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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song qian-qian wan Yu-Ming wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Neuroprotective Effect of Da-Bu-Yin-wan and qian-Zheng-San on Mitochondrial quality in Parkin overexpression SHSY5Y Cells of Parkinson's Disease

Neuroprotective Effect of Da-Bu-Yin-Wan and Qian-Zheng-San o...

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中国神经科学学会第十二届全国学术会议

作者： Tian-yao qiang Cong Gai wan-di Feng Hao-jie Ma Yuan Chai Shu-jing Zhang Jing-Hong Hu Hong-Mei Sun Zhen-Yu Guo Yuan-yuan wang School of Preclinical Medicine Beijing University of Chinese Medicine

Objective To investigate the protective effect and possible mechanism of DaBu-Yin-wan and qian-Zheng-San(DBYW&QZS)on mitochondrial quality in a cell model of Parkinson’s disease(PD) associated with Parkin overexpression. Methods: Human neuroblastoma SH-SY5 Y cells were transfected with EGFP–Parkin, expressions of Parkin m RNA and protein evaluated by Quantitative RT-PCR and Western blotting, and then treated with neurotoxin MPP and Chinese medicine prescription DBYW&QZS. The cell viability was measured by the CCK-8 assay. Mitochondrial Morphology Probed by Staining with Mito Tracker-Red CMXRos and mitochondria membrane potential(ΔΨm) Probed with TMRM was observed by laser scanning confocal microscope. The cellular ATP content were also measured with ATP assay Kit. The protein expressions of mitochondrial fusion(mitofusin1, Mfn1, mitofusin2) and fission(dynamic related protein1, drp1 and mitochondrial fission protein1, Fis1) were detected by Western blotting. In addition, Triple immunofluorescence imaging with Laser Scanning Confocal Microscopy was applicated for the colocalization of Parkin, PINK1 and TOM20. Results: After EGFP–Parkin transfection, the m RNA and protein expression of Parkin were significantly increased, while no significant change in the control group and negative control group. After MPP+ treatment,the cell survival rate, the form-factor, the ATP production, ΔΨm and the protein expression of mitochondrial fission and fusion were reduced apparently. However, the Pearson’s Coefficient of Parkin, PINK1 and TOM20 remained unchanged. DBYW&QZS decreased the MPP+-induced toxicity by increasing the cell survival rate, the form-factor, ΔΨm, ATP content markedly. Overexpression of Parkin combined with DBYW&QZS enhanced the augment of ΔΨm, ATP content;moreover, the colocalization coefficient of Parkin and PINK1 and the expression of Mfn1 ascended while the expression of Fis1 descended observably. Conclusion: These results highlight a protective effect of DBYW

关键词： Parkinson’s disease qian-Zhen-San Da-Bu-Yin-wan Parkin mitochondria

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EFFECTS OF HIGH-ENERGY BALL MILLING ON STRUCTURE AND MECHANICAL PROPERTIES OF L1_2 INTERMETALLIC COMPOUND Al_(67)Mn_8Ti_(25)

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中国有色金属学会会刊：英文版 1998年第3期8卷 57-61页

作者： Yunyi, Fu qian, wan Gengxiang, Hu Shanghai Jiao Tong Univ Shanghai China

１ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｏｒｄｅｒｅｄｉｎｔｅｒｍｅｔａｌｉｃｃｏｍｐｏｕｎｄＡｌ３Ｔｉｉｓｎｏｔｉｃｅａｂｌｅｂｅｃａｕｓｅｏｆｉｔｓｌｏｗｄｅｎｓｉｔｙ（３．４ｇ／ｃｍ３），ｅｘｃｅｌｅｎｔｈｉｇｈｔｅ... 详细信息

１ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｏｒｄｅｒｅｄｉｎｔｅｒｍｅｔａｌｉｃｃｏｍｐｏｕｎｄＡｌ３Ｔｉｉｓｎｏｔｉｃｅａｂｌｅｂｅｃａｕｓｅｏｆｉｔｓｌｏｗｄｅｎｓｉｔｙ（３．４ｇ／ｃｍ３），ｅｘｃｅｌｅｎｔｈｉｇｈｔｅｍｐｅｒａｔｕｒｅｏｘｉｄａｔｉｏ...

