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Health Hazards among Coastal Villagers of Pakistan Due to Arsenic Contaminated Drinking water

Journal of water Resource and Protection 2013年第12期5卷 1235-1241页

作者： Syed Sanwer Ali Nasim Karim Alia Bano Munshi Ishratullah Siddqui Farooq A. khan Bahria University Medical & Dental College (BUMDC) Karachi Pakistan Center for Environmental Studies PCSIR Labs. Complex Karachi Pakistan Department of Community Health Sciences Hamdard College of Medicine & Dentistry (HCM&D) Hamdard University Karachi Pakistan

water supply has become insufficient for the rapidly rising population in Pakistan. As in other parts of Pakistan, coastal villagers also become helpless to use ground water for drinking and daily consumption, due to their need and their not knowing about the quality of water. A number of patients arrived to Karachi hospitals, suffering from a strange disease and this study has been done to find the exact cause of this disease by assuming that arsenic contaminated drinking water may be one of the possibilities. Maximum permissible limit (MRL) of arsenic in drinking water of Pakistan has been calculated by analysis of 50 samples of supply water as 0.05 mg/l. It was observed that most of the residents of Ibrahim Hyderi, Rehri, Chashma, Mubarak, Fagheer Muhammad and Gul Hasan Goths (villages) of the coastal belt of the Karachi city were suffering from melanosis, leuco-melanosis, keratosis, hyperkeratosis, dorsum, non-pitting oedema, gangrene and skin cancer that might be due to arsenic contamination in drinking water. Studied subjects were seriously affected due to paralyzing lower limbs, arms and other body parts in the coastal belt of Karachi, which was observed to be the most prominent health hazards of arsenic. The majority of victims were children. This community problem demands proper addressing and extensive research for improving the quality of life of these villagers.

关键词： Coastal Villages Pakistan Ground water Arsenic Contamination Arsenic in Urine Nails Hair Skin

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NUMERICAL SIMULATION OF THE THERMO-MECHANICAL PROCESS FOR BEAM BLANK CONTINUOUS CASTING

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Acta Metallurgica Sinica(English Letters) 2007年第4期20卷 241-250页

作者： w. Chen Y.Z. Zhang C.J. Zhang L.G. Zhu B.X. wang w.G. Lu J.H. Ma Key Laboratory of Metastable Materials Science and Technology College of Materials Science and Engineering Yanshan University Qinhuangdao 066004 China College of Metallurgy and Energy Engineering Hebei Polytechnic University Tangshan 063009 China Tangshan Heavy Plate Co. Ltd. Tangshan 063610 China Hebei Jinxi Steel Stock Co. Ltd Tangshan 064302 China College of Mechanical Engineering Yanshan University Qinhuangdao 066004 China

The aim of this study was to simulate the solidification process of beam blank continuous casting, and then find the reasons for the typical defects of the beam blank. A two-dimensional transient coupled finite element model has been developed to compute the temperature and stress profile in beam blank continuous casting. The enthalpy method was used in the heat conduction equation. The thermo-mechanical property in the mushy zone was taken into consideration in this calculation. It is shown that at the mold exit the thickness of the shell had its maximum value at the flange tip and its minimum value at the fillet. The temperature had a great fluctuation on the surface of the beam blank in the secondary cooling zone. At the unbending point, the surface temperature of the web was in the brittleness temperature range under the present condition. To ensure the quality, it is necessary to weaken the intensity of secondary cooling. At the mold exit the equivalent stress and strain have higher values at the flange tip and at the web. From the spray 1 to the unbending point, the maximum values of stress and strain gradually moved to the internal section of the flange tip and the web. However, whenever, there were bigger stress and strain values near the flange tip and the web than in the other parts, it must be very easy to generate cracks at those positions. Now, online verification of this simulation has been developed, which has proved to be very useful and efficient to instruct the practical production of beam blank continuous casting.

