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Effects of mixture of lidocaine and ropivacaine at different concentrations on the central nervous system and cardiovascular toxicity in rats

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Chinese Medical Journal 2010年第1期123卷 79-83页

作者： wan qiu-xia bo yu-long li hai-bo li wen-zhi Department of Anesthesiology Second Affiliated Hospital ofHarbin Medical University Harbin Heilongjiang 150086 China

Background lidocaine and ropivacaine are often combined in clinical practice to obtain a rapid onset and a prolonged duration of action. However, the systemic toxicity of their mixture at different concentrations is unclear. This study aimed to compare the systemic toxicity of the mixture of ropivacaine and lidocaine at different concentrations when administered intravenously in rats. Methods Forty-eJght male WJstar rats were randomly divided into 4 groups （n=12 each）： 0.5% ropJvacaine （group Ⅰ）; 1.0% ropivacaine and 1.0% lidocaine mixture （group Ⅱ）; 1.0% ropivacaine and 2.0% lidocaine mixture （group Ⅲ）; and 1.0% lidocaine （group Ⅳ）. Local anesthetics were infused at a constant rate until cardiac arrest. Electrocardiogram, electroencephalogram and arterial blood pressure were continuously monitored. The onset of toxic manifestations （seizure, dysrhythmia, and cardiac arrest） was recorded, and then the doses of local anesthetics were calculated. Arterial blood samples were drawn for the determination of local anesthetics concentrations by high-performance liquid chromatography. Results The onset of dysrhythmia was later significantly in group IV than in group Ⅰ, group Ⅱ, and group Ⅲ （P 〈0.01）, but there was no significant difference in these groups （P 〉0.05）. The onset of seizure, cardiac arrest in group Ⅰ （（9.2±1.0） min, （37.0±3.0） min） was similar to that in group Ⅱ（（9.1±0.9） min, （35.0±4.0） min）（P 〉0.05）, but both were later in group Ⅲ （（7.5±0.7） min, （28.0±3.0） min）（P 〈0.05）. The onset of each toxic manifestation was significantly later in group Ⅳ than in group Ⅰ （P 〈0.01）. The plasma concentrations of the lidocaine-alone group at the onset of dysrhythmia （DYS）, cardiac arrest （CA）（（41.2±6.8） min, （59.0±9.0） min） were higher than those of the ropivacaine alone group （（20.5±3.8） min, （38.0±8.0） min）（P 〈0.05）. The plasma concentrations of ropivacaine inducing toxic manifestation were not significantly different among groups Ⅰ, Ⅱ, and Ⅲ（P 〉0.05）. Conclusions The

关键词： ropivacaine lidocaine concentration of local anesthetic local anesthetic toxicity

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Large area^(3)He tube array detector with modular design for multi‑physics instrument at CSNS

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Nuclear Science and Techniques 2023年第1期34卷 1-12页

作者： lin Zhu Jian‑Rong Zhou yuan‑Guang xia liang xiao Hong Luo xiao‑Juan Zhou wen‑Qin Yang Bei‑Ju Guan Xing‑Fen Jiang Yan‑Feng wang Hong Xu hai‑yun Teng li‑Xin Zeng Jia‑Jie li Lei Hu Ke Zhou Yong‑xiang qiu Pei‑Xun Shen Jun Xu li‑Jiang liao xiao‑Zhuang wang Gui‑An Yang Huai‑Chan Chen Ju‑Ping Xu zhi‑Duo li Song‑lin wang Jian Zhuang yu‑Bin Zhao Jun‑Rong Zhang wen Yin zhi‑Jia Sun yuan‑bo Chen Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China University of Chinese Academy of Sciences Beijing 100049China

The multi-physics instrument(MPI)is the first user cooperative instrument at the China Spallation Neutron Source(CSNS).It was designed to explore the structures of complex materials at multiple scales based on the neutron total scattering *** imposes the requirements for the detector,including a high detection efficiency to reduce the measurement time and a large solid angle coverage to cover a wide range of momentum *** satisfy these demands,a large-area array of 3He-filled linear position-sensitive detectors(LPSDs)was constructed,each with a diameter of 1 inch and pressure of 20 *** uses an orbicular layout of the detector and an eight-pack module design for the arrangement of 3He LPSDs,covering a range of scattering angles from 3°to 170°with a total detector area of approximately 7 *** detector works in air,which is separated from the vacuum environment to facilitate installation and *** characteristics of the MPI detector were investigated through Monte Carlo(MC)simulations using Geant4 and experimental *** results suggest that the detectors are highly efficient in the wavelength range of the MPI,and an efficiency over 25%is achievable for above 0.1 A neutrons.A minimal position resolution of 6.4 mm full width at half maximum(FWHM)along the tube length was achieved at a working voltage of 2200 V,and a deviation below 2 mm between the real and measured positions was attained in the beam *** detector module exhibited good consistency and an excellent counting rate capacity of up to 80 kHz,which satisfied the requirements of experiments with a high event *** of its operation over the past year have shown that the detector works steadily in sample experiments,which allows the MPI to serve the user program successfully.

