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Pharmacological approach to restoring steroid sensitivity in respiratory diseases

中国药理学与毒理学杂志 2018年第4期32卷 242-243页

作者： w.s. fred wong Department of Pharmacology Yong Loo Lin School of Medicine National University Health System 117600 Singapore Immunology Program Life Science Institute National University of Singapore 117456 Singapore singapore-HUJ Alliance for Research a

Inhaled corticosteroid is the first-line controller for asthma and ***,about 10% of the asthmatics(severe/refractory asthma) and most of the COPD patients are resistant to the beneficial effects of *** is a pressing unmet medical need to develop novel therapeutic agents to restore corticosteroid efficacy in affected *** have been reports showing the promise of theophylline and rapamycin in reversing steroid resistance in *** laboratory has demonstrated that andrographolide,a bioactive diterpenoid lactone isolated from the plant Andrographis paniculata,is an effective anti-inflammatory and anti-oxidative compound in both asthma and COPD experimental *** a severe asthma mouse model using combined IFN-γ/LPs exposure,production of IL-27 and methacholine-induced airway hyperresponsiveness(AHR) were found to be *** w.s.found to restore the anti-inflammatory effect of dexamethasone in LPs/IFN-γ-induced IL-27 levels in bronchoalveolar lavage(BAL) fluid and AHR in ***/IFN-γ markedly reduced the nuclear level of histone deacetylase-2(HDAC2),an essential epigenetic enzyme that mediates corticosteroid anti-inflammatory *** significantly restored nuclear HDAC2 levels and diminished total HAT/HDAC activity ratio in mouse lungs exposed to LPs/IFN-γ,probably via suppression of PI3K/Akt/HDAC2 phosphorylation and up-regulation of the antioxidant transcription factor Nrf2 *** a cigarette smoke(Cs)-induced COPD model,andrographolide markedly restored dexamethasone actions in inhibiting Cs-induced lung *** addition,andrographolide facilitated dexamethasone actions to suppress BAL fluid IL-6,IL-1b,KC and IL-17 *** lung lysates,andrographolide markedly restored total nuclear HDAC *** complete steroid re-sensitization mechanism of andrographolide remains to be ***,our existing data strongly implicate a potentially novel steroid re

关键词：皮质类固醇治疗方法药物治疗哮喘

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Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin Xie Yuanhui Guo Yun Chen Hao Zhang Jiawei Xiao Maoxiang Hou Huilong Liu Li Ma Xin Chen Chingping wong state Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China school of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China school of Materials science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

with the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review.s.stematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode self-powered sensor

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Gene silencing of Receptor-Interacting Protein 2 （RIP2） Attenuates Allergic Airway

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中国药理通讯 2013年第3期30卷 7-8页

作者： w. s. fred wong Department of Pharmacology Yong Loo Lin School of Medicine National University Health System Singapore Immunology Program Life Science Institute National University of Singapore Singapore

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Predicting air pressure in drainage stack of high-rise building

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Applied Mathematics and Mechanics(English Edition) 2013年第3期34卷 351-362页

作者： E. s. w. wong 李应林朱祚金 Industrial Center The Hong Kong Polytechnic University school of Engineering science University of Science and Technology of China

It is necessary to understand the features of air pressure in a drainage stack of a high-rise building for properly designing and operating a drainage system. This paper presents a mathematical model for predicting the stack performance. A step function is used to describe the effect of the air entrainment caused by the water discharged from branch pipes. An additional source term is introduced to reflect the gas-liquid interphase interaction （GLII） and stack base effect. The drainage stack is divided into upper and base parts. The air pressure in the upper part is predicted by a total variation diminishing （TVD） scheme, while in the base part, it is predicted by a characteristic line method （CLM）. The predicted results are compared with the data measured in a real-scale high- rise test building. It is found that the additional source term in the present model is effective. It intensively influences the air pressure distribution in the stack. The air pressure is also sensitive to the velocity-adjusting parameter （VAP）, the branch pipe air entrainment, and the conditions on the stack bottom.

