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Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han Yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

档案视角下中华优秀传统文化的数智化传播研究

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山西档案 2024年第6期 143-146页

作者：马麟银川能源学院银川750105

党的十九届五中全会明确提出实施国家文化数字化战略,为新时代中华优秀传统文化传承与发展指明了方向。档案作为中华传统文化的重要载体,在数智化传播方面大有可为。基于档案学视角,系统探讨了中华优秀传统文化档案数智化传播的内涵特... 详细信息

党的十九届五中全会明确提出实施国家文化数字化战略,为新时代中华优秀传统文化传承与发展指明了方向。档案作为中华传统文化的重要载体,在数智化传播方面大有可为。基于档案学视角,系统探讨了中华优秀传统文化档案数智化传播的内涵特征、实践探索、优化路径及其深远的发展意义。在推动中华传统文化档案数智化传播过程中,应立足多元主体协同,加强内容供给,拓展传播渠道,优化传播效果评估,以有效推动国家文化大数据中心的建设,从而为中华文化的数字化传播提供坚实的档案支撑。传统文化档案数智化传播是新时代文化自信自强、建设社会主义文化强国的重要抓手。因此,档案工作应顺应数字变革大势,持续推动优秀传统文化档案资源的数字化转型与创新传播,为坚定文化自信、实现中华民族伟大复兴的中国梦贡献智慧与力量。

关键词：中华传统文化传统文化传统文化传播档案数智化传播档案文化

Application Value of NLR,PLR,LMR,HEART score,and POCT in Early warning and Accurate Graded Diagnosis of High-Risk Chest Pain in Emergency Medicine

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Journal of Clinical and Nursing Research 2024年第4期8卷 93-98页

作者： Shaochang ma Chunhua Lin Yanmei Li Yan Chen Guohui Zhang Guandu District People’s Hospital Kunming 650200Yunnan ProvinceChina Guanshang Street Health Service Center Guandu DistrictKunming 650200Yunnan ProvinceChina

Objective: To evaluate the application value of neutrophils/lymphocytes (NLR), platelets/lymphocytes (PLR), lymphocytes/monocytes (LMR), HEART (history, electrocardiogram, age, risk factors, and troponin) score, and point-of- care testing (POCT) in the early warning and precise diagnosis of high-risk chest pain in emergency medicine. Methods: A total of 157 patients with acute chest pain who were admitted to the emergency department and chest pain treatment unit of our hospital between August 2022 and September 2023 were selected. Rapid testing of bedside myocardial markers (ultrasensitive troponin (hs-cTnI), myoglobin (MYO), creatine kinase isoenzyme (CK-MB), D-dimer (D-Dimer), and N-terminal B-type natriuretic peptide precursor (NT-proBNP)) was performed on the patients using a POCT device (thermoKing BioMQ60proB). A HEART score was used to classify the patients into low (n = 53), intermediate (n = 59), and high-risk (n = 45) groups, and the NLR, PLR, and LMR were calculated. the NLR, PLR, and LMR values were compared among the three groups of patients, and the optimal cutoff values as well as sensitivity and specificity were determined based on receiver operating characteristic (ROC) analysis. Results: the HEART scores of patients in the low-risk, intermediate-risk, and high-risk groups were (2.72 ± 0.24), (4.75 ± 0.56), and (5.32 ± 0.73) respectively, and the differences were statistically significant (P with the low-risk group, the intermediate-risk group and high-risk group had a significantly higher NLR and PLR, and a significantly lower LMR;the high-risk group had higher NLR and PLR and lower values of LMR as compared to the other two groups, and the difference was statistically significant (P the ROC curves suggested that the area under the curve, sensitivity, and specificity of the combined diagnosis of NLR, PLR, LMR, HEART score, and POCT were greater than those of LR, PLR, and LMR with HEART score and POCT alone. Conclusion: th

关键词： NLR PLR LMR POCT myocardial markers HEART score Emergency high-risk chest pain

