检索结果-南通市图书馆

A harmonisation approach to traditional Chinese medicine registration in Asian countries

泥石流及洪水灾害防御国际学术讨论会

作者： S.Y.Liong w.t.chan C.L.Law 章武华国立新加坡大学土木系

本文讨论了知识库系统KBSwMM模型的主要特点.KBSwMM用作暴雨雨水管理模型(SwMM模型)的迳流程序块(RunoffBolck)的校定模型·然后用这一模型预测新加坡境内某一流域的迳流.模型校定和验证均已完成·结果表明,KBSwMM不仅省时,经验不太多...

本文讨论了知识库系统KBSwMM模型的主要特点.KBSwMM用作暴雨雨水管理模型(SwMM模型)的迳流程序块(RunoffBolck)的校定模型·然后用这一模型预测新加坡境内某一流域的迳流.模型校定和验证均已完成·结果表明,KBSwMM不仅省时,经验不太多的使用者会用,而且,在某些情况下,较之传统的SwMM校定法,能获得更佳的迳流模拟.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of traditional Chinese Medical Sciences 2024年第2期11卷 143-147页

作者： Vivian S.w.chan Fung Independent Scholar 2 Woodward PlaceSt IvesNSW 2075Australia

the traditional Chinese medicine(tCM)industry is critical to not only for public health but also for economic *** to the European Union(EU)directives,under the EU framework for(traditional)herbal medicinal products,herbal medicines with long history of use can be registered in ***,there is a condition in this directive in which only those that have at least 10e15 years in the EU market are accepted for registration and/or marketing *** author opinion,the condition of 10-15 years of use in EU countries set within the EU regulatory framework is with consideration of the genetic differences which can result in variation in adverse drug responses among different world *** this concept in mind,it is reasonable to project the principal of the EU directive to the Asian countries where tCM is *** like China,Singapore,Japan and South Korea that have well established drug registration framework are in best position in executing the best practice and facilitate harmonization of registration for tCM within the ***,the registration process itself allows more safety and efficacy data to be collected systemically before and after product registration/marketing *** are valuable information for future drug *** therapeutic value of tCM is limitless,it has been left out in the EU regulatory framework,and the opportunity for it to be expanded and carried forward in modern medicines is shadowed by the limited number of tCM that are qualified to be registered under the EU regulatory *** early establishment of a harmonized risk-based registration process for tCM in Asian countries is *** will strengthen the database to substantiate the history of safe use and further preserving and expanding the therapeutic values of tCM within and beyond the Asian region.

关键词： traditional Chinese medicines Population genetic Harmonization Registration Asian countries

Finite barrier bound state

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第4期13卷 664-671页

作者： tao Liu Kai Bai Yicheng Zhang Duanduan wan Yun Lai C.t.chan Meng Xiao Key Laboratory of Artificial Micro-and Nano-structures of Ministry of Education and School of Physics and technology Wuhan University430072 WuhanChina. National Laboratory of Solid State Microstructures School of Physicsand Collaborative Innovation Center of Advanced MicrostructuresNanjing University210093 NanjingChina. Department of Physics The Hong Kong University of Science and TechnologyClear Water BayKowloon999077Hong KongChina. wuhan Institute of Quantum technology 430206 WuhanChina

A boundary mode localized on one side of a finite-size lattice can tunnel to the opposite side which results in unwanted *** wisdom tells that the tunneling probability decays exponentially with the size of the system which thus requires many lattice sites before eventually becoming negligibly *** we show that the tunneling probability for some boundary modes can apparently vanish at specific ***,similar to bound states in the continuum,a boundary mode can be completely trapped within very few lattice sites where the bulk bandgap is not even *** intriguingly,the number of trapped states equals the number of lattice sites along the normal direction of the *** provide two configurations and validate the existence of this peculiar finite barrier-bound state experimentally in a dielectric photonic crystal at microwave *** work offers extreme flexibility in tuning the coupling between localized states and channels as well as a new mechanism that facilitates unprecedented manipulation of light.

关键词： boundary state eventually

Superplasticity of fine-grained Mg-10Li alloy prepared by severe plastic deformation and understanding its deformation mechanisms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第1期12卷 316-331页