关键词： Neutron detector LPSD Position resolution Counting rate capacity

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Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： Jun liu Dan-Dan li Wei Dong yu-Qi liu Yang Wu Da-Xuan Tang Fu-Chun Zhang Meng qiu Qi Hua Jing-yu He Jun li Bai Du Ting-hai Du lin-lin Niu Xue-Jun Jiang bo Cui Jiang-Bin Chen Yang-Gan wang hai-Rong wang Qin yu Jing He Yi-lin Mao xiao-Fang Bin yue Deng yu-Dan Tian Qing-Hua Han Da-Jin liu li-Qin Duan Ming-Jun Zhao Cui-Ying Zhang hai-Ying Dai Ze-Hua li Ying xiao You-zhi Hu xiao-yu Huang Kun Xing Xin Jiang Chao-Feng liu Jing An Feng-Chun li Tao Tao Jin-Fa Jiang Ying Yang Yao-Rong Dong Lei Zhang Guang Fu Ying li Shu-Wei Huang li-Ping Dou Lan-Jun Sun Ying-Qiang Zhao Jie li yun xia Jun liu Fan liu wen-Jin He Ying li Jian-Cong Tan Yang lin Ya-Bin Zhou Jian-Fei Yang Guo-Qing Ma Hui-Jun Chen He-Ping liu Zong-Wu liu Jian-Xiong liu xiao-Jia Luo xiao-Hong Bin Ya-Nan yu hai-xia Dang Bing li Fei Teng wang-Min Qiao xiao-long Zhu Bing-Wei Chen Qi-Guang Chen Chun-Ti Shen Yong-Yan wang yun-Dai Chen Zhong wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-Heng Zhao Gang Zhao li-Cai Deng xiao-Wei liu Yi-Peng Jing Gang wang Hao-Tong Zhang Jian-Rong Shi xiang-Qun Cui Yao-Quan Chu Guo-Ping li Zhong-Rui Bai yue Wu Yan Cai Shu-yun Cao Zi-Huang Cao Jeffrey L.Carlin hai-yuan Chen Jian-Jun Chen Kun-Xin Chen li Chen Xue-Lei Chen xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong bo-Zhong Gu Yan-Xin Guo Zhan-wen Han bo-liang He Jin-liang Hou Yong-Hui Hou wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-wen Hu zhi-Ying Huo Lei Jia Fang-Hua Jiang xiang Jiang zhi-bo Jiang Ge Jin xiao Kong Xu Kong Ya-Juan Lei Ai-Hua li Chang-Hua li Guang-Wei li hai-Ning li Jian li Qi li Shuang li Sha-Sha li Xin-Nan li Yan li Yin-Bi li Ye-Ping li yuan liang Chien-Cheng lin Chao liu Gen-Rong liu Guan-Qun liu zhi-Gang liu wen-zhi Lu yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao yuan Tian Dan wang Da-Qi wang Feng-Fei wang Guo-Min wang hai wang Hong-Chi wang Jian wang Jia-Ning wang Jian-ling wang Jian-Ping wang Jun-xian wang Lei wang Meng-Xin wang Shou-Guan wang Shu-Qing wang xia wang Ya-Nan wang You wang yue-Fei wang You-Fen wang Peng Wei Ming-zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu yu-Zhong Wu xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-qiu Yao Yong yu Hui yuan hai-bo yuan hai-long yuan Wei-Min yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang li-Pin Zhang Wei Zhang Yong Zhang Yan-xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin ling Qiao-Nan Shan Xu-Yong Wei Rui wang Chang-Ku Jia li Zhuang Tian Shen li-Min Ding zhi-Dan Xu Lai-Bang Luo li-bo Sun Guang-Ming li Tai-Shi Fang Nan Jiang Kun Zhang Zhao-Jie Su zhi-hai Peng Ren Lang Tao Jiang Qiang He lin-Sen Ye Yang Yang yu-Ting He wen-zhi Guo liu-Gen Lan Xu-Yong Sun Dong Chen zhi-Shui Chen Da-Wei Zhou Shao-Jun Ye Qi-Fa Ye Min Tian Jian-Hua Shi bo wang Jiang liu Qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen wang lin Zhong Jing-Sheng Ma Qi-Gen li Sheng-Dong Wu Chang-Jiang Lu Cai-De Lu Dong-Hua Zhang Xuan wang Zi-Qiang li Mu-Jian Teng Jun-Jie li wen-Tao Jiang Jian-Hua li Quan-Bao Zhang Ning-Qi Zhu Zheng-Xin wang Kang He Qiang xia Shao-Hua Song zhi-Ren Fu Wei qiu Guo-yue Lv Rui-Peng Song Ji-Zhou wang Zheng wang Jian Zhou Gang Chen Ying-Peng Zhao li li Ze-Min Hu Qi-Jie Luo Zhong-Zhou Si Bin Xie xiao-Shun He zhi-Yong Guo Shu-Sen Zheng xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma liver transplantation Conversion