Depositional model of the Member Deng-2 marginal microbial mound-bank complex of the Dengying Formation in the southwestern Sichuan Basin, Sw China: Implications for the Ediacaran microbial mound construction and hydrocarbon exploration

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Petroleum Science 2024年第2期21卷 806-822页

作者： Jin-Min Song Xin Jin Zhong Luo Shu-Gen Liu Shao-Bo Liu Xing-Zhi ma Zhi-wu Li Xue-Song Lu Ling-Li Zhao Ke-Ran Li Jia-Xin Ren Li-Zhou Tian Hao-Shuang Deng State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu610059SichuanChina PetroChina Research Institute of Petroleum Exploration and Development Beijing100083China Xihua University Chengdu610039SichuanChina

Recent advances in hydrocarbon exploration have been made in the Member Deng-2 marginal microbial mound-bank complex reservoirs of the Dengying Formation in the western Sichuan Basin, Sw China,where the depositional process is regarded confusing. the microfacies, construction types, and depositional model of the Member Deng-2 marginal microbial mound-bank complex have been investigated using unmanned aerial vehicle photography, outcrop section investigation, thin section identification,and seismic reflections in the southwestern Sichuan Basin. the microbialite lithologic textures in this region include thrombolite, dendrolite, stromatolite, fenestral stromatolite, spongiostromata stone,oncolite, aggregated grainstone, and botryoidal grapestone. Based on the comprehensive analysis of“depositional fabrics-lithology-microfacies”, an association between a fore mound, mound framework,and back mound subfacies has been proposed based on water depth, current direction, energy level and lithologic assemblages. the microfacies of the mound base, mound core, mound flank, mound cap, and mound flat could be recognized among the mound framework subfacies. Two construction types of marginal microbial mound-bank complex have been determined based on deposition location, mound scale, migration direction, and sedimentary facies association. Type Jinkouhe microbial mound constructions(TJMMCs) develop along the windward margin owing to their proximity to the seaward subfacies fore mound, with a northeastwardly migrated microbial mound on top of the mud mound,exhibiting the characteristics of large-sized mounds and small-sized banks in the surrounding area. Type E'bian microbial mound constructions(TEMMCs) primarily occur on the leeward margin, resulting from the presence of onshore back mound subfacies, with the smaller southwestward migrated microbial mounds existing on a thicker microbial flat. the platform margin microbial mound depositional model can be correlated with certain late

关键词： Sichuan Basin the Member Deng-2 marginal microbial mound-bank complex Depositional model Exploration implications

宁夏河东沙区柠条和新疆杨在纯林和混交林中的水分利用策略

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林业科学 2024年第10期60卷 40-49页

作者：柳利利韩磊王娜娜周鹏马云蕾马军宁夏大学地理科学与规划学院银川750021 中阿旱区特色资源与环境治理国际合作联合实验室银川750021 宁夏旱区资源评价与环境调控重点实验室银川750021 宁夏大学林业与草业学院银川750021

【目的】探究柠条和新疆杨在纯林和混交林中的水分利用策略,分析这2个树种在混交林中的水分利用关系、土壤水利用率的影响因子以及种植方式对土壤水分环境的影响,为旱区防护林的林分结构优化调控提供理论指导。【方法】于2018年生长季(5... 详细信息

