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中华医学杂志(英文版) 2024年第14期137卷 1750-1752页

作者： Xie Xinsheng Zhang wei Fu weiguo Zhang wayne w. wang Lixin Department of Vascular Surgery Xiamen Branch Zhongshan Hospital Fudan University Xiamen Fujian China Department of Vascular Surgery Zhongshan Hospital Fudan University Shanghai China Department of Plastic surgery Plastic Surgery Hospital Peking Union Medical College Beijing China Department of Division of Vascular and Endovascular Surgery Seattle VA Medical Center University of Washington Seattle WA USA

To the Editor: Thoracic endovascular aortic repair (TEVAR) has been widely accepted as the first-line treatment when aortic repair is indicated. However, TEVAR is still limited by anatomic conditions in many circumstances, and the most common exclusion situations are inadequate proximal and/or distal landing zones when important branch vessels are involved. The incidence of insufficient distal landing zone in descending TEVAR ranges from 2.5% to 15.2%, and different approaches to extend it were described. Hybrid surgery with combined TEVAR and open revascularization of visceral vessels has been employed from the early stage of endovascular aortic repair but it is associated with poor outcomes. Endovascular visceral artery revascularization, such as branched and fenestrated endograft, has been used more recently. Outcomes of stenting visceral arteries during fenestrated/branched aortic repair were explored by several studies and promising results were exhibited. However, these techniques demand heavily on available device and technical skills. Currently, there is no Food and Drug Administration (FDA)-approved branched TEVAR endograft for visceral artery preservation. Chimney or snorkel procedures are relatively easier to perform, but it is associated with a higher incidence of endoleaks.

关键词： ANEURYSM TRUNK TEVAR

Resistive field generation in intense proton beam interaction with solid targets

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Matter and Radiation at Extremes 2024年第1期9卷 35-43页

作者： w.Q.wang J.J.Honrubia Y.Yin X.H.Yang F.Q.Shao Department of Physics National University of Defense TechnologyHunanChina ETSI Aeronáutica y del Espacio Universidad Politécnica de MadridMadridSpain Department of Nuclear Science and Technology National University of Defense TechnologyHunanChina

The Brown-Preston-Singleton(BPS)stopping power model is added to our previously developed hybrid code to model ion beam-plasma *** simulations show that both resistive field and ion scattering effects are important for proton beam transport in a solid target,in which they compete with each *** the target is not completely ionized,the self-generated resistive field effect dominates over the ion scattering ***,when the target is completely ionized,this situation is ***,it is found that Ohmic heating is important for higher current densities and materials with high *** energy fraction deposited as Ohmic heating can be as high as 20%-30%.Typical ion divergences with half-angles of about 5°-10°will modify the proton energy deposition substantially and should be taken into account.

关键词： interaction beam intense

Viral etiologies of acute liver failure

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world Journal of Virology 2024年第3期13卷 26-40页

作者： Brian w McSteen Xiao-Han Ying Catherine Lucero Arun B Jesudian Department of Medicine New York-Presbyterian/Weill Cornell CampusNew YorkNY 10021United States Department of Gastroenterology and Hepatology Weill Cornell MedicineNew YorkNY 10021United States

Acute liver failure(ALF)is a rare cause of liver-related mortality worldwide,with an estimated annual global incidence of more than one million *** drug-induced liver injury,including acetaminophen toxicity,is the leading cause of ALF in the western world,viral infections remain a significant cause of ALF and the most common cause in many developing *** the high mortality rates associated with ALF,healthcare providers should be aware of the broad range of viral infections that have been implicated to enable early diagnosis,rapid treatment initiation when possible,and optimal management,which may include liver *** review aims to provide a summary of viral causes of ALF,diagnostic approaches,treatment options,and expected outcomes.

