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The Villin/Gelsolin/Fragmin Superfamily Proteins in Plants

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Journal of Integrative Plant Biology 2007年第8期49卷 1183-1191页

作者： Hui Su Ting wang Huaijian Dong haiyun Ren (Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education and College of Life Sciences Beijing Normal University Beijing 100875 China Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education and College of Life Sciences Beijing Normal University Beijing 100875 China

The villin/gelsolin/fragmin superfamily is a conserved Ca^2＋-dependent family of actin-regulating proteins that is widely present both in mammalian and non-mammalian organisms. They have traditionally been characterized by the same core of three or six tandem gelsolin subdomains. The study in vertebrates and lower eukaryotic cells has revealed that the villin/gelsolin/fragmin superfamily of proteins has versatile functions including severing, capping, nucleating or bundling actin filaments. In plants, encouraging progress has been made in this field of research in recent years. This review will summarize the identified plant homologs of villin/gelsolin/fragmin superfamily, thus providing a basis for reflection on their biochemical activities and functions in plants.

关键词： actin-binding protein actin cytoskeleton Villin/Gelsolin/Fragmin.

小儿豉翘清热颗粒联合复方鱼腥草糖浆治疗儿童上呼吸道感染临床研究

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新中医 2024年第3期56卷 104-109页

作者：赵杰朱萍苌俊明别静洋李德亮王海云杨柳南阳市中心医院新生儿重症监护病区河南南阳473000

目的:观察小儿豉翘清热颗粒联合复方鱼腥草糖浆治疗儿童上呼吸道感染对症状控制、炎性细胞因子、免疫功能的影响。方法:选取116例儿童上呼吸道感染患儿为研究对象,按随机数字表法分为对照组及观察组各58例。对照组给予氨酚麻美干混悬剂... 详细信息

目的:观察小儿豉翘清热颗粒联合复方鱼腥草糖浆治疗儿童上呼吸道感染对症状控制、炎性细胞因子、免疫功能的影响。方法:选取116例儿童上呼吸道感染患儿为研究对象,按随机数字表法分为对照组及观察组各58例。对照组给予氨酚麻美干混悬剂、复方鱼腥草糖浆、布洛芬混悬液治疗,观察组在对照组基础上联合小儿豉翘清热颗粒治疗。比较2组临床疗效、症状控制时间及不良反应发生情况。比较2组治疗前、治疗3 d、5 d炎性细胞因子[白细胞介素-6 (IL-6)、肿瘤坏死因子-α (TNF-α)、C-反应蛋白(CRP)、白细胞介素-1 (IL-1)]、免疫球蛋白A (IgA)、免疫球蛋白M (IgM)、免疫球蛋白G (IgG)、T细胞亚群(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))水平。结果:观察组总有效率98.28%,高于对照组84.48%(P0.05)。治疗3 d、5 d后,2组血清IgA、IgM、IgG水平均逐渐升高(P0.05)。结论:小儿豉翘清热颗粒联合复方鱼腥草糖浆治疗儿童上呼吸道感染,能加快症状缓解,促进患儿恢复,增强机体细胞和体液免疫功能。

关键词：上呼吸道感染儿童小儿豉翘清热颗粒复方鱼腥草糖浆炎性细胞因子免疫功能

新生儿病理性黄疸血清总胆红素、AST、ALT、ALB水平与蓝光治疗效果的关系

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分子诊断与治疗杂志 2024年第2期16卷 379-382页

作者：王海云苌俊明赵杰朱萍杨柳张伟业薛燕高航龚辉王颖源南阳市中心医院新生儿重症监护病区河南南阳473000 河南省儿童医院新生儿重症监护病区河南郑州450017

目的研究新生儿病理性黄疸血清总胆红素、谷草转氨酶(AST)、谷丙转氨酶(ALT)、白蛋白(ALB)水平与蓝光治疗效果的关系。方法收集2020年6月至2022年12月期间于南阳市中心医院新生儿重症监护病区诊治的97例新生儿病理性黄疸的病历资料,... 详细信息

目的研究新生儿病理性黄疸血清总胆红素、谷草转氨酶(AST)、谷丙转氨酶(ALT)、白蛋白(ALB)水平与蓝光治疗效果的关系。方法收集2020年6月至2022年12月期间于南阳市中心医院新生儿重症监护病区诊治的97例新生儿病理性黄疸的病历资料,根据患儿蓝光照射治疗效果评估结果分为有效组和无效组,其中有效组共57例,无效组共40例。两组患儿均接受蓝光照射治疗,并进行血清总胆红素、AST、ALT、ALB检测。比较两组治疗前黄疸指数、血清总胆红素、AST、ALT、ALB水平,并分析患儿治疗前血清总胆红素、AST、ALT、ALB水平与蓝光治疗效果相关性。结果治疗前,有效组黄疸指数低于无效组,差异有统计学意义(t=3.346,P<0.05);有效组血清总胆红素、AST、ALT水平低于无效组,血清ALB水平高于无效组,差异有统计学意义(t=3.635、2.273、2.167、8.689,P<0.05);经Logistic多因素分析,总胆红素、AST、ALT水平变化均为影响新生儿病理性黄疸病情严重程度的独立危险因素,ALB水平变化为影响新生儿病理性黄疸病情严重程度的独立保护因素(P<0.05);经Spearman相关性分析显示,患儿治疗前血清总胆红素、AST、ALT与病情严重程度成正比,ALB水平与病情严重程度成反比(P<0.05)。结论治疗前新生儿病理性黄疸血清总胆红素、AST、ALT水平越低,ALB越高,可提示患儿病情程度越轻,从而越有利于蓝光治疗效果。

