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Anti-Obesity Effects of Chang-Chul-Eui-Ee-ln-Tang(苍术薏苡仁汤) in Female Rats with Diet-Induced Obesity

Chinese Journal of Integrative Medicine 2011年第12期17卷 925-932页

作者： Sunmin Park Jung Bok Lee James w.Daily Department of Food and Nutrition Obesity/Diabetes Research InstitutesHoseo UniversityAsan(336-795)South Korea Daily Manufacturing IncRockwellNC

Objective： To investigate the effects of Chang-ChuI-Eui-Ee-ln-Tang （苍术薏苡仁汤, CCEET）, modified CCEET （MCCEET）, and Semen Coicis （SC, a major component of CCEET） on energy and glucose homeostasis. The possible mechanism of action of CCEET was also determined. Methods： A total of 100 Sprague Dawley female rats were randomly assigned to 5 groups, with 20 in each group. Rats in 4 groups were fed with a high fat diet supplementation （2 g/kg body weight）, and water extracts of CCEET, MCCEET, SC, and cellulose （negative control）, respectively. The last group was fed with a low-fat diet as a positive control. Results： CCEET and MCCEET decreased body weight and body fat （mesenteric and retroperitoneal fat） more than SC. This decrease was due to decreased energy intake and increased energy expenditure and fat oxidation. The improvement in energy homeostasis was associated with the enhancement of the hypothalamic leptin signalling pathway involving potentiating the phosphorylation of the signal transducer and activator of transcription-3, as well as attenuating the phosphorylation of 5＇ adenosine monophosphate-activated protein kinase （AMPK）. Both CCEET and MCCEET improved glucose tolerance without changing serum insulin levels during an oral glucose tolerance test but MCCEET had a better effect than CCEET. Conclusions： Both CCEET and MCCEET safely exerted anti-obesity effects by enhancing energy balance in female rats with diet-induced obesity; MCCEET showed a better effect on glucose homeostasis.

关键词： Chang-ChuI-Eui-Ee-ln-Tang Semen Coicis leptin signal transducer and activator oftranscription-3 5' adenosine monophosphate-activated protein kinase hypothalamus

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锌掺杂半导体材料的共振电离质谱分析

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光谱学与光谱分析 1999年第1期19卷 16-18页

作者：彭慰先蒋占魁郭川 Ledingham K.w.D 仇伯仓吉林大学物理系中国科学院长春应用化学研究所

本文简要地描述了激光共振电离质谱的实验装置和测量方法，给出了用共振电离质谱方法对锌掺杂化合物半导体材料进行分析的光谱和质谱图，并估计了用这种方法进行痕量分析可能达到的检测限。

关键词：半导体锌掺杂 RIMS 光谱质谱

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Plasma lipidomics reveal systemic changes persistent throughout early life following a childhood burn injury

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Burns & Trauma 2023年第1期11卷 814-824页

作者： Eva Kierath Monique Ryan Elaine Holmes Jeremy K.Nicholson Mark w.Fear Fiona M.wood Luke whiley Nicola Gray 无 Australian National Phenome Centre Health Futures InstituteMurdoch UniversityHarry Perkins Institute5 Robin Warren DriveMurdochPerthWA 6150Australia Fiona wood Foundation Fiona Stanley HospitalFiona Wood FoundationFiona Stanley HospitalLevel 411 Robin Warren DriveMurdochWA 6150Australia Burn injury research unit School of Biomedical SciencesUniversity of Western Australia6 Verdun streetNedlandsWA 6009 Australia Department of Metabolism Digestion and ReproductionFaculty of MedicineImperial College LondonSir Alexander Fleming BuildingSouth KensingtonLondon SW72AZUK Centre for Computational Medicine Health Futures InstituteMurdoch University5 Robin Warren DriveMurdochPerthWA 6150Australia Medical School University of Western AustraliaHarry Perkins InstituteMurdochPerthWA 6150Australia Faculty of Medicine Institute of Global Health InnovationImperial College LondonLevel 1Faculty Building South Kensington CampusLondon SW72AZUK Burns Service of western Australia WA Department of Health11 Robin Warren driveMurdochWA 6150Australia Perron Institute for Neurological and Translational Science NedlandsWAAustralia

