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Enhanced bifunctional oxygen electrochemical catalytic performance using La-doped CoFe_(2)O_(4)spinel supported by 3D-G for Zn-air batteries

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Journal of Energy Chemistry 2024年第7期94卷 778-788页

作者： Yinggang Sun Tingwei Zhang Peng Sun jigang wang Wenjie Duan Yanqiong Zhuang Likai wang Zhongfang Li School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255049ShandongChina

The preparation of bifunctional catalysts for oxygen reduction(ORR)and oxygen evolution(OER)is crucial for Zn-air ***,we report a La doped CoFe_(2)O_(4) spinel catalyst supported on threedimensional graphene(3D-G),where La can facilitate electron transfer from Co to Fe,leading to increased electron cloud density in Fe and improved catalytic *** redshift of the G peak in the Raman spectra indicates the interaction between theπbond of 3D-G and d orbitals in La_(0.2)CoFe_(1.8)O_(4).La_(0.2)CoFe_(1.8)/3D-G exhibits superior ORR performance(E_(1/2)=0.86 V ***)and OER performance(E_(j=10)=1.55 V ***)to CoFe_(2)O_(4)/3D-G(E_(1/2)=0.831 V ***,E_(j=10)=1.603 V ***).Furthermore,it demonstrates excellent bifunctional oxygen catalytic performance while maintaining high power density and stability in liquid zinc-air batteries(ZABs)and flexible ZABs(F-ZABs).This work presents a viable strategy for utilizing rare earth element doped spinels to enhance oxygen catalyst and ZABs performance.

关键词： Zn-air batteries Electrocatalysts La_(0.2)CoFe_(1.8)/3D-G Electron pump Bifunctional oxygen catalytic performance

维普期刊数据库

Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery

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Research 2024年第1期2023卷 315-337页

作者： Chong Qiu Fei Xia Junzhe Zhang Qiaoli Shi Yuqing Meng Chen wang Huanhuan Pang Liwei Gu Chengchao Xu Qiuyan Guo jigang wang Artemisinin Research Center and Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Nephrology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhenGuangdong 518020China

Nanocarriers have therapeutic potential to facilitate drug delivery,including biological agents,smallmolecule drugs,and nucleic ***,their efficiency is limited by several factors;among which,endosomal/lysosomal degradation after endocytosis is the most *** review summarizes advanced strategies for overcoming endosomal/lysosomal barriers to efficient nanodrug delivery based on the perspective of cellular uptake and intracellular transport *** strategies include promoting endosomal/lysosomal escape,using non-endocytic methods of delivery to directly cross the cell membrane to evade endosomes/lysosomes and making a detour pathway to evade endosomes/*** the basis of the findings of this review,we proposed several promising strategies for overcoming endosomal/lysosomal barriers through the smarter and more efficient design of nanodrug delivery systems for future clinical applications.

关键词： somal drugs finding

Neuroinflammation attenuation effects by celastrol and PDIA3 in the amygdala, hippocampus and dorsal raphe nucleus of obese mice

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Journal of Pharmaceutical Analysis 2024年第2期14卷 287-290页

作者： Chunyan Zhu Xuemin Yao Dandan Liu Guoxin Zhang Yongping Zhu Hongyu Chi Shuangpan Zhang Jun Yang Ying Liu jigang wang Na Lin Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing100700China

Nowadays,roughly 603.7 million people are bothered by obesity[1].More seriously,obesity brings inflammation to the peripheral and central nervous system,which compromises the comorbidity of obesity,major depression[2],and cognitive deficits[3].Drug competent in the comorbidity is still *** 2015,Liu et al.[4]reported celastrol(CEL)as a powerful anti-obesity *** our previous study.