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The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST)

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Research in Astronomy and Astrophysics 2012年第9期12卷 1197-1242页

作者： xiang-Qun Cui Yong-Heng Zhao Yao-Quan Chu Guo-Ping li Qi li li-Ping Zhang Hong-Jun Su Zheng-qiu Yao Ya-Nan wang xiao-Zheng Xing Xin-Nan li Yong-Tian Zhu Gang wang bo-Zhong Gu A-li Luo Xin-Qi Xu Zhen-Chao Zhang Gen-Rong liu Hao-Tong Zhang De-Hua Yang Shu-yun Cao hai-yuan Chen Jian-Jun Chen Kun-Xin Chen Ying Chen Jia-Ru Chu Lei Feng Xue-Fei Gong Yong-Hui Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-wen Hu Lei Jia Fang-Hua Jiang xiang Jiang Zi-bo Jiang Ge Jin Ai-Hua li Yan li Ye-Ping li Guan-Qunliu zhi-Gang liu Huo-Ming Shi Zheng-Hong Tang Qing-Sheng Tao xiang-Yan yuan Chao Zhai Jing Zhang Yan-xia Zhang Yong Zhang Ming Zhao Fang Zhou Guo-Hua Zhou Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China yzhao @ *** Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Tecfinologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, also called the Guo Shou Jing Telescope) is a special reflecting Schmidt telescope. LAMOST’s special design allows both a large aperture (effective aperture of 3.6 m–4.9 m) and a wide field of view (FOV) (5°). It has an innovative active reflecting Schmidt configuration which continuously changes the mirror’s surface that adjusts during the observation process and combines thin deformable mirror active optics with segmented active optics. Its primary mirror (6.67m×6.05 m) and active Schmidt mirror (5.74m×4.40 m) are both segmented, and composed of 37 and 24 hexagonal sub-mirrors respectively. By using a parallel controllable fiber positioning technique, the focal surface of 1.75 m in diameter can accommodate 4000 optical fibers. Also, LAMOST has 16 spectrographs with 32 CCD cameras. LAMOST will be the telescope with the highest rate of spectral acquisition. As a national large scientific project, the LAMOST project was formally proposed in 1996, and approved by the Chinese government in 1997. The construction started in 2001, was completed in 2008 and passed the official acceptance in June 2009. The LAMOST pilot survey was started in October 2011 and the spectroscopic survey will launch in September 2012. Up to now, LAMOST has released more than 480 000 spectra of objects. LAMOST will make an important contribution to the study of the large-scale structure of the Universe, structure and evolution of the Galaxy, and cross-identification of multiwaveband properties in celestial objects.

关键词： techniques: wide field telescope - active optics - multi fiber - spectroscopy survey - data reduction

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Diagnosis and Treatment of Cholangiocarcinoma: A Consensus from Surgical Specialists of China