关键词： air pressure in drainage stack characteristic line method stack base effect,interphase interaction

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Carrier Density and Plasma Frequency of Alummum Nanofilms

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Journal of Materials science & Technology 2003年第4期19卷 365-367页

作者： HaoDU JunGONG ChaosUN RongfangHUANG lIsHIwEN w.Y.Cheung s.P.wong InstituteofMetalResearch ChineseAcademyofSciencesShenyang110016China TheChinsesUniversityofHongKong HongKongChina

In this work, the prerequisite and mode of electromagnetic response of Al nanof ilms to electromagnetic wave field w.s.suggested. Reflectance, transmittance in infrared region and carrier density of the films w.s.measured. with the carrier density of the films, the dependence of their plasma frequencies on the film thickness w.s.obtained. On the other hand, the dependence of absorptance on the frequency of electromagnetic wave field w.s.set up by using the measured reflectance and transmittance, which provided plasma frequency-film thickness relation as well. similarity of both plasma frequency-film thickness relations proved plasma resonance as a mode of electromagnetic response in Al nanofilms.

关键词： Aluminum nanofilm Electromagnetic response size effect

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The Challenges of Multidisciplinary Education in Computer science

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Journal of Computer science & Technology 2011年第4期26卷 636-642页

作者： fred s.Roberts DIMACs Center Rutgers UniversityJerseyNew BrunswickNJU.S.A.

some of the most important problems facing the United states and China, indeed facing our entire planet, require approaches that are fundamentally multidisciplinary in nature. Many of those require skills in computer science （Cs）, basic understanding of another discipline, and the ability to apply the skills in one discipline to the problems of another. Modern training in computer science needs to prepare students to work in other disciplines or to work on multidisciplinary problems. what do we do to prepare them for a multidisciplinary world when there are already too many things we want to teach them about computer science？ This paper describes successful examples of multidisciplinary education at the interface between Cs and the biological sciences, as well as other examples involving Cs and security, Cs and sustainability, and Cs and the social and economic sciences. It then discusses general principles for multidisciplinary education of computer scientists.

关键词： multidisciplinary biology sustainability security social sciences economics education

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Nitric oxide removal by w.s.ewater bacteria in a biotrickling filter

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Journal of Environmental sciences 2014年第3期26卷 555-565页

作者： Hejingying Niu Dennis Y C Leung Chifat wong Tong Zhang Mayngor Chan fred C C Leung Department of Mechanical Engineering The University of Hong Kong school of Biological sciences The University of Hong Kong Department of Civil Engineering The University of Hong Kong

Nitric oxide （NO） is one of the most important air pollutants in atmosphere mainly emitted from combustion source. A biotriclding filter w.s.designed and operated to remove NO from an air stream using bacteria extracted from the sewage sludge of a municipal sewage treatment plant. To obtain the best operation conditions for the biotrickling filter, orthogonal experiments （L9（34）） were designed. Inlet oxygen concentration w.s.found to be the most significant factor of the biotrickling filter and has a significant negative effect on the system. The optimal conditions of the biotrickling filter occurred at a temperature of 40℃, a pH of 8.0 and a chemical oxygen demand of 165 mg/L in the recycled water with no oxygen in the system. The bacteria sample w.s.detected by DNA sequencing technology and showed 93%-98% similarity to Pseudomonas mendocina. Moreover, a full gene sequencing results indicated the bacterium w.s.a brand new.s.rain and named as P. mendocina DLHK. This strain can transfer nitrate to organic nitrogen. The result suggested the assimilation nitrogen process in this system. Through the isotope experimental analysis, two intermediate products （^15NO and ^15N2O） were found. The results indicated the denitrification function and capability of the biotrickling filter in removing NO.

关键词： NO reduction biotrickling filter orthogonal experiment Pseudomonas mendocina isotope labeling

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Robust H_∞ control for aseismic structures with uncertainties in model parameters

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Earthquake Engineering and Engineering Vibration 2007年第4期6卷 409-416页

作者：宋刚林家浩赵岩 w. Paul Howson fred w williams state Key Laboratory of structural Analysis for Industrial Equipment Faculty of Vehicle Engineering and Mechanics Dalian University of Technology Cardiff school of Engineering Cardiff University Cardiff CF24 3AA Wales U.K.