关键词： inflammation obesity obese

Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1661-1676页

作者： Junhui Chen Qian Zhang Jinan Guo Di Gu Jing Liu Piao Luo Yunmeng Bai Jiayun Chen Xinzhou Zhang Sheng Nie Chunbo Chen Yulin Feng jigang wang National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine Jiangxi University of Chinese MedicineNanchang 330006China Department of Pulmonary and Critical Care Medicine Shenzhen Institute of Respiratory Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalFirst Affiliated Hospital of Southern University of Science and TechnologySecond Clinical Medical College of Jinan UniversityShenzhen 518020China School of Traditional Chinese Medicine and School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospitalthe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Urology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Nephrology Shenzhen Key Laboratory of Kidney Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospitalthe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Nephrology Nanfang Hospitalthe First Affiliated Hospital of Southern Medical UniversityGuangzhou 510515China Department of Critical Care Medicine Shenzhen People's Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020China State Key Laboratory for Quality Esurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Oncology the Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China

Diabetic nephropathy(DN)is a severe complication of diabetes,characterized by changes in kidney structure and *** natural product rosmarinic acid(RA)has demonstrated therapeutic effects,including anti-inflammation and anti-oxidative-stress,in renal damage or *** this study,we characterized the heterogeneity of the cellular response in kidneys to DN-induced injury and RA treatment at single cell *** results demonstrated that RA significantly alleviated renal tubular epithelial injury,particularly in the proximal tubular S1 segment and on glomerular epithelial cells known as podocytes,while attenuating the inflammatory response of macrophages,oxidative stress,and cytotox-icity of natural killer *** findings provide a comprehensive understanding of the mechanisms by which RA alleviates kidney damage,oxidative stress,and inflammation,offering valuable guidance for the clinical application of RA in the treatment of DN.

关键词： Rosmarinic acid Diabetic nephropathy scRNA sequencing Injury Oxidative stress Infiammation Proteomics

Single-cell transcriptomics systematically discloses the immune-inflammatory responses of peripheral blood mononuclear cells for diabetic nephropathy

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Genes & Diseases 2024年第4期11卷 82-85页

作者： Jiangpeng wu Nan Hu Baochun Guo Hualin Ma Lulin Xie Yisha Huang Siyu Xia Yuke Jiang Zhije Li jigang wang Xinzhou Zhang Zhen Liang Department of Nephrology Shenzhen Key Laboratory of Kidney Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdong 518020China Department of Geriatrics and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdong 518020China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China

Diabetic nephropathy(DN)has become the leading cause of end-stage renal disease with high morbidity and mortality among individuals with diabetes *** functional alterations of renal infiltrating immune cells have been reported as part of the pathological mechanism of DN,the understanding of the immune response underlying peripheral blood mononuclear cells(PBMCs)in DN remains ***,single-cell RNA sequencing(scRNA-seq)was used toprofile the transcriptomic signatures of PBMCs from DN patients.

关键词： nephropathy alterations mortality

Transient and Steady Spray Characteristics of Soybean Oil/2,5-Dimethylfuran Blended Fuel in an Underwater Stirling Engine

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Journal of Shanghai Jiaotong university(Science) 2024年第2期29卷 216-229页

作者：王继刚乔信起周枫王林涛 School of Mechanical Engineering Yangzhou UniversityYangzhou 225127JiangsuChina Key Laboratory of Power Machinery and Engineering of Ministry of Education Shanghai Jiao Tong UniversityShanghai 200240China School of Energy and Power Engineering Wuhan University of TechnologyWuhan 430063China Zhejiang Marine Development Research Institute Zhoushan 316021ZhejiangChina Shanghai Marine Diesel Engine Research Institute Shanghai 201108China

The reduction of oxygen consumption is a key factor to improve the energy density of underwater Stirling engine.A series of fundamental experiments are carried out to elucidate the spray characteristics of soybean oil/2,5-dimethylfuran(DMF)blended fuel in an underwater Stirling *** characteristics such as spray penetration,spray angle,spray area,and light intensity level under low injection and ambient pressures are obtained using image post-processing *** results show that the effects of injection pressure,ambient pressure,and nozzle diameter on the transient spray characteristics of underwater Stirling engine are similar to those of diesel ***,in the steady spray process,the injection pressure has little effect on spray near angle,and the spray far angle increases with the increase of the injection *** with the spray far angle at injection pressure of 3 MPa,the spray far angle at 5 MPa and 7 MPa increased by 11.38%and 18.14%*** addition of DMF can obviously improve the atomization of soybean oil/DMF blended *** spray angle of blended fuel in transient process increases with the increase of the DMF *** spray near angle has exceeded that of diesel(46.21°)when the DMF volume fraction exceeds 25%.The spray far angle is equivalent to that of diesel when the DMF volume fraction reaches 75%.Moreover,the spray with gas ejection no longer keeps conical,the droplet diameter distribution is more dispersed,and the droplet diameter is smaller.