关键词： Al 67 Mn 8Ti 25 alloy high energy ball milling powder metallurgy structure evolution intermetallic compound

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China launches the “IAS1000 Project”

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Journal of Integrative Agriculture 2018年第12期17卷 2840-2841页

作者： qian wan-qiang wan Fang-hao Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Institute of Plant Protection Chinese Academy of Agricultural Sciences

1. IAS1000 Project The rapid development of omics provides new technologies *** Genomics Institute at Shenzhen (CAAS-AGIS)andInstituteofPlantProtection,ChineseAcademyof AgriculturalSciences(CAAS-IPP)initiatedthe"IAS1000Project"-A genome project of 1 000 invasive alien species,and established the "IAS1000 Alliance" in Shenzhen, China,on November 14, *** deep-mining of omics data,theprojectaimsforbetterunderstandingtheecological processesandmolecularmechanismsofbiological invasion, and developing new technologies and products for prevention and management of invasive alien ***

关键词： IAS1000 Project Project China launches the

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Recent progress on the synthesis of 2-deoxy glycosides

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Science China Chemistry 2017年第9期60卷 1162-1179页

作者： Jing Zeng Yang Xu Hao wang Lingkui Meng qian wan 0030 China Institute of Brain Research Huazhong University of Science and TechnologyWuhan 410030China

2-Deoxy glycosides are widely presented in natural products and clinical *** presence of 2-deoxy glycosides is essential for bioactivities of these *** report provides an overview of the recent advances in the stereoselective synthesis of 2-deoxy ***,the contents of this review covered the work published since the earlier reviews on this topic by Marzabadi(2000),Lowary(2009),Ding(2012) and Nagorny(2012).

关键词： 2-deoxy glycosides, glycosylation, stereoselective synthesis, oligosaccharides

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Fault-tolerant FADS system development for a hypersonic vehicle via neural network algorithms

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Theoretical & Applied Mechanics Letters 2023年第5期13卷 357-366页

作者： qian wan Minjie Zhang Guang Zuo Tianbo Xie LandSpace Technology Corporation Ltd.H1 Zhonghang Intl Plaza 13 Ronghua South RoadBeijing 100176China Department of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA 90089-1189USA

Hypersonic vehicles suffer from extreme aerodynamic heating during flights, especially around the area of leading edge due to its small curvature. Therefore, flush air data sensing(FADS) system has been developed to perform accurate measurement of the air data parameters. In the present study, the method to develop the FADS algorithms with fail-operational capability for a sharp-nosed hypersonic vehicle is provided. To be specific, the FADS system implemented with 16 airframe-integrated pressure ports is used as a case study. Numerical simulations of different freestream conditions have been conducted to generate the database for the FADS targeting in 2 ≤ Ma ≤ 5 and 0 km ≤ H ≤ 30 km. Four groups of neural network algorithms have been developed based on four different pressure port configurations, and the accuracy has been validated by 280 groups of simulations. Particularly, the algorithms based on the 16-port configuration show an excellent ability to serve as the main solver of the FADS, where 99. 5% of the angle-of-attack estimations are within the error band ±0. 2°. The accuracy of the algorithms is discussed in terms of port configuration. Furthermore, diagnosis of the system health is present in the paper. A fault-tolerant FADS system architecture has been designed, which is capable of continuously sensing the air data in the case that multi-port failure occurs, with a reduction in the system accuracy.

关键词： FADS System Hypersonic vehicle Neural network Numerical simulation Fault detection Redundancy management

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Dynamic separation of Xe and Kr by metal-organic framework and covalent-organic materials： a comparison with activated charcoal

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Science China Chemistry 2016年第5期59卷 643-650页

作者： qian wan Shunshun Xiong Zhonghua Xiang Shuming Peng Xiaolin wang Dapeng Cao Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China

We systematically investigate dynamic separation of Xe and Kr at room temperature using four representative porous materials(Cu-BTC, ZIF-8, COP-4 and activated carbon(AC)). Results indicate that among the four materials, Cu-BTC not only shows the highest retention volume per gram(V_g=788 m L g^(-1), which is 1.8 times of activated carbon(436 m L g^(-1))) under flowing condition, but also can separate 350 ppm Xe from 35 ppm Kr mixture in air with a high Xe/Kr selectivity of 8.6 at room temperature and 200 k Pa, due to its suitable pore morphology, open metal sites, small side pockets in the framework. Moreover, the Cu-BTC also performs well on individual separation of Xe, Kr, CO_2 from five-component gas mixture(Xe:Kr:CO_2:Ar:N_2= 1:1:1:1:0.5, V/V) and has the longest retention time for Xe(20 min) in gas chromatographic separation, suggesting that it is a good candidate for potential applications as polymeric sieves.

关键词： metal-organic framework covalent-organic materials noble gas gas chromatographic separation breakthrough

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Characteristics and distribution of microstructures in high pressure die cast alloys with X-ray microtomography:A review

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China Foundry 2024年第5期21卷 427-444页

作者： Hai-dong Zhao Xue-ling wang qian wan Wen-hui Bai Fei Liu School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou 510640China

Al and Mg alloy high pressure die castings(HPDC)are increasingly used in automotive *** microstructures in the castings have decisive effect on the casting mechanical properties,in which the microstructure characteristics are fundamental for the investigation of the microstructure-property *** the past decade,the microstructure characteristics of HPDC Al and Mg alloys,especially micro-pores andα-Fe,have been investigated from two-dimensional(2D)to threedimensional with X-ray micro-computed tomography(μ-CT).This paper provides an overview of the current understanding regarding the 3D characteristics and formation mechanisms of microstructures in HPDC alloys,their spatial distributions,and the impact on mechanical ***,it outlines future research directions for the formation and control of heterogeneous microstructures in HPDC alloys.

