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南非HIV-1感染患儿接受补锌疗法的安全性与疗效研究:随机双盲、安慰剂对照试验

世界核心医学期刊文摘（儿科学分册） 2006年第4期2卷 2-3页

作者： Bobat R. Coovadia H. Stephen C. w.j. moss 张振 Department of Epidemiology Bloomberg School of Public Health Johns Hopkins University Baltimore MD 21205 United States.Dr

Background: Zinc deficiency is associated with impaired immune function and an increased risk of infection. Supplementation can decrease the incidence of diarrhoea and pneumonia in children in resource-poor countries. However, in children with HIV- 1 infection, the safety of zinc supplementation is uncertain. we aimed to assess the role of zinc in HIV- 1 replication before mass zinc supplementation is recommended in regions of high HIV- 1 prevalence. Methods: we did a randomised double-blind placebo-controlled equivalence trial of zinc supplementation at Grey’s Hospital in Pietermaritzburg, South Africa. 96 children with HIV- 1 infection were randomly assigned to receive 10 mg of elemental zinc as sulphate or placebo daily for 6 months. Baseline measurements of plasma HIV- 1 viral load and the percentage of CD4+ T lymphocytes were established at two study visits before randomisation, and measurements were repeated 3, 6, and 9 months after the start of supplementation. The primary outcome measure was plasma HIV- 1 viral load. Analysis was per protocol. Findings: The mean log10 HIV- 1 viral load was 5.4 (SD 0.61) for the placebo group and 5.4 (SD 0.66) for the zinc-supplemented group 6 months after supplementation began (difference 0.0002, 95% CI - 0.27 to 0.27). 3 months after supplementation ended, the corresponding values were 5.5 (SD 0.77) and 5.4 (SD 0.61), a difference of 0.05 (- 0.24 to 0.35). The mean percentage of CD4+ T lymphocytes and median haemoglobin concentrations were also similar between the two groups after zinc supplementation. Two deaths occurred in the zinc supplementation group and seven in the placebo group (p=0.1). Children given zinc supplementation were less likely to get watery diarrhoea than those given placebo. watery diarrhoea was diagnosed at 30 (7.4% ) of 407 clinic visits in the zinc-supplemented group versus 65 (14.5% ) of 447 visits in the placebo group (p=0.001). Interpretation. Zinc supplementation of HIV- 1- infected children does

关键词：补锌 HIV-1感染随机双盲疗效研究安慰剂对照水样腹泻锌缺乏细胞百分数病毒载量病毒复

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Protease supplementation reduced the heat increment of feed and improved energy and nitrogen partitioning in broilers fed maize-based diets with supplemental phytase and xylanase

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Animal Nutrition 2022年第3期10卷 19-25页

作者： Klint w.McCafferty Mingan Choct Sosthene Musigwa Natalie K.Morgan Aaron j.Cowieson Amy F.moss USDA-ARS Poultry Research Unit School of Environmental and Rural SciencesMississippi State39762United States University of New England ArmidaleNSW2351Australia DSM Nutritional Products Kaiseraugst4303Switzerland

An experiment was conducted to explore the effects of digestible amino acid(dAA)concentrations and supplemental protease on live performance and energy partitioning in *** 308 male broilers(n?288)were distributed into 24 floor pens and offered 1 of 4 dietary treatments with 6 replicates from 1 to 35 d of *** treatments consisted of a 2×2 factorial arrangement with dAA concentrations(standard and reduced[34 g/kg below standard])and supplemental protease(without or with)as the main *** 1,15,28,and 35 d of age,feed and broilerswereweighed to determine live ***20 to 23 d of age,a total of 32 birds(2 birds/chamber,4 replicates)were placed in closed-calorimeter chambers to determine respiratory exchange(heat production,HP),apparent metabolisable energy(AME),retained energy(RE),and net energy(NE).From 29 to 35 d of age,supplemental protease in the reduced-dAA diet decreased broiler feed conversion ratio(FCR)by 5.6 points,whereas protease supplementation in the standard-dAA diet increased FCR by 5.8 *** indirect calorimetry assay revealed that supplemental protease decreased(Pj/***,from 20 to 23 d of age,broilers offered the reduced-dAA diet with supplemental protease had a higher daily body weight gain(BwG)(t10.4%),N intake(t7.1%),and N retention(t8.2%)than those offered the standard-dAA with supplemental *** offered the reduced-dAA without supplemental protease exhibited a 3.6%higher AME-to-crude protein(CP)ratio than those offered other *** supplementation in the standard-and reduced-dAA diets resulted in 2.7%and 5.6%lower AME intake-to-N retention ratios,respectively,compared with the unsupplemented ***-dAA increased(P<0.05)AME intake(t4.8%),RE(t9.8%),NE intake(t5.8%),NE intake-to-CP ratio(t3.0%),and RE fat-to-RE ratio(t8.6%).Protease supplementation increased(P<0.05)respiratory quotient(t1.2%)and N retention-to-N intake ratio(t2.2%),