【目的】探究柠条和新疆杨在纯林和混交林中的水分利用策略,分析这2个树种在混交林中的水分利用关系、土壤水利用率的影响因子以及种植方式对土壤水分环境的影响,为旱区防护林的林分结构优化调控提供理论指导。【方法】于2018年生长季(5—10月),在宁夏河东沙区选择柠条纯林、新疆杨纯林和柠条+新疆杨混交林,利用氢氧稳定同位素技术和IsoSource混合模型,分析柠条和新疆杨在纯林和混交林中的水分来源,采用相似性比例指数(PS指数)计算柠条和新疆杨在混交林中的水分利用关系;同时,监测土壤含水量、土壤养分和根系生物量,并利用结构方程模型(SEM)量化不同因子对林地植物土壤水利用率的影响;计算土壤储水量、土壤水分亏缺和土壤水消耗率,分析柠条、新疆杨纯林及混交林对土壤水分环境的影响。【结果】1)在纯林和混交林中,整个生长季的柠条的主要水分来源土层基本一致,而新疆杨则表现出不一致性。2)混交林中柠条和新疆杨在整个生长季的相似性比例指数(PS)为62.75%,表明两者之间存在较弱的水分竞争,在生长季不同时期,2个树种的主要水分来源土层不同,能通过水分利用的时间和空间分离来应对干旱。3)土壤含水量对3个林地的植物土壤水利用率的总效应最高,土壤含水量和土壤养分与柠条纯林的土壤水利用率呈极显著负相关(P<0.01),而与混交林中柠条的土壤水利用率呈极显著正相关(P<0.01),与新疆杨纯林和混交林的植物土壤水利用率呈显著正相关(P<0.05);根系生物量对3个林地的植物土壤水利用率呈显著正相关(P<0.05)。4)混交林土壤储水量高于柠条和新疆杨纯林,而土壤水分亏缺和土壤水消耗率低于柠条和新疆杨纯林。【结论】柠条在纯林和混交林中的水分利用策略基本一致,新疆杨在纯林和混交林中的水分利用策略存在差异;混交林中的柠条和新疆杨通过时间和空间上的水分利用的差异来应对干旱,且混交林相比纯林可更有效降低土壤干旱化风险;土壤含水量和土壤养分是影响3个林地植物土壤水利用率的主要因素。

关键词：水分来源水分利用关系氢氧稳定同位素结构方程模型土壤水分亏缺

应用研究型大学:理论内涵、功能定位与路径探索

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高等工程教育研究 2024年第1期 10-15页

作者：马宏伟东莞理工学院党委

党的二十大报告将教育、科技、人才进行统筹部署,亟需建设一批高水平应用研究型大学提供战略支撑。应用研究型大学聚焦高水平应用型创新人才培养、应用导向的科学研究和区域产业科技创新服务,发挥科技第一生产力、人才第一资源、创新第... 详细信息

党的二十大报告将教育、科技、人才进行统筹部署,亟需建设一批高水平应用研究型大学提供战略支撑。应用研究型大学聚焦高水平应用型创新人才培养、应用导向的科学研究和区域产业科技创新服务,发挥科技第一生产力、人才第一资源、创新第一动力的重要交汇功能。东莞理工学院主动适应国家战略需求和区域产业布局,持续强化办学顶层设计的前瞻谋划,在构建一流人才培养体系、布局建设特色化学科专业集群、打造高水平科技创新体系、深化教育教学评价改革等方面探索应用研究型大学建设路径。

关键词：应用研究型大学功能定位应用逻辑产业科技创新

从共同到共通:青年流动人才的数字生活及多元归属感

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西安交通大学学报（社会科学版） 2024年第3期44卷 125-132页

作者：郭扬马锋西北大学新闻传播学院陕西西安710127 西安外国语大学新闻与传播学院陕西西安710128

尽快培育青年流动人才对迁入城市的归属感,是实现中国城市可持续发展的活力源泉。既往新媒介为流动人口建构线上社区的研究承袭滕尼斯的“共同体”概念,却较少关注其对一致性、接近性的强调是否适用于智能手机形塑的“线上—线下”混杂... 详细信息

尽快培育青年流动人才对迁入城市的归属感,是实现中国城市可持续发展的活力源泉。既往新媒介为流动人口建构线上社区的研究承袭滕尼斯的“共同体”概念,却较少关注其对一致性、接近性的强调是否适用于智能手机形塑的“线上—线下”混杂的数字城市新经验。通过深入青年流动人才的数字生活实践,思考智能手机中介化实践过程建构归属感的独特性所在,以此审视旧概念的新嬗变。研究发现,数字技术重构了归属感内涵,将“属于某地”的共同体认同改写为“差异中共在”的共通体归属。具体来说,智能手机混杂了“去空间化”的人际交往与“差异中共在”的城市感知,使亲密关系与人地关系交织共置却彼此分离,建构出一种具有松散性、差异化、不稳定性的多元归属感。