关键词： beam blank continuous basting thermo-mechanical process simulation

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巴基斯坦西瓦里克道克派珊组豕脊齿象属(长鼻目)新材料（英文）

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古脊椎动物学报 2018年第4期56卷 295-305页

作者： Sayyed Ghyour ABBAS Muhammad Akbar khan Muhammad Adeeb BABAR Muhammad HANIF Muhammad AKHTAR 巴基斯坦旁遮普大学动物学系阿布·巴克尔博士化石展示与研究中心托合尔54590 巴基斯坦农业大学动物学、野生动物和渔业系费萨拉巴德38000

褶齿豕脊齿象(Choerolophodon corrugatus)是豕脊齿象属在巴基斯坦西瓦里克群发现的唯一种。其首次发现是在西瓦里克亚群下部的卡米列组(中新世晚期),而后大量见于西瓦里克亚群中段的道克派珊组(中新世晚期至上新世早期)。本次报道的褶... 详细信息

褶齿豕脊齿象(Choerolophodon corrugatus)是豕脊齿象属在巴基斯坦西瓦里克群发现的唯一种。其首次发现是在西瓦里克亚群下部的卡米列组(中新世晚期),而后大量见于西瓦里克亚群中段的道克派珊组(中新世晚期至上新世早期)。本次报道的褶齿豕脊齿象新材料发现于道克派珊模式产地及其邻近区域。发现的材料包括象牙、下颌、上颌碎片以及一些乳前臼齿和臼齿。新材料与欧洲的Ch. pentelici的牙齿特征极其相似,但在头骨和下颌特征上有所区别。

关键词：西瓦里克群道克派珊组中新世上新世豕脊齿象属

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MicroPath-A pathway-based pipeline for the comparison of multiple gene expression profiles to identify common biological signatures

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Journal of Biomedical Science and Engineering 2009年第2期2卷 106-116页

作者： Mohsin khan Chandrasekhar Babu Gorle Ping wang Xiao-Hui Liu Su-Ling Li Immunology Group Institute of Cell and Molecular Sciences Barts and London School of Medicine London UK. Intelligent Data Analysis Group Department of Information Systems and Computing Molecular Immunology & bioinformatics Group Microarray Facility Division of Bio-Sciences Brunel University Uxbridge UB8 3PH UK

High throughput gene expression analysis is swiftly becoming the focal point for deciphering molecular mechanisms underlying various dif-ferent biological questions. Testament to this is the fact that vast volumes of expression profiles are being generated rapidly by scientists worldwide and subsequently stored in publicly available data repositories such as ArrayEx-press and the Gene Expression Omnibus (GEO). Such wealth of biological data has motivated biologists to compare expression profiles gen-erated from biologically-related microarray ex-periments in order to unravel biological mecha-nisms underlying various states of diseases. However, without the availability of appropriate software and tools, they are compelled to use manual or labour-intensive methods of com-parisons. A scrutiny of current literature makes it apparent that there is a soaring need for such bioinformatics tools that cater for the multiple analyses of expression profiles. In order to contribute towards this need, we have developed an efficient software pipeline for the analysis of multiple gene expression data-sets, called Micropath, which implements three principal functions;1) it searches for common genes amongst n number of datasets using a number crunching method of comparison as well as applying the principle of permutations and combinations in the form of a search strat-egy, 2) it extracts gene expression patterns both graphically and statistically, and 3) it streams co-expressed genes to all molecular pathways belonging to KEGG in a live fashion. we sub-jected MicroPath to several expression datasets generated from our tolerance-related in-house microarray experiments as well as published data and identified a set of 31 candidate genes that were found to be co-expressed across all interesting datasets. Pathway analysis revealed their putative roles in regulating immune toler-ance. MicroPath is freely available to download from: ***/micropath.

