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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Mazhar Malik Ashfaq M.Sheikh George Merz w.ted brown Department of Neurochemistry NY State Institute for Basic Research in Developmental DisabilitiesNew YorkNY 10314USA

＜正＞Objective Recent studies suggest that one of the major pathways to the pathogenesis of autism is reduced cell migration,since the linkage between RELN and autism is a replicated genetic *** Reelin protein,encoded by the RELN gene,plays a pivotal role in neuronal *** adhesion kinase（FAK） has an important functional role in neural migration,dendritic morphology,axonal branching and synapse *** FAK/Src complex activated by up-stream reelin and integrinβ1 can initiate a cascade of phosphorylation events to trigger multiple intracellular pathways including MEK/ERK and PI3K/Akt *** aims of this study is to 1) determine whether integrinβ1 and FAK-Src signaling are abnormally regulated in autism by using B lymphoblasts as a study model, and 2) whether abnormal FAK-Src signaling leads to defects in B lymphoblast adhesion,migration,proliferation, and IgG *** Both autistic lymphoblasts and control lymphoblasts from the normal siblings were obtained from Autism Genetic Resource Exchange（AGRE,USA）.In this study,western blot analyses were used to detect the expression and activity levels of Integrin,FAK,Src and *** adhesion assay,modified Boyden chamber migration assay and cell proliferation assay were used to examine the lymphoblasts’ adhesion,migration and proliferation.A human IgG ELISA kit was used to measure the immunoglobulin *** staining and computer-assisted morphometry were performed to determine the morphology of *** we show that（1） the protein expression of both integrinβ1 and FAK are significantly decreased in autistic lymphoblasts and（2） Src protein expression and the phosphorylation of active site（Y416） are also significantly *** findings suggest a reduced FAK-Src signaling activity in autistic *** also found that lymphoblasts from autistic subjects exhibit significantly decreased migration and increased adhesion properties,as well as an i

关键词： autism focal adhesion kinase Src lymphoblasts

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PCBP1的新伴侣蛋白分子的研究(英文)

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北京大学学报（医学版） 2009年第4期41卷 402-408页

作者：霍丽蓉申晨 wei-na JU 邹俊华闫武 w. ted brown Nanbert ZHONG 北京大学医学遗传中心北京100191 山西医科大学基础医学院微生物学与免疫学教研室 New York State Institute for Basic Research in Developmental Disabilities Staten Island NY 10314 USA

Objective:PCBP1 is a family member of heterogeneous nuclear ribonucleoproteins (hnRNPs) that belong to RNA-binding proteins and bear three KH domains. The protein plays a pivotal role in post-transcriptional regulation for RNA metabolism and RNA function in gene expression. we hypothesized and were going to identify that the regulatory function of PCBP1 is performed through different complexes of proteins that include PCBP1. Methods:To test our hypothesis,approaches of protein wal-king with a yeast two-hybrid system (Y2H),pulling down in yeasts,co-immunoprecipitation and immunofluorescent microscopy assay were employed in this study. The PCBP1 was used as the initial "walker" to search for its interaction partner(s). Results:Candidate proteins including MYL6,PECAM1,CSH1,RAB7,p57KIP2,ACTG1,RBMS1 and PSG4-like were identified with selection mediums and preceding methods. Conclusion:with these candidate protein molecules,some protein complexes associating with PCBP1 are proposed,which may help in a better understanding of physiological functions of PCBP1 and proved evidence that PCBP1 is involved in variant biological pathways.