关键词：青年流动人才数字生活智能手机中介化实践归属感共同体共通体

Cancer immunotherapy with envelopedself-amplifying mRNA CARG-2020 thatmodulates IL-12,IL-17 and PD-L1 pathways toprevent tumor recurrence

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Acta Pharmaceutica Sinica B 2024年第1期14卷 335-349页

作者： Ju Chen Bhaskara Reddy madina Elham Ahmadi Timur Olegovich Yarovinsky marie marthe Krady Eileen Victoria Meehan Isabella China wang Xiaoyang Ye Elise Pitmon Xian-Yong ma Bijan Almassian Valerian Nakaar Kepeng wang Department of Immunology School of MedicineUniversity of Connecticut Health CenterFarmingtonCT 06030USA CaroGen Corporation FarmingtonCT 06030USA the Eighth Clinical Medical College of Guangzhou University of Chinese Medicine Foshan Hospital of Traditional Chinese MedicineFoshan 528000China the Loomis Chaffee School WindsorCT 06095USA

Targeting multiple immune mechanisms may overcome therapy resistance and further improve cancer immunotherapy for ***,we describe the application of virus-like vesicles(VLV)for delivery of three immunomodulators alone and in combination,as a promising approach for cancer *** vectors were designed to deliver single chain interleukin(IL)-12,shorthairpin RNA(shRNA)targeting programmed death ligand 1(PD-L1),and a dominant-negative form of IL-17 receptor A(dn-IL17RA)as a single payload or as a combination *** delivery of the VLV vector expressing IL-12 alone,as well as the trivalent vector(designated CARG-2020)eradicated large established ***,only CARG-2020 prevented tumor recurrence and provided long-term survival benefit to the tumor-bearing mice,indicating a benefit of the combined *** abscopal effects of CARG-2020 on the non-injected contralateral tumors,as well as protection from the tumor cell re-challenge,suggest immune-mediated mechanism of protection and establishment of immunological ***,CARG-2020 potently activates th1 immune mechanisms and inhibits expression of genes related to T cell exhaustion and cancer-promoting *** ability of CARG-2020 to prevent tumor recurrence and to provide survival benefit makes it a promising candidate for its development for human cancer immunotherapy.

关键词： Virus-like vesicles Oncolytic virus IL-12 IL-17 PD-L1 T cell exhaustion Combination therapy Cancer immunotherapy

家族治理与企业创新投入——基于中国私营企业调查数据的分析

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管理评论 2024年第8期36卷 79-92页

作者：马骏何轩江南大学商学院无锡214122 广东外语外贸大学经济贸易学院广州510006

家族企业治理实际是企业治理和家族治理的共同过程,但既有研究大多从企业系统关注企业治理问题,忽视了家族内部的治理问题。尤其是,随着越来越多的中国家族企业进入一二代交接班进程,仅仅关注企业治理显然无法保证企业的稳定经营和顺利... 详细信息

家族企业治理实际是企业治理和家族治理的共同过程,但既有研究大多从企业系统关注企业治理问题,忽视了家族内部的治理问题。尤其是,随着越来越多的中国家族企业进入一二代交接班进程,仅仅关注企业治理显然无法保证企业的稳定经营和顺利传承,家族治理机制的设计和实施将变得不可或缺。鉴于此,本文利用第十四次中国私营企业调查数据库,重点关注家族治理对企业创新投入的影响机制和效应。研究发现:家族治理显著提升了企业的创新投入水平。进一步,随着企业生命周期的发展、家族涉入水平以及企业主对家族身份认同的提升,家族治理的积极作用逐渐增强,其与企业治理的联合效应也从替代转变为协同作用。机制检验发现,家族治理能够通过强化家族传承意愿、降低人力和融资成本来提升企业的创新投入水平。本文有助于加深对家族企业中家族治理效应的认识和理解,从而为家族企业如何适时、适当地设计和实施家族治理提供一定的现实启示。

关键词：家族企业家族治理企业治理企业创新