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Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression

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Neural Regeneration Research 2024年第9期19卷 1890-1898页

作者： Qiuqin Han Wenhui Li Peiqing Chen lijuan wang Xiwen Bao Renyan Huang Guobin Liu Xiaorong Chen Department of Scientific Research Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghaiChina Department of Traditional Chinese Vascular Surgery Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Physiology Laboratory of Neurodegenerative DiseasesChangzhi Medical CollegeChangzhiShanxi ProvinceChina

Previous studies have demonstrated a bidirectional relationship between inflammation and *** of the nucleotide-binding oligomerization domain,leucine-rich repeat,and NLR family pyrin domain-containing 3(NLRP3)inflammasomes is closely related to the pathogenesis of various neurological *** patients with major depressive disorder,NLRP3 inflammasome levels are significantly *** the role that NLRP3 inflammasome-mediated neuroinflammation plays in the pathogenesis of depression may be beneficial for future therapeutic *** this review,we aimed to elucidate the mechanisms that lead to the activation of the NLRP3 inflammasome in depression as well as to provide insight into therapeutic strategies that target the NLRP3 ***,we outlined various therapeutic strategies that target the NLRP3 inflammasome,including NLRP3 inflammatory pathway inhibitors,natural compounds,and other therapeutic compounds that have been shown to be effective in treating ***,we summarized the application of NLRP3 inflammasome inhibitors in clinical trials related to ***,there is a scarcity of clinical trials dedicated to investigating the applications of NLRP3 inflammasome inhibitors in depression *** modulation of NLRP3 inflammasomes in microglia holds promise for the management of *** investigations are necessary to ascertain the efficacy and safety of these therapeutic approaches as potential novel antidepressant treatments.

关键词： depression microglia neuroinflammation NLRP3 inflammasome

Unveiling microplastic distribution and interactions in the benthic layer of the Yangtze River Estuary and East China Sea

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Environmental Science and Ecotechnology 2024年第4期20卷 114-122页

作者： Xinyu Ge Feng Xu Bo Li Lili Liu Xiao Lu lijuan wang Yunxiao Zhang Jiangpeng Li Jiawei Li Yuanyuan Tang School of Environmental Science and Engineering College of EngineeringSouthern University of Science and TechnologyShenzhen518055China State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process School of Resource and Environmental EngineeringEast China University of Science and TechnologyShanghai200237China School of Marine Science and Technology Zhejiang Ocean UniversityZhoushan316004China

Microplastics(MPs),recognized as an emerging global environmental concern,have been extensively detected worldwide,with specific attention directed towards the Yangtze River Estuary(YRE)and East China Sea(ECS)*** their critical research significance,there remains a knowledge gap concerning the distribution of MPs in the benthic layer within this area,particularly regarding interactions governing their *** we illuminate the distribution of MPs within the benthic layer and unravel the intricate interplay between bottom water and sediment in the YRE and *** find that MPs are notably more abundant in bottom water,ranging from 8 to 175 times higher than in surface *** MPs predominantly consist of polyester fibers,exhibit a size range between 0.5 and 5.0 mm,and display distinct ***-occurrence network analysis and Principal Coordinate Analysis confirm a robust correlation between MPs in bottom water and sediment,signifying the pivotal role of bottom water in mediating the distribution and transportation of MPs within the benthic ***,a positive correlation between MPs in sediment and bottom water turbidity underscores the impact of surface sediment resuspension and upwelling on MPs *** study clarifies the intricate interactions within the benthic layer and highlights the crucial role of bottom water as a mediator in the vertical distribution of MPs,advancing our understanding of the“source-to-sink”transport processes governing MPs within water-sediment systems.