This paper presents a robust H∞ output feedback control approach for structural systems with uncertainties in model parameters by using available acceleration measurements and proposes conditions for the existence of such a robust output feedback controller. The uncertainties of structural stiffness, damping and mass parameters are assumed to be norm-bounded. The proposed control approach is formulated within the framework of linear matrix inequalities, for which existing convex optimization techniques, such as the LM1 toolbox in MATLAB, can be used effectively and conveniently. To illustrate the effectiveness of the proposed robust H∞ strategy, a six-story building w.s.subjected both to the 1940 E1 Centro earthquake record and to a suddenly applied Kanai-Tajimi filtered white noise random excitation. The results show that the proposed robust H∞ controller provides satisfactory results with or without variation of the structural stiffness, damping and mass parameters.

关键词： structural control robust H∞ control linear matrix inequality dynamic output feedback parameter uncertainty seismic excitation

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Tribological behavior of lubricant-impregnated porous polyimide

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Friction 2024年第4期12卷 711-725页

作者： Jinbang LI Ningning ZHOU Janet s.s.wong school of Mechanical Engineering and Mechanics Ningbo UniversityNingbo 315211China Beijing Key Laboratory of Long-life Technology of Precise Rotation and Transmission Mechanisms Beijing Institute of Control EngineeringBeijing 100029China Department of Mechanical Engineering Imperial College LondonLondon SW72AZUK

Porous materials impregnated with lubricants can be used in conditions where limited lubricant is *** this work,three porous polyimides(PPI)with different densities were ***(PAO)impregnated PPI(iPPI)discs were rubbed against steel and sapphire *** operando observations of the iPPI-sapphire contacts show that oil is released under an applied load,forming a meniscus around *** at the outlet is created at high sliding *** amount of released oil increases with increasing PPI *** moduli,E*,estimated based on the actual contact size show that trapped oil in iPPIs contributes to load *** higher speeds,tribological rehydration of the contact occurs in low density iPPI,with that E*rises with *** high density PPIs,high speeds give a constantly high E*which is limited by the viscoelastic properties of the PPI network and possibly the rate of oil *** of iPPI-steel contacts is governed by the mechanical properties of the PPI,the flow of the lubricant,and the roughness of the PPI *** low-and medium-density(highly porous,high roughness)PPIs,large amount of oil is released,and lubrication is mainly via lubricant restricted in the contact in the pores and possibly tribological *** high density(low porosity)PPI,with lower roughness,hydrodynamic lubrication is achieved which gives the low.s. *** results show that polymeric porous materials for effective lubrication require the optimization of its surface roughness,stiffness,oil flow,and oil retentions.

关键词： polyimide porous material friction mechanism polymer limited lubrication

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Overview of automotive engine friction and reduction trends-Effects of surface, material, and lubricant-additive technologies

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Friction 2016年第1期4卷 1-28页

作者： Victor w.wong simon C.TUNG Massachusetts Institute of Technology Cambridge MA 02139 USA Vanderbilt Chemicals LLC Norwalk CT 06856 USA

The increasing global environmental awareness, evidenced by recent worldwide calls for control of climate change and greenhouse emissions, has placed significant new technical mandates for automotives to improve engine efficiency, which is directly related to the production of carbon dioxide, a major greenhouse gas. Reduction of parasitic losses of the vehicle, powertrain and the engine systems is a key component of energy conservation. For engine efficiency improvement, various approaches include improvements in advanced combustion systems, component system design and handling—such as down-sizing, boosting, and electrification—as well as w.s.e heat recovery systems etc. Among these approaches, engine friction reduction is a key and relatively cost-effective approach, which has been receiving significant attention from tribologists and lubricant-lubrication engineers alike. In this paper, the fundamentals of friction specific to the environments of engine components tribology are reviewed, together with discussions on the impact of developing vehicle powertrain technologies, surface and material technologies, as well as lubricant and additive technologies on promises of continuing friction and wear reduction trends. The international accords on climate change require further gains in fuel efficiency and energy sustainability from all industry sectors including those in the automotive and the broader internal combustion engine industries, and the latter encompass off-highway, power generation, marine, and rail industries as well. This paper focsuses on friction reduction in mainly automotive engines, however. The paper starts with a clarification of the common descriptors of mechanical losses and friction in the engine, followed by the topic of lubrication fundamentals such as lubrication regimes. Then the lubrication of the contacting surfaces in each of the major engine subsystems is discussed in turn. These subsystems include the piston assembly: ring-pack/liner,

关键词： powertrain tribology automotive lubricants additive formulation mechanical design surface coatings and textures friction wear

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