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采用同步解析支撑液膜新技术提取浓缩头孢拉定

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采用同步解析支撑液膜新技术提取浓缩头孢拉定

The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a Drosophila model of Parkinson’s disease

2010年中国药学大会暨第十届中国药师周

作者：刘卫唐宇翔 w.s.winston ho 杨祥良华中科技大学国家纳米药物工程技术研究中心美国俄亥俄州立大学化学与生物分子工程系

采用同步解析支撑液膜（sLM-sD）新技术从生物发酵液中提取浓缩头孢菌素类抗生素药物头孢拉定（Cefradine）。研究了料液相、有机液膜相和解析相的组成,提取剂（载体）和解析剂的选择,过程参数（膜压力差、管程中料液相流速、壳程中有... 详细信息

采用同步解析支撑液膜（sLM-sD）新技术从生物发酵液中提取浓缩头孢菌素类抗生素药物头孢拉定（Cefradine）。研究了料液相、有机液膜相和解析相的组成,提取剂（载体）和解析剂的选择,过程参数（膜压力差、管程中料液相流速、壳程中有机液膜相和解析相流速、解析相搅拌速度等）对提取和解析过程的影响,对活性分子的提取浓缩过程的传质动力学进行了分析,评价了sLM-sD体系有机液膜的稳定性。相关研究工作为开发应用于头孢菌素类抗生素药物的分离纯化新技术提供实验依据。

关键词：同步解析支撑液膜技术头孢拉定提取浓缩中空纤维膜组件载体促进传质

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Neural Regeneration Research 2024年第5期19卷 1150-1155页

作者： shuanglong Yi Linfang wang Margaret s.ho shiping Zhang school of Life science and Technology ShanghaiTech UniversityShanghaiChina College of Life sciences University of Chinese Academy of SciencesBeijingChina

Parkinson’s disease is a progressive neurodegenerative disease characterized by motor deficits,dopaminergic neuron loss,and brain accumulation ofα-synuclein aggregates called Lewy *** in protein degradation pathways,such as autophagy,has been demonstrated in neurons as a critical mechanism for eliminating protein aggregates in Parkinson’s ***,it is less well understood how protein aggregates are eliminated in glia,the other cell type in the *** the present study,we show that autophagy-related gene 9(Atg9),the only transmembrane protein in the autophagy machinery,is highly expressed in Drosophila glia from adult *** from immunostaining and live cell imaging analysis reveal that a portion of Atg9 localizes to the trans-Golgi network,autophagosomes,and lysosomes in ***9 is persistently in contact with these *** glial atg9 reduces the number of omegasomes and autophagosomes,and impairs autophagic substrate *** suggests that glial Atg9 participates in the early steps of autophagy,and hence the control of autophagic ***,loss of glial atg9 induces parkinsonian symptoms in Drosophila including progressive loss of dopaminergic neurons,locomotion deficits,and glial *** findings identify a functional role of Atg9 in glial autophagy and establish a potential link between glial autophagy and Parkinson’s *** results may provide new insights on the underlying mechanism of Parkinson’s disease.

关键词： Atg9 autophagy glia Parkinson’s disease

Inclusive quasielastic neutrino-nucleus scattering with energy density functional nuclear models

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Chinese Physics C 2024年第8期48卷 153-158页

作者： K.s.Kim soonchul Choi Hana Gil Chang ho Hyun school of liberal arts and science korea aerospace universitygoyang 10540korea Center for exotic nuclear studies institute for basic sciencedaejeon 34126korea Center for extreme nuclear matters korea universityseoul 02841korea Department of physics education daegu universitygyeongsan 38453korea

In this study,we calculated the inclusive charged-current neutrino-nucleus scattering from ^(40)Ar in the quasielastic *** explore the effect of uncertainties stemming from the nuclear structure,we used the KIDs(Korea-IBs-Daegu-sKKU)nuclear energy density functional and skyrme force models,namely sLy4,skI3,and *** models were selected to have distinct behavior in terms of the density dependence of the symmetry energy and the effective mass of the *** the charged-current neutrino scattering,the single-and double-differential cross sections were calculated for various *** cross sections are reported as a function of the incident neutrino *** theoretical cross sections were compared with experimental data,and the roles of the effective mass and symmetry energy were investigated in terms of charged-current neutrino-nucleus scattering.

