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Science China(Life Sciences) 2005年第5期48卷 515-522页

作者： wang guangming FENG Yougang HAO Jie LI Ailing GAO Xiang XIE Shusheng Department of Immunology Peking University Health Science CenterBeijing 100083China

It has been demonstrated that prolonged graft survival can be achieved through inhibiting the activation of T cells,and addition of soluble CTLA4Ig and OX40Ig proteins to mixed lymphocyte reactions can effectively inhibit T cell *** explore the potential of this type of treatment in xenotransplantation,we infected streptozotocin-induced diabetic BalB/c mice(H-2d)(200 mg/kg,IV)with 5×108 pfu AdCTLA4Ig-IRES-OX40Ig on day 1 before islets trans-plantation through the tail *** results showed that this treatment prolonged the islet xeno-grafts survival *** reaction to exogenous glucose stimulation was normal and the cytokine secretion of the type Th1 cells was *** AdCTLA4Ig-IRES-OX40Ig-mediated treatment effectively induced the T cells into anergy and the Th1/Th2 cells into *** results strongly supported the therapeutic potential of blockade of costimulation by Ad-CTLA4Ig-IRES-OX40Ig genes transfer in inducing the organ transplantation tolerance.

关键词： CD28-B7 OX40-OX40L streptozotocin Adenovirus islet transplantation Type 1 diabetes mellitus

血清CYFRA21-1、CAR及IL-6联合检测对食管癌同步放化疗疗效的评估价值

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分子诊断与治疗杂志 2024年第6期16卷 1178-1182页

作者：张震王光明刘玉平常娟娟安徽省阜阳市肿瘤医院放疗科3病区安徽阜阳236000

目的探讨血清细胞角蛋白19片段抗原21-1(CYFRA21-1)、C反应蛋白与白蛋白比值(CAR)及白细胞介素-6(IL-6)联合检测对食管癌(EC)同步放化疗疗效的评估价值。方法选取2020年1月7日至2023年7月20日期间安徽省阜阳市肿瘤医院放射治疗科收治... 详细信息

目的探讨血清细胞角蛋白19片段抗原21-1(CYFRA21-1)、C反应蛋白与白蛋白比值(CAR)及白细胞介素-6(IL-6)联合检测对食管癌(EC)同步放化疗疗效的评估价值。方法选取2020年1月7日至2023年7月20日期间安徽省阜阳市肿瘤医院放射治疗科收治的,经病理学确诊为EC的患者共计93例作为研究对象。根据治疗后肿瘤组织病变情况分为治疗有效组(n=62)与治疗无效组(n=31)。比较两组患者临床资料及实验室指标,采用多因素Logistic分析血清CYFRA21-1、CAR及IL-6与EC同步放化疗疗效的相关性,绘制受试者工作特性曲线(ROC)评估血清三者联合检测对EC同步放化疗疗效的诊断价值。结果两组患者的年龄、淋巴结转移、临床分期、以及血清CYFRA21-1、CAR和IL-6表达水平比较,差异均具有统计学意义(P<0.05);多因素Logistic回归分析显示年龄的增加、有淋巴结转移、临床分期为Ⅲ期、血清CYFRA21-1、CAR及IL-6表达水平的升高均为影响EC同步放化疗效的独立危险因素(P<0.05)。ROC曲线显示,血清CYFRA21-1、CAR、IL-6以及三者联合检测曲线下面积为0.989、0.726、0.727以及0.995。结论血清CYFRA21-1、CAR及IL-6均能有效预测EC同步放化疗疗效,且三者联用预测价值更高。

关键词：血清细胞角蛋白19 C反应蛋白与白蛋白比值白细胞介素-6

Time-frequency analysis of wheel-rail shock in the presence of wheel flat

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Journal of Traffic and Transportation Engineering(English Edition) 2014年第6期1卷 457-466页

作者： Jianming Ding Jianhui Lin guangming wang Jie Zhao State Key Laboratory of Traction Power Southwest Jiaotong University CNR Tangshan Railway Vehicle Co. Ltd.