关键词： high pressure die casting microstructure three-dimensional characteristics distribution Al and Mg alloys

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Molecular analysis of the chloroplast Cu/Zn-SOD gene(AhCSD2) in peanut

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The Crop Journal 2015年第3期3卷 246-257页

作者： Xiurong Zhang qian wan Fengzhen Liu Kun Zhang Aiqing Sun Bing Luo Li Sun Yongshan wan State Key Laboratory of Crop Biology Shandong Key Laboratory of Crop Biology Shandong Agricultural University

Superoxide dismutase(SOD, EC 1.***.1.1) plays a key role in response to drought stress, and differences in SOD activity changes among cultivars are important under drought conditions. We obtained the full-length DNA of the chloroplast Cu/Zn-SOD gene(Ah CSD2)from 11 allotetraploid cultivars and 5 diploid wild species in peanut. BLAST search against the peanut genome showed that the Ah CSD2 genes g CSD2-1 and g CSD2-2 are located at the tops of chromosome A03(A genome) and B03(B genome), respectively, and both contain 8exons and 7 introns. Nucleotide sequence analyses indicated that g CSD2-2 sequences were identical among all the tested cultivars, while g CSD2-1 sequences showed allelic *** amino acid sequences deduced from g CSD2-1 and g CSD2-2 both contain a chloroplast transit peptide and are distinguished by 6 amino acid(aa) residue differences. The other 2aa residue variations in the mature peptide regions give rise to three-dimensional structure changes of the protein deduced from the genes g CSD2-1 and g CSD2-2. Sequences analyses of cultivars and wild species showed that g CSD2-2 of Arachis hypogaea and g Aip CSD2(Arachis ipaensis) are identical, and despite the abundant polymorphic loci between g CSD2-1 of *** and sequences from A genome wild species, the deduced amino acid sequence of Ah CSD2-1(A. hypogaea) is identical to that of Adu CSD2(Arachis duranensis), whereas Aco CSD2(Arachis correntina) and Aca CSD2(Arachis cardenasii) both have 2 aa differences in the transit peptide region compared with Ah CSD2-1(A. hypogaea). Based on the Peanut Genome Project, promoter prediction revealed many stress-related cis-acting elements within the potential promoter regions(pp-A and pp-B). pp-A contains more binding sites for drought-associated transcriptional factors than pp-B. We hypothesize that the marked changes in SOD activity in different cultivars under drought stress are tightly regulated by transcription factors through transcription and expre

关键词： Peanut SOD activity AhCSD2 gene Bioinformatics analysis Drought resistance

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Modal Parameter Identification Method of Jacket Platform Structure Based on AFDD and Optimized FBFFT

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China Ocean Engineering 2023年第3期37卷 393-407页

作者： LENG Jian-cheng MA Jin-yong FAN Zong-heng qian wan-dong FENG Hui-yu School of Mechanical Science and Engineering Northeast Petroleum UniversityDaqing 163318China

Offshore platforms are susceptible to structural damage due to prolonged exposure to random loads,such as wind,waves,and *** is particularly true for platforms that have been in service for an extended *** the modal parameters of offshore platforms is crucial for damage diagno sis,as it serves as a prerequisite and foundation for the ***,it holds great significance to prioritize the identification of these *** at the shortcomings of the traditional Fast Bayesian Fast Fourier Transform(FBFFT) method,this paper proposes a modal parameter identification method based on Automatic Frequency Domain Decomposition(AFDD) and optimized *** introducing the AFDD method and Powell optimization algorithm,this method can automatically identify the initial value of natural frequency and solve the objective function efficiently and *** order to verify the feasibility and effectiveness of the proposed method,it is used to identify the modal parameters of the IASC-ASCE benchmark model and the j acket platform structure model,and the Most Probable Value(MPV) of the modal parameters and their respective posterior uncertainties are successfully *** identification results of the IASC-ASCE benc hmark model are compared with the identification re sults of the MODE-ID method,which verifies the effectivene ss and accuracy of the proposed method for identifying modal *** provides a simple and feasible method for quantifying the influence of uncertain factors such as environmental parameters on the identification results,and also provide s a reference for modal parameter identification of other large structures.

关键词： jacket platform uncertain modal parameter identification FBFFT method environmental excitation AFDD method Powell optimization

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