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The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing ning Shi Lv Qian wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

Mutation of plakophUin-2 gene in arrhythmogenic right ventricular cardiomyopathy

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Chinese Medical Journal 2009年第4期122卷 403-407页

作者： WU Shu-lin wang pei-ning HOU Yue-shuang ZHANG Xu-chao SHAN Zhi-xin YU Xi-yong DENG Mei Department of Cardiology Guangdong General Hospital Guangdong Provincial Cardiovascular Institute GuangzhouGuangdong 510080 China Research Center of Guangdong Academy of Medical Science Guangdong General HospitalGuangdong Provincial Cardiovascular Institute GuangzhouGuangdong 510080 China

Background Arrhythmogenic right ventricular cardiomyopathy （ARVC） is one of the leading causes of sudden cardiac death. Recent studies have shown that ARVC, which is an inheritable genetic change, results from mutations in genes encoding desmosomal proteins. Plakophilin-2 is an important component of the desmosome. Because the full range of genetic variations related to ARVC is unknown and no related studies of the Chinese population have been reported, we aimed to investigate the genetic variation of plakophilin-2 in ARVC patients from the Southern Region of China. Methods Genomic DNA was isolated from peripheral blood samples of all 34 ARVC patients, who were screened through a clinical evaluation. They were used to detect variations in the sequences of the plakophilin-2 genes by polymerase chain reaction amplification in combination with direct sequencing. Results In exon-1 of the plakophilin-2 gene, a deletion mutation （c.145_148 del GACA） was found in one family pedigree. The mutation was also found in exon-2, 4, and 11 of the plakophilin-2 gene. The QT interval dispersion of the ECG was considerably longer in the mutation group than in the non-mutation group of ARVC patients, and this result was statistically significant （P 〈0.05）. Conclusion We discovered a plakophilin-2 mutation that prolongs the QT interval dispersion in the southern Chinese ARVC population.

关键词： arrhythmogenic right ventricular cardiomyopathy plakophilin-2 gene mutation

Occluded Gait Emotion Recognition Based on Multi-Scale Suppression Graph Convolutional Network

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Computers, Materials & Continua 2025年第1期82卷 1255-1276页

作者： Yuxiang Zou ning He Jiwu Sun Xunrui Huang Wenhua wang Beijing Key Laboratory of Information Service Engineering Beijing Union UniversityBeijing100101China College of Smart City Beijing Union UniversityBeijing100101China

In recent years,gait-based emotion recognition has been widely applied in the field of computer ***,existing gait emotion recognition methods typically rely on complete human skeleton data,and their accuracy significantly declines when the data is *** enhance the accuracy of gait emotion recognition under occlusion,this paper proposes a Multi-scale Suppression Graph ConvolutionalNetwork(MS-GCN).TheMS-GCN consists of three main components:Joint Interpolation Module(JI Moudle),Multi-scale Temporal Convolution Network(MS-TCN),and Suppression Graph Convolutional Network(SGCN).The JI Module completes the spatially occluded skeletal joints using the(K-Nearest Neighbors)KNN interpolation *** MS-TCN employs convolutional kernels of various sizes to comprehensively capture the emotional information embedded in the gait,compensating for the temporal occlusion of gait *** SGCN extracts more non-prominent human gait features by suppressing the extraction of key body part features,thereby reducing the negative impact of occlusion on emotion recognition *** proposed method is evaluated on two comprehensive datasets:Emotion-Gait,containing 4227 real gaits from sources like BML,ICT-Pollick,and ELMD,and 1000 synthetic gaits generated using STEP-Gen technology,and ELMB,consisting of 3924 gaits,with 1835 labeled with emotions such as“Happy,”“Sad,”“Angry,”and“Neutral.”On the standard datasets Emotion-Gait and ELMB,the proposed method achieved accuracies of 0.900 and 0.896,respectively,attaining performance comparable to other ***,on occlusion datasets,the proposedmethod significantly mitigates the performance degradation caused by occlusion compared to other methods,the accuracy is significantly higher than that of other methods.