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2014年第4期34卷 469-475页

作者： Jian-qiang Cai Shou-wang Cai wen-ming Cong Min-shan Chen Ping Chen xiao-ping Chen Yan-ling Chen Yi-fa Chen Chao-liu Dai Qiang Huang zhi-yong Huang bo Jiang Bin Jiang Ke-wei Jiang bo li Zong-fangli li-jian liang Bin liu Hui-chun liu lian-xin liu Qing-guang liu Rong liu Ying-bin liu Jian-guo Lu Shi-chun Lu Yi Lu Yi-lei Mao Bin Mei Jun Niu Bao-gang Peng xiao Qin yu-dong qiu Guang-yi wang Yao-don wangg zhi-ming wang Ren-hua wan Ya-fu Wu Bao-cai Xing Feng xia Ge-liang Xu Jia-mei Yang xiao-fang yu Yong Zeng Yong-yi Zeng Bi-xiang Zhang Bin-hao Zhang Qi-yu Zhang Shui-jun Zhang wan-guang Zhang Yong-jie Zhang zhi-wei Zhang Dong Zhou Wei-ping Zhou Cancer Institute and Hospital Chinese Academy of Medical Sciences Chinese PLA General Hospital Eastern Hepatobiliary Surgery Hospital of Second Military Medical University Sun Yat-sen University Cancer Center Daping Hospital of Third Military Medical University Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology Fujian Medical University Union Hospital Shengjing Hospital of China Medical University Anhui Provincial Hospital Hunan Provincial People’s Hospital Taihe Hospital Affiliated to Hubei University of Medicine Peking University People’s Hospital West China Hospital Sichuan University The Second Affiliated Hospital of Xi’an Jiao Tong University The First Affiliated Hospital Sun Yat-sen University First Affiliated Hospital of Kunming Medical University The First Affiliated Hospital of Bengbu Medical College The First Affiliated Hospital of Harbin Medical University The First Affiliated Hospital of Xi’an Jiao Tong University Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Tangdu Hospital of Fourth Military Medical University Peking Union Medical College Hospital Qilu Hospital of Shandong University The First Affiliated Hospital of Guangxi Medical University Nanjing Drum Tower Hospital The First Affiliated Hospital of Jilin University Fujian Provincial Hospital xiangya Hospital of Central South University The First Affiliated Hospital of Nanchang University Beijing Cancer Hospital Southwest Hospital of Third Military Medical University Shenzhen People’s Hospital The First Affiliated Hospital of Fujian Medical University The First Affiliated Hospital of wenzhou Medical University The First Affiliated Hospital of Zhengzhou University Fujian Provincial Cancer Hospital

Cholangiocarcinoma refers to malignant tumors that develop in epithelial lining of biliary system, and it is divided into two categories according to tumor location, intrahepatic cholangiocarcinoma （ICC） and extrahepatic cholangiocarcinoma （ECC）. ICC occurs from the epithelial cells of the intrahepatic bile duct, its branches and interlobular biliary tree; and ECC is divided into hilar cholangiocarcinoma and distal cholangiocarcinoma by the circumscription at the confluence of cystic duct and the common hepatic duct.

关键词： A Consensus from Surgical Specialists of China Diagnosis and Treatment of Cholangiocarcinoma

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Data release of the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第9期12卷 1243-1246页

作者： A-li Luo Hao-Tong Zhang Yong-Heng Zhao Gang Zhao xiang-Qun Cui Guo-Ping li Yao-Quan Chu Jian-Rong Shi Gang wang Jian-Nan Zhang Zhong-Rui Bai xiao-Yan Chen Feng-Fei wang Yan-Xin Guo Jian-Jun Chen Bing Du xiao Kong Ya-Juan Lei Yin-Bi li Yi-Han Song yue Wu Yan-xia Zhang Xin-lin Zhou Fang Zuo Peng Du lin He wen Hou Yi-Qiao Dong Jian li Guang-Wei li Shuang li Jing Song yuan Tian Meng-Xin wang Yong-Hui Hou zhi-Ying Huo Hong-Zhuan Hu Ning-Sheng Hu Zhong-wen Hu Lei Jia Fang-Hua Jiang xiang Jiang Zi-bo Jiang Ge Jin Ai-Hua li Qi li Yin-Dun Mao Zheng-Hong Tang Qing-Sheng Tao liang-Ping Tu Da-Qing wang Dan wang Jian-Ping wang Lei wang Shou-Guan wang Shu-Qing wang Ya-Nan wang You wang yue-Fei wang Ming-zhi Wei xiang-xiang Xue xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu De-Hua Yang Shi-hai Yang Zheng-qiu Yao Yong yu Hui yuan Chao Zhai En-Peng Zhang Jing Zhang li-Ping Zhang WeiZhang Yong Zhang Zhen-Chao Zhang Ming Zhao Fang Zhou Yong-Tian Zhu Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China lal @ lamost o rg Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Technologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects.

