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Optimizing mechanical properties of HIPs fabricated with low-cost desktop 3D printers:investigating the impact of process parameters

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Advances in manufacturing 2024年第2期12卷 379-395页

作者： Jin-Ting Xu Guang-wei Zhang man-man Chen school of Automotive Engineering Dalian University of TechnologyDalian116024People’s Republic of China

Recently,low-cost desktop three-dimensional(3D)printers,employing the fused deposition modeling(FDM)technique,have gained widespread ***,most users cannot test the strength of printed parts,and little information is available about the mechanical properties of printed high-impact polystyrene(HIPs)parts using desktop 3D *** this study,the user-adjustable parameters of desktop 3D printers,such as crisscross raster orientation,layer thickness,and infill density,were *** experimental plans were designed using the Box-Behnken method,and tensile,3-point bending,and compression tests were carried out to determine the mechanical responses of the printed *** prediction models of the process parameters were regressed to produce the optimal combination of process *** experimental results showcase that the crisscross raster orientation has significant effects on the flexural and compression strengths,but not on the tensile *** an increase in the layer thickness,the tensile,flexural,and compression strengths first decreased and then increased,reaching their minimum values at approximately 0.16 mm layer *** addition,they all increased with an increase of infill *** was demonstrated that when the raster orientation,layer thickness,and infill density were 13.08°/–76.92°,0.09 mm,and 80%,respectively,the comprehensive mechanical properties of the printed HIPs were *** results can help end-users of desktop 3D printers understand the effects of process parameters on the mechanical properties,and offer practical suggestions for setting proper printing parameters for fabricating HIPs parts.

关键词： Desktop three-dimensional(3D)printers Fused deposition modeling(FDM) High-impact polystyrene(HIPs) Process parameters

Recurrent malignant hyperthermia after scoliosis correction surgery

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world Journal of Emergency Medicine 2024年第1期15卷 70-72页

作者： Junfeng su man Huang Department of General Intensive Care Unit the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310052China Key Laboratory of Early warning and Intervention of Multiple Organ Failure Ministry of Education of the People's Republic of ChinaHangzhou 310052China

Malignant hyperthermia(MH)is a genetic disorder of skeletal muscle cells that affects muscle cytoplasmic calcium homeostasis,with high mortality and low ***,it presents with non-specific signs of a hypermetabolic response,including high fever,tachycardia,and elevated end-tidal carbon dioxide(ETCO_(2)).The successful treatment lies in the timely recognition and early use of dantrolene.[1]As an inhibitor of Ca2+release through ryanodine receptor(RYR)channels,the skeletal muscle relaxant dantrolene has proven to be both a valuable experimental probe of intracellular Ca2+signaling and a lifesaving treatment for MH.[2]Dominant mutations in the skeletal muscle RYR1 gene are well-recognized causes of both malignant hyperthermia susceptibility(MHs)and central core disease(CCD).

关键词： hyperthermia malignant elevated

Evaluating the historical,clinical,and cultural value of the Tian Hui Yi Jian

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Journal of Traditional Chinese Medicine 2024年第1期44卷 220-221页

作者： YU Linyong GU man China Academy of Chinese Medical sciences Beijing 100700China Institute for History of Medicine and Medical Literature China Academy of Chinese Medical SciencesBeijing 100700China

Tian Hui Yi Jian was compiled by the Tianhui Medical manuscripts Compilation Group,which includes scholars from the Institute for History of Medicine and Medical Literature of the China Academy of Chinese Medical sciences(CACMs),Chengdu University of Traditional Chinese Medicine,Chengdu Institute of Cultural Relics and Archaeology,and Jingzhou Cultural Relics Protection *** was published by the Cultural Relics Press in November *** volume includes images of eight medical manuscripts,along with the Team's annotations,and photographs of a lacquered figurine with meridian-channels and words on its surface.