关键词： Microplastics Bottom water Sediment Distribution Correlation analysis

Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi Liu Fangxia Xu Chengcheng Zhou Kaimei Lu Bin Fang lijuan wang Lina Huang Zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

惯例转移要素分析:来自京津冀地区大气污染治理利基项目间学习的实证研究

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东北大学学报（社会科学版） 2024年第2期26卷 48-57,128页

作者：王江王丽娟北京化工大学经济管理学院北京100029 全国人才交流中心北京100013

针对项目间学习的惯例转移进行研究,梳理了惯例转移的概念及内涵,从理论上探讨惯例转移与内外部环境、知识能力以及团队互动之间的相互作用。基于主成分分析和随机森林模型,构建影响惯例转移的重要因素组合,通过对要素的相互作用和关系... 详细信息

针对项目间学习的惯例转移进行研究,梳理了惯例转移的概念及内涵,从理论上探讨惯例转移与内外部环境、知识能力以及团队互动之间的相互作用。基于主成分分析和随机森林模型,构建影响惯例转移的重要因素组合,通过对要素的相互作用和关系的定量化分析,以评价惯例转移难易程度。通过2015—2019年京津冀大气污染治理惯例转移定量分析,发现惯例转移受不同环境要素影响,并且处在不断进化的学习过程中。知识资源、经济环境对于多数惯例转移是重要的、起作用的要素,易于在其他环境中发生转移,而末端型治理增加了知识资源(通用知识)的转移难度。自然资源和自然环境等要素是惯例转移过程的主要冲突因素,使惯例难以在其他环境中发生转移。

关键词：惯例转移项目间学习大气污染治理要素分析环境要素组合

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乡村振兴战略目标下农民法律意识的提升

江苏农业科学 2024年第8期52卷 259-264页

作者：王莉娟江苏第二师范学院江苏南京210000

目前,根据中央农村工作的部署和依法治国战略的要求,农村地区法制建设已经展开,农民对法律的认识和意识正在逐步提高,对自身合法权益的保护也有了更深刻的认识。然而,由于历史原因、法律环境和社会发展的不均衡等问题,导致农民法律意识... 详细信息

目前,根据中央农村工作的部署和依法治国战略的要求,农村地区法制建设已经展开,农民对法律的认识和意识正在逐步提高,对自身合法权益的保护也有了更深刻的认识。然而,由于历史原因、法律环境和社会发展的不均衡等问题,导致农民法律意识的深度还不够、法律知识面还不够广,很多农民对国家法律法规的了解还十分有限。而提高农民的法律意识是加强法治建设、确保社会公平正义、维护社会稳定的核心任务之一。促进乡村振兴,必须提高农民的法律意识。在深入分析当前农民法律意识现状和原因的基础上,提出应加强农村法律教育宣传工作、落实农村法律服务体系、开展法律培训活动、增加农村法治建设资金投入、加强法律监督和农村农民维权保障体系建设和农村综合治理工作等对策,以期乡村振兴战略目标顺利实现。

关键词：乡村振兴农民法律意识途径与对策

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Research on the Employment View of Acupuncture and Tuina Undergraduates in Minority Border Areas from Students’ Perspective

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Journal of Contemporary Educational Research 2024年第8期8卷 265-275页

作者： Rongshuang Yang Kai Yuan Minjie Yin Ruilu Liu Zhihao Zhang lijuan wang Yanfang Yang Xinghe Zhang The Second Clinical Medical College of Yunnan University of Chinese Medicine Kunming 650500Yunnan ProvinceChina

With the popularization of higher education in China,the employment situation of college students is more complex and *** paper adopts the questionnaire method to explore the employment view of acupuncture and tuina undergraduates of Yunnan University of Traditional Chinese *** employment concept of acupuncture and tuina undergraduates in the minority border areas has changed *** graduation,97.95%of students choose to work in fields related to medicine and acupuncture,prefer positions close to home,and are attracted to high-salary companies,among other ***,enhancing the competitive advantages of medical students by guiding their career planning,providing employment selection advice,fostering innovation and entrepreneurship,improving basic skills,and offering graduate entrance examination guidance is crucial for broadening their employment opportunities.