关键词： Co-Expression Analysis Microarray Permutations and Combinations Multiple Gene Expression Analysis

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Spontaneous atraumatic dislocation of sternoclavicu- lar joint in Reiter＇s syndrome

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Chinese Journal of Traumatology 2012年第4期15卷 251-253页

作者： Vijay Kumar Digge Sanjay Meena Shah Alam khan Ravi Mittal Department of Orthopaedics All India Institute of Medi-cal Sciences(AIIMS)Ansari NagarNew Delhi 110029India

Reactive arthritis or Reiter＇s syndrome characteristically affects the joint of the lower limb in an asymmetrical pattern. Usually it does not affect the axial skeleton or upper limbs. Although cases of atraumatic at- lantoaxial subluxations have been reported, no case of spon- taneous sternoclavicular dislocation in Reiter＇s syndrome has been reported. This paper describes a case of a 26 year old male patient who developed a spontaneous posterior sternoclavicular joint dislocation. No attempt of reduction was made and the patient was managed conservatively with good results.

关键词： Arthritis, reactive Sternoclavicularjoint Dislocations

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Assessing the Effectiveness of a Practice Improvement Project to Reduce Falls after Discharge from an Inpatient Rehabilitation Facility

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Open Journal of Therapy and Rehabilitation 2018年第2期6卷 65-75页

作者： Jun Zhang Jamal khan Claudia Echaide Karen Imbrosciano-Kemper Michael Scicchitano Jennifer Semel St Charles Hospital Port Jefferson NY USA

Objective: To undertake a qualitative investigation of Fall Prevention and Home Safety Education Program’s efficacy to decrease the risk of falling after discharge from inpatient rehabilitation facility. Design: Structured Telephone interviews. Setting: Inpatient Rehabilitation Facility. Participants: 1317 inpatients from the Rehabilitation Unit. Interventions: The Fall Prevention and Home Safety Education program. Main Outcome Measures: The percentage of patients that fell. Results: Since the inception of the program the fall rate has reduced significantly (χ2 = 6.38;P Conclusions: Implementation of a Fall Prevention and Home Safety Education program significantly reduced the rate of falls in the three months post discharge from acute inpatient rehabilitation.

关键词： Fall Inpatient Rehabilitation

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Silver Nanoparticles: Green Route, Stability and Effect of Additives

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Journal of Biomaterials and Nanobiotechnology 2011年第4期2卷 390-399页

作者： Zaheer khan Javed Ijaz Hussain Sunil Kumar Athar Adil Hashmi Maqsood Ahmad Malik 不详

Colloidal silver nanoparticles were prepared by reducing silver nitrate with oxalic acid in presence of cetyltrimethylammonium bromide (CTAB). The synthesized silver particles show an intense surface plasmon band in the visible region. The work reported in this paper describes the effect of concentration of various additives (NaCl, NaBr, NaNO3, Na2SO4 and NaH2PO4) and ammonia on the growth and stability of Ag-nanoparticles. In all the cases the rate decreases as the [electrolytes] or [ammonia] increases. The nature, polarizability and coordinating ability of the anions play vital roles for nucleus formation and the growth process, which subsequently form different size particles. Transmission electron microscopy, selected areas electron diffraction, and UV-visible spectroscopy have been employed to characterize Ag-nanoparticles. The effect of the following variables on the particle size and size distribution was investigated: the [oxalic acid], [CTAB] and [Ag+].The nanoparticles are stable in NaNO3 and NaH2PO4 solutions;but NaCl, NaBr and Na2SO4 causes their aggregation.

关键词： Silver Nanoparticles Stability Oxalic Acid Additives Ammonia

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Bioactive potency of epidermal mucus extracts from greasy grouper,Epinephelus tauvina(Forsskal,1775)

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Journal of Coastal Life Medicine 2016年第7期4卷 510-520页

作者： Ganesh Manikantan Somasundarannair Lyla Syed Ajmal khan Packiaraj Vijayanand George Edward Gnana Jothi Centre of Advanced Study in Marine Biology Faculty of Marine SciencesAnnamalai UniversityParangipettai-608502Tamil NaduIndia