Background:Non-severe paediatric burns can result in poor long-term health *** occurs even in cases with good acute burn-related outcomes,including minimal *** mechanisms that underpin the transition from non-severe burn to sustained negative long-term health impacts are currently ***,sustained metabolic and immune changes have been observed in paediatric burn studies,suggesting these changes may be *** plasma lipidome consists of a rich pool of bioactive metabolites that play critical roles in systemic processes including molecular signalling and *** hypothesised that changes in the plasma lipidome may reflect underlying changes in health status and be linked to long-term health after burn ***:This study analysed the lipidome in children who had previously experienced a non-severe burn,compared to non-injured ***-three participants were recruited between the ages of 5 and 8 years who had experienced a non-severe burn between the ages of 1 and 3 *** samples were also collected from a non-injured,healthy,age and gender matched control group(n=21).Plasma lipids were measured using reversed-phase liquid chromatographymass spectrometery(LC-MS).Results:In total 838 reproducible lipid species from 19 sub-classes passed quality control procedures and progressed to statistical *** of individual lipid metabolites showed significantly higher concentrations of lysophosphatidylethanolamines and phosphatidylethanolamines,and significantly lower concentrations in myristic,palmitic and palmitoleic acids in the plasma of those who had experienced burn injury compared to ***:Long-term changes in the lipid profile may give insight into the mechanisms underlying poor long-term health subsequent to non-severe burn *** work to investigate the relationship between long-term pathology and lipidomic changes may lead to a better understanding of the causes of seconda

关键词： Lipidomics Lipids Burns Trauma Paediatric Children Mass spectrometry

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Study of the CKM angleγsensitivity using flavor untagged B_(s)^(0)→D^(+)^(0)Ф decays

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Chinese Physics C 2021年第2期45卷 56-92页

作者： D.Ao D.Decamp w.B.Qian S.Ricciardi H.Sazak S.T’Jampens V.Tisserand Z.R.wang Z.w.Yang S.N.Zhang X.K.Zhou University of Chinese Academy of Sciences Beijing 100049China UnivGrenoble Alpes UnivSavoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance STFC Rutherford Appleton Laboratory DidcotUnited Kingdom UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Center for High Energy Physics Tsinghua UniversityBeijing 100084China School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China

A sensitivity study on the measurement of the CKM angle γ from B_(s)^(0)→D^(+)^(0)Ф decays is conducted us-ing the D-meson reconstructed in the quasi flavour-specific modes Kπ,K3π,and Kππ^(0),as well as CP-eigenstate modes KK and m,where the notation DO corresponds toa D0 or D0 *** LHCb experiment is presented as a use case.A statistical uncertainty of approximately 8°-19°can be achieved with the pp collision data collcted in the LHCb experiment from 2011 to *** sensitivity to r should be of the order 3°-8°after accumulating 23 fb^(-1) of pp collision data by 2025,whereas it is expected to improve further by 300 fb^(-1) by the second half of the 2030 *** accuracy is dependent on the strong parameters r and og,which together with ydescribe the interfer-ence between the leading ampliudes of the B_(s)^(0)→D^(+)^(0)Ф decays.

关键词： sensitivity study CKM angleyγ B_(s)^(0)→D^(+)^(0)Фdecays

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磷酸钙涂覆炭织物体外细胞毒性的评价(英文)

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新型炭材料 2008年第2期23卷 139-143页

作者：韩红梅 Gary J．Phillips Sergey V．Mikhalovsky Andrew w．Lloyd 仲恺农业技术学院化工系广东广州510225 布来顿大学生物分子科学与药学院英国布来顿BN2 4GJ

医用植入体的成功与否常常取决于器件植入后细胞与材料表面间的相互作用。采用生物体外测试法考察了声电化学法制备的磷酸钙涂层对炭织物的骨细胞附着、增殖能力的影响。借助MTS检测技术、扫描电子显微镜,选择人类成骨细胞(MG63)作为细... 详细信息

医用植入体的成功与否常常取决于器件植入后细胞与材料表面间的相互作用。采用生物体外测试法考察了声电化学法制备的磷酸钙涂层对炭织物的骨细胞附着、增殖能力的影响。借助MTS检测技术、扫描电子显微镜,选择人类成骨细胞(MG63)作为细胞模型,通过测定细胞与炭织物、磷酸钙涂覆炭织物、以及其各自的提取液作用后的存活能力,研究了细胞/材料的相互作用,并对基底材料的细胞毒性进行了评价。结果表明,炭织物、磷酸钙涂覆炭织物均不具有细胞毒性,且磷酸钙涂层可提高成骨细胞的附着和增殖。SEM图像显示,细胞形貌正常,与对照组相比较生长增殖情况相似。

关键词：炭纤维磷酸钙细胞毒性生物体外测试

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Adsorption of 1,3-propanediol from synthetic mixture using polymeric resin as adsorbents