关键词： Poly(C)结合蛋白质1 酵母菌杂交遗传蛋白质结合

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IL-6 elevation in brain causes neural circuitry imbalance and mediates autism-like behavior

IL-6 elevation in brain causes neural circuitry imbalance an...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Kathryn K.Chadman Daniel P.McCloskey Ashfaq M.Sheikh Mazhar Malika w.ted brown Department of Neurochemistry NY State Institute for Basic Research in Developmental DisabilitiesNew YorkNY 10314USA Department of Psychology and Center for Developmental Neuroscience College of Staten IslandNew YorkNY 10314USA

＜正＞Objective Autism is a severe neurodevelopmental disorder characterized by problems in communication, social skills,and repetitive *** immune responses have been suggested to be associated with autism. Cytokines including IL-6,IL-8,IL-12,IL-1β,TNF-α,IFN-7,TGF-β1 and MCP-1 were reported to be increased in the blood,brain,or cerebrospinal fluid of autistic *** IL-6 is the most consistent finding in autism. However,the mechanisms of how IL-6 being involved in the pathogenesis of autism are poorly *** A mouse model of stably over-expressing IL-6 in brain was developed by injecting adenovirus encoding GFP IL-6 fusion protein into the cerebral lateral ventricles of P0.5 mice.A set of behavior tests was carried out to investigate the behavior in IL-6-over-expressed *** expression of synaptic vesicle proteins was tested using the fluorescence *** Dil labeling was used to outline dendritic spines in pyramidal *** synaptic function was measured with extracellular field excitatory post-synaptic potentials recordings in CA1 area of the hippocampus in acute *** we showed for the first time that elevation of IL-6 in the mouse brain produced certain autistic features,including impaired cognitive abilities,deficits in learning,abnormal anxiety-like traits and habituation, as well as decreased social interactions in older *** investigate how IL-6 elevation leads to the development of autistic phenotype,we detected that an IL-6 elevation resulted in increased excitatory synaptic formations and a decreased number of inhibitory ***-6 elevation produced an increase in the length of dendritic spines and also stimulated the formation of mushroom-shaped dendritic *** addition,we demonstrated that IL-6 elevation reduced postexcitatory inhibition in the mouse *** An abnormal elevation of IL-6 in the brain could lead to the development of autism phenotype through its impairments

关键词： autism IL-6 synapse development synaptic transmission autistic-like behavior

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A Conversation with Professor ted Kaptchuk,a Key Architect of Modern TCM in the west

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Chinese Medicine and Culture 2024年第1期7卷 5-18页

作者： Ioannis Solos Charles Buck ted Kaptchuk Saint George Clinic and Research Institute Scottsdale 85251the United States of America Northern College of Acupuncture Micklegate YO16LJthe United Kingdom Harvard Medical School Boston 02115the United States of America

The interview was conducted on November 20th,2022 by Ioannis Solos and Charles *** Kaptchuk(泰开阳)is a Professor of Medicine and a Professor of Global Health&Social Medicine at Harvard Medical *** 1975,he graduated from the Macao Institute of Chinese Medicine,Macao,*** returning to the west,ted taught Chinese medicine throughout the States,Europe,Latin America,and ***’s book,The web that Has No weaver:Understanding Chinese Medicine is a groundbreaking explanation of East Asian medicine that continues to shape the discourse of the Chinese medicine profession in the west and has been translated into 13 *** 1990,ted was recruited in Harvard Medical School to help research Chinese *** encountering high placebo responses in multiple acupuncture clinical trials,ted decided to switch his career to primarily studying *** has published over 300 peer-reviewed *** has been awarded the Lifetime Achievement Award from the Society of Acupuncture Research(2015),the Lifetime Achievement Award from the Society for Interdisciplinary Placebo Studies(2021),and the william Silen Lifetime Achievement Award in Mentoring from Harvard Medical School(2022).

关键词： Acupuncture acupuncture TCM

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Sustainable Connectivity in a Community Repository

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Data Intelligence 2024年第2期6卷 409-428页

作者： ted Habermann Metadata Game Changers 452414th St.Unit 7H BoulderBoulderColorado 80304USA

