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A survey of ventilation strategies during cardiopulmonary resuscitation

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World Journal of Emergency Medicine 2019年第4期10卷 222-227页

作者： Ye-cheng Liu Yan-meng Qi Hui Zhang joseph walline Hua-dong Zhu Department of Emergency Medicine Peking Union Medical College HospitalBeijingChina Accident and Emergency Medicine Academic Unit Prince of Wales HospitalThe Chinese University of Hong KongHong KongChina

BACKGROUND:Many controversies still exist regarding ventilator parameters during cardiopulmonary resuscitation(CPR).This study aimed to investigate the CPR ventilation strategies currently being used among physicians in Chinese tertiary ***:A survey was conducted among the cardiac arrest team physicians of 500 tertiary hospitals in China in August,*** data included physician and hospital information,and preferred ventilation strategy during ***:A total of 438(88%)hospitals completed the survey,including hospitals from all 31 Chinese mainland *** 41.1%of respondents chose delayed or no ventilation during CPR,with delayed ventilations all starting within 12 *** all the respondents who provided ventilation,83.0%chose to strictly follow the 30:2 strategy,while 17.0%chose ventilations concurrently with uninterrupted *** 38.3%respondents chose to intubate after initiating CPR,while 61.7%chose to intubate immediately when resuscitation *** bagvalve-mask ventilation,only 51.4%of respondents delivered a frequency of 10 breaths per *** terms of ventilator settings,the majority of respondents chose volume control(VC)mode(75.2%),tidal volume of 6–7 mL/kg(72.1%),PEEP of 0–5 cmH2O(69.9%),and an FiO2 of 100%(66.9%).However,62.0%of respondents had mistriggers after setting the ventilator,and 51.8%had high pressure ***:There is a great amount of variability in CPR ventilation strategies among cardiac arrest team physicians in Chinese tertiary *** are needed with specific recommendations on ventilation during CPR.

关键词： Cardiopulmonary resuscitation Ventilation strategy Questionnaire survey Cardiac arrest team

Do corticosteroids have a role in treating Ebola virus disease?

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Science China(Life Sciences) 2015年第1期58卷 111-113页

作者： XU Jun TAN DingYu FU YangYang walline joseph YU XueZhong Emergency Department Peking Union Medical HospitalChinese Academy of Medical sciences Division of Emergency Medicine Department of SurgerySaint Louis University Hospital

Dear Editor,Humans have been fighting Ebola virus disease(EVD)since its first outbreak in 1976 in Yambuku village in the Democratic Republic of the Congo(previously Zaire).EVD is part of the Filoviridae family of viruses that includes Ebola and Marburg *** date,EVD,one of the most deadly communicable diseases known to humans,has had15 outbreaks in *** 2014,the most severe and complicated outbreak yet swept through the West African countries of Guinea,Liberia,Nigeria,Senegal and Sierra Leone,

关键词：糖皮质激素刚果民主共和国出血治疗病毒病 EVD 利比里亚尼日利亚

Adenovirus sneak attacks during the H7N9 flu season

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Science China(Life Sciences) 2013年第9期56卷 863-864页

作者： XU Jun LI Chen walline joseph YU XueZhong Chinese Academy of Medical Sciences Peking Union Medical Hospital Division of Emergency Medicine Department of Surgery Saint Louis University Hospital

The H7N9 influenza virus made headlines recently, with outbreaks in Chinese urban centers. These infections continue a recent trend of novel virus outbreaks, such as those involving SARS coronavirus and the H1N1 influenza virus. These outbreaks have been likened to tropical storms, and like prior ＇viral storms＇ the latest H7N9 influenza virus has aroused public panic despite the fact that H7N9 infection rates are sporadic.

关键词：流感病毒腺病毒 SARS冠状病毒偷袭季节热带风暴城市中心感染率

My mother is looking blue

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World Journal of Emergency Medicine 2019年第4期10卷 251-252页

作者： Howard Tat Chun Chan Anselm Wang Hei Hui Colin Graham joseph walline Department of Accident and Emergency Medicine Hong Kong Hospital AuthorityPrince of Wales HospitalShatinHong KongChina Accident and Emergency Medicine Academic Unit The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina

Dear editor,A 76-year-old Chinese female presented by ambulance to the Emergency Department complaining of dizziness,headache and *** son claimed that the patient“turned blue”three hours prior to onset of the patient’s *** noted the patient’s SpO2 was 83%on room air with no improvement with a nonrebreather *** medical history was signifi cant for diabetes and ***,social and medication history were non-contributory.