作者： H.t.Jeong S.w.Lee w.J.Kim Department of Materials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

the superplastic behavior and associated deformation mechanisms of a fine-grained Mg-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)with a grain size of 3.2μm,primarily composed of the BCCβphase and a small amount of the HCPαphase,were examined in a temperature range of 473 K to 623 *** microstructural refinement of this alloy was achieved by employing high-ratio differential speed *** best superplasticity was achieved at 523 K and at strain rates of 10^(-4)-5×10^(-4)s^(-1),where tensile elongations of 550±600%were *** the heating and holding stage of the tensile samples prior to tensile loading,a significant increase in grain size was observed at temperatures above 573 ***,it was important to consider this effect when analyzing and understanding the superplastic deformation behavior and *** the investigated strain rate range,the superplastic flow at low strain rates was governed by lattice diffusion-controlled grain boundary sliding,while at high strain rates,lattice diffusion-controlled dislocation climb creep was the rate-controlling deformation *** was concluded that solute drag creep is unlikely to *** the late stages of deformation at 523 K,it was observed that grain boundary sliding led to the agglomeration of theαphase,resulting in significant strain *** mechanism maps were constructed forβ-Mg-Li alloys in the form of 2D and 3D formats as a function of strain rate,stress,temperature,and grain size,using the constitutive equations for various deformation mechanisms derived based on the data of the current tests.

关键词： Magnesium-lithium alloy Superplasticity Severe plastic deformation Grain size Grain growth

维普期刊数据库

Editorial for Multiscale&Multifield Coupling in Geomechanics

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 1919-1921页

作者： Min wang Pengzhi Pan Andrew H.C.chan Y.t.Feng t-3 Fluid Dynamics and Solid Mechanics Theoretical DivisionLos Alamos National LaboratoryNew MexicoUSA Institute of Rock and Soil Mechanics Chinese Academy of SciencesWuhanChina School of Engineering University of TasmaniaTasmaniaAustralia College of Engineering Swansea UniversityWalesUK

we are delighted to serve as guest editors for this special issue in the Journal of Rock Mechanics and Geotechnical *** purpose of this special issue is dedicated to gathering the latest research work on Multiscale&Multifield Coupling in Geomechanics,where we delve into the intricate interplay of various fields and scales that govern the behavior of *** total,30 manuscripts from USA,China,UK,Germany,Canada,India and United Arab Emirates are selected to be included in this issue.

关键词： materials. gathering mechanics

Structural engineering of antimicrobials for optimal broad-spectrum activity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Chemical Engineering 2024年第4期5卷 473-482页

作者： Arunmozhiarasi Armugam Diane S.w.Lim Siti Nurhanna Riduan Shook Pui chan Jerome Asugan Yugen Zhang Institute of Bioengineering and Bioimaging Institute of Sustainability for Chemicals Energy and Environment(ISCE2) Agency for Science Technology and Research (A*STAR) Diploma in Biomedical Science School of Chemical and Life SciencesSingapore Polytechnic

Antimicrobial materials are a crucial component in eradicating and managing the spread of infectious *** are expected to act on a broad-spectrum of microbes, including emerging pathogens which could cause the next Disease X. Herein, we reassessed a series of antimicrobial imidazolium polymers on our shelves and uncovered extended functionality through dual modes of action. By redesigning their structures, a truly broadspectrum antimicrobial material with optimized activity against bacteria(G +ve, G-ve) and fungi, as well as enveloped and non-enveloped viruses was developed. we demonstrated that the imidazolium polymer exhibits dual modes of function against microbes: targeting the microbial membrane and binding DNA. the latter DNA binding affinity was found to be key against non-enveloped viruses. with this insight, we designed small molecule compounds that exhibited optimum broad-spectrum antimicrobial activity and excellent efficacy against ESKAPE group of pathogens that are responsible for some of the deadliest nosocomial infections worldwide. Our results could also shed light on the design of broad-spectrum antimicrobial compounds against Disease X.

关键词： Broad-spectrum Antimicrobial Polyimidazolium Structure-function Membrane active

Global collaboration of eye research--personal experience

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第6期17卷 985-990页

作者： Chi-Chao chan Laboratory of Immunology National Eye InstituteNational Institutes of HealthBethesdaMD 20892-1858USA Zhongshan Ophthalmic Center Sun Yat-sen UniversityGuangzhou 5410060Guangdong ProvinceChina

On December 9,2023,I was privileged to be honored and participate in the *** Chao chan Symposium on Global Collaboration of Eye Research as the Global Eye Genetic Consortium(GEGC)session,which was held in the 16th Congress of the Asia-Pacific Vitreo-Retina Society(APVRS)in Hong *** with my talk on“Global collaboration of eye research:personal experience”,other prominent international speakers provided their own perspectives on opportunities for networking,collaboration,and exchange of ideas with global leaders and experts in ophthalmic practice,research,and education.

