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The Epigenome as a therapeutic target for Parkinson's disease

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Neural Regeneration Research 2016年第11期11卷 1735-1738页

作者： Shane V.Hegarty Aideen M.Sullivan Gerard w.O'Keeffe Department of Anatomy and Neuroscience Biosciences InstituteUniversity College Cork

Parkinson＇s disease （PD） is a common, progressive neurodegenerative disease characterised by degeneration of nigrostriatal dopaminergic neurons, aggregation of α-synuclein and motor symptoms. Current dopamine-replacement strategies provide symptomatic relief, however their effectiveness wear off over time and their prolonged use leads to disabling side-effects in PD patients. There is therefore a critical need to develop new drugs and drug targets to protect dopaminergic neurons and their axons from degeneration in PD. Over recent years, there has been robust evidence generated showing that epigenetic dysregulation occurs in PD patients, and that epigenetic modulation is a promising therapeutic approach for PD. This ar- ticle first discusses the present evidence implicating global, and dopaminergic neuron-specific, akerations in the methylome in PD, and the therapeutic potential of pharmacologically targeting the methylome. It then focuses on another mechanism of epigenetic regulation, histone acetylation, and describes how the histone acetyltransferase （HAT） and histone deacetylase （HDAC） enzymes that mediate this process are attractive therapeutic targets for PD. It discusses the use of activators and/or inhibitors of HDACs and HATs in models of PD, and how these approaches for the selective modulation of histone acetylation elicit neuroprotective effects. Finally, it outlines the potential of employing small molecule epigenetic modulators as neuroprotective therapies for PD, and the future research that will be required to determine and realise this therapeutic potential.

关键词： Parkinson's disease epigenetics methylation acetylation histone acetyltransferase histonedeacetyIase small molecules

Considerations for effective ground support in evaporites

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International journal of Mining Science and Technology 2019年第1期29卷 113-118页

作者： j.R.Nopola C.A.Vining RESPEC

Evaporites, such as salt and potash, pose unique problems to ground-support designs that are not encountered in other rock types. Evaporites are subject to continual creep and no amount of ground support can successfully arrest this process. Common ground-support techniques that are useful for most rock types may reduce the effective life of bolts in evaporite mines and create unseen hazards. A different approach to ground support must be applied to provide long-term support in areas where high creep rates are present. The goal of effective ground-support designs in these situations is not to contain and prevent the rock from moving; rather, the ground-support design must be able to move along with the rock and contain any fully detached slabs until additional remediation measures can be *** most appropriate ground-support designs will consider the expected movement of the rock and the duration that the area needs to remain accessible.

关键词： Ground support Ground control Rock mechanics And salt mechanics

Numerical analysis of thermal plasma scrubber for CF4 decomposition

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Plasma Science and Technology 2019年第6期21卷 9-14页

作者： j KO T H KIM S CHOI Department of Nuclear and Energy Engineering Jeju National University Jeju 63243 Republic of Korea Institute for Nuclear Science and Technology Jeju National University Jeju 63243 Republic of Korea

CF4 gas emitted in the semiconductor and display manufacturing process is a very harmful greenhouse *** must be removed or converted safely due to its extreme *** a CF4 decomposition system using a thermal plasma scrubber was commercialized,its removal efficiency is *** this work,a numerical analysis of CF4 decomposition in the thermal plasma scrubber was carried out in order to propose an efficient decomposition *** decomposition and recombination temperatures of CF4 were analyzed using thermodynamic equilibrium *** chemical reaction of CF4 decomposition into carbon and fluorine gas was considered in this numerical *** injection position and angle of the CF4 were controlled in order to enhance the decomposition *** vertical injection of CF4 near the torch exit improved the mixing of the CF4 with the thermal plasma *** addition,it was confirmed that the high temperature region expanded due to a vortex generated by strong turbulence in the bottleneck-shaped *** a result,it is revealed that the CF4 injection location and the reactor configuration are the most important factors in improving the decomposition rate.

