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BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： qin wang qing-Rong Li Lei Xu Zi-Chun Yuan Xiao Liu Mao-Ju Tang Man Luo Xiao-Wu Zhong Qiang Ma Xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

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掺杂对单层石墨烯纳米梁振动频率的影响

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原子与分子物理学报 2025年第3期42卷 67-71页

作者：王志钦王静新疆大学物理科学与技术学院乌鲁木齐830017

石墨烯优异的力学和电学等性能,使其成为纳米机电谐振器的理想材料.通过分子动力学模拟方法研究了掺杂元素和掺杂浓度对单层石墨烯纳米梁振动特性的影响.研究结果表明,单层石墨烯纳米梁的振动频率随纳米梁长度的增加而减小,硼(B)掺杂、... 详细信息

石墨烯优异的力学和电学等性能,使其成为纳米机电谐振器的理想材料.通过分子动力学模拟方法研究了掺杂元素和掺杂浓度对单层石墨烯纳米梁振动特性的影响.研究结果表明,单层石墨烯纳米梁的振动频率随纳米梁长度的增加而减小,硼(B)掺杂、硼-硼(B-B)掺杂、铍(Be)掺杂和铍-铍(Be-Be)掺杂均会导致单层石墨烯纳米梁的振动频率降低.此外,随着硼(B)/铍(Be)掺杂浓度的增加,单层石墨烯纳米梁的振动频率逐渐降低.且随着掺杂浓度的增加,硼(B)掺杂石墨烯纳米梁的振动频率和铍(Be)掺杂石墨烯纳米梁的振动频率的差异逐渐增大.这对石墨烯纳米机械谐振器、振荡器等纳米器件的设计具有一定的理论指导意义.

关键词：石墨烯振动频率分子动力学

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Homologous temperature of olivine: Implications for creep of the upper mantle and fabric transitions in olivine

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Science China Earth Sciences 2016年第6期59卷 1138-1156页

作者： wang qin State Key Laboratory for Mineral Deposits Research School of Earth Sciences and Engineering Nanjing University

The homologues temperature of a crystalline material is defined as T/Tm, where T is temperature and Tm is the melting （solidus） temperature in Kelvin. It has been widely used to compare the creep strength of crystalline materials. The melting temperature of olivine system, （Mg,Fe）2SiO4, decreases with increasing iron content and water content, and increases with confining pressure. At high pressure, phase transition will lead to a sharp change in the melting curve of olivine. After calibrating previous melting experiments on fayalite （Fe2SiO4）, the triple point of fayalite-Fe2SiO4 spinel-liquid is determined to be at 6.4 GPa and 1793 K. Using the generalized means, the solidus and liquidus of dry olivine are described as a function of iron content and pressure up to 6.4 GPa. The change of T/Tm of olivine with depth allows us to compare the strength of the up- per mantle with different thermal states and olivine composition. The transition from semi-brittle to ductile deformation in the upper mantle occurs at a depth where T/Tm of olivine equals 0.5. The lithospheric mantle beneath cratons shows much smaller T/Tm of olivine than orogens and extensional basins until the lithosphere-asthenosphere boundary where T/Tm 〉 0.66, suggesting a stronger lithosphere beneath cratons. In addition, T/Tm is used to analyze deformation experiments on olivine. The results indicate that the effect of water on fabric transitions in olivine is closely related with pressure. The hydrogen-weakening effect and its relationship with T/Tm of olivine need further investigation. Below 6.4 GPa （〈200 kin）, T/TIn of olivine controls the transition of dislocation glide from [100] slip to [001] slip. Under the strain rate of 10-12-10-15 s-1 and low stress in the upper mantle, the [100]（010） slip system （A-type fabric） becomes dominant when T/TIn〉 0.55-0.60. When T/Tm〈 0.55-0.60, [001] slip is easier and low T/Tm favors the operation of [001]（100） slip system （C-type fabric）. This is consistent with

关键词： Olivine Homologous temperature Lattice preferred orientation Water Seismic anisotropy Upper mantle

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The Coarse l^(p)-Novikov Conjecture and Banach Spaces with Property(H)

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Chinese Annals of Mathematics,Series B 2024年第2期45卷 193-220页

作者： Huan wang qin wang Research Center for Operator Algebras School of Mathematical SciencesEast China Normal UniversityShanghai 200241China Key Laboratory of MEA Ministry of Educationand Shanghai Key Laboratory of PMMPEast China Normal UniversityShanghai 200241China

In this paper,for 1

关键词： The coarse l^(p)-Novikov conjecture Banach spaces with Property(H) Coarse geometry K-Theory

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Persistence Approximation Property for Maximal Roe Algebras

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Chinese Annals of Mathematics,Series B 2020年第1期41卷 1-26页

作者： qin wang Zhen wang Research Center for Operator Algebras School of Mathematical SciencesShanghai Key Laboratory of Pure Mathematics and Mathematical PracticeEast China Normal UniversityShanghai 200241China Research Center for Operator Algebras School of Mathematical SciencesEast China Normal UniversityShanghai 200241China

Persistence approximation property was introduced by Hervé Oyono-Oyono and Guoliang Yu. This property provides a geometric obstruction to Baum-Connes conjecture. In this paper, the authors mainly discuss the persistence approximation property for maximal Roe algebras. They show that persistence approximation property of maximal Roe algebras follows from maximal coarse Baum-Connes conjecture. In particular, let X be a discrete metric space with bounded geometry, assume that X admits a fibred coarse embedding into Hilbert space and X is coarsely uniformly contractible, then Cmax*(X) has persistence approximation property. The authors also give an application of the quantitative K-theory to the maximal coarse Baum-Connes conjecture.

