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Gut microbiota-dependent phenylacetylglutamine in cardiovascular disease:current knowledge and new insights

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Frontiers of Medicine 2024年第1期18卷 31-45页

作者： Yaonan Song Haoran Wei Zhitong Zhou huiqing wang Weijian Hang Junfang Wu Dao Wen wang Division of Cardiology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan430030China

Phenylacetylglutamine(PAGln)is an amino acid derivate that comes from the amino acid *** are increasing studies showing that the level of PAGln is associated with the risk of different cardiovascular *** this review,we discussed the metabolic pathway of PAGln production and the quantitative measurement methods of *** summarized the epidemiological evidence to show the role of PAGln in diagnostic and prognostic value in several cardiovascular diseases,such as heart failure,coronary heart disease/atherosclerosis,and cardiac *** underlying mechanism of PAGln is now considered to be related to the thrombotic potential of platelets via adrenergic ***,other possible mechanisms such as inflammatory response and oxidative stress could also be induced by ***,since PAGln is produced across different organs including the intestine,liver,and kidney,the cross-talk among multiple organs focused on the function of this uremic toxic ***,the prognostic value of PAGln compared to the classical biomarker was discussed and we also highlighted important gaps in knowledge and areas requiring future investigation of PAGln in cardiovascular diseases.

关键词： PAGln cardiovascular disease gut microbiota uremic metabolite biomarker

Effects of micro-oxygenation on the aroma of Cabernet Sauvignon wine from Ningxia,China

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International Journal of Agricultural and Biological Engineering 2022年第4期15卷 251-263页

作者： Zhong Zhang Qingchen Zhang huiqing wang Hongchuan Xia Lijun Sun Junxiang Zhang School of Life Sciences Ningxia UniversityYinchuan 750021China College of Pharmacy University of FloridaGainesville FL32610USA School of Agriculture Ningxia UniversityYinchuan 750021China School of Food and Wine Ningxia UniversityYinchuan 750021China China Wine Industry Technology Institute Yinchuan 750021China

Micro-oxygenation (MOX) is an effective post-harvest technique for the flavor improvement of grape wine. This study investigated the effect of MOX on the aroma quality of Ningxia wine for the first time. Three sub-region Cabernet Sauvignon dry red wines were treated with different levels of oxygen before or after malolactic fermentation. The wine aroma was analyzed through gas chromatography-mass spectrometry (GC-MS) and quantitative descriptive analysis (QDA) after six months of aging. The data obtained demonstrated that the dose and timing of oxygen addition were key factors influencing the effectiveness of MOX. The most noticeable modifications in wine aroma compounds were generated by an oxygen dosage of 30 (mL/L)/month added before malolactic fermentation. Predominantly, the concentrations of 2-phenylethanol, benzaldehyde, diacetyl, and 2,3-pentanedione showed an increased pattern upon MOX treatments. The sensory analysis revealed that MOX improved the aroma quality of wine by decreasing green and animal odors, meanwhile enhancing the olfactory intensities of dried fruits, flowers, and nuts. This work confirmed that MOX was suitable for aroma modification of Cabernet Sauvignon dry red wine from Ningxia and established a preliminary MOX procedure that can serve as a reference for future applications.

关键词： grape wine micro-oxygenation volatile organic compounds aroma profiles Ningxia

The Long-Term Impacts of COVID-19 on Physical and Psychological Health—Beijing Municipality,China,December 2022–April 2023

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China CDC weekly 2023年第40期5卷 894-899页

作者： Tian Tian Chuan Yang Xiaoyu Long Fei Kong Yu Fu Fang Liu Ling Tuo Xiujun Guo Lei Li Xingxing Zhao Qun wang Guangti Yuan huiqing wang Yuanyuan wang Jie Qiao Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijingChina State Key Laboratory of Female Fertility Promotion BeijingChina National Clinical Research Center for Obstetrics and Gynecology(Peking University Third Hospital) BeijingChina Key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijingChina Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology BeijingChina Personnel Department Peking University Third HospitalBeijingChina Office of Hospital Management Peking University Health Science CenterBeijingChina The Second Outpatient Department of Peking University Third Hospital BeijingChina Capital Airport sub-district DongPingLi Community Health Center BeijingChina Zizhuyuan Community Service Station in Haidian District BeijingChina Beijing Advanced Innovation Center for Genomics BeijingChina Peking-Tsinghua Center for Life Sciences Peking UniversityBeijingChina.