关键词： Exogenous enzyme Mono-component protease Net energy Amino acid

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Deformation-based support design for highly stressed ground with a focus on rockburst damage mitigation

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journal of Rock Mechanics and Geotechnical Engineering 2022年第1期14卷 50-66页

作者： P.K.Kaiser A.moss Laurentian University SudburyONP3E 2C6Canada GeoK Inc.680 Ramsey Lake Road SudburyONP3E 6H5Canada Sonal Mining Technology Inc. 2488 Shadbolt LaneWest VancouverBCV7S 3J1Canada

As mines go deeper,mine designs become more fragile and effective rock support becomes a strategic element for ground control to facilitate timely construction and cost-effective access for uninterrupted *** article focuses on the design of integrated support systems for brittle ground when large displacements due to gradual bulking of stress-fractured rock or sudden violent bulking during rockbursts are induced by static and dynamic *** provides an overview of support design principles for a rational approach to ground control in deep mines when large deformations are anticipated near *** designs must not only account for load equilibrium but also for deformation *** importantly,the design approach must account for the fact that the support’s displacement capacity is being consumed as it is deformed after support *** is therefore necessary to design for the remnant support capacity,*** capacity remaining when the support is ***,if the support capacity can be consumed,it can also be restored by means of preventive support maintenance(PSM).The PSM concept for cost-effective ground control is introduced and illustrated by quantitative and operational *** to other design approaches,the deformation-based support design(DBSD)approach provides the capacity of an integrated support system as a function of imposed *** in this support capacity due to mininginduced deformation renders excavations increasingly more vulnerable if located within the influence of active mining and seismic *** deformation measurements are robust indicators of the decay in support capacity,scanning and other displacement monitoring technologies enable measurements to verify the DBSD approach,to assess the remnant safety margin of the deformed support,and to make operational support maintenance decisions.

关键词： Deep mining Deformation-based support design(DBSD) Cost-effective support Support consumption Preventive support maintenance(PSM)

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An operational approach to ground control in deep mines

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journal of Rock Mechanics and Geotechnical Engineering 2022年第1期14卷 67-81页

作者： A.moss P.K.Kaiser Sonal Mining Technology Inc. 2488 Shadbolt LaneWest VancouverBCV7S 3J1Canada Laurentian University SudburyONP3E 2C6Canada GeoK Inc. 680 Ramsey Lake RoadSudburyONP3E 6H5Canada

As mines go deeper and get larger,mine designs become more fragile largely due to the response of the rock mass to *** control and rock support become important levers in the mine construction schedule,production performance,and excavation *** example,in cave mines,the production footprint together with associated mine infrastructure are significant investments in a modern caving *** investment must be protected and maintained to reduce the risk of ground-related production *** is necessary to preserve the health of these excavations and their maintenance through an effective rock support *** support thus becomes a strategic element in asset *** article focuses on support design for brittle ground when displacements induced by stress-fracturing consume much of the support’s *** deals with the functionality of the support in deforming *** interlinked concepts are important when assessing excavation *** must not only account for load equilibrium but also for deformation compatibility and capacity *** importantly,the support’s displacement capacity is being consumed when the rock mass is deformed after support ***,it is necessary to design for the support capacity remaining at the time when the support is *** support capacity can be consumed,it can also be restored by means of preventive support maintenance(PSM).This concept for cost-effective ground control is introduced and illustrated on operational ***,how design can impact construction costs and schedule are *** is installed to provide a safe environment and preserve an operationally functional *** also must assure senior management that investments in high quality support and its maintenance will substantially reduce delays and with it,*** is demonstrated that the use of‘gabion-like’support systems can achieve these goals.A technical summary of th

关键词： Ground control Rock support Deformation-based support design(DBSD) Gabion panel Deep mining Support consumption Preventive support maintenance(PSM) Asset management

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Effects of L-arginine,guanidinoacetic acid and L-citrulline supplementation in reduced-protein diets on bone morphology and mineralization of laying hens

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Animal Nutrition 2023年第3期14卷 225-234页

作者： Hiep Thi Dao Amy F.moss Emma j.Bradbury Robert A.Swick School of Environmental and Rural Science Faculty of ScienceAgricultureBusiness and LawUniversity of New EnglandArmidaleNew South Wales2351Australia Faculty of Animal Science Vietnam National University of AgricultureTrau Quy TownGia Lam DistrictHanoi100000Vietnam Baiada Poultry Pty Limited Pendle HillNew South Wales2145Australia