关键词： spray angle steady spray soybean oil 2 5-dimethylfuran(DMF) Stirling engine

Optimization of High-Concurrency Conflict Issues in Execute-Order-Validate Blockchain

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ZTE Communications 2024年第2期22卷 19-29页

作者： MA Qianli ZHANG Shengli wang Taotao YANG Qing wang jigang Shenzhen University Shenzhen 518000China ZTE Corporation Shenzhen 518057China

With the maturation and advancement of blockchain technology,a novel execute-order-validate(EOV)architecture has been proposed,allowing transactions to be executed in parallel during the execution ***,parallel execution may lead to multi-version concurrency control(MVCC)conflicts during the validation phase,resulting in transaction *** on different causes,we categorize conflicts in the EOV blockchain into two types:within-block conflicts and cross-block conflicts,and propose an optimization solution called FabricMan based on Fabric *** within-block conflicts,a reordering algorithm is designed to improve the transaction success rate and parallel validation is implemented based on the transaction conflict *** also merge transfer transactions to prevent triggering multiple version *** cross-block conflicts,a cache-based version validation mechanism is implemented to detect and terminate invalid transactions in *** comparisons are conducted between FabricMan and two other systems,Fabric and Fabric++.The results show that FabricMan outperforms the other two systems in terms of throughput,transaction abort rate,algorithm execution time,and other experimental metrics.

关键词： blockchain MVCC conflict reordering parallel validation transaction merging

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Secure SSL/TLS Communication System Based on Quantum Keys

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ZTE Communications 2024年

作者： wang jigang LU Yuqian WEI Liping JIANG Xinzao ZHANG Han State Key Laboratory of Mobile Network and Mobile Multimedia Department of Cyberspace Security， ZTE Corporation School of Cyber Science and Engineering， Southeast University

Secure Sockets Layer (SSL) and Transport Layer Security (TLS) protocols facilitates a secure framework for identity authentication， data encryption， and message integrity verification. However， with the recent development in quantum computing technology， the security of conventional key-based SSL/TLS protocols faces vulnerabilities. In this paper， we propose a scheme by integrating the quantum key into the SSL/TLS framework. Furthermore， the application of post-quantum algorithms is used to enhance and complement the existing encryption suites. Experimental results show that the proposed SSL/TLS communication system based on quantum keys exhibits high performance in latency and throughput. Moreover， the proposed system showcases good resilience against quantum attacks.

关键词：

Secure SSL/TLS Communication System Based on Quantum Keys

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ZTE Communications 2024年第3期22卷 106-115页

作者： wang jigang LU Yuqian WEI Liping JIANG Xinzao ZHANG Han State Key Laboratory of Mobile Network and Mobile Multimedia Shenzhen 518055China Department of Cyberspace Security ZTE CorporationShenzhen 518057China School of Cyber Science and Engineering Southeast UniversityNanjing 211102China

Secure Sockets Layer(SSL)and Transport Layer Security(TLS)protocols facilitates a secure framework for identity authentication,data encryption,and message integrity ***,with the recent development in quantum computing technology,the security of conventional key-based SSL/TLS protocols faces *** this paper,we propose a scheme by integrating the quantum key into the SSL/TLS ***,the application of post-quantum algorithms is used to enhance and complement the existing encryption *** results show that the proposed SSL/TLS communication system based on quantum keys exhibits high performance in latency and ***,the proposed system showcases good resilience against quantum attacks.

关键词： SSL/TLS protocols quantum key post-quantum cryptography