关键词： Acute liver failure Viral hepatitis Hepatitis B Hepatitis C Hepatitis A Liver disease Hepatology

Management of a Retained Epidural Catheter in a Pregnant Patient: A Case Report and Review of Literature

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Open Journal of Anesthesiology 2024年第8期14卷 175-183页

作者： Kevin w. Tang Mingzhuo Pei Aamod George Antoine Anderson Ming Xiong Rutgers New Jersey Medical School Newark New Jersey USA Department of Anesthesia & Perioperative Care Rutgers New Jersey Medical School Newark New Jersey USA

Background: Epidural anesthesia is an effective intervention to treat labor pain and provide analgesia for orthopedic procedures. A rare complication of this technique is epidural catheter retention. Case Presentation: In this case report, we present an otherwise healthy 21-year-old G2P0010 woman at 39 weeks and 3 days gestation whose anesthetic management was complicated by a symptomatic retained epidural catheter fragment. Computed tomography (CT) imaging of her spine showed the fractured catheter within her paraspinal muscles and neurosurgery recommended no surgical intervention at that time. The patient reported resolution of back pain while in the postpartum unit which she continues to endorse two weeks after discharge. Conclusion: Retained epidural catheter is a medical emergency that requires immediate imaging and neurological evaluation. while magnetic resonance imaging is typically regarded as the standard imaging modality for this complication, in epidural sets that contain metallic components, we suggest using CT to avoid the risk of thermal nerve damage. In cases where the patient does not report any acute complaints, nonsurgical management may be appropriate but close follow-up is required to monitor for catheter migration.

关键词： Epidural Obstetric Anesthesia Neuraxial Anesthesia Retained Catheter Computed Tomography

Nav1.7调节软骨细胞并作为骨关节炎的治疗靶点

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中国疼痛医学杂志 2024年第6期30卷 404-406页

作者： Fu w Vasylyev D Bi Y 戈家宜(译) 刘兴君(校) 不详南通大学药学院

骨关节炎(osteoarthritis,OA)是常见的关节疾病。目前还没有能够同时防止关节退化和减少疼痛的治疗方法。有证据表明软骨细胞中存在电压门控钠通道(voltage gated sodium channels,VGSCs),但它们在软骨细胞和OA中的表达和功能仍不清楚... 详细信息

骨关节炎(osteoarthritis,OA)是常见的关节疾病。目前还没有能够同时防止关节退化和减少疼痛的治疗方法。有证据表明软骨细胞中存在电压门控钠通道(voltage gated sodium channels,VGSCs),但它们在软骨细胞和OA中的表达和功能仍不清楚。该研究发现,Nav1.7作为一个与OA相关的VGSCs,人OA软骨细胞以0.1~0.15个/μm2和350~525个通道/细胞的密度表达功能性Nav1.7。在通过基因操作抑制Nav1.7的一系列小鼠模型上发现,表达在背根神经节(dorsal root ganglion,DRG)神经元中的Nav1.7参与疼痛的调控,而表达在软骨细胞中的Nav1.7调节OA进程。使用选择性或临床常用的泛Nav通道阻断剂,可显著改善结构性关节损伤,并减轻OA疼痛。Nav1.7阻断剂调节细胞内Ca2+信号和软骨细胞的分泌组,进而影响软骨细胞生物学和OA进程。该研究证实,Nav1.7为一个新发现的、在软骨细胞表达的OA相关VGSCs,可作为具有双重靶点特性的用于治疗OA和镇痛的非阿片类镇痛药。

关键词：骨关节炎软骨细胞关节疾病基因操作背根神经节治疗靶点关节损伤电压门控钠通道

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Genotypes and Phenotypes of Uygur Children with Xeroderma Pigmentosum: A Case Study in Xinjiang, China

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International Journal of Dermatology and Venereology 2024年第3期7卷 144-149页

作者： Qiu Y. wang w.-J. Liang J.-Q. Yakeya B. wang P. Zhang J.-Z. Kang X.-J. Department of Dermatology and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang Clinical Research Center for Dermatologic Diseases Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang Key Laboratory of Dermatology Research (XJYS1707) Xinjiang Uygur Autonomous Region Urumqi 830001 China