Persistent identifiers for research objects, researchers, organizations, and funders are the key to creating unambiguous and persistent connections across the global research infrastructure(GRI). Many repositories are implementing mechanisms to collect and integrate these identifiers into their submission and record curation processes. This bodes well for a well-connected future, but metadata for existing resources submitted in the past are missing these identifiers, thus missing the connections required for inclusion in the connected infrastructure. Re-curation of these metadata is required to make these connections. This paper introduces the global research infrastructure and demonstrates how repositories, and their user communities, can contribute to and benefit from connections to the global research infrastructure. The Dryad Data Repository has existed since 2008 and has successfully re-curated the repository metadata several times, adding identifiers for research organizations, funders, and researchers. Understanding and quantifying these successes depends on measuring repository and identifier connectivity. Metrics are described and applied to the entire repository here. Identifiers(Digital Object Identifiers, DOIs) for papers connected to datasets in Dryad have long been a critical part of the Dryad metadata creation and curation processes. Since 2019, the portion of datasets with connected papers has decreased from 100% to less than 40%. This decrease has significant ramifications for the re-curation efforts described above as connected papers have been an important source of metadata. In addition, missing connections to papers make understanding and re-using datasets more difficult. Connections between datasets and papers can be difficult to make because of time lags between submission and publication, lack of clear mechanisms for citing datasets and other research objects from papers, changing focus of researchers, and other obstacles. The Dryad community

关键词： Metadata curation Re-Curation Connectivity FAIR data Persistent identifiers

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Impacts of the retinal environment and photoreceptor type on functional regeneration

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Neural Regeneration Research 2017年第3期12卷 376-379页

作者： Michèle G.Du Val w.ted Allison Department of Biological Sciences University of Alberta Department of Medical Genetics University of Alberta

Retinal regeneration is a promising central nervous system（CNS） target amongst the various stem cell therapy pursuits,due to its accessibility for manipulation and its disposition towards longitudinal monitoring of treatment safety and *** offer our perspective on current hurdles towards functional regeneration of cone *** are key：For patients suffering vision loss,cone photoreceptors are a required cellular component to restoring daytime vision,colour vision,and high acuity *** challenges of regenerating cones contrast with logistic challenges of regenerating rod photoreceptors,which underlines the importance of evaluating context in degeneration and regeneration *** research is required to delineate the factors required to generate a diversity of cones in the human macula,and to coax both remaining and newly regenerating cones to rewire towards restoring daytime colour vision.A complex interplay between cell-intrinsic factors and the retinal environment determine both the specification of cone fates and the synaptic plasticity enabling their functional *** revelations that cellular materials are transferred amongst photoreceptor progenitors further emphasize the critical role of neighbouring cells in directing stem cell *** our vantage point,translation of stem cell therapies to restore the cone-rich human macula must be borne upon foundational research in cone-rich *** frameworks centered on patient outcomes should prioritize animal models and functional outputs that enable and report functional restoration of cone-mediated vision.

关键词： zebrafish synaptic plasticity horizontal cells material transfer vision neural development

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Biomarker bust:meta-analyses reveal unreliability of neuronal extracellular vesicles for diagnosing parkinsonian disorders

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Neural Regeneration Research 2025年第1期20卷 201-202页

作者： Hash brown Taha Leonard Davis School of Gerontology University of Southern CaliforniaLos AngelesCAUSA

A range of neurodegenerative disorders,collectively termed parkinsonian disorders,present with a complex array of both motor and non-motor *** in this group are Parkinson’s disease(PD),dementia with Lewy bodies(DLB),multiple system atrophy(MSA),corticobasal syndrome(CBS),and progressive supranuclear palsy(PSP).These disorders are differentiated neuropathologically by their dominant protein pathologies involvingα-synuclein(α-syn)and/or tau,the types of brain cells affected,such as neurons,oligodendroglia,and astrocytes,and the specific brain regions involved(Tolosa et al.,2021).