Against the deficiencies of traditional time domain and frequency domain analysis in detecting wheel-rail （W-R） system hidden risks which wheel flats generate, the time-frequency characteristics of W-R shock caused by wheel flat are analyzed and the vehicle-rail dynamic model with wheel flat is investigated. The 10 degrees of freedom （DOF） vehicle model is built up. 90-DOF rail model is constructed. The wheel flat excitation model is built up. The vehicle-track coupling dynamic model including wheel flat excitation is set up through nonlinear Hertzian contact theory. The vertical accelerations of axle box are calculated at different speeds and flat sizes based on the vehicle-track coupling dynamic model with wheel flat. Frequency slice wavelet transform （FSWT） is employed to analyze time- frequency characteristics of axle box accelerations to detect the W-R noncontact risks, which the traditional time domain or frequency domain method does not analyze. The results show that the small flat size and high running speed lead to high frequency W-R impact. Large flat size and high running speed result in momentary loss of W-R contact, and there exist security risks between wheel and rail. The conclusion that the phase of axle box accelerations is same to W-R forces lays a theoretical foundation of monitoring W-R contact safety from axle box acceleration instead of traditional W-R force detection.

关键词： railway vehicle wheel flat wheel-rail shock frequency slice wavelet transform timefrequency characteristic

云南盐津2个地震序列震源参数测定及发震构造探讨

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地震研究 2024年第3期47卷 391-404页

作者：顾慧冬姜金钟李姣张演杨跃文王光明张帅姚远云南省地震局云南昆明650224 云南大学地球科学学院云南昆明650504 中国地震局昆明地震预报研究所云南昆明650224

2021年1月23日云南盐津发生M L5.2地震,在此次地震前后该区域已经发生了多次中小地震。为了更好地评估该地区的地震危险性及识别发震构造,利用云南和四川地震台网的近震波形资料,采用CAP方法和2种速度模型反演了盐津M L≥3.5地震的震源... 详细信息

2021年1月23日云南盐津发生M L5.2地震,在此次地震前后该区域已经发生了多次中小地震。为了更好地评估该地区的地震危险性及识别发震构造,利用云南和四川地震台网的近震波形资料,采用CAP方法和2种速度模型反演了盐津M L≥3.5地震的震源机制解和震源深度,结合sPn深度震相测定了盐津M L5.2地震的震源深度,最后采用双差定位法对盐津地震序列进行重定位。结果表明:①最大震级为M L5.2的“孤立型”地震序列发震断层为逆断层,走向近SN向、倾向东、倾角约50°,是一次沿断层面自下而上破裂较为充分的浅源地震;②最大震级为M L3.9的“震群型”地震序列发震断层为走滑型断层,走向为NNW向、倾向北东、倾角约为80°,该序列内3次M L≥3.5地震的震源机制解略有差异,可能是由于该区域复杂的断层结构和应力环境影响所致;③最大震级为M L3.9的“震群型”地震序列的发震断层可能为盐津—筠连断裂,而最大震级为M L5.2的“孤立型”地震序列的发震断层可能为华蓥山断裂与盐津—筠连断裂共同作用产生的一条未知隐伏断裂。

关键词：盐津地震序列震源机制解重定位 sPn震相发震构造

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Ultra-thin circularly polarized lens antenna based on single-layered transparent metasurface

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Chinese Physics B 2018年第8期27卷 235-241页

作者： Kaiyue Liu guangming wang Tong Cai Wenlong Guo Yaqiang Zhuang Gang Liu Air Force Engineenng University Xi＇an 710051China

Circularly polarized （CP） lens antenna has been applied to numerous wireless communication systems based on its unique advantages such as high antenna gain, low manufacturing cost, especially stable data transmission between the transmitter and the receiver. Unfortunately, current available CP lens antennas mostly suffer from high profile, low aperture efficiency as well as complex design. In this paper, we propose an ultra-thin CP lens antenna based on the designed single- layered Pancharatnam-Berry （PB） transparent metasurface with focusing property. The PB metasurface exhibits a high transmissivity, which ensures a high efficiency of the focusing property. Launched the metasurface with a CP patch antenna at its focal point, a low-profile lens antenna is simulated and measured. The experimental results show that our lens antenna exhibits a series of advantages including high radiation gain of 20.7 dB, aperture efficiency better than 41.3%, and also narrow half power beam width （HPBW） of 13°at about 14GHz. Our finding opens a door to realize ultra-thin transparent metasurface with other functionalities or at other working frequencies.