关键词： Quantitative K-theory Persistence approximation property Maximal coarse Baum-Connes conjecture Maximal Roe algebras

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Viscosity approximation methods with weakly contractive mappings for nonexpansive mappings

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第10期8卷 1691-1694页

作者： wang Ya-qin Mathematics and Sciences College Shanghai Normal University Shanghai 200234 China

Let K be a closed convex subset of a real reflexive Banach space E, T：K→K be a nonexpansive mapping, and f：K→K be a fixed weakly contractive （may not be contractive） mapping. Then for any t∈（0, 1）, let x1∈K be the unique fixed point of the weak contraction x1→tf（x）＋（1-t）Tx. If T has a fixed point and E admits a weakly sequentially continuous duality mapping from E to E^＊, then it is shown that {xt} converges to a fixed point of T as t→0. The results presented here improve and generalize the corresponding results in （Xu, 2004）.

关键词： Viscosity approximation methods Weakly contractive mapping Fixed point Weakly sequentially continuous duality mapping

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Weak and strong convergence of an explicit iteration scheme with perturbed mapping for nonexpansive mappings

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第12期8卷 2032-2036页

作者： wang Ya-qin Mathematics and Sciences College Shanghai Normal University Shanghai 200234 China

In this paper, we consider an explicit iteration scheme with perturbed mapping for nonexpansive mappings in real q-uniformly smooth Banach spaces. Some weak and strong convergence theorems for this explicit iteration scheme are established. In particular, necessary and sufficient conditions for strong convergence of this explicit iteration scheme are obtained. At last, some useful corollaries for strong convergence of this explicit iteration scheme are given.

关键词： Nonexpansive mapping Iteration scheme with perturbed mapping Opial condition Completely continuous

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p-adic Transcendence and p-adic Transcendence Measures for the Values of Mahler Type Functions

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Acta Mathematica Sinica,English Series 2006年第1期22卷 187-194页

作者： Tian qin wang Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 P. R. China College of Computer Sciences Henan University Kaifeng 475001 P. R. China

We prove the p-adic transcendence and p-adic transcendence measures for the values of some Mahler type functions.

关键词： p-adic transcendence p-adic transcendence measure Mahler type function

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Lightweight and Manageable Digital Evidence Preservation System on Bitcoin

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Journal of Computer Science & Technology 2018年第3期33卷 568-586页

作者： Mingming wang Qianhong Wu Bo qin qin wang Jianwei Liu Zhenyu Guan School of Electronic and Information Engineering Beihang University Beijing 100191 China School of Information Renmin University of China Beijing 100872 China

An effective and secure system used for evidence preservation is essential to possess the properties of anti- loss, anti-forgery, anti-tamper and perfect verifiability. Traditional architecture which relies on centralized cloud storage is depressingly beset by the security problems such as incomplete confidence and unreliable regulation. Moreover, an expensive, inefficient and incompatible design impedes the effort of evidence preservation. In contrast, the decentralized blockchain network is qualified as a perfect replacement for its secure anonymity, irrevocable commitment, and transparent traceability. Combining with subliminal channels in blockchain, we have weaved the transaction network with newly designed evidence audit network. In this paper, we have presented and implemented a lightweight digital evidence-preservation architecture which possesses the features of privacy-anonymity, audit-transparency, function-scalability and operation-lightweight. The anonymity is naturally formed from the cryptographic design, since the cipher evidence under encrypted cryptosystem and hash-based functions leakages nothing to the public. Covert channels are efficiently excavated to optimize the cost, connectivity and security of the framework, transforming the great computation power of Bitcoin network to the value of credit. The transparency used for audit, which relates to the proof of existence, comes from instant timestamps and irreversible hash functions in mature blockchain network. The scalability is represented by the evidence chain interacted with the original blockchain, and the extended chains on top of mainchain will cover the most of auditors in different institutions. And the lightweight, which is equal to low-cost, is derived from our fine-grained hierarchical services. At last, analyses of efficiency, security, and availability have shown the complete accomplishment of our system.

关键词： blockchain covert channel data auditing digital evidence

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Permanence of Metric Sparsification Property under Finite Decomposition Complexity

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Chinese Annals of Mathematics,Series B 2014年第5期35卷 751-760页

作者： qin wang Wenjing wang Xianjin wang Research Center for Operator Algebras Department of Mathematics East China Normal University Department of Applied Mathematics Donghua University College of Mathematics and Statistics Chongqing University

The notions of metric sparsification property and finite decomposition complexity are recently introduced in metric geometry to study the coarse Novikov conjecture and the stable Borel conjecture. In this paper, it is proved that a metric space X has finite decomposition complexity with respect to metric sparsification property if and only if X itself has metric sparsification property. As a consequence, the authors obtain an alternative proof of a very recent result by Guentner, Tessera and Yu that all countable linear groups have the metric sparsification property and hence the operator norm localization property.

关键词： Metric space Metric sparsification Asymptotic dimension Decomposi- tion complexity Permanence property

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