关键词： mother looking blue Emergency Department

Tension hydropneumothorax in a Boerhaave syndrome patient:A case report

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World Journal of Emergency Medicine 2021年第3期12卷 235-237页

作者： Chun-ting Wang Hui Jiang joseph walline Yan Li Jian Wang Jun Xu Hua-dong Zhu Emergency Department Peking Union Medical College HospitalBeijing 100730China Emergency Department Civil Aviation General HospitalBeijing 100123China Accident and Emergency Medicine Academic Unit the Chinese University of Hong KongHong Kong 999077China Department of Radiology Peking Union Medical College HospitalBeijing 100730China

Dear editor,Boerhaave syndrome,firstly described by Hermann Boerhaave in 1724,is a rare and life-threatening condition characterized by spontaneous transmural tear of the oesophagus.[1]The early diagnosis of Boerhaave syndrome is extremely important since a delay in the diagnosis can increase the mortality rate.[2]Here,we reported a Boerhaave syndrome patient combined with tension hydropneumothorax.

关键词： diagnosis patient mortality

Morbidity and mortality risk factors in emergency department patients with Acinetobacter baumannii bacteremia

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World Journal of Emergency Medicine 2020年第3期11卷 164-168页

作者： Rui-xue Sun Priscilla Song joseph walline He Wang Ying-chun Xu Hua-dong Zhu Xue-zhong Yu Jun Xu Emergency Department Peking Union Medical College HospitalBeijing 100010China Department of Anthropology Washington University in Saint LouisSaint Louis 63101USA Division of Emergency Medicine Saint Louis UniversitySaint Louis 63101USA Laboratory Department Peking Union Medical College HospitalBeijingChina

BACKGROUND:Acinetobacter baumannii(AB)bacteremia is an increasingly common and often fatal nosocomial *** of morbidity and mortality risk factors for AB bacteremia in emergency department(ED)patients may provide ways to improve the clinical outcomes of these ***:The records for 51 patients with AB bacteremia and 51 patients without AB infection were collected and matched in a retrospective case-control study between 2013 and 2015 in a singlecenter *** factors were analyzed by Chi-square and multivariate logistic regression statistical ***:A significant risk factor for morbidity was the presence of a central venous catheter(CVC)(P<0.001).The mortality rate for the 51 patients with AB bacteremia was 68.6%.Risk factors for mortality were the presence of a CVC(P=0.021)and an ED stay longer than two weeks(P=0.015).CONCLUSION:AB infections lead to high morbidity and *** presence of a CVC was associated with higher morbidity and mortality in patients with AB *** CVC insertions may improve outcomes in ED patients with AB bacteremia.

关键词： Acinetobacter baumannii Bacteremia Morbidity Mortality

Venous thromboembolism in the emergency department:A survey of current best practice awareness in physicians and nurses in China

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World Journal of Emergency Medicine 2019年第1期10卷 5-13页

作者： Wen-hua Zhou Jian-qiang He Shi-gong Guo joseph walline Xiao-ying Liu Li-yuan Tian Hua-dong Zhu Xue-zhong Yu Yi Li Emergency Department Peking Union Medical College Hospital Oxford Centre for Enablement Nuffi eld Orthopaedic Centre Accident and Emergency Medicine Academic Unit Prince of Wales Hospital The Chinese University of Hong Kong

BACKGROUND: For emergency department(ED) patients, risk assessment, prophylaxis, early diagnosis and appropriate treatment of venous thromboembolism(VTE) are essential for preventing morbidity and mortality. This study aimes to investigate knowledge amongst emergency medical staff in the management of VTE. METHODS: We designed a questionnaire based on multiple scales. The questionnaire was distributed to the medical and nursing clinical staff in the large urban ED of a medical center in Northern China. Data was described with percentages and the Kruskal-Wallis test was used to compare ranked data between different groups. The statistical analysis was done using the SPSS 22.0 ***: In this survey, 180 questionnaires were distributed and 174 valid responses(response rate of 96.67%) were collected and analyzed. In scores of VTE knowledge, no signifi cant differences were found with respect to job(doctor vs. nurse), the number of years working in clinical medicine, education level, and current position, previous hospital experience and nurses' current work location within the ED. However, in pair wise comparison, we found participants who worked in ED for more than 5 years(n=83) scored signifi cantly higher on the questionnaire than those under 5 years(n=91)(95.75 vs. 79.97, P=0.039). There was a signifi cant difference in some questions based on gender, age, job, and nurse work location, number of working years, education level, and different ED working ***: Our survey has shown defi ciencies among ED medical staff in knowledge and awareness of the management of VTE. We recommend several changes be considered, such as the introduction of an interdisciplinary workshop for medical staff; the introduction of a standardized VTE protocol; a mandatory study module on VTE for new physicians and nurses; the introduction of a mandatory reporting system for adverse events(including VTE).