关键词： lens antenna ultra-thin transparent Pancharatnam-Berry (PB) metasurface single-layered

A LOW POWER TIME-TO-DIGITAL CONVERTER FOR ALL-DIGITAL PHASE-LOCKED LOOP

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Journal of Electronics(China) 2011年第3期28卷 402-408页

作者： Yu guangming wang Yu Yang Huazhong Department of Electronic Engineering Tsinghua National Laboratory for Information Science and Technology （ TNList） Tsinghua University Beijing 100084 China

Time-to-Digital Converter (TDC) is a key block used as the phase/frequency detector in an All-Digital Phase-Locked Loop (ADPLL). Usually, it occupies a large proportion of ADPLL's total power consumption up to about 30% to 40%. In this paper, the detailed power consumption of different components in the TDC is analyzed. A Power Management Block (PMB) is presented for the TDC to reduce its power consumption. A 24-bits TDC core with the proposed PMB is implemented in HJTC 0.18 μm CMOS technology. Simulation results show that up to 84% power reduction is achieved using our proposed technique.

关键词： Low power Power management All-Digital Phase-Locked Loop (ADPLL) Time-to-Digital Converter (TDC)

Mechanical properties and interfacial characteristics of 6061 Al alloy plates fabricated by hot-roll bonding

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1890-1899页

作者： Zongan Luo Xin Zhang Zhaosong Liu Hongyu Zhou Mingkun wang guangming Xie State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China

This work aims to investigate the mechanical properties and interfacial characteristics of 6061 Al alloy plates fabricated by hotroll bonding(HRB)based on friction stir *** results showed that ultimate tensile strength and total elongation of the hot-rolled and aged joints increased with the packaging vacuum,and the tensile specimens fractured at the matrix after exceeding 1 ***-equilibrium grain boundaries were formed at the hot-rolled interface,and a large amount of Mg_(2)Si particles were linearly precipitated along the interfacial grain boundaries(IGBs).During subsequent heat treatment,Mg_(2)Si particles dissolved back into the matrix,and Al_(2)O_(3) film remaining at the interface eventually evolved into *** addition,the local IGBs underwent staged elimination during HRB,which facilitated the interface healing due to the fusion of grains at the *** process was achieved by the dissociation,emission,and annihilation of dislocations on the IGBs.

关键词： 6061 Al alloy hot-roll bonding vacuum mechanical properties interfacial grain boundaries

Effect of dissolved organic nitrogen on the bloom of Prorocentrum donghaiense and Karenia spp. in the East China Sea coastal waters

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Acta Oceanologica Sinica 2024年第6期43卷 71-85页

作者： Xiaoru Cui guangming Zhen Jing Zhao Keqiang Li Xiulin wang Key Laboratory of Marine Chemistry Theory and Technology/Frontiers Science Center for Deep Ocean Multispheres and Earth System of Ministry of Education Ocean University of ChinaQingdao 266100China College of Environmental Science and Engineering Ocean University of ChinaQingdao 266100China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China

Understan ding the mechanism of harmful algal bloom formation is vital for effectively preventing algal bloom outbreaks in coastal *** *** in the East China Sea show a significant correlation with nutrient ***,the impact of key components of nutrients,especially dissolved organic nitrogen(DON),on the blooms of Karenia *** not *** research is still *** this study,the cruise observations,field mesocosm-flask culture experiments,and a multinitrogen-tri-phytoplankton-detritus model(NTPD) are combined to reveal the quantitative influence of nutrient regimes on the shift of Prorocentrum donghaiense and Karenia *** the East China *** has a synchronism rhythm of *** spp.-diatom loop in the field culture experiment,which is consistent with the results of the cruise *** results showed that the processes of terrigenous DON(TeDON) and dissolved inorganic nitrogen(DIN:NO_(3)^(-)-N,NH_(4)^(+)-N) absorption promoted *** to become the dominant algae in the community;whereas the processes of DON from *** absorption promoted Karenia *** become the dominant algae in ambient DIN *** addition,the three-dimensional fluorescence components of humus C,tyrosine and fulvic acid can indicate the processes of growth and extinction of *** and Karenia spp.,*** study infers that *** and Karenia *** shift mechanism associated with the nutrient regime in coastal waters,which provides a scientific basis for the environmental management of coastal eco system health.