关键词： KNN interpolation multi-scale temporal convolution suppression graph convolutional network gait emotion recognition human skeleton

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循环流化床锅炉床压降对其燃烧效率的影响

煤炭学报 2016年第10期41卷 2484-2489页

作者：刘雪敏尹炜迪汪佩宁杨海瑞清华大学热科学与动力工程教育部重点实验室北京100084 中国特种设备检测研究院北京100029

基于循环流化床锅炉流态优化,研究了改变床压降运行对其燃烧效率的影响。以480 t/h CFB锅炉为对象,实验测量了不同床压降下的飞灰、底渣含碳量变化,并建立一维CFB燃烧模型进行了计算。结果表明,建立的一维燃烧模型可以较好地预测流态优... 详细信息

基于循环流化床锅炉流态优化,研究了改变床压降运行对其燃烧效率的影响。以480 t/h CFB锅炉为对象,实验测量了不同床压降下的飞灰、底渣含碳量变化,并建立一维CFB燃烧模型进行了计算。结果表明,建立的一维燃烧模型可以较好地预测流态优化对锅炉燃烧效率的影响。床压降降低时,炉膛内床存量下降,颗粒停留时间变短;同时,过渡区物料浓度明显下降,使得二次风穿透效果改善。因此,多数情况下呈现飞灰含碳量下降而底渣含碳量上升的趋势。床压降降低时,底渣质量份额增加,固体未完全燃烧损失随床压降呈现非单调变化的趋势。CFB锅炉流态优化过程中,当合理的控制给煤粒度并使得床压降在一定范围内下降时,可使得燃烧效率基本保持不变或略有升高。

关键词：循环流化床(CFB)锅炉流态优化床压降燃烧效率

Transcatheter aortic valve replacement(TAVR) for severe aortic valve stenosis with left main artery disease:A case report

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South China Journal of Cardiology 2022年第3期23卷 240-243页

作者： wang pei-ning Maimaitishawuti Yimamu Abudureyimu Alimujiang LI Guang DONG Hao-jian The Cardiovascular Department The First People's Hospital of KashiXinjiang 844099China TheC ardiovascular Department the Guangdong Provincial People's HospitalGuangzhouGuangdong510100China

Introduction: This is the first case of Transcatheter Aortic Valve Replacement(TAVR) in the prefecture level hospital of Xinjiang Province in China. It also proves that severe left main coronary artery disease(LM)is not the contraindication to this operation of TAVR. Patient concerns:The patient had dyspnea for two years, with the 4/6 spurious murmur at the aortic valve. The cardiac ultrasound revealed a severe aortic valve stenosis(AS) and severe mitral regurgitation(MR). Coronary angiography(CAG)showed 80% stenosis of the left main artery. Diagnosis: The severe aortic valve stenosis(AS). Interventions: He received the TAVR, which also is the first case in the First People's Hospital of Kashi Prefecture. Outcomes: The patient's symptoms were significantly improved. The cardiac ultrasound showed that no obvious regurgitation was found in the implanted artificial aortic valve and the MR was significantly reduced. So far, the patient has recovered well for five months after TAVR. Conclusion:TAVR is an effective method for the severe AS patients with serve LM and loss of surgical opportunity.

关键词： Transcatheter Aortic Valve Replacement left main coronary artery disease aortic valve stenosis

日本沼虾表皮几丁质结合蛋白基因的克隆以及KK-42对其表达的影响

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河南师范大学学报（自然科学版） 2016年第5期44卷 106-111页

作者：张宇王佩吕艳杰宁黔冀河南师范大学生命科学学院河南新乡453007

为探讨KK-42缩短日本沼虾蜕皮周期的可能机制,首次从日本沼虾步足表皮组织克隆了编码几丁质结合蛋白的一个新基因——MnCBP-1部分cDNA序列,对其序列进行生物信息学分析,qRT-PCR技术检测MnCBP-1基因的表达水平以及KK-42的影响.结果表明,M... 详细信息

为探讨KK-42缩短日本沼虾蜕皮周期的可能机制,首次从日本沼虾步足表皮组织克隆了编码几丁质结合蛋白的一个新基因——MnCBP-1部分cDNA序列,对其序列进行生物信息学分析,qRT-PCR技术检测MnCBP-1基因的表达水平以及KK-42的影响.结果表明,MnCBP-1基因部分cDNA序列为1396bp,含有特征性的几丁质结合结构域(chitin-bind-4),经BLAST比对,MnCBP-1与蚤状溞相似性为44%.qRT-PCR结果显示,步足表皮组织内MnCBP-1基因表达量随着蜕皮前期(D0-2)的开始逐渐增多.KK-42处理后,蜕皮间期(C)幼虾内MnCBP-1基因表达水平分别在6、12、24和48h比对照组显著升高,而在D0-2期和D3-4期MnCBP-1基因转录物仅在个别时间点有所增多.研究表明,MnCBP-1基因表达与蜕皮周期有关,KK-42处理可显著诱导MnCBP-1基因表达,且表达的高峰提前至C期,这可能是KK-42缩短蜕皮周期的机制之一.