关键词： Emergency Venous thromboembolism Staff knowledge Emergency doctor Emergency nurse

Role of penehyclidine in acute organophosphorus pesticide poisoning

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World Journal of Emergency Medicine 2020年第1期11卷 37-47页

作者： Shi-yuan Yu Yan-xia Gao joseph walline Xin Lu Li-na Zhao Yuan-xu Huang Jiang Tao An-yong Yu Na Ta Ren-ju Xiao Yi Li Department of Emergency Medicine Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijingChina Department of Emergency Medicine the First Affi liated Hospital of Zhengzhou UniversityZhengzhouChina Accident and Emergency Medicine Academic Unit Prince of Wales Hospitalthe Chinese University of Hong KongHong KongChina Department of Emergency Medicine the Fourth Affi liated Hospital of Jishou UniversityHuaihuaChina Department of Emergency Medicine the First Affi liated Hospital of Zunyi Medical UniversityZunyiChina Department of Emergency Medicine Chifeng Municipal HospitalChifengChina Department of Emergency Medicine Xingyi People's HospitalXingyiChina

BACKGROUND:Penehyclidine is a newly developed anticholinergic *** aimed to investigate the role of penehyclidine in acute organophosphorus pesticide poisoning(OP)***:We searched the Pubmed,Cochrane library,EMBASE,Chinese National Knowledge Infrastructure(CNKI),Chinese Biomedical literature(CBM)and Wanfang *** controlled trials(RCTs)recruiting acute OP patients were identifi ed for *** outcomes included cure rate,mortality rate,time to atropinization,time to 60%normal acetylcholinesterase(AchE)level,rate of intermediate syndrome(IMS)and rate of adverse drug reactions(ADR).RESULTS:Sixteen RCTs involving 1,334 patients were identifi *** with the atropineor penehyclidine-alone groups,atropine combined with penehyclidine significantly increased the cure rate(penehyclidine+atropine ***,0.97 vs.0.86,RR 1.13,95%CI[1.07–1.19];penehyclidine+atropine ***,0.93 vs.0.80,RR 1.08,95%CI[1.01–1.15])and reduced the mortality rate(penehyclidine+atropine ***,0.015 vs.0.11,RR 0.17,95%CI[0.06–0.49];penehyclidine+atropine ***,0.13 vs.0.08,RR 0.23,95%CI[0.04–1.28]).Atropine combined with penehyclidine in OP patients also helped reduce the time to atropinization and AchE recovery,the rate of IMS and the rate of *** with a single dose of atropine,a single dose of penehyclidine also signifi cantly elevated the cure rate,reduced times to atropinization,AchE recovery,and rate of ***:Atropine combined with penehyclidine benefi ts OP patients by enhancing the cure rate,mortality rate,time to atropinization,AchE recovery,IMS rate,total ADR and duration of *** combined with atropine is likely a better initial therapy for OP patients than atropine alone.

关键词： Penehyclidine Organophosphorus pesticide poisoning Meta-analysis

糖皮质激素在埃博拉病毒病治疗中可能的作用及应用前景

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中国科学：生命科学 2015年第1期45卷 101-103页

作者：谈定玉徐军付阳阳 joseph walline 于学忠北京协和医院急诊科北京100730 Saint Louis University Hospital Saint Louis Missouri 63110 USA

埃博拉病毒病（Ebola virus disease，EVD），过去称为埃博拉出血热，是一种由埃博拉病毒（Ebola virus，EBOV）引起的严重的、高病死率的流行性出血热．1976年，EVD第一次出现在中部非洲的扎依尔（现为刚果民主共和国）和南苏丹．此后... 详细信息

埃博拉病毒病（Ebola virus disease，EVD），过去称为埃博拉出血热，是一种由埃博拉病毒（Ebola virus，EBOV）引起的严重的、高病死率的流行性出血热．1976年，EVD第一次出现在中部非洲的扎依尔（现为刚果民主共和国）和南苏丹．此后的40多年里，非洲发生不同规模的埃博拉疫情共24次，导致1590人死亡，总体病死率高达66．61％．

关键词：病毒病糖皮质激素流行性出血热刚果民主共和国 virus 应用治疗埃博拉病毒