The alterations in feed ingredients and the nutrient matrix to produce reduced-protein diets may affect bone morphology and mineralization in laying *** study was implemented to determine the effects of L-arginine(Arg),guanidinoacetic acid(GAA),and L-citrulline(Cit)supplementation to Argdeficient reduced-protein diets on bone morphology,strength,and mineralization status of laying *** housed Hy-Line Brown laying hens were evenly distributed to five dietary treatments with 25 replicates per treatment from 20 to 40 wk of *** consisted of a standard protein diet(17%crude protein,SP),a reduced-protein diet deficient in Arg(13%crude protein,RP),and RP supplemented with Arg(0.35%Arg,RP-Arg),GAA(0.46%GAA equivalent to 0.35%Arg,RP-GAA),or Cit(0.35%Cit equivalent to 0.35%Arg,RP-Cit)to reach the Arg level of SP *** fed the SP diet had similar bone weight,ash,length,width,Seedor index,breaking strength,and serum mineral concentration,but higher toe B level(Pwk *** fed the SP diet consumed more but also excreted more K and B compared to those fed the RP diet(Pwer Cu digestibility(P=0.01)and higher B retention(Pweight and length(Pw mineral intake by increasing mineral ***,bone morphology and breaking strength,and serum mineral level in laying hens were not influenced by dietary CP *** Arg,GAA,or Cit supplementation were effective in improving bone morphology and

关键词： Ash Breaking strength Femur Low protein Minerals Digestibility

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Failed biliary cannulation: Clinical and technical outcomes after tertiary referral endoscopic retrograde cholangiopancreatography

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world journal of Gastroenterology 2011年第45期17卷 4993-4998页

作者： Michael P Swan Michael j Bourke Stephen j williams Sina Alexander Alan moss Rick Hope David Ruppin Department of Gastroenterology and Hepatology Westmead Hospital

AIM: Prospective evaluation of repeat endoscopic retrograde cholangiopancreatography (ERCP) for failed Schutz grade 1 biliary cannulation in a high-volume center. METHODS: Prospective intention-to-treat analysis of patients referred for biliary cannulation following recent unsuccessful ERCP. RESULTS: Fifty-one patients (35 female; mean age: 62.5 years; age range: 40-87 years) with previous failed biliary cannulation were referred for repeat ERCP. The indication for ERCP was primarily choledocholithiasis (45%) or pancreatic malignancy (18%). Successful biliary can- nulation was 100%. The precut needle knife sphincterotomy (NKS) rate was 27.4%. Complications occurred in 3.9% (post-ERCP pancreatitis). An identif iable reason for initial unsuccessful biliary cannulation was present in 55% of cases. Compared to a cohort of 940 nave pa-pilla patients (female 61%; mean age: 59.9 years; age range: 18-94 years) who required sphincterotomy over the same time period, there was no statistical difference in the cannulation success rate (100% vs 98%) or postERCP pancreatitis (3.1% vs 3.9%). Precut NKS use was more frequent (27.4% vs 12.7%) (P = 0.017). CONCLUSION: Referral to a high-volume center following unsuccessful ERCP is associated with high technical success, with a favorable complication rate, compared to routine ERCP procedures.

关键词： Failed endoscopic retrograde cholangiopancreatography Failed biliary cannulation Unsuccessful biliary cannulation Tertiary referral endoscopic retrograde cholangiopancreatography Needle knife sphincterotomy Biliary cannulation Precut sphincterotomy Post endoscopic retrograde cholangiopancreatography pancreatitis

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Nonlinear integrated photonics

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Photonics Research 2018年第5期6卷 I0024-I0025页

作者： ERIC CASSAN CHRISTIAN GRILLET DRAGOMIR N.NESHEV DAVID j.moss Centre for Nanosciences and Nanotechnologies (C2N) Paris-Sud University CNRS Senior research fellow continuing position Institut des Nanotechnologies de Lyon (INL)Ecole centrale de Lyon Nonlinear Physics Centre Australian National University Director of the Center for Micro-Photonics (CMP) Swinburne University of Technology

The field of nonlinear photonics is in full development. This special issue of Photonics Research takes you through the current issues of this fast-growing field of research, drawing on the current state of the art an... 详细信息

关键词： Nonlinear integrated photonics full development

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在多中心的自动除颤器植入试验II中预防性植入除颤器后心力衰竭的原因及后果

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世界核心医学期刊文摘（心脏病学分册） 2007年第1期3卷 12-13页

作者： Goldenberg I. moss A.j. Hall w.j. 杜媛 Heart Research Follow-up Program Box 653 University of Rochester Medical Center Rochester NY 14642 United StatesDr