关键词： Undergraduate Employment Minority border areas Acupuncture and tuina

基于要素、效应、环境的区域文旅融合发展评价与类型划分——以河南省为例

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经济地理 2024年第4期44卷 201-209页

作者：王镜邱爽张又萍王丽娟郑州大学管理学院河南郑州450001

加快文旅融合发展是增强国家软实力和满足人民日益增长的物质文化需要的重要手段。文章基于河南省18个地区的截面数据,运用3E体系构建文旅融合发展水平测度模型、相对发展度以及障碍度模型,实证分析了河南省2010—2021年的文旅融合发展... 详细信息

加快文旅融合发展是增强国家软实力和满足人民日益增长的物质文化需要的重要手段。文章基于河南省18个地区的截面数据,运用3E体系构建文旅融合发展水平测度模型、相对发展度以及障碍度模型,实证分析了河南省2010—2021年的文旅融合发展水平、演变类型以及障碍因素。研究发现:(1)2010—2021年河南省文旅融合发展水平由严重失调向中度失调转变,整体处于萌芽阶段,各地区融合等级在逐年提升,且整体呈现南高北低、中高东西低的聚集趋势;(2)根据融合发展类型归纳出3种融合类型、6种文旅融合演变类型,融合发展类型逐渐向优先文化发展演进的地区增多;(3)发展环境作为文化与旅游子系统中最显著的障碍因素,是河南省实现高质量文旅融合发展需要重点攻克的因素,在文旅融合实践过程中以旅彰文显著,但以文促旅不足,旅游需积极向文化借力,实现文旅融合高质量发展。

关键词： 3E体系文旅融合水平测度演变类型障碍因素

血脂异常与神经系统脱髓鞘疾病的相关性研究进展

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中华预防医学杂志 2024年第9期58卷 1295-1301页

作者：李响王利娟张国军首都医科大学附属北京天坛医院检验科北京100070 北京市免疫试剂临床工程技术研究中心北京100070 体外诊断试剂质量控制重点实验室北京100070

神经系统脱髓鞘疾病是神经系统的一大类疾病,以髓鞘脱失伴炎性细胞浸润为主要病理特点,可发生于中枢或周围神经系统。前者主要包括多发性硬化症(MS)、视神经脊髓炎谱系疾病(NMOSD),后者主要以吉兰-巴雷综合征(GBS)为代表。研究表明血脂... 详细信息

神经系统脱髓鞘疾病是神经系统的一大类疾病,以髓鞘脱失伴炎性细胞浸润为主要病理特点,可发生于中枢或周围神经系统。前者主要包括多发性硬化症(MS)、视神经脊髓炎谱系疾病(NMOSD),后者主要以吉兰-巴雷综合征(GBS)为代表。研究表明血脂水平异常可能与神经系统脱髓鞘疾病的发生和发展有关,但国内对相关进展的分析总结较少。因此,本文综述血脂异常与神经系统脱髓鞘疾病的关联性研究进展,深入探讨血脂异常与神经系统脱髓鞘疾病之间的相互关系,为神经系统脱髓鞘疾病的预防和治疗提供参考。

关键词：神经系统脱髓鞘疾病脂质代谢血脂异常

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面向密度峰值聚类的高效相似度度量

山东大学学报（工学版） 2024年第3期54卷 12-21,29页

作者：王丽娟徐晓丁世飞中国矿业大学计算机科学技术学院江苏徐州221116 徐州工业职业技术学院信息工程学院江苏徐州221114

针对密度峰值聚类(density peaks clustering,DPC)计算复杂度高的问题,提出一种面向密度峰值聚类的高效相似度度量(efficient similarity measure,ESM)法,通过仅度量最近邻之间的相似度构建不完全相似度矩阵。最近邻的选择基于一个随机... 详细信息

针对密度峰值聚类(density peaks clustering,DPC)计算复杂度高的问题,提出一种面向密度峰值聚类的高效相似度度量(efficient similarity measure,ESM)法,通过仅度量最近邻之间的相似度构建不完全相似度矩阵。最近邻的选择基于一个随机第三方数据对象,无需另外引入参数。基于ESM法构建相似度矩阵,提出一种改进的高效密度峰值聚类(efficient density peaks clustering,EDPC)算法,在保持准确率的同时提高DPC识别聚类中心的效率。理论分析和试验结果表明,ESM法通过减少一定不相似的相似度,可以有效提高DPC及其改进算法基于K最近邻的密度峰值聚类(density peaks clustering based on K-nearest neighbors,DPC-KNN)和模糊加权K最近邻密度峰值聚类(fuzzy weighted K-nearest neighbors density peaks clustering,FKNN-DPC)的计算效率,具有较强的可扩展性。

关键词：密度峰值聚类聚类中心相似度矩阵计算复杂度大规模数据集