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Frontiers of Chemical Science and Engineering 2009年第1期3卷 52-57页

作者： w.LUERRUK A.SHOTIPRUK V.TANTAYAKOM P.PRASITCHOKE C.MUANGNAPOH Department of Chemical Engineering Faculty of EngineeringChulalongkorn UniversityBangkok 10330Thailand Department of Innovation and Technology PTT Chemical Public Company LimitedRayong 21150Thailand

The aim of this work was to separate 1,3-PDO from a synthetic mixture using polymeric resins,Amberlite XAD-7 and XAD-16 *** equilibrium adsorption of 1,3-PDO onto two polymeric resins were investigated in binary and tertiary *** results of binary component adsorption equilibrium indicated that the adsorption capacity(q)of 1,3-PDO at 160 g/L onto XAD-7 and XAD-16 was 835.96 and 584.61 mg 1,3-PDO/g dry resin,*** adsorption isotherms were closely predicted by the Langmuir-Freundlich model among the two isotherm model *** value of n of 1,3-PDO adsorbed on XAD-7 are much higher than those on *** result suggested that XAD-7 resin has a higher afﬁnity for the 1,3-PDO adsorption than XAD-16 ***,the value of adsorption capacity of 1,3-PDO in the binary and tertiary component were compared at the same *** the tertiary system,although the selectivity of 1,3-PDO from XAD-7 was approximately six times higher than XAD-16,the adsorption capacity of 1,3-PDO at 160 g/L onto XAD-16 was higher than ***,the reusability of XAD-7 and XAD-16 resins in the three cycle times shows a slight loss of adsorption ***,the investigation about desorption by an ethanol/water mixture at 50%(V/V)indicated that the desorption yield of 1,3-PDO from XAD-7 was lower than XAD-16 resin for both the binary and tertiary *** was due to the more favorable adsorption characteristics of XAD-7 resin than XAD-16 resin.

关键词： adsorption 1 3-propanediol glycerol poly-meric resin adsorption isotherm

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Nuclear physics program at MAX-lab

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Chinese Physics C 2009年第12期33卷 1159-1166页

作者： w.J. Briscoe Jason Brudvik K.G. Fissum K. Hansen L. Isaksson M. Lundin B. Nilsson B. Schroder Center for Nuclear Studies The George Washington University Washington DC 20052 USA Department of Physics Lund University Lund SE-221 00 Sweden MAX-lab Lund SE-221 00 Sweden

The upgrade of the MAX-lab injector and the construction of MAX Ⅲ, provided the opportunity for upgrading the tagged-photon facility and thus lead to the possibility of more extensive program in nuclear physics research. This upgrade increased the injected electron energy to an eventual maximum of 250 MeV and allows for the extraction of electrons from the MAX Ⅰ ring operated in the stretcher mode. The first stretched beam was delivered in September 2005. The tagged-photon facility was commissioned in parallel with the commissioning of new experimental equipment. The PAC approved experimental program is current in progress, including measurements of pion photoproduction below the △（1232）. The efforts at the tagged photon-facility are pursued within an international collaboration with around fifty members.

关键词： photonuclear reactions pion production compton scattering

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A new species of the genus Raorchestes(Anura:Rhacophoridae) from Yunnan Province, China

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Zoological Research 2019年第6期40卷 558-563页

作者： Yun-He wu Chatmongkon Suwannapoom Kai Xu Jin-Min Chen Jie-Qiong Jin Hong-Man Chen Robert w. Murphy Jing Che State Key Laboratory of Genetic Resources and Evolution State Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Kunming College of Life Science University of the Chinese Academy of SciencesKunming Yunnan 650204China School of Agriculture and Natural Resources University of PhayaoPhayao 56000Thailand Centre for Biodiversity and Conservation Biology Royal Ontario MuseumToronto Ontario M5S 2C6Canada

DEAR EDITOR,A new bush frog species, Raorchestes cangyuanensis sp. nov., from Cangyuan, Yunnan Province, China, is described based on morphological and molecular analyses. It differs from all known congeners by a combination of the following characters: body size small, adult snout-vent length (SVL) 16.1–20.0 mm in males (n=3);tympanum indistinct;tips of all fingers and toes expanded into discs with circummarginal grooves;rudimentary webbing between toes;fingers and toes with lateral dermal fringes;inner and outer metacarpal tubercles present;heels meeting when limbs held at right angles to body;crotch with a distinct black patch;discs of fingers and toes orange;male with external single subgular vocal sac and reddish nuptial pad at the base of first finger.