关键词： numerical simulation decomposition CF4 thermal plasma scrubber

Green Resource Allocation for Multiple OFDMA Based Networks: A Survey

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journal of Electronic Science and Technology 2016年第2期14卷 170-182页

作者： A.S.Khan j.Abdullah H.Lenando j.M.Nazim Facutly of Computer Science and Information Technology Universiti Malaysia Sarwak

Orthogonal frequency division multiple access （OFDMA） is a popular and widely accepted multiple access technique to provide high data rate services in a mobile environment in the area of wireless communications. OFDMA can provide better flexibility in allocating the radio spectra by utilizing subcarrier allocations, scheduling, and energy control to obtain multi-dimension diversity gains. Due to its resource allocation flexibility, OFDMA has been widely used as a green air interface technology for the emerging broadband wireless access networks. This paper extensively addresses the integration of green OFDMA to the future air interface technologies, for instance： two-tier cellular, multi radio access technologies （RATs）, FemtoCell, and relay networks. The main focus of the paper is to review and analyze the current OFDMA techniques to address the green resource allocation in multiuser diversity, where the critical constraints are the computational complexity, energy efficiency, and the sub-channel assignment. The future trend of OFDMA based networks will aim to maximize the energy efficiency of the exclusive channel assignment through a joint sub-channel and power allocation to accommodate high data traffic networks specially the relay based 5G cellular networks.

关键词： Dynamic multiuserorthogonai frequency division multiple accessresource allocation subcarriers. diversity,(OFDMA),

Hybrid versus global thermostatting in molecular-dynamics simulation of methane-hydrate crystallisation

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Chinese journal of Chemical Engineering 2019年第9期27卷 2180-2188页

作者： Niall j.English Mohammad Reza Ghaani School of Chemical and Bioprocess Engineering University College Dublin

Molecular-dynamics(MD)simulations have been performed for the growth of a spherical methane-hydrate nano-crystallite,surrounded by a supersaturated water–methane liquid phase,using both a hybrid and globalsystem thermostatting *** was found that hybrid thermostatting led to more sluggish growth and the establishment of a radial temperature profile about the spherical hydrate crystallite,in which the growing crystal phase is at a higher temperature than the surrounding liquid phase in the interfacial region,owing to latent-heat *** addition,Onsager’s-hypothesis fluctuation–dissipation analysis of fluctuations in the number of crystal-state water molecules at the interface shows slower growth.

关键词： Molecular dynamics Clathrate hydrates Crystallisation Thermostatting Radial temperature profile Fluctuation–dissipation

Nucleon Finite Volume Effect and Nuclear Matter Properties in a Relativistic Mean-Field Theory

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Communications in Theoretical Physics 2006年第6X期46卷 1052-1058页

作者： R. Costa A.j. Santiago H. Rodrigues j. Sa Borges Instituto de Fisica Universidade do Estado do Rio de Janeiro Rio de Janeiro-RJ 20559-900 Brazil Centro Federal de Educ~ao Tecnológica Rio de janeiro Brazil

Effects of excluded volume of nucleons on nuclear matter are studied, and the nuclear properties that follow from different relativistic mean-field model parametrizations are compared. we show that, for all tested parametrizations, the resulting volume energy al and the symmetry energy j are around the acceptable values of 16 MeV and 30 MeV, and the density symmetry L is around 100 MeV. On the other hand, models that consider only linear terms lead to incompressibility Ko much higher than expected. For most parameter sets there exists a critical point （pc, δc）, where the minimum and the maximum of the equation of state are coincident and the incompressibility equals zero. This critical point depends on the excluded volume parameter r. If this parameter is larger than 0.5 fm, there is no critical point and the pure neutron matter is predicted to be bound. The maximum value for neutron star mass is 1.85M⊙, which is in agreement with the mass of the heaviest observed neutron star 4U0900-40 and corresponds to r = 0.72 fm. we also show that the light neutron star mass （1.2M⊙） is obtained for r ≌ 0.9 fro.

关键词： nuclear matter relativistic models nuclear matter aspects of neutron stars

A Note on Teleportation of an Arbitrary Two-Particle State without Bell-State Measurement in Cavity QED

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Communications in Theoretical Physics 2009年第8期52卷 241-243页

作者： A.D.dSouza w.B.Cardoso A.T.Avelar B.Baseia Instituto de Fisica Universidade Federal de Goias

we present a scheme using four two-level atoms and a bimodal cavity to get approximate conditional teleportation of an arbitrary entangled atomic state without using the Bell-state measurement.

关键词： teleportation Bell-state bimodal cavity

Visual Basic 6数据库编程大全 G

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ANALYSIS OF THERMOSTATIC POwER IN OVEN-CONTROLLED QUARTZ CRYSTAL OSCILLATORS

丛书名：美国IDG“高级开发工具”丛书

1999年

作者：（美）（j.w.弗龙科威克）john w.Fronckowiak （美）（D.赫尔达）David j.Helda 全刚等译

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ANALYSIS OF THERMOSTATIC POWER IN OVEN-CONTROLLED QUARTZ CRY...