关键词： energy density functional neutrino-nucleus scattering symmetry energy effective mass of the nucleon

Pressure-induced hydrogen-dominant high-temperature superconductors

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National science Review 2024年第7期11卷 14-16页

作者： ho-kwang Mao shanghai Advanced Research in Physical sciences Center for High Pressure science and Technology Advanced Research

Recent studies of hydrogen-dominant（superhydride） materials have led to putative discoveries of near-room temperature superconductivity at high pressures. The idea started more than half-a-century ago as a by-product of the quest for metallic hydrogen for which a natural consequence of its very high Debye temperature and phonon frequency due to the very low mass of the hydrogen atoms would lead to a high superconducting critical temperature （Tc） in weak coupling Bardeen-Cooper-schrieffer（BCs） expression.

关键词： HYDRIDE LANTHANUM

Direct 4D printing of functionally graded hydrogel networks for biodegradable,untethered,and multimorphic soft robots

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International Journal of Extreme Manufacturing 2024年第2期6卷 407-416页

作者： soo Young Cho Dong Hae ho sae Byeok Jo Jeong ho Cho Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Mechanical Engineering Virginia TechBlacksburgVA 24061United States of America school of Chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea sKKU Institute of Energy science and Technology(sIEsT) Sungkyunkwan UniversitySuwon 16419Republic of Korea

Recent advances in functionally graded additive manufacturing(FGAM)technology have enabled the seamless hybridization of multiple functionalities in a single *** robotics can become one of the largest beneficiaries of these advances,through the design of a facile four-dimensional(4D)FGAM process that can grant an intelligent stimuli-responsive mechanical functionality to the printed ***,we present a simple binder jetting approach for the 4D printing of functionally graded porous multi-materials(FGMM)by introducing rationally designed graded multiphase feeder *** graded cross-linking agents gradually form stable porous network structures within aqueous polymer particles,enabling programmable hygroscopic deformation without complex mechanical ***,a systematic bed design incorporating additional functional agents enables a multi-stimuli-responsive and untethered soft robot with stark stimulus *** biodegradability of the proposed 4D-printed soft robot further ensures the sustainability of our approach,with immediate degradation rates of 96.6%within 72 *** proposed 4D printing concept for FGMMs can create new opportunities for intelligent and sustainable additive manufacturing in soft robotics.

关键词： intelligent and sustainable additive manufacturing multi-material four-dimensional printing untethered soft robot multi-stimuli-responsive soft robot biodegradable soft robotics

Enhancing visible-light-driven NO oxidation through molecular‐level insights of dye-loaded sea sands

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Rare Metals 2024年第2期43卷 543-554页

作者： Yu-Han Li Bang-Fu Chen sónia A.C.Carabineiro You-Yu Duan Ping Tan wing-Kei ho Fan Dong Engineering Research Center for waste Oil Recovery Technology and Equipment Ministry of EducationChongqing Key Laboratory of Catalysis and New Environmental MaterialsChongqing Technology and Business UniversityChongqing400067China Nanchang Institute of Technology Nanchang33044China LAQV-REQUIMTE Department of ChemistryNOVA School of Science and TechnologyUniversidade NOVA de Lisboa2829-516CaparicaPortugal College of Physics and Center of Quantum Materials and Devices Chongqing UniversityChongqing401331China Department of science and Environmental studies The Education University of Hong KongHong Kong999077China

Natural minerals,abundant and easily obtained through simple physical processing,offer a cost-effective and environmentally friendly solution for dyeing wastewater disposal and air pollution *** study investigates the photocatalytic removal of NO using natural different types of dyes,loaded on natural sand,under visible light *** examining various coating concentrations of dyes and sand weights,we discovered that sand loaded with Rhodamine B(RhB)exhibits high activity for the photo-oxidation of NO.A combination results of X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPs),Fourier transform infrared spectroscopy(FTIR)and thermogravimetric(TG)analyses confirm the presence of siO_(2),CaCO_(3),Al_(2)O_(3)and iron oxides as the main components of the ***,studying RhB-loaded individual components reveals that CaCO_(3)plays a crucial role in enhancing the NO removal *** results and theoretical calculations demonstrate the establishment of a directional charge transfer channel from CaCO_(3)to RhB,facilitating the adsorption and activation of molecular NO and O_(2).This work not only promotes the utilization of natural mineral resources but also enriches the fields of environmental photochemistry and semiconductor photocatalysis.