关键词：新生儿病理性黄疸总胆红素 AST ALT ALB 蓝光治疗

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超声波飞行时间测量的数字增益补偿

仪器仪表学报 2018年第9期39卷 82-90页

作者：燕学智王海云王昕吉林大学通信工程学院长春130022 吉林大学机械工程学院长春130022

针对短基线三维超声定位系统的超声波飞行时间测量问题,提出了数字增益补偿方法。首先提高时间基准的精度,作为时间基准的红外脉冲信号通过收发两端I/O端口直接相连接以有线的方式从发射端传输到接收端,接收端可以准确获知信号发送的瞬... 详细信息

针对短基线三维超声定位系统的超声波飞行时间测量问题,提出了数字增益补偿方法。首先提高时间基准的精度,作为时间基准的红外脉冲信号通过收发两端I/O端口直接相连接以有线的方式从发射端传输到接收端,接收端可以准确获知信号发送的瞬时时刻,同时红外脉冲信号以无线的方式经空气传输至接收端,接收端测量衰减的红外脉冲信号的宽度,通过最小二乘法,建立时间基准误差与红外脉冲宽度的二次曲线方程,计算出时间基准误差。实验表明该方法补偿的时间基准误差约为3～11μs。以高精度时间基准为基础,数字增益补偿方法通过测量与超声波发射传感器距离相等且数字增益置为不同值的两个接收传感器的超声波飞行时间,通过差分思想建立超声波信号延迟时间与数字增益的线性关系,利用最小二乘法确定线性关系的两个系数,通过该线性方程算出数字增益补偿量,该方法同时能消除共模干扰。实验表明该方法补偿的最大数字增益误差约为3μs。

关键词：超声波定位短基线飞行时间时间基准数字增益高精度

Cloning and characterization of two putative seven-transmembrane receptor genes from cotton

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Progress in Natural Science:Materials International 2008年第10期18卷 1225-1231页

作者： Peng Gao Piming Zhao Juan wang haiyun wang Guiling wang Guixian Xia National Key Laboratory of Plant Genomics,Institute of Microbiology,Chinese Academy of Sciences,Datun Road,Chaoyang District,Beijing 100101,China National Center for Plant Gene Research,Beijing 100101,China National Key Laboratory of Plant Genomics Institute of Microbiology Chinese Academy of Sciences Datun Road Chaoyang District Beijing 100101 China National Center for Plant Gene Research Beijing 100101 China

Using rapid amplification of cDNA ends (RACE)-PCR,two full-length cDNAs encoding putative seven-transmembrane receptors (designated Gh7TMpRI and Gh7TMpR2) were cloned from cotton *** blot and an ApaL1 restriction site polymorphism analyses revealed that Gh7TMpRI was derived from the ancestral A diploid genome,while Gh7TMpR2 was from the D subgenome. Northern blot hybridization indicated that both Gh7TMpR1 and GhTTMpR2 were expressed preferentially in the elongation phase of fiber *** of the Gh7TMpRl proteins were located within the membrane structure and displayed a punctuate pattern of *** of Gh7TMpR1 in fission yeast disrupted the polar growth and caused the formation of rounded cells. These results suggest that GhT7MpRl may play a critical role in cotton fiber development,perhaps as a signaling receptor that is involved in controlling fiber elongation.

关键词： Cotton Seven-transmembrane protein Fiber elongation Alloalleles

Forming electron traps deactivates self-assembled crystalline organic nanosheets toward photocatalytic overall water splitting

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Science Bulletin 2021年第3期66卷 265-274,M0004页

作者： Lei wang Jia Liu haiyun wang Hao Cheng Xiaojun Wu Qun Zhang Hangxun Xu Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Soft Matter ChemistryDepartment of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at the Microscale Synergetic Innovation Center of Quantum Information and Quantum PhysicsDepartment of Chemical PhysicsUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Materials for Energy ConversionDepartment of Materials Science and Engineeringand CAS Center for Excellence in NanoscienceUniversity of Science and Technology of ChinaHefei 230026China

Most biological photoredox reactions occur in sophisticated molecular assemblies consisting of highly organized light-harvesting moieties and catalytic *** these prototypes by creating supramolecular assemblies could be a potentially viable approach toward artificial *** self-assembled organic materials are known to carry out water splitting reactions,developing self-assembled organic materials for photocatalytic overall water splitting still remains a critical ***,we first demonstrate that crystalline organic nanosheets assembled from linear oligo(phenylene butadiynylene)(OPB)are able to catalyze overall water splitting under visible light *** investigations reveal that the photocatalytic activity of self-assembled organic structures is closely related to the crystalline structure along with the corresponding electronic *** disorders in OPB nanosheets and extrinsic factors such as adsorbed water molecules will induce the formation of electron traps which can make the OPB nanosheets thermodynamically unfavorable for photocatalytic overall water *** deactivation mechanism unveiled in this study provides crucial insights into the assembling of artificial organic materials for future solar-to-chemical energy conversion.