关键词： surface Chengdu Tian

Interplay of laser power and pore characteristics in selective laser melting of ZK60 magnesium alloys:A study based on in-situ monitoring and image analysis

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Journal of Magnesium and Alloys 2024年第4期12卷 1346-1366页

作者： weijie Xie Hau-Chung man Chi-wai Chan Department of Industrial and systems Engineering The Hong Kong Polytechnic UniversityHong KongChina school of Mechanical and Aerospace Engineering Queen’s UniversityBelfast BT95AHUK Research Institute for Advanced manufacturing The Hong Kong Polytechnic UniversityHong KongChina

This study offers significant insights into the multi-physics phenomena of the sLM process and the subsequent porosity characteristics of ZK60 Magnesium(Mg)***-speed in-situ monitoring was employed to visualise process signals in real-time,elucidating the dynamics of melt pools and vapour plumes under varying laser power conditions specifically between 40 w and 60 *** morphological analysis was performed using scanning-Electron Microscopy(sEM),demonstrating a critical correlation between laser power and pore *** laser power led to increased pore coverage,whereas a denser structure was observed at higher laser *** laser power influence on porosity was further confirmed via Optical Microscopy(OM)conducted on both top and cross-sectional surfaces of the *** increase in laser power resulted in a decrease in pore coverage and pore size,potentially leading to a denser printed part of Mg alloy.X-ray Computed Tomography(XCT)augmented these findings by providing a 3D volumetric representation of the sample internal structure,revealing an inverse relationship between laser power and overall pore *** laser power appeared to favour the formation of interconnected pores,while a reduction in interconnected pores and an increase in isolated pores were observed at higher *** interplay between melt pool size,vapour plume effects,and laser power was found to significantly influence the resulting porosity,indicating a need for effective management of these factors to optimise the sLM process of Mg alloys.

关键词： selective laser melting(sLM) Magnesium(Mg)alloys Biodegradable implants Porosity In-situ monitoring

Ferroptosis inhibitors reduce celastrol toxicity and preserve its insulin sensitizing effects in insulin resistant HepG2 cells

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Journal of Integrative Medicine 2024年第3期22卷 286-294页

作者： Jia-jia Liu Xue Zhang Bang-lan Cai man-man Qi Yong-bin Chi Bin Peng Deng-hai Zhang school of Medicine Shanghai UniversityShanghai 200444China shanghai Health Commission Key Lab of Artificial Intelligence-Based management of Inflammation and Chronic Diseases Shanghai Pudong Gongli HospitalSecondary Military Medical UniversityShanghai 200135China school of Basic Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

Objective:Research has shown that celastrol can effectively treat a variety of diseases,yet when passing a certain dosage threshold,celastrol becomes toxic,causing complications such as liver and kidney damage and erythrocytopenia,among *** this dichotomy in mind,it is extremely important to find ways to preserve celastrol’s efficacy while reducing or preventing its ***:In this study,insulin-resistant Hep G2(IR-Hep G2)cells were prepared using palmitic acid and used for in vitro ***-Hep G2 cells were treated with celastrol alone or in combination with Nacetylcysteine(NAC)or ferrostatin-1(Fer-1)for 12,24 or 48 h,at a range of *** counting kit-8assay,western blotting,quantitative reverse transcription-polymerase chain reaction,glucose consumption assessment,and flow cytometry were performed to measure celastrol’s cytotoxicity and whether the cell death was linked to ***:Celastrol treatment increased lipid oxidation and decreased expression of anti-ferroptosis proteins in IR-Hep G2 *** downregulated glutathione peroxidase 4(GPX4)m *** docking models predicted that solute carrier family 7 member 11(sLC7A11)and GPX4 were covalently bound by ***,we found for the first time that the application of ferroptosis inhibitors(especially NAC)was able to reduce celastrol’s toxicity while preserving its ability to improve insulin sensitivity in IR-Hep G2 ***:One potential mechanism of celastrol’s cytotoxicity is the induction of ferroptosis,which can be alleviated by treatment with ferroptosis *** findings provide a new strategy to block celastrol’s toxicity while preserving its therapeutic effects.