关键词： Raorchestes Yunnan

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Mo、Mo2C、Mo2N和MoO的电子结构及其对合成氨的催化性质（英文）

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天津大学学报(自然科学与工程技术版) 1985年第1期 107-122页

作者：钟顺和,M.Boudart,w.A.Harrison 天津大学化学工程系美国Stanford大学化学工程系美国Stanford大学应用物理系

本文用原子球近似（ASA）法计算了4d过渡金属Mo及它的三种化合物Mo2C、Mo2N和MoO的电子结构,得出了它们相应的S、P和d能带宽度、能带位置、费米能级EF和功函数φd的能值,给出了它们相应的能带结构简图。应用能带计算结果,根据woodward-H... 详细信息

本文用原子球近似（ASA）法计算了4d过渡金属Mo及它的三种化合物Mo2C、Mo2N和MoO的电子结构,得出了它们相应的S、P和d能带宽度、能带位置、费米能级EF和功函数φd的能值,给出了它们相应的能带结构简图。应用能带计算结果,根据woodward-Hoffmann分子轨道对称守恒原理和前线分子轨道作用法则,用前线分子轨道对称性分析和能量计算相结合的方法,讨论了Mo、Mo2C、Mo2N和MoO对合成氨反应（N2+3H2→2NH3）的催化性质,得到的催化活性顺序是Mo2C>Mo2N>MoO>Mo。此结果与实验事实完全一致。本文不仅对开发新型高效合成氨催化剂具有重要的现实意义,而且提供了一个用量子物理和量子化学计算设计工业催化剂的行之有效的理论方法。

关键词： Mo2N 催化性质

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Lztfl1/BBS17 controls energy homeostasis by regulating the leptin signaling in the hypothalamic neurons

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Journal of Molecular Cell Biology 2018年第5期10卷 402-410页

作者： Qun wei Yi-Feng Gu Qing-Jun Zhang Helena Yu Yan Peng Kevin w. williams Ruitao wang Kajiang Yu Tiemin Liu Zhi-Ping Liu Department of Surgical Oncology and Institute of Clinical Medicine Sir Run Run Shaw Hospital College of Medicine Zhejiang University Hangzhou 310016 China Department of Internal Medicine UT Southwestern Medical Center Dallas TX 75235 USA Department of Pathology UT Southwestern Medical Center Dallas TX 75235 USA Department of Intensive Care Unit The Third Affiliated Hospital Harbin Medical University Harbin 150081 China Sate Key Laboratory of Genetic Engineering School of Life Sciences Department of Endocrinology and Metabolism Zhongshan Hospital Collaborative Innovation Center for Genetics and Development Fudan University Shanghai 200438 China Department of Molecular Biology UT Southwestern Medical Center Dallas TX 75235 USA

Leptin receptor （LepRb） signaling pathway in the hypothalamus of the forebrain controls food intake and energy expenditure in response to an altered energy state. Defects in the LepRb signaling pathway can result in leptin-resistance and obesity. Leucine zipper transcription factor like 1 （Lztfl1）/BBS17 is a member of the Bardet-Biedl syndrome （BBS） gene family. Human BBS patients have a wide range of pathologies including obesity. The cellular and molecular mechanisms underlying Lztfl1-regulated obesity are unknown. Here, we generated Lztfl1lf/f mouse model in which Lztfl1 can be deleted globally and in tissue-specific manner. Global Lztfl1 deficiency resulted in pleiotropic phenotypes including obesity. Lztfl1^-/- mice are hyperphagic and showed similar energy expenditure as wT littermates. The obese phenotype of Lztfl1-/- mice is caused by the loss of Lztfl1 in the brain but not in the ***1-/- mice are leptin-resistant. Inactivation of Lztfl1 abolished phosphorylation of Stat3 in the LepRb signaling pathway in the hypothalamus upon leptin stimulation. Deletion of Lztfl1 had no effect on LepRb membrane localization. Furthermore, we observed that Lztfl1-/- mouse embryonic fibroblasts （MEFs） have significantly longer cilia than wT MEFs. we identified several proteins that potentially interact with Lztfl1. As these proteins are known to be involved in regulation of actin/cytoskeleton dynamics, we suggest that Lztfl1 may regulate leptin signaling and ciliary structure via these proteins. Our study identified Lztfl1 as a novel player in the LepRb signaling pathway in the hypothalamus that controls energy homeostasis.

关键词： obesity BBS leptin-resistance cilia actin/cytoskeleton

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