-octyl acrylate compared with the ***,male wasps showed a remarkable preference for n-octyl acrylate in a simulated field condition behavioral trial;simultaneously,n-octyl acrylate standard could also trigger significant courtship behavior in *** propose that n-octyl acrylate,as a candidate vital sex pheromone component,could be utilized to design behavioral regulators of *** to implement the protection and utilization of natural enemies.

关键词： behavioral assay courtship behavior GC-EAD analysis Microplitis mediator sex pheromone

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How mesenchymal stem cells transform into adipocytes:Overview of the current understanding of adipogenic differentiation

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World Journal of Stem Cells 2024年第3期16卷 245-256页

作者： shan-shan Liu Xiang Fang Xin Wen Ji-shan Liu Miribangvl Alip Tian Sun Yuan-Yuan wang Hong-Wei Chen Department of Reumatology and Immunology Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Emergency Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China Anhui Key Laboratory of Infection and Immunity Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

Mesenchymal stem cells(MSCs)are stem/progenitor cells capable of self-renewal and differentiation into osteoblasts,chondrocytes and *** transformation of multipotent MSCs to adipocytes mainly involves two subsequent steps from MSCs to preadipocytes and further preadipocytes into adipocytes,in which the process MSCs are precisely controlled to commit to the adipogenic lineage and then mature into *** studies have shown that the master transcription factors C/enhancer-binding protein alpha and peroxisome proliferation activator receptor gamma play vital roles in ***,the mechanism underlying the adipogenic differentiation of MSCs is not fully ***,the current knowledge of adipogenic differentiation in MSCs is reviewed,focusing on signaling pathways,noncoding RNAs and epigenetic effects on DNA methylation and acetylation during MSC ***,the relationship between maladipogenic differentiation and diseases is briefly *** hope that this review can broaden and deepen our understanding of how MSCs turn into adipocytes.

关键词： Mesenchymal stem cell Adipogenic differentiation Signaling pathway Noncoding RNA Epigenetic regulation

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