关键词： speakers collaboration Global

BMPRⅡ^(+)neural precursor cells isolated and characterized from organotypic neurospheres:an in vitro model of human fetal spinal cord development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第2期19卷 447-457页

作者： Michael w.weible II Michael D.Lovelace Hamish D.Mundell tsz wai Rosita Pang tailoi chan-Ling Bosch Institute Discipline of Anatomy and Histology(F13)University of SydneySydneyNSWAustralia School of Environment and Science Griffith UniversityNathanQLDAustralia Discipline of Medicine Nepean Clinical SchoolFaculty of Medicine and HealthUniversity of SydneyKingswoodNSWAustralia New South wales Brain tissue Resource Centre School of Medical SciencesFaculty of Medicine and HealthUniversity of SydneyCharles Perkins Centre(D17)SydneyNSWAustralia

Roof plate secretion of bone morphogenetic proteins(BMPs)directs the cellular fate of sensory neurons during spinal cord development,including the formation of the ascending sensory columns,though their biology is not well ***-ⅡBMP receptor(BMPRⅡ),the cognate receptor,is expressed by neural precursor cells during embryogenesis;however,an in vitro method of enriching BMPRⅡ^(+)human neural precursor cells(hNPCs)from the fetal spinal cord is *** was undertaken on intact second-trimester human fetal spinal cord using antibodies to BMPRⅡand leukemia inhibitory factor(LIF).Regions of highest BMPRⅡ^(+)immunofluorescence localized to sensory *** and meningeal-associated BMPRⅡ^(+)vascular cells were identified in both intact fetal spinal cord and cortex by co-positivity with vascular lineage markers,CD34/*** immunostaining identified a population of somas concentrated in dorsal and ventral horn interneurons,mirroring the expression of LIF receptor/CD118.A combination of LIF supplementation and high-density culture maintained culture growth beyond 10 passages,while synergistically increasing the proportion of neurospheres with a stratified,*** neurospheres were characterized by BMPRⅡ^(+)/MAP2ab^(+/–)/βⅢ-tubulin^(+)/nestin^(–)/vimentin^(–)/GFAP^(–)/NeuN^(–)surface hNPCs surrounding a heterogeneous core ofβⅢ-tubulin^(+)/nestin^(+)/vimentin^(+)/GFAP^(+)/MAP2ab^(–)/NeuN^(–)multipotent *** cultures from tripotential neurospheres contained neuronal(βⅢ-tubulin^(+)),astrocytic(GFAP+),and oligodendrocytic(O4+)lineage ***-activated cell sorting-sorted BMPRⅡ^(+)hNPCs were MAP2ab^(+/–)/βⅢ-tubulin^(+)/GFAP^(–)/O4^(–)in *** is the first isolation of BMPRⅡ^(+)hNPCs identified and characterized in human fetal spinal *** data show that LIF combines synergistically with high-density reaggregate cultures to support the organotypic reorganization of neurospheres,characterize

关键词： BMPRⅡ bone morphogenetic protein histotypic human spinal cord development leukemia inhibitory factor neurosphere organotypic reaggregate sensory columns

维普期刊数据库

tetradentate Pt(Ⅱ)complex as a singlet exciton sensitizing host for highly efficient green fluorescent organic light-emitting diodes

在线全文

学校读者我要写书评

暂无评论

Science China Materials 2024年第8期67卷 2618-2627页

作者： Unhyeok Jo Seung chan Kim chan Hee Ryu Kang Mun Lee Jae-Min Kim Jun Yeob Lee School of Chemical Engineering Sungkyunkwan University2066Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea Department of Chemistry Institute for Molecular Science and Fusion TechnologyKangwon National UniversityChuncheonGangwon 24341Republic of Korea Department of Advanced Materials Engineering Chung-Ang University4726Seodong-daeroDaedeok-myeonAnseong-siGyeonggi-do 17546Republic of Korea SKKU Advanced Institute of Nano technology Sungkyunkwan University2066Seobu-roJangan-guSuwonGyeonggi 16419Republic of Korea SKKU Institute of Energy Science and technology Sungkyunkwan University2066Seobu-roJangan-guSuwonGyeonggi 16419Republic of Korea

Efficient green fluorescent organic light-emitting diodes were designed with a phosphorescent metal complex as a singlet exciton sensitizing host(SESH)for achieving high efficiency and low efficiency roll-off through exciton and polaron *** Pt(Ⅱ)complex(Pt-trz)possessing a tetradentate ligand with a bulky blocking group not only suppresses the severe formation of excimer or dimer itself but also transfers radiative excitons to fluorescent dopant *** SESH assisted fluorescence(SESHF)device with Pt-trz as the host exhibits the maximum external quantum efficiency of 13.3%and a lower efficiency roll-off compared with exciplex host device which is a general approach for harvesting triplet *** exciton dynamics modeling unravels that the SESHF device effectively utilizes triplet excitons in the host by intersystem crossing and resonance energy transfer from the triplet state of the host to the singlet state of the terminal *** quenching rates of the SESHF device are reduced by 11 times for triplet-triplet annihilation and 1.8 times for tripletpolaron annihilation compared with the exciplex device,which demonstrates that Pt-trz could be a platform to be used as an efficient host for fluorophores.

关键词： singlet annihilation polaron

维普期刊数据库