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Accurate, automatic annotation of peptidases with hotpep-protease

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Green Chemical Engineering 2020年第2期1卷 124-130页

作者： peter kamp Busk Department of Science and Environment Roskilde UniversityUniversitetsvej 1DK-4000RoskildeDenmark

peptidases are essential for intracellular protein processing,signaling and homeostasis,physiological processes and for digestion of ***,peptidases are important biotechnological enzymes used in processes such as industrial food processing,leather manufacturing and the washing *** of peptidases is a crucial step in their characterization but peptidase annotation is not a trivial task due to their large sequence *** the present study short,conserved sequence profiles were generated for all peptidase families with more than four members in the comprehensive Merops peptidase *** sequence profiles were combined with the Homology to peptide pattern(Hotpep)method for automatic annotation of *** method is a standalone software that annotates protease sequences to Merops family and subgroup and is suitable for large-scale sequence *** to the Mammalian Degradome Database Hotpep-protease had an accuracy of 92%and a sensitivity of 96%for annotation of the human *** by commonly used methods(Blast and conserved domains)had an accuracy of 69%and a sensitivity of 78%.For fungal genomes,there were large differences between annotation with Hotpep-protease,Blast-and Hidden Markov Model-based annotation and the Merops annotation,which confirms the difficulty of large-scale peptidase *** annotation indicated that Hotpep-protease had a positive prediction rate of 0.90 compared to a positive prediction rate of 0.67 for Blast ***,Hotpep-protease is highly accurate method for fast and accurate annotation of peptidases.

关键词： Gene annotation proteinase proteolytic enzyme peptidase Merops

Glacial Lakes in the Andes under a Changing Climate:A Review

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Journal of Earth Science 2021年第6期32卷 1575-1593页

作者： Bijeesh Kozhikkodan Veettil Ulrich kamp Environmental Engineering and Management Research Group Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Environment and Labour Safety Ton Duc Thang UniversityHo Chi Minh CityVietnam Department of Natural Sciences University of Michigan-DearbornDearbornMI48128USA

In this article, we review the current knowledge of the glacial recession and related glacial lake development in the Andes of South America. Since the mid-1980 s, hundreds of glacial lakes either expanded or formed, and predictions show that additional hundreds of lakes will form throughout the 21 st century. However, studies on glacial lakes in the Andes are still relatively rare. Many glacial lakes pose a potential hazard to local communities, but glacial lake outburst floods(GLOFs) are understudied. we provide an overview on hazards from glacial lakes such as GLOFs and water pollution, and their monitoring approaches. In real-time monitoring, the use of unmanned aerial systems(UASs) and early warning systems(EwSs) is still extremely rare in the Andes, but increasingly authorities plan to install mitigation systems to reduce glacial lake risk and protect local communities. In support, we propose an international remote sensing-based observation initiative following the model of, for example, the Global Land Ice Measurements from Space(GLIMS) one, with the headquarters in one of the Andean nations.

关键词： Andes glacial change glacial lake glacial lake outburst flood remote sensing water pollution

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Liquefaction-Mudflow may Cause the Destruction of prehistoric Lajia Ruins,China

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Journal of Earth Science 2024年第6期35卷 2154-2157页

作者： Haijun Qiu Yingdong wei Ulrich kamp Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity College of Urban and Environmental SciencesNorthwest UniversityXi’an710127China Institute of Earth Surface System and Hazards Northwest UniversityXi’an710127China Earth and Environmental Sciences Discipline Department of Natural SciencesUniversity of Michigan-DearbornDearbornMI48104USA

0 INTRODUCTION The Lajia Site in Guanting Basin in the Upper Reaches of the Yellow River,China,is known as the'pompeii of the East'.It is adjacent to Xunhua and Hualong counties,and is also situated in the transitiona... 详细信息

关键词： situated transitional Tibetan

Integrability of auto-B?cklund transformations and solutions of a torqued ABS equation

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Communications in Theoretical physics 2021年第7期73卷 42-46页

作者： Xueli wei peter H van der kamp Da-jun Zhang Department of Mathematics Shanghai UniversityShanghai 200444China Department of Mathematics and Statistics La Trobe UniversityVictoria 3086Australia

An auto-B?cklund transformation for the quad equation Q1_(1) is considered as a discrete equation,called H2^(a),which is a so called torqued version of *** equations H2^(a) and Q1_(1) compose a consistent cube,from which an auto-B?cklund transformation and a Lax pair for H2^(a) are *** generally it is shown that auto-B?cklund transformations admit auto-Backlund *** the auto-Backlund transformation for H2^(a)we derive a seed solution and a one-soliton *** this solution it is seen that H2^(a) is a semi-autonomous lattice equation,as the spacing parameter q depends on m but it disappears from the plane wave factor.

关键词： auto-Bocklund transformation consistency Lax pair soliton solution torqued ABS equation semi-autonomous

Dietary Fibres and whole Grain products for Improving Health and Reducing Disease Risks

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食品科学 2004年第10期25卷 421-422页

作者： Jan willem van der kamp TNO Nutrition and Food Research P.O.Box 360 3700 AJ Zeist The Netherlands and ICC International Associa-tion for Cereal Science and