Objective:To study the bio-potency of epidermal mucus fromEpinephelus ***:Mucus was extracted with acidic,organic and aqueous ***,carbohydrate,lipid,amino acid and fatty acid content of mucus extracts were quantified by UV-spectrophotometer,high performance liquid chromatography and gas chromatography-mass spectrometer,*** activity was tested against five human and fish pathogens by using agar well diffusion *** molecular weight of peptides was determined using sodium dodecyl sulfate-polyacrylamide gel *** haemolytic activity of extracts was tested against chick,goat,cow and human red blood ***:Protein contributed with maximum of 26.25%in crude *** was recorded maximum of(133.9 nmol/mL)in crude mucus.2,4,6-Decatrienoic acid and bis(a-chloroethyl)sulfone were confirmed in organic *** antimicrobial activity of acidic extract was *** the human pathogens,maximum zone of inhibition[(26.0±0.3)mm]was observed againstProteus ***,among fish pathogens maximum zone of inhibition[(25.0±0.1)mm]was observed againstVibrio *** activity of other two extracts was not *** molecular weight of peptides ranged from 115.5-37.1 kDa in acidic extract was *** and goat blood were found to be highly vulnerable to the ***:The whole mucus could be a promising source with numerous ***,this preliminary information suggested that mucus is a source of novel antimicrobial agents for fish and human health related applications.

关键词： Epinephelus tauvina Mucus extracts Proximate analysis Antimicrobial peptides SDS-PAGE Haemolytic assay

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Educational Application for Special Needs Is a Learning Tool the way Forward？

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Computer Technology and Application 2016年第2期7卷 83-95页

作者： Zeenath Reza khan Yusra Yakub Ibrahim Sonia C. Sadhwani Sharifa Taimur Salum Faculty of Engineering and Information Science University of Wollongong Dubai

As the 21st century brings in a revolutionary change in the way students study at schools and universities, technology continues to play a crucial role in helping students achieve more conceptual and practical knowledge of topics taught in classrooms. Students with special needs too are now able to study in a general classroom setting, access relevant technologies and use them for higher cognitive development, helping them integrate with their surroundings. However, existing literature shows that though multiple learning tools exist that do enhance learning in special needs students, they either cater to specific areas of development such as Mathematics and English, or that are targeted towards a specified category of studentswith special needs such as autism and cerebral palsy. Furthermore, despite multiple laws and regulations supporting the right to education launched by the UAE （United Arab Emirates） government for special needs students, there seems to exist a need to provide classrooms across the country with educational applications that have a universal approach particularly in the UAE in order to include students with almost any special needs. This paper looks closely at the existing literature and highlights this gap, especially in the UAE and proposes to develop such a tool based on existing learning concepts.

关键词： Assistive learning distance learning special needs learning tool universal learning approach VARK theory.

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Spectroscopic, Kinetic Studies of Polyaniline-Flyash Composite

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Advances in Chemical Engineering and Science 2011年第2期1卷 37-44页

作者： Raju khan Puja Khare Bimala Prasad Baruah Ajit Kumar Hazarika Nibaran Chandra Dey 不详

Polyaniline-fly ash (PANI-FA) composites were prepared by oxidative polymerization of aniline with fly ash in presence of ammonium persulphate (APS). The PANI-FA composites were prepared with different concentrations of fly ash to aniline ratio. The composites, so prepared, were characterized by UV-vis spectroscopy, Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). The thermal stability was studied by TGA and total weight loss of PANI, FA and PANI-FA composites having FA composition of 0.02%, 0.1%, 0.5% and 1.0% were found to be 82%, 39.%, 67% 65%, 62% and 61%, respectively. The UV-vis spectroscopy of the PANI-FA polymeric composite shows absorption maxima at 315 and 350 nm (due to π-π* transition of the benzenoid rings), and 578-712 nm (due to charge transfer excitations of the quinoid structure), which are characteristic of emeraldine base. FTIR spectra of the PANI-FA composite is similar to that of pure polyaniline (PANI) but with the bands for C=N, C=C and C-N shifted to lower wave numbers, i.e., 1585, 1494, 1327 and 1113 cm?1 due to strong interaction of Fe2O3 and PANI matrix. SEM shows the complexation of metal oxide with emaraldine base of PANI, significantly changing the aggregate state of polymeric molecular chain.

关键词： Polyaniline Fly-Ash TGA UV-Vis Spectroscopy FT-IR Kinetic Study and SEM

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