关键词： disorders parkin

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Quantum-mechanical effects in photoluminescence from thin crystalline gold films

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Light(Science & Applications) 2024年第4期13卷 783-794页

作者： Alan R.Bowman Alvaro Rodríguez Echarri Fatemeh Kiani Fadil Iyikanat ted V.Tsoulos Joel D.Cox Ravishankar Sundararaman F.Javier García de Abajo Giulia Tagliabue Laboratory of Nanoscience for Energy Technologies(LNET) STIÉcole Polytechnique Fédérale de Lausanne(EPFL)LausanneSwitzerland ICFO–Institut de Ciencies Fotoniques The Barcelona Institute of Science and TechnologyCastelldefels(Barcelona)Spain. MBI–Max-Born-Institut BerlinGermany. POLIMA–Center for Polariton-driven Light–Matter Interactions University of Southern DenmarkOdense MDenmark. Danish Institute for Advanced Study University of Southern DenmarkOdense MDenmark. Department of Materials Science&Engineering Rensselaer Polytechnic InstituteTroyNYUSA. Department of Physics Applied Physicsand AstronomyRensselaer Polytechnic InstituteTroyNYUSA. ICREA–Institucio Catalana de Recerca i Estudis Avancats BarcelonaSpain

Luminescence constitutes a unique source of insight into hot carrier processes in metals,including those in plasmonic nanostructures used for sensing and energy ***,being weak in nature,metal luminescence remains poorly understood,its microscopic origin strongly debated,and its potential for unraveling nanoscale carrier dynamics largely ***,we reveal quantum-mechanical effects in the luminescence emanating from thin monocrystalline gold ***,we present experimental evidence,supported by first-principles simulations,to demonstrate its photoluminescence origin(i.e.,radiative emission from electron/hole recombination)when exciting in the interband *** model allows us to identify changes to the measured gold luminescence due to quantum-mechanical effects as the gold film thickness is ***,such effects are observable in the luminescence signal from flakes up to 40 nm in thickness,associated with the out-of-plane discreteness of the electronic band structure near the Fermi *** qualitatively reproduce the observations with first-principles modeling,thus establishing a unified description of luminescence in gold monocrystalline flakes and enabling its widespread application as a probe of carrier dynamics and light-matter interactions in this *** study paves the way for future explorations of hot carriers and charge-transfer dynamics in a multitude of material systems.

关键词： luminescence quantum crystalline

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Projective Hilbert modules and sequential approximations

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Science China Mathematics 2024年

作者： Lawrence G.brown Huaxin Lin Department of Mathematics Purdue University Department of Mathematics East China Normal University Department of Mathematics University of Oregon

we show that when A is a separable C*-algebra, every countably generated Hilbert A-module is projective(with bounded module maps as morphisms). we also study the approximate extensions of bounded module maps. In the case where A is a σ-unital simple C*-algebra with strict comparison, and every strictly positive lower semicontinuous affine function on quasitraces can be realized as the rank of an element in the Cuntz semigroup, we show that the Cuntz semigroup is equivalent to unitarily equivalent classes of countably generated Hilbert A-modules if and only if A has stable rank one.

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Exploring the Social Impact of the Short-Stay Market(SSM)in Regional Areas:An Empirical Study

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Fudan Journal of the Humanities and Social Sciences 2024年第2期17卷 243-277页

作者： Emeka Ndaguba Kerry brown Dora Marinova Uma Jogulu School of Business and Law Edith Cowan UniversityPerthAustralia Curtin University Sustainability Policy Institute Curtin UniversityPerthAustralia

The discourse on microentrepreneurs and their involvement in the short stay market (SSM) was non-existent until 2008. while several concepts and constructs have been developed and empirically tested since 2009, many of them relate to economics, leaving the social, cultural, and environmental factors underdeveloped. Thus, this study aimed to fll the gap and identify and assess the social impact of the short-stay market (SSM) in a regional area. The study included 16 face-to-face interview sessions conducted with 18 participants, and the Leximancer software was employed to analyse the data. The study revealed that the social impact on SSM is not generic, rather pluralistic, multidimensional, and dynamic. The study also found that the limitation clause instituted by the council is a direct disconnect between the council and property owners/managers. Furthermore, despite ample opportunities provided by the short-stay market (SSM) in regional areas, encumbrances cannot be overlooked. Therefore, there is a need for a comprehensive approach to understand the social impact on policy frameworks in regional areas.

关键词： Short-stay market Experience economy Long-term rentals wine economy Regulation

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