关键词： Celastrol Insulin resistance Ferroptosis N-Acetylcysteine Palmitic acid Molecular docking

Ensemble projections of climate and streamflow in a typical basin of semi-arid steppes in Mongolian Plateau of 2021-2100

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Advances in Climate Change Research 2024年第2期15卷 230-243页

作者： Hang PAN Jian-Ping TANG Liang CHENG man-Chun LI Jiangsu Provincial Key Laboratory of Geographic Information science and Technology Nanjing UniversityNanjing 210023China school of Geography and Ocean science Nanjing UniversityNanjing 210023China Key Laboratory of Mesoscale severe weather/Ministry of Education Nanjing UniversityNanjing 210023China school of Atmospheric sciences Nanjing UniversityNanjing 210023China

The Kherlen River is the main water source for Hulun Lake,the largest lake in northern *** to reduced inflow from the Kherlen River,Hulun Lake experienced rapid shrinkage at the beginning of the 21st century,posing a serious threat to the ecological security of northern ***,there is still a significant lack of projections regarding future climate change and its hydrological response in the Kherlen River *** study analyzed the projected climate and streamflow changes in the Kherlen River basin,a vital yet vulnerable international semi-arid steppes type basin.A combination of multi-model ensemble projection techniques,and the soil and water assessment tool(swAT)model was employed to examine the spatio-temporal changes in precipitation,temperature,streamflow,and the associated uncertainties in the *** temperature(an increase of 1.84-6.42℃)and the precipitation(an increase of 15.0-46.0 mm)of Kherlen River basin are projected to increase by 2100,leading to a rise in streamflow(1.08-4.78 m^(3) s^(-1)).The upstream of the Kherlen River exhibits remarkable increasing trends in precipitation,which has a dominant influence on streamflow of Kherlen *** increases in streamflow are observed in April,August,september,and October compared to the reference period(1971-2000).These findings suggest a partial alleviation of water scarcity in the Kherlen River,but also an increased likelihood of hydrological extreme *** projected temperature increase in the Kherlen River basin exhibits the smallest uncertainty,while more pronounced uncertainties are found in precipitation and *** spread among the results of CMIP6 models is greater than that of CMIP5 models,with lower signal-to-noise ratio(sNR)values for temperature,precipitation,and streamflow.

关键词： Climate change Flow projection Uncertainty swAT Mongolian Plateau

Effects of proton pump inhibitors on inflammatory bowel disease:An updated review

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world Journal of Gastroenterology 2024年第21期30卷 2751-2762页

作者： Yu Liang Zhen Meng Xue-Li Ding man Jiang Department of Pharmacy The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina Department of Intervention The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

Inflammatory bowel disease(IBD)is believed to be caused by various factors,including abnormalities in disease susceptibility genes,environmental factors,immune factors,and intestinal *** pump inhibitors(PPIs)are the primary drugs used to treat acid-related *** are also commonly prescribed to patients with *** studies have suggested a potential association between the use of certain medications,such as PPIs,and the occurrence and progression of *** this review,we summarize the potential impact of PPIs on IBD and analyze the underlying *** findings may provide insights for conducting further investigations into the effects of PPIs on IBD and serve as an important reminder for physicians to exercise caution when prescribing PPIs to patients with IBD.

关键词： Drug safety Proton pump inhibitor Inflammatory bowel disease Ulcerative colitis Crohn’s disease

synergistic Ru/RuO_(2) heterojunctions stabilized by carbon coating as efficient and stable bifunctional electrocatalysts for acidic overall water splitting

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Nano Research 2024年第8期17卷 6931-6939页

作者： man wu Yuying Fan Yang Huang Dongxu wang Ying Xie Aiping wu Chungui Tian Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080China