关键词： sand dyes Rhodamine B Photo-oxidation of NO Visible light illumination

Post-fontan circulation hepatocellular carcinoma:Open and laparoscopic hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 90-93页

作者： Karin KY ho wong hoi she simon HY Tsang Kevin s Lo Tan To Cheung Department of surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina Department of Anaesthesiology Queen Mary Hospital102 Pok Fu Lam RoadHong KongChina

To the Editor:Fontan-associated liver disease shows increasing incidence as advances in pediatric cardiology have prolonged life expectancy in patients with single ventricle congenital heart defects[1].Their unique physiology and procedure-related sequelae present an increasingly relevant challenge in hepatic *** hereby reported a series of patients suffering from hepatocellular carcinoma(HCC)who successfully underwent open and laparoscopic hepatectomy.

关键词： hepatocellular hepatectomy surgery

Label-free biosensing with singular-phaseenhanced lateral position shift based on atomically thin plasmonic nanomaterials

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Light(science & Applications) 2024年第5期13卷 810-822页

作者： shaodi Zhu Rodolphe Jaffiol Aurelian Crunteanu Cyrille Vézy sik-To Chan wu Yuan ho-Pui ho shuwen Zeng Light Nanomaterials&Nanotechnologies(L2n)CNRS-EMR 7004University of Technology of Troyes10000 TroyesFrance. Department of Biomedical Engineering The Chinese University of Hong KongShatinNew TerritoriesHong KongChina XLIM Research Institute UMR 7252 CNRS/University of Limoges123Avenue Albert ThomasLimogesFrance

Rapid plasmonic biosensing has attracted wide attention in early disease diagnosis and molecular biology ***,it was still challenging for conventional angle-interrogating plasmonic sensors to obtain higher sensitivity without secondary amplifying labels such as plasmonic *** address this issue,we developed a plasmonic biosensor based on the enhanced lateral position shift by phase *** singularity presents as a sudden phase retardation at the dark point of reflection from resonating plasmonic substrate,leading to a giant position shift on reflected ***,for the first time,the atomically thin layer of Ge2sb2Te5(GsT)on silver nanofilm was demonstrated as a novel phase-response-enhancing plasmonic *** GsT layer was not only precisely engineered to singularize phase change but also served as a protective layer for active silver *** new configuration has achieved a record-breaking largest position shift of 439.3μm measured in calibration experiments with an ultra-high sensitivity of 1.72×10^(8)nm RIU−1(refractive index unit).The detection limit was determined to be 6.97×10^(−7)RIU with a 0.12μm position ***,a large figure of merit(FOM)of 4.54×10^(11)μm(RIU∙°)^(−1)was evaluated for such position shift interrogation,enabling the labelfree detection of trace amounts of *** targeted biosensing experiments,the optimized sensor has successfully detected small cytokine biomarkers(TNF-αand IL-6)with the lowest concentration of 1×10^(−16)*** two molecules are the key proinflammatory cancer markers in clinical diagnosis,which cannot be directly screened by current clinical *** further validate the selectivity of our sensing systems,we also measured the affinity of integrin binding to arginylglycylaspartic acid(RGD)peptide(a key protein interaction in cell adhesion)with different Mn2+ion concentrations,ranging from 1 nM to 1 mM.

关键词： diagnosis protective silver

Application of Thermodynamic Database to Corrosion of ZrO_(2) Containing submerged Entry Nozzle in steel Continuous Casting Process

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China's Refractories 2024年第2期33卷 10-15页

作者： In-ho JUNG Department of Materials science and Engineering Seoul National UniversitySeoul 08826South Korea Research Institute of Advanced Materials Seoul National UniversitySeoul 08826South Korea

The CALPHAD thermodynamic databases are very useful to analyze the complex chemical reactions happening in high temperature material *** Factsage thermodynamic database can be used to calculate complex phase diagrams and equilibrium phases involving refractories in industrial *** this study,the Factsage thermodynamic database relevant to ZrO_(2)-based refractories was reviewed and the application of the database to understanding the corrosion of continuous casting nozzle refractories in steelmaking was presented.

关键词： thermodynamic database ZrO_(2)containing submerged entry nozzle continous casting