Summary What is already known about this topic?Reports detailing the clinical presentation of coronavirus disease 2019(COVID-19)are extensive in ***,data remains limited regarding the long-term effects of the 2022 outbreak on the community and healthcare workers(HCWs).What is added by this report?In the follow-up study conducted with 1,069 community members and 3,309 HCWs infected with COVID-19,we observed that five months postoutbreak,39.2%of community members and 28.7%of HCWs reported experiencing at least one *** symptoms most frequently reported included fatigue or muscle weakness,insomnia,cognitive dysfunction,hair loss,joint or muscle pain,and persistent *** tended to experience fewer long-term physical consequences and their symptoms had an expedited recovery time compared to the community ***,HCWs displayed a higher prevalence of moderate to severe depression and anxiety.

关键词： clinical consequences COV

Predictive Fuzzy Control for Grinding and Classification

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Predictive Fuzzy Control for Grinding and Classification

An amorphous FeMoO_(4) nanorod array enabled high-efficiency oxygen evolution electrocatalysis in alkaline seawater

2011 International Conference on Internet Computing and Information Services （ICICIS 2011）

作者： wang huiqing Hubei Province Key Laboratory of Intelligent Robot Wuhan Institute of Technology School of Computer Science and Engineering Wuhan Institute of Technology

It is difficult to establish accurate and practical mathematic models for the process of grinding and classification due to their complicated mechanism and interrelated affecting factors. A new control algorithm is put forward to deal with the complex process in this paper by drawing the function of the prediction, feedback and emendation in DMC（Dynamic Matrix Control） based on Fuzzy Control system. Computer simulation tests of the classified control system for milling grinding indicate that predictive fuzzy control technique is better than fuzzy control to complex systems, especially having well adaptability in the slow time-varying and large time-lag systems.

关键词： Predictive Control DMC Fuzzy Control

来源： cnki会议评论

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Nano Research 2024年第4期17卷 2270-2275页

作者： Jie Tang Shengjun Sun Xun He Hui Zhang Chaoxin Yang Min Zhang Meng Yue Hefeng wang Yuntong Sun Yonglan Luo Sulaiman Alfaifi Asmaa Farouk Mohamed S.Hamdy Xuping Sun huiqing wang Binwu Ying Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Chemistry Department Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Chemistry College of ScienceKing Khalid UniversityAbha 61413Saudi Arabia Medical Simulation Centre West China Second University HospitalSichuan UniversityChengdu 610041China

The development of highly efficient and durable oxygen evolution reaction(OER)catalysts for seawater electrolysis is of great importance for ***,an amorphous FeMoO_(4) nanorod array on Ni foam is reported as a highly active OER electrocatalyst in alkaline seawater,requiring only overpotentials of 303 and 332 mV to achieve 100 and 300 mA·cm^(-2),***,it shows strong long-term electrochemical durability for at least 50 h.

关键词： amorphous material FeMoO_(4) nanorod array electrocatalyst seawater electrolysis oxygen evolution reaction

Facile synthesis of UCNPs/Zn_xCd_(1-x)S nanocomposites excited by near-infrared light for photochemical reduction and removal of Cr(Ⅵ)

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Chinese Journal of Catalysis 2018年第7期39卷 1240-1248页

作者： Mengli Zhao Wanni wang Chenxi Huang wang Dong Yang wang Sheng Cheng huiqing wang Haisheng Qian School of Biological and Medical Engineering Hefei University of TechnologyHefei 230009AnhuiChina Instrumental Analysis Center Hefei University of TechnologyHefei 230009AnhuiChina School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009AnhuiChina

Photocatalysis driven by near-infrared（NIR）light is of scientific and technological interest for ex-ploiting solar *** this study,we demonstrate a facile hydrothermal process to synthesize core-shell nanoparticles combining upconversion nanoparticles（UCNPs）and alloyed ZnxCwhich can be excited using NIR or visible ***,phase,and chemical composition have been investigated using field-emission scanning electron microscopy,transmission electron mi-croscopy,X-ray diffraction analysis,and atomic absorption ***,we found that amorphous TiO2 layers existing in the final samples play an important role in formation ofyolk-shell nanoparticles,which bind the as-prepared ZnxCnanoparticlescan be tuna-ble by adjusting the amount of the Cd and Zn source *** photochemical reduction of Cr（Ⅵ）in water has been performed to study the photocatalytic performance under irradiation by NIR light or a simulated solar light,showing efficient photoreduction and Cr（Ⅵ）removal over the/TiO2 yolk-shell *** as-prepared UCNPs@ZnxC/TiO2 nanoparticles show excellent production of hydroxyl radicals,which are responsible for the photochemical reduction of Cr（Ⅵ）to Cr（Ⅲ）.This study will provide an alternative strategy for en-vironmental wastewater treatment,making full use of solar energy.