The development of highly active and stable acidic water oxidation electrocatalysts is of great significant for promoting the industrial application of proton exchange membrane ***-based catalysts have broad application prospects in acidic water oxidation,but their limitations in stability and activity hinder their further ***,a nitrogen-doped carbon(NC)coated porous Ru/RuO_(2) heterojunctional hollow sphere(Ru/RuO_(2)/NC)is designed as high-active and stable bifunctional electrocatalyst for acidic oxygen evolution reaction(OER)and hydrogen evolution reaction(HER).In synthesis,the key is to use mesoporous polydopamine spheres as a template for forming hollow spheres,a source of NC coating and a reducing agent for forming Ru/RuO_(2) *** Ru/RuO_(2) heterojunction adjusts the electronic structure of Ru active sites,optimizing the adsorption of intermediate ***,the NC coating and the interaction between NC and Ru/RuO_(2) effectively prevent Ru from over-oxidation and *** porous hollow structure provides more exposed active sites and promotes mass ***,Ru/RuO_(2)/NC exhibits outstanding OER and HER performance with low overpotentials of 211 and 32 mV at 10 mA·cm^(−2),respectively,and shows excellent *** acid water splitting electrolyzer,based on the bifunctional Ru/RuO_(2)/NC,requires low cell voltages of 1.46 and 1.76 V at 10 and 100 mA·cm^(−2),respectively,with good stability for over 100 h operation,surpassing Pt/C||RuO_(2) and most of the reported catalysts.

关键词： hollow heterojunction bifunctional electrocatalysts oxygen evolution hydrogen evolution acidic water splitting

Tanshinone ⅡA improves Alzheimer’s disease via RNA nuclearenriched abundant transcript 1/microRNA-291a-3p/member RAs oncogene family Rab22a axis

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world Journal of Psychiatry 2024年第4期14卷 563-581页

作者： Long-Xiu Yang man Luo sheng-Yu Li Department of Neurology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530000Guangxi Zhuang Autonomous RegionChina Department of Neurology Wuming Hospital of Guangxi Medical UniversityNanning 530199Guangxi Zhuang Autonomous RegionChina

BACKGROUND Alzheimer’s disease(AD)is a neurodegenerative condition characterized by oxidative stress and *** ⅡA(Tan-ⅡA),a bioactive compound isolated from salvia miltiorrhiza plants,has shown potential neuroprotective effects;however,the mechanisms underlying such a function remain *** To investigate potential Tan-ⅡA neuroprotective effects in AD and to elucidate their underlying *** Hematoxylin and eosin staining was utilized to analyze structural brain tissue *** assess changes in oxidative stress and neuroinflammation,we performed enzyme-linked immunosorbent assay and western ***,the effect of Tan-ⅡA on AD cell models was evaluated in vitro using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** changes related to the long non-coding RNA(lncRNA)nuclear-enriched abundant transcript 1(NEAT1)/microRNA(miRNA,miR)-291a-3p/member RAs oncogene family Rab22a axis were assessed through reverse transcription quantitative polymerase chain *** In vivo,Tan-ⅡA treatment improved neuronal morphology and attenuated oxidative stress and neuroinflammation in the brain tissue of AD *** vitro experiments showed that Tan-ⅡA dose-dependently ameliorated the amyloid-beta 1-42-induced reduction of neural stem cell viability,apoptosis,oxidative stress,and *** this process,the lncRNA NEAT1-a potential therapeutic target-is highly expressed in AD mice and downregulated via Tan-ⅡA ***,NEAT1 promotes the transcription and translation of Rab22a via miR-291a-3p,which activates nuclear factor kappa-B(NF-κB)signaling,leading to activation of the pro-apoptotic B-cell lymphoma 2-associated X protein and inhibition of the anti-apoptotic B-cell lymphoma 2 protein,which exacerbates ***-ⅡA intervention effectively blocked this process by inhibiting the NEAT1/miR-291a-3p/Rab22a axis and NF-κB *** This study demonstrates that

关键词： TanshinoneⅡA Alzheimer’s disease Nuclear-enriched abundant transcript 1 Member of RAs oncogene family Rab22a Reactive oxygen species