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Garcinia xanthochymus extract protects PC12 cells from H2O2-induced apoptosis through modulation of PI3K/AKT and NRF2/HO-1 pathways

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Chinese Journal of Natural Medicines 2017年第11期15卷 825-833页

作者： XU Jing GAN Sheng LI Jun wand de-bing CHEN Yu HU Xin YANG Guang-Zhong Laboratory for Natural Products Chemistry School of Pharmaceutical Sciences South-Central University for NationalitiesWuhan 430074 China College of Chemistry and Material Sciences South Central University for Nationalities Wuhan 430074 China

The aim of the present study was to investigate the protective effects and underlying mechanisms of Garcinia xanthochymus, a perennial medicinal plant native to Yunnan, China, against H2 O2-induced oxidative damage in rat pheochromacytoma PC12 cells. Preincubation of PC12 cells with fruit Et OAc fraction(fruit-EFr., 12.5–50 μmol·L^(-1)) of G. xanthochymus for 24 h prior to H_2O_2 exposure markedly improved cell viability and increased the activities of antioxidant enzymes(superoxide dismutase, catalase, and heme oxygenase-1 [HO-1]), prevented lactate dehydrogenase release and lipid peroxidation malondialdehyde production, attenuated the decrease of matrix metalloproteinases(MMP), and scavenged reactive oxygen species(ROS). Fruit-EFr. also reduced BAX and cytochrome C expression and improved BCL-2 expression, thereby decreasing the ratio of BAX to BCL-2. Fruit-EFr. activated the nuclear translocation of NRF2 to increase HO-1 and induced the phosphorylation of AKT. Its cytoprotective effect was abolished by LY294002, a specific inhibitor of PI3 K. Taken together, the above findings suggested that *** G. xanthochymus could enhance cellular antioxidant defense capacity, at least in part, through upregulating HO-1 expression and activating the PI3 K/AKT pathway and that it could suppress H_2O_2-induced oxidative damage via PI3 K/AKT and NRF2/HO-1 signaling pathways.

关键词： Garcinia xanthochymus Oxidative stress PC12 PI3K/Akt pathway Nrf2/HO-1 signaling pathways

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吴之邗城非干国考辨

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中国历史地理论丛 2009年第1期24卷 120-128页

作者：王冰扬州博物馆江苏扬州225125

一直以来,人们都将《管子.小问》中的"吴干战"与《左传》记载的"吴城邗"联系起来,并因此认定吴王夫差是在干国故都"城邗,沟通江淮"。本文通过对相关历史文献和考古资料的深入研究与辨析,提出吴干战不在江北之广陵,邗城不是干国,邗王是... 详细信息

一直以来,人们都将《管子.小问》中的"吴干战"与《左传》记载的"吴城邗"联系起来,并因此认定吴王夫差是在干国故都"城邗,沟通江淮"。本文通过对相关历史文献和考古资料的深入研究与辨析,提出吴干战不在江北之广陵,邗城不是干国,邗王是晋人专称的观点。

关键词：吴干战干国邗王邗城

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Is the Double Giant Dipole Resonance Process Responsible for Alpha Emission in Ternary Fission?

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Chinese Physics Letters 2001年第11期18卷 1454-1456页

作者： HAN Hong-Yin wand Yi-Hua G.Mouze China Institute of Atomic Energy P.O.Box 275(46)Beijing 102413 Facultédes Sciences 06108 Nice Cedex 2France

The Monte Carlo program built on the double giant dipole resonance model proposed by Mouze et al. [Nuovo Cimento A 110(1997)1097] was employed to calculate the energy spectrum of alpha particles emitted in the spontaneous ternary fission of 252Cf. It has been found that in the case of the zero orbital angular momentum of alpha particles in the alpha decay of the fragments, the measured alpha spectrum can be reproduced approximately by the model without any adjustable parameter.

关键词： spectrum Ternary momentum

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Current-Induced Light Emission from a Laterally Anodizing Porous Silicon device

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Chinese Physics Letters 1992年第10期9卷 555-557页

作者： SHI Hongtao ZHENG Youdou wand Yongbin YUAN Renkuan department of Physics Nanjing UniversityNanjing 210008

We report the current-induced light emission(CILE)at RT from a porous silicon(PS)Schottky device exhibiting good rectifying characteristics with the ideal factor of *** photoluminescence spectrum from the PS layer fabricate by laterally anodization peaks at 668 *** intensity of CILE increases with increasing *** has run for more than two hours and still keeps *** mechanism of CILE is discussed.

关键词： Schottky Porous Silicon

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Modeling study of regional severe hazes over mid-eastern China in January 2013 and its implications on pollution prevention and control

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Science China Earth Sciences 2014年第1期57卷 3-13页

作者： WANG ZiFa LI Jie WANG Zhe YANG WenYi TANG Xiao GE BaoZhu YAN PinZhong ZHU LiLi CHEN XueShun CHEN HuanSheng wand Wei LI JianJun LIU bing WANG XiaoYan wand Wei ZHAO YiLin LU Ning SU deBin State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of Sciences China National Environmental Monitoring Center Beijing Meteorological Bureau

The Nested Air Quality Prediction Model System(NAQPMS)was used to investigate the temporal and spatial variations of PM2.5over tropospheric central eastern China in January *** impact of regional transport and its implications on pollution prevention and control were also *** between simulated and observed PM2.5showed NAQPMS was able to reproduce the evolution of PM2.5during heavy haze *** results indicated that regional transport of PM2.5played an important role in regional haze episodes in the city cluster including Hebei,Beijing and Tianjin(HBT).The cross-city clusters transport outside HBT and transport among cities inside HBT contributed 20%–35%and 26%–35%of PM2.5as compared with local emission,in HBT *** meet the Air Quality Standards for Grade II,90%,90%and65%of emissions would have to be cut down in Hebei,Tianjin and Beijing,if non-control strategy was taken in the surrounding city clusters of *** implicated that control of emissions in one city cluster is not sufficient to reduce regional haze events,and joint efforts among city clusters are *** regional transports,two-way feedback between boundary-layer evolution and PM2.5also significantly contributed to the formation of heavy hazes,which contributed 30%of monthly average PM2.5concentration in HBT.