Objective: Xeroderma pigmentosum (XP) is a rare autosomal recessive dermatosis caused by genetic defects of DNA repair. This study was performed to detect and analyze the genes of 2 Uygur patients with XP and their families and assess the patients' phenotypes, which may enrich the understanding of the genetic skin disorder spectrum in Xinjiang area. Methods: we collected the clinical data from 2 patients with XP and peripheral blood samples from the patients and their family members. The patients' DNA was sequenced and detected by Sanger sequencing, and gene mutations were screened. Results: The proband in family 1 presented with brown maculae at the exposure site and squamous cell carcinoma secondary to a facial rash. The proband had a homozygous nucleotide variation of XPC c.2251-2A> G (A change from A to G in the penultimate position of the intron before the 2251 position in the coding region), which was a shear mutation. In this family, both parents were heterozygous, and no similar mutation detected in the sister. In family 2, the proband had scattered black brown spots and papules on the trunk and limbs. and his younger sister was also a patient. The proband and his younger sister had homonucleotide variation of XPA c.631C> T, which was nonsense mutation, resulting in the codon for Arg No.211 being changed into termination codon (***211X), thus terminating the peptide chain synthesis prematurely. All the normal individuals in the two families were heterozygotes, and homozygous mutations occurred in all the patients, which was consistent with the autosomal recessive inheritance. Conclusion: XP is rare in Uygur population. This study expanded the mutation spectrum of XP and provided a basis for early diagnosis, treatment, prognostic prediction, and prenatal genetic consultation. © 2022 Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences, and Chinese Medical Association, published by wolters Kluwer, Inc.

关键词： gene mutation xeroderma pigmentosum XPA gene XPC gene

Electrocatalytic Reduction of CO_(2)to CO with Almost 100%Faradaic Efficiency Using Oxygen-Vacancy Enriched Two-Dimensional MgO

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CCS Chemistry 2024年第6期6卷 1477-1486页

作者： Yu Han Sunggi An Xinyu Zhan Leiduan Hao Liang Xu Song Hong Dongmin Park Yuxin Chen Yiwen Xu Jiwen Zhao Xinyi Tan Alex w.Robertson Yousung Jung Zhenyu Sun State Key Laboratory of Organic-Inorganic Composites College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029 Department of Chemical and Biomolecular Engineering(BK21four) Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141 Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081 Department of Physics University of WarwickCoventry

The design and development of cheap,abundant,and efficient electrocatalysts for selective CO_(2)electroreduction is highly desirable yet remains an ongoing ***,we report on our discovery of the use of two-dimensional MgO rich in oxygen vacancies(VO)as an electrocatalyst for the efficient reduction of CO_(2)to yield CO in 1-butyl-3-methylimidazolium hexafluorophosphate dissolved in *** faradaic efficiency toward CO reaches as high as 99.6±0.24%with a current density of up to 40.8 mA cm−*** functional theory calculations illustrate that the introduction of VO in MgO substantially lowers the reaction-free energy for the transformation of ^(*)COO^(−) to ^(*)COOH,the potential determining step,which greatly boosts CO_(2)conversion *** work opens the way to realizing economic and efficient CO_(2)electrolysis of group II metals.

关键词： CO_(2)reduction electrocatalysis CO MgO ionic liquid oxygen-vacancy

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互惠合作系统的非对称性和不确定性

Journal of Plant Ecology 2024年第1期17卷 172-186页

作者： Rui-wu wang An-Na Shi Xiao-wei Zhang Min Liu K.Charlotte Jandér Derek w.Dunn School of Ecology and Environment Northwestern Polytechnical UniversityXi’an 710072China Faculty of Education University of MalayaKuala Lumpur 50400Malaysia College of Life Sciences Shaanxi Normal UniversityXi’an 710119China Department of Organismic and Evolutionary Biology Harvard UniversityMA 02138USA College of Life Sciences Northwest UniversityXi’an 710069China

过去的几十年里,尽管对互惠合作系统稳定性的理解取得了较大的进展,但在解释互惠关系如何保持稳定方面仍然存在两个基本问题。(i)如何解决互惠合作双方之间的资源冲突?(ii)当存在不怎么合作和/或完全不合作的共生体时,为什么合作的共生... 详细信息