关键词：日本沼虾几丁质结合蛋白 KK-42 克隆基因表达

Recent Advancements in the Optimization Capacity Configuration and Coordination Operation Strategy of Wind-Solar Hybrid Storage System

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Energy Engineering 2025年第1期122卷 285-306页

作者： Hongliang Hao Caifeng Wen Feifei Xue HaoQiu ning Yang Yuwen Zhang Chaoyu wang Edwin E.Nyakilla Department of New Energy Storage Peking University Ordos Research Institute of EnergyOrdos017010China School of Energy and Power Engineering Inner Mongolia University of TechnologyHohhot010080China Key Laboratory of Wind Energy and Solar Energy Utilization Technology Inner Mongolia University of TechnologyHohhot010051China

Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy *** paper proposes a wind-solar hybrid energy storage system(HESS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MOGA)and state of charge(SOC)region division for the batteries are introduced to solve the objective function and configuration of the system capacity,***/Simulink was used for simulation *** optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 ***,the cycle count of the electrochemical energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations *** proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems.

关键词： Electric-thermal hybrid storage modal decomposition multi-objective genetic algorithm capacity optimization allocation operation strategy

Preparation of Modified Composite Nanofiltration Membrane Synergistically Using Carboxylic Multi- walled Carbon Nanotube and β-cyclodextrin

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 232-239页

作者： LIU Peng MAO Junpeng FANG Yanfeng YU Yunwu CHEN Changxiu TANG ning WAN Ye GU Yaxin LIU Yunxue wang Lihua School of Materials Science and Engineering Shenyang Jianzhu UniversityShenyang 110168China

A new modified blend ultrafiltration(UF)membrane with good hydrophilicity,high porosity and excellent anti-fouling performance was developed by using carboxylic multi-walled carbon nanotube(CMWCNT)as casting solution ***,a composite nanofiltration(NF)membrane with large water flux and good retention rate was fabricated by using the PVDF/CMWCNT blend UF membrane as the substrate,and polyvinyl alcohol(PVA),β-cyclodextrin(β-CD)and polyethylenimine(pei)as the coating *** results show that with the appropriate addition of CMWCNT in the casting solution,the surface roughness,porosity and recovery rate of the PVDF/CMWCNT blend UF membrane is obviously *** water flux of blend UF membrane is significantly improved when the CMWCNT content increases from 0 wt%to 0.2 wt%.The water flux of blend UF membrane with 0.2 wt%CMWCNT is 162.7 L/(m^(2)·h),which is 44.3%higher than that of the pure PVDF ***β-CD content is 0.8 wt%,the retention rate of Congo red by PVDF/CMWCNT/β-CD composite NF membrane reaches 98.7%,which is 28.3%higher than that of single PVA/pei modified *** research will provide a new idea and simple method for developing novel high-performance composite NF membranes.

关键词： CMWCNT cyclodextrin nanofiltration membrane

从低速存储器到高速FPGA配置的位流解压缩

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科学技术与工程 2013年第24期21卷 7255-7261页

作者：包朝伟刘仕东王佩宁深圳市国微电子有限公司深圳518057 中兴通讯股份有限公司微电子研究院深圳518005

如果配置FPGA的位流很大,存储位流的存储器就会需要更大的空间,同时配置时间也会很长。为了节约存储空间和提高配置速度,提出了一种解决途径,即在存储芯片(比如Flash存储器)内嵌一个解压缩结构。为了实现这个目标,讨论了两种压缩算法:PD... 详细信息

如果配置FPGA的位流很大,存储位流的存储器就会需要更大的空间,同时配置时间也会很长。为了节约存储空间和提高配置速度,提出了一种解决途径,即在存储芯片(比如Flash存储器)内嵌一个解压缩结构。为了实现这个目标,讨论了两种压缩算法:PDLZW和LZSS。通过对这两种算法的改进,使其适合设计的要求:好的压缩比,解压缩器消耗硬件资源少和有较好的数据吞吐率。实验表明,提出的压缩和解压缩算法,不仅可以减少近30%的存储空间,还能提高将近一倍的数据输出速率。

关键词： FPGA PDLZW算法 LZSS算法压缩解压缩数据吞吐率