关键词： Self-assembly Water splitting Photocatalysis Conjugated polymers Deactivation

Three-Gorges Reservoir “Aigae Bioom” Conditions—An investigation

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Chinese Journal Of Geochemistry 2006年第B8期25卷 148-149页

作者： haiyun wang Lei HUANG Ning ZOU Shenggao CHENG Environmental Assessment institute China University of Geosciences Wuhan 430074 China Department of Environment Engineering Three Gorges University Yichang 443002 China

Epstein-Barr virus-encoded RNAs as a survival predictor in nasopharyngeal carcinoma

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Chinese Medical Journal 2014年第2期127卷 294-299页

作者： Ke Kengjian wang haiyun Fu Sha Zhang Zichen Duan Liping Liu Dabo Ye Jin Department of Otolaryngology Guangzhou Women and Children's Medical Center Guangzhou Children's Hospital Guangzhou Guangdong 510120 China State Key Laboratory of Oncology in South China Department of Molecular Diagnostics Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 China Institute of Scientific and Technical Information of China (ISTIC) Beijing 100038 China Department of Otolaryngology the Third Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510623 China

Background Epstein-Barr virus （EBV） infection is one of the most important factors of nasopharyngeal carcinoma （NPC）endemic *** of EBV-encoded non-polyadenylated RNAs （EBERs） are presented in most of NPC *** EBERs as a prognostic marker for NPC might further be informative about the biology and the progression of the *** aim of this study was to analyze the role of EBV latency in the clinical management of nasopharyngeal carcinoma （NPC）,by detecting *** RNA in situ hybridization （ISH） for detecting EBERs was carried out on 908 NPC tumor *** survival （OS） curves were analyzed with the Kaplan-Meier method and the Cox proportional-hazards regression *** The median follow-up time was 70 months （1-120 months）.Eight hundred and sixteen （89.9％） from a total of 908 consecutive NPC cases were found to be EBV-EBER ***-ISH staining revealed nuclear localization in NPC *** the Kaplan-Meier analysis for OS,high EBER expression levels in NPC patients were statistically significant positive prognostic factors for survival （log-rank,P=0.022）,especially in adults aged 17-40 years （P=0.023） and in those with advanced stage disease （log-rank,P=0.002）.Cox proportional-hazards regression model analysis showed that the EBER expression level was an independent risk factor for OS （hazard ratio 0.724,P=0.005）.Conclusions EBERs were frequently detected in NPC tumor tissues,and high-level EBER expression correlated with good prognosis in NPC patients,especially in adult patients and in those with advanced stage *** may serve as a potential prognostic predictor in NPC.

关键词： Epstein-Barr virus-encoded RNAs nasopharyngeal carcinoma endemic areas prognosis

Structural basis of negative regulation of CRISPR-Cas7-11 by TPR-CHAT

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2716-2725页

作者： Tian Hong Qinghua Luo haiyun Ma Xin wang Xinqiong Li Chongrong Shen Jie Pang Yan wang Yuejia Chen Changbin Zhang Zhaoming Su Haohao Dong Xiaodi Tang Department of Laboratory Medicine State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduChina Frontiers Medical Center Tianfu Jincheng LaboratoryWest China HospitalSichuan UniversityChengduChina

CRISPR‒Cas7-11 is a Type Ⅲ-E CRISPR-associated nuclease that functions as a potent RNA editing ***-peptide repeat fused with Cas/HEF1-associated signal transducer(TPR-CHAT)acts as a regulatory protein that interacts with CRISPR RNA(crRNA)-bound Cas7-11 to form a CRISPR-guided caspase complex(Craspase).However,the precise modulation of Cas7-11’s nuclease activity by TPR-CHAT to enhance its utility requires further ***,we report cryo-electron microscopy(cryo-EM)structures of Desulfonema ishimotonii(Di)Cas7-11-crRNA,complexed with or without the full length or the N-terminus of *** structures unveil the molecular features of the Craspase *** analysis,combined with in vitro nuclease assay and electrophoretic mobility shift assay,reveals that DiTPR-CHAT negatively regulates the activity of DiCas7-11 by preventing target RNA from binding through the N-terminal 65 amino acids of DiTPR-CHAT(DiTPR-CHAT_(NTD)).Our work demonstrates that DiTPRCHAT_(NTD) can function as a small unit of DiCas7-11 regulator,potentially enabling safe applications to prevent overcutting and offtarget effects of the CRISPR‒Cas7-11 system.

关键词： CRISPR crRNA TPR