关键词： techniques: spectroscopic survey — data reduction — data release

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Expert Consensus on Pathological Diagnosis of Intrahepatic Cholangiocarcinoma(2022 version)

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Journal of Clinical and Translational Hepatology 2023年第7期11卷 1553-1564页

作者： Han wang Jun Chen Xin Zhang xia Sheng xiao-Yan Chang Jie Chen Min-Shan Chen Hui Dong Guang-Jie Duan He-Ping Hu zhi-Yong Huang Wei-Dong Jia xiao-Qing Jiang Dong Kuang Shan-Shan li Zeng-Shan li Chang-li Lu Shu-Kui Qin Xue-Shan qiu li-Juan Qu Chun-Kui Shao Feng Shen Guo-Ming Shi Su-Sheng Shi yu-Jun Shi Hui-Chuan Sun xiao-Dong Teng Bin wang Zhan-bo wang Tian-Fu wen Jia-Mei Yang Qiao-Qiao Yang Sheng-long Ye Hong-Fang Yin Zhen-Gang yuan Jing-Ping yun Feng-lin Zang Hong-Qi Zhang li-Hong Zhang Jing-Min Zhao Jian Zhou Wei-Xun Zhou Jia Fan xiao-Ping Chen wan Yee Lau yuan Ji wen-Ming Cong Chinese Society of liver Cancer of Chinese Anti-Cancer Association Digestive Disease Group of Chinese Society of Pathology,Chinese Medical Association Chinese Society of Pathology of Chinese Anti-Cancer Association Hepatic Surgery Group of Chinese Society of Surgery,Chinese Medical Association Biliary Tract Tumor Committee of China Anti-Cancer Association Chinese Society of Clinical Oncology IDepartment of Pathology Eastern Hepatobilary Surgery HospitalNaval Medical UniversityShanghaiChina Department of Pathology the Affiliated Drum Tower HospitalNanjing University Medical SchoolNanjingJiangsuChina Department of Pathology Zhongshan HospitalFudan UniversityShanghaiChina Department of Pathology Minhang HospitalFudan Uni-versityShanghaiChina Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sci-ences and Peking Union Medical CollegeBeijingChina Department of liver Surgery Sun Yat-Sen University Cancer CenterGuangzhouGuangdongChina Department of Pathology The First Affiliated HospitalArmy Medical UniversityChongqingChina Department of Hepatobiliary Medicine Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghaiChina Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWu-hanHubeiChina Department of General Surgery The First Affliated Hospital of USTCDivision of Life Science and Medi-cineUniversity of Science and Technology of ChinaHefeiAnhuiChina Department of Biliary Surgery I Eastern Hepatobil-iary Surgery HospitalNaval Medical UniversityShanghaiChina Department of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Pathology The First Afiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenanChina Department of Pathology Xijing Hospi-talAir Force Medical UniversityXi'anShaanxiChina Department of Pathology West China HospitalSichuan UniversityChengduSichuanChina Cancer Center of Jinling Hospital Nanjing University of Chinese MedicineNanjingJiangsuChina Department of Pathology The First Affiliated HospitalChina Medical UniversityShenyangLiaoningChina Department of Pathology The 900 Hospital of the Chinese People's Liberation Army Joint Logistics TeamFuzhouFujianChina Department of Pathology The Third Affiliated HospitalSun Yat-Sen UniversityGuangz

Intrahepatic cholangiocarcinoma(iCCA)can originate from the large bile duct group(segment bile ducts and area bile ducts),small bile duct group(septal bile ducts and interlobular bile ducts),and terminal bile duct group(bile ductules and canals of Hering)of the intrahepatic biliary tree,which can be histopathological corresponding to large duct type iCCA,small duct type iCCA and iCCA with ductal plate malformation pattern,and cholangiolocarcinoma,*** challenge in pathological diagnosis of above subtypes of iCCA falls in the distinction of cellular morphologies,tissue structures,growth patterns,invasive behaviors,immunophenotypes,molecular mutations,and surgical *** these reasons,this expert consensus provides nine recommendations as a reference for standardizing and refining the diagnosis of pathological subtypes of iCCA,mainly based on the 5th edition of the World Health Organization Classification of Tumours of the Digestive System.

关键词： Intrahepatic cholangiocarcinoma Pathology Histological type Immunohistochemistry Molecular variation

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电流-频率转化法放大电离室探测器微电流信号

引用

核电子学与探测技术 2022年第6期42卷 1044-1047页

作者：李昆万波田皓文韦文彬尹秋升黎刚吴志强王海波韩文兴中国核动力研究设计院核反应堆系统设计技术国家级重点实验室成都610041

首次提出了一种基于电流-频率转化的电离室探测器微电流信号放大技术,测试结果表明其性能指标满足甚至优于目前市场上同类技术.该技术具有广泛的应用前景.

关键词：核仪表微电流电流-频率(I-F)转化

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