过去的几十年里,尽管对互惠合作系统稳定性的理解取得了较大的进展,但在解释互惠关系如何保持稳定方面仍然存在两个基本问题。(i)如何解决互惠合作双方之间的资源冲突?(ii)当存在不怎么合作和/或完全不合作的共生体时,为什么合作的共生体没有被不合作的个体竞争排斥掉?过去许多关于互惠稳定性的解释都假设互惠合作双方的相互作用是对称的。然而,在大多数共生关系中,宿主和共生体之间的相互作用在不同水平上表现出不同程度的非对称性。本文我们回顾了互惠合作系统中的三种主要的非对称相互作用:(i)收益非对称,也就是合作双方的实力非对称性;(ii)潜在进化速率非对称性;(iii)宿主和共生体之间的信息非对称性。我们认为,互惠合作系统非对称性有助于解释合作和冲突行为的不确定性(合作与竞争的内生不确定性),以及为什么宿主和共生体都呈现出多样化的表型特征,而合作仍可占主导地位。

关键词：互利共生不对称相互作用宿主惩罚进化速率欺骗

轴重和频率对激光修复316L不锈钢涂层在铁路车轮踏面制动中摩擦学性能的影响

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表面工程与再制造 2024年第2期24卷 51-52页

作者： Li S. Xiao Q. Yang w. Yang C. wang Y. State Key Laboratory of Performance Monitoring and Protecting of Rail Transit Infrastructure East China Jiaotong University Nanchang 330013 China School of Mechatronics and Vehicle Engineering East China Jiaotong University Nanchang 330013 China Railway Industry Key Laboratory of Intelligent Operation and Maintenance of Rolling Stock East China Jiaotong University Nanchang 330013 China

研究复杂制动环境对修复熔覆层服役性能的影响,对提高列车轮轨系统抵御极端恶劣环境的能力具有重要意义。本文针对火车车轮踏面局部损伤问题,利用激光熔覆修复技术在损伤处制备316L不锈钢涂层。采用MS-HT1000高温磨损试验机进行磨损实... 详细信息

研究复杂制动环境对修复熔覆层服役性能的影响,对提高列车轮轨系统抵御极端恶劣环境的能力具有重要意义。本文针对火车车轮踏面局部损伤问题,利用激光熔覆修复技术在损伤处制备316L不锈钢涂层。采用MS-HT1000高温磨损试验机进行磨损实验。然后,分析不同制动条件对修复试样在室温和高温下摩擦磨损性能的影响。

关键词：激光修复铁路车轮局部损伤磨损实验车轮踏面磨损试验机服役性能踏面制动

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动静脉移植物内瘘并发症的干预原则

中华医学杂志 2024年第32期104卷 2980-2983页

作者：王宇飞张玮郑州大学第一附属医院血液净化中心郑州华盛顿大学医学院血管外科美国西雅图

动静脉移植物内瘘(AVG)的主要并发症包括狭窄、血栓形成及感染等。狭窄常采用腔内技术处理, 特殊部位可采用旁路、间置、补片等外科修复技术。血栓处理常包括血栓减容与纠正狭窄两部分, 前者包括导管接触性溶栓、腔内介入技术、外科修... 详细信息

动静脉移植物内瘘(AVG)的主要并发症包括狭窄、血栓形成及感染等。狭窄常采用腔内技术处理, 特殊部位可采用旁路、间置、补片等外科修复技术。血栓处理常包括血栓减容与纠正狭窄两部分, 前者包括导管接触性溶栓、腔内介入技术、外科修复技术或杂交技术。经验性抗生素应用前留取病原学检测是感染处理的第一步, 针对不同感染范围可分别采取移植物部分切除并置换、移植物全切、移植物部分切除手段。积极预防、及时发现和正确干预并发症可以改善AVG结局。AVG并发症的干预方案应在系统评估的基础上个体化制订。

关键词：血液透析动静脉移植物内瘘并发症干预