关键词： Upconversion nanoparticle ZnxCd1-xS alloyed semiconductor Yolk-shell Photocatalysis Hydrothermal synthesis

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嵌入式GIS的数据模型构造方法

东南大学学报（自然科学版） 2005年第3期35卷 480-483页

作者：裴凌王庆王慧青东南大学仪器科学与工程系南京210096

分析了桌面GIS数据模型和嵌入式系统的特点,针对嵌入式GIS底图构建了混合式数据模型,空间数据与属性数据之间的联系通过惟一标识号建立,设计了非拓扑的分层分级分格的数据结构.根据底图要素类型的不同分层、地物外接矩形的大小分级及每... 详细信息

分析了桌面GIS数据模型和嵌入式系统的特点,针对嵌入式GIS底图构建了混合式数据模型,空间数据与属性数据之间的联系通过惟一标识号建立,设计了非拓扑的分层分级分格的数据结构.根据底图要素类型的不同分层、地物外接矩形的大小分级及每一级底图坐标,将底图均分为若干个网格,每次显示其中的4个网格.对野外采集的嵌入式GIS空间数据,构建了面向对象的数据模型.实际工程应用表明,GIS运行速度显著提高,解决了嵌入式系统内存不足的问题.

关键词：嵌入式系统 GIS 数据模型面向对象

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一种处理交点退化现象的高效多边形裁剪算法

东南大学学报（自然科学版） 2016年第4期46卷 702-707页

作者：王慧青崇素文东南大学仪器科学与工程学院南京210096 展讯通信(上海)有限公司上海201203

针对复杂多边形裁剪中出现的多边形彼此间重点和重边现象,提出了一种能够处理交点退化现象的高效多边形裁剪算法.该算法利用单向链表实现多边形的存储,同时基于单调链的平面扫描法求解多边形间的交点,减少了多边形顶点的遍历次数和求交... 详细信息

针对复杂多边形裁剪中出现的多边形彼此间重点和重边现象,提出了一种能够处理交点退化现象的高效多边形裁剪算法.该算法利用单向链表实现多边形的存储,同时基于单调链的平面扫描法求解多边形间的交点,减少了多边形顶点的遍历次数和求交次数;对于重点和重边现象,通过交点关联的线段间的方向关系判别交点的进出性;最后更新多边形顶点序列,获取裁剪结果.实验结果表明,该算法能够完成对含内环多边形的裁剪,在交点退化情况下也能获得准确的裁剪结果.且该算法裁剪效率较Greiner-Hormann算法大幅提高,具有很高的执行效率和实用性.

关键词：多边形裁剪交点退化单向链表方向关系

Effects of resolvin D1 on inflammatory responses and oxidative stress of lipopolysaccharide-induced acute lung injury in mice

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Chinese Medical Journal 2014年第5期127卷 803-809页

作者： Yuan Ruixia wang Lei Yao Chengyue Wu Qingping Marie Christelle Xie Wanli Zhang Xingcai Sun Wei wang huiqing Yao Shanglong Department of Anesthesia and Critical Care Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan Hubei 430022 China

Background A variety of inflammatory mediators and effector cells participate together in acute lung injury,and lead to secondary injury that is due to an inflammatory cascade and secondary diffuse lung parenchyma *** is associated with an oxidative stress reaction,which is produced in the development of airway inflammation,and which has positive feedback on inflammation *** D1 can reduce the infiltration of neutrophils,regulate cytokine levels and reduce the inflammation reaction,and thereby promote the resolution of *** purpose of this study is to investigate the effects of resolvin D1 on an inflammatory response and oxidative stress during lipopolysaccharide （LPS）-induced acute lung *** LPS （3 mg/kg） was used to induce the acute lung injury *** resolvin D1 （100 ng/mouse） was given to mice 30 minutes before inducing acute lung *** were observed at 6 hours,12 hours,1 day,2 days,3 days,4 days and 7 days after LPS was administrated,then they were humanely *** collected bronchoalveolar lavage fluid （BALF） and the lung tissues for further *** section and HE staining of the lung tissues were made for histopathology *** of the lung tissues were evaluated for wet-to-dry （W/D） weight *** necrosis factor （TNF）-α,inter leukin （IL）-1β,IL-10 and myeloperoxidase （MPO） were detected by enzyme-linked immunosorbent assay （ELISA）.A lipid peroxidation malondialdehyde （MDA） assay kit was used to detect MDA.A total superoxide dismutase assay kit with WST-1 was used to analyze superoxide dismutase （SOD）.We determined the apoptosis of neutrophils by Flow Cytometry.A real-time quantitative PCR Detecting System detected the expression of mRNA for heme oxygenase （HO）-*** Pretreatment with resolvin D1 reduced the pathological damage in the lung,decreased the recruitment of neutrophils and stimulated their *** markedly decreased the expressions of TNF-α,IL-

关键词： acute lung injury resolvin D1 resolvins oxidative stress