关键词： Karenia spp. Prorocentrum donghaiense nutrients multinitrogen-tri-phytoplankton-detritus model three-dimensional fluorescence

Solid particle size characterization by a high-frequency collision response in pneumatic particulate flow

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Particuology 2024年第3期86卷 39-54页

作者： Kai wang Yichen Li Ziang Chang Min Qin guangming Fu Bangtang Yin Gang wang jiaqi Tian School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580China Key Laboratory of Unconventional Oil&Gas Development China University of Petroleum(East China)Ministry of EducationQingdao266580China National Engineering Research Center of Oil&Gas Drilling and Completion Technology Qingdao266580China Shock and Vibration of Engineering Materials and Structures Key Lab ofSichuan Province Southwest University of Science and TechnologyMianyang621000China

A novel triaxial vibration method is developed for the real-time characterization of the solid particle size distribution(PsD)in pneumatic particulate flow,which is critical for chemical *** this work,the particle-wall collision and friction behaviours were analysed by the time-domain statistical and timefrequency joint methods to narrow the high-frequency response range by the initial experiment of free fall for a single particle,interparticle,and multiple ***,verification experiments of PSD characterization in pneumatic flow were ***,the quantitative triaxial energy response model that considers the particle size,shape,and mass factors were ***,a good agreement of the particle number identification was found between the triaxial vibration energy and mean particle size of 150-550μ***,the performance with the best accuracy was focused on a range of 42-43 kHz in the x-axis and z-axis and 36.8-38.8 kHz in the ***,the individual particle energy was inversely analysed by the triaxial vibration response within the optimized frequency bands,and the PSD was characterized in real-time by a low error rate,that is,5.2% from the XZ-axis direction of sand(42-43 kHz)and 5.6% from the XYZ-axis of glass(30.9-33.9 kHz,46.2-47.2 kHz,38.3-41.3 kHz for each axis response).Therefore,this research complements the existing approaches for PsD characterization in particulate multiphase flow.

关键词： Solid particulate flow Triaxial vibration High-frequency response Particle wall Particle size distribution

Combination of CTLA4-FasL gene transfer and allogeneic bone marrow transplantation led to durable macrochimerism and donor-specific tolerance in mouse model

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Chinese Science Bulletin 2005年第20期50卷 2311-2317页

作者： FENG Yougang wang guangming HAO Jie LI Ailing YUAN Guohong LI Chong ZENG Fuqing XlE Shusheng Institute of Urology Union Hospital. Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Immunology Peking University Health Science Center Beijing 100083 China

Mixed hemopoietic chimerism is capable of inducing donor specific tolerance, thus eliminating the chronic immunosuppressive therapy following organ trans- plantation. As yet no safe and effective tolerance protocol is available for clinical implementation. Here we describe an alternative nonmyeloablative based strategy of using a single injection of recombination adenovirus vector encoding CTLA4-FasL fusing gene and donor bone marrow cells to promote durable mixed macrochimerism (>20% on 140 d). Chimeras exhibited robust donor-specific tolerance, as evi- denced by acceptance of fully allogeneic skin grafts (the mean survival time (MST)>200 d) and rejection of third- party skin grafts in a normal manner (MST<10 d). In this model, the frequencies of helper T lymphocyte precursor (HTLp) and cytotoxic T lymphocyte precursor (CTLp) were greatly reduced on day 14 after transplantation, suggesting that CTLA4-FasL led to rapid systemic peripheral tolerance to facilitate the bone marrow engraftment, while both HTLp and CTLp remained at low level only in recipient mice with mixed chimerism on day 140 after transplantation, demon- strating that long-term skin grafts tolerance was associated with stable mixed chimerism, and central deletion of donor specific T cell may be the main mechanism for tolerance maintenance.

关键词：老鼠动物模型骨髓移植嵌合现象免疫抑制力成活率