关键词： regional hazes trans-boundary transport feedback between boundary-layer evolution and PM2.5 pollution preventionand control

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Effect of Mg and Fe Doping on Optical Absorption of LiNbO3 Crystal through First Principles Calculations

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Chinese Physics Letters 2014年第3期31卷 125-128页

作者： HUANG Duo-Hui YANG Jun-Sheng CAO Qi-Long WAN Ming-Jie LI Qiang SUN Liang wand Fan- Hou Computational Physics Key Laboratory of Sichuan Province Yibin University Yibin 644007

Using first principles calculations, we investigate the structural, optical, and electronic properties of LiNbO3 （LN） and M doped LN （M=Mg, Fe）. The density of states are calculated to analyze the effect of doping Mg and Fe ions on the absorption spectra and electronic properties of LN. The results show an ultraviolet shift in the optical absorption edge of Mg-doped LN compared with that of intrinsic LN. On the contrary, the absorption edge of Fe-doped LN crystal reveals a red shift. The optical absorption spectra show an improved optical response in the visible range for Mg-doped LN, which significantly differs from that obtained for Fe-doped LN. The electronic excitations from the valence band to the conduction band of LN leads to an improved optical absorption response in the visible region as observed experimentally. The obvious changes of the doped LN crystal are found in some cases, which provide a helpful guide for preparing doped LN crystal.

关键词： LITHIUM niobate -- Optical properties RESEARCH SEMICONDUCTOR doping LIGHT absorption MAGNESIUM PHYSICS research

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Treasures of Taibei Palace Museum

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China's Tibet 1994年第6期5卷 34-35页

作者： wand Yao

Ilectured at the Taipei Universi-ty of Political Science for three months between May and Aur gust 1994,This gave me a chance to visit the Tibet Buddhist Objects Show put up by the Taiwan Palace Museum,

关键词： Treasures of Taibei Palace Museum

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The role of latanoprost in an inflammatory bowel disease flare

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Gastroenterology Report 2014年第3期2卷 232-234页

作者： Sonali Paul Martin wand Geoffrey T.Emerick James M.Richter department of Gastroenterology and Hepatology Tufts Medical CenterBostonMAUSA department of Ophthalmology University of Connecticut School of Medicine and Consulting OphthalmologistsFarmingtonCTUSA department of Gastroenterology Massachusetts General HospitalBostonMAUSA

Ulcerative colitis and Crohn’s disease(CD)are characterized by inflammation of the intestinal mucosa and symptoms of abdominal pain and *** studies have shown an association between elevated levels of prostaglandins and mucosal damage in inflammatory bowel *** report a 50-year-old woman with a history of CD and open-angle *** glaucoma was treated with latanoprost,a prostaglandin analog,which was associated with an exacerbation of her *** discontinuation of latanoprost,her CD symptoms disappeared *** case suggests that in a patient with CD,topical administration of latanoprost may result in sufficient systemic absorption and circulation to promote a relapse of *** finding has important implications,not only for patients with inflammatory bowel disease and glaucoma,but also for both ophthalmologists and gastroenterologists.

关键词： lantanoprost Crohn’s disease prostaglandin glaucoma

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MITOCHONDRIAL DYSFUNCTION AT THE EARLY STAGE OF CISPLATIN-INDUCED ACUTE RENAL FAILURE IN RATS

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2000年第1期 94-99页

作者：谢立平 C.Skrezek H.wand F.Reibe

The present study was undertaken to clarify the pathogenesis of cisplatin induced acute renal failure at the early stage. Male Sprague Dawley rats were given an intravenous administration of 10 mg/kg cisplatin. 0.9% saline was infused into them at a rate of 2 ml/h for 3 h, starting with a 2 ml bolus injection before cisplatin administration. 3 h following cisplatin administration, no evident morphological abnormalities were found by both light and electron microscopy; there were also no significant changes in GFR. Thirty min after cisplatin injection, urine sodium and potassium excretion increased by 56% and 260% those of the control animals, respectively. Apparent renal mitochondrial respiration dysfunction was observed in cisplatin treated rats 3 h later; the state 4 respiration increased by 100% and state 3 respiration, respiratory control ratio and carbonyl cyanide p trifluoromethoxyphenyl hydrazone uncoupled respiration decreased by 46%, 74% and 47% of the controls, respectively. The present data suggest that mitochondrial dysfunction may be a very early event in cisplatin induced acute renal failure in rats.

关键词： acute renal failure cisplatin pathogenesis kidney tubule mitochondria

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The transcription factors and the relevant signaling pathways activated by low concentration MNNG

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癌变．畸变．突变 2001年第4期13卷 221-222页

作者： Guliang wand Yingnian Yu departmentofPathophysiology ZhejiangUniversitySchoolofMedicineHangzhouZhejiang310031China departme

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