背景:埋藏式心脏复律除颤器(ICD)治疗与发生心力衰竭(HF)风险的增加有关。本研究探讨了ICD植入后HF的发生率、病因以及后果。方法和结果:以1218例参与了多中心自动除颤器植入试验II(MADIT-II)的患者为对象,对这些患者纳入后HF事件相关... 详细信息

背景:埋藏式心脏复律除颤器(ICD)治疗与发生心力衰竭(HF)风险的增加有关。本研究探讨了ICD植入后HF的发生率、病因以及后果。方法和结果:以1218例参与了多中心自动除颤器植入试验II(MADIT-II)的患者为对象,对这些患者纳入后HF事件相关的临床因素和预后进行回顾性分析。与常规治疗相比,ICD治疗后初发和再发HF事件的校正后风险比(HR)分别为1.39(P=0.02)和1.58(P<0.001)。

关键词： II 单腔事件相关临床因素死亡风险双腔风险转化

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Negative consequences of reduced protein diets supplemented with synthetic amino acids for performance,intestinal barrier function,and caecal microbiota composition of broiler chickens

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Animal Nutrition 2023年第2期13卷 216-228页

作者： Reza Barekatain Peter V.Chrystal Tanya Nowland Amy F.moss Gordon S.Howarth Thi Thu Hao Van Robert j.Moore South Australian Research and Development Institute Roseworthy CampusRoseworthySAAustralia School of Animal and Veterinary Sciences Roseworthy CampusUniversity of AdelaideRoseworthySAAustralia School of Science RMIT UniversityBundoora West CampusBundooraVICAustralia School of Environmental and Rural Science University of New EnglandArmidaleNSWAustralia School of Envi1ronmental and Rural Science University of New EnglandArmidaleNSWAustralia

The consequences of feeding broiler chickens with reduced protein(RP)diets for gut health and barrier function are not well *** study was performed to elucidate the effect of reducing dietary protein and source of protein on gut health and performance *** experimental diets included 2 control diets with standard protein levels either containing meat and bone meal(CMBM)or an all-vegetable diet(CVEG),a medium RP diet(17.5%in growers and 16.5%in finisher),and a severe RP diet(15.6%in grower and 14.6%in finisher).Off-sex Ross 308 birds were assigned to each of the 4 diets and performance measurements were taken from d 7 to 42 *** diet was replicated 8 times(10 birds per replicate).A challenge study was conducted on additional 96 broilers(24 birds per diet)from d 13 to *** of the birds in each dietary treatment were challenged by dexamethasone(DEX)to induce a leaky *** birds with RP diets decreased weight gain(Pwith control *** was no difference be-tween CVEG and CMBM control diets for any *** diet containing 15.6%protein increased(Pwas downregulated(Pwas a significant interaction between diet and DEX(Pwnregulated claudin-2 expression in DEX-challenged *** overall composition of the caecal microbiota was affected in birds fed 15.6%pro-tein having a significantly lower richness of microbiota in both sham and DEX-injected ***-bacteria was the main phylum driving the differences in birds fed 15.6%*** the family level,Bifidobacteriaceae,Unclassified Bifidobacteriales,Enterococcaceae,Enterobacteriaceae,and Lachnospir-aceae were the main taxa in birds fed 15.6%*** supplementation of synthetic amino acids,severe reduction of dietary pro

关键词： Gut health Microbiota Tight junction protein Inflammation Broiler

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Photonic radio frequency channelizers based on Kerr optical micro-combs

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journal of Semiconductors 2021年第4期42卷 17-32页

作者： Mengxi Tan Xingyuan Xu jiayang wu Thach G.Nguyen Sai T.Chu Brent E.Little Roberto Morandotti Arnan Mitchell David j.moss Optical Sciences Centre Swinburne University of TechnologyHawthornVIC 3122Australia Electro-Photonics Laboratory Department of Electrical and Computer Systems EngineeringMonash UniversityVIC3800Australia School of Engineering RMIT UniversityMelbourneVIC 3001Australia Department of Physics City University of Hong KongHong KongChina State Key Laboratory of Transient Optics and Photonics Xi'an Institute of Optics and Precision MechanicsChinese Academy of ScienceXi'an 710119China INRS-Énergie Matériaux et Télécommunications1650 Boulevard Lionel-BouletVarennesQuébecJ3X 1S2Canada Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China

we review recent work on broadband RF channelizers based on integrated optical frequency Kerr micro-combs combined with passive micro-ring resonator filters,with microcombs having channel spacings of 200 and 49 *** approach to realizing RF channelizers offers reduced complexity,size,and potential cost for a wide range of applications to microwave signal detection.

关键词： microwave photonic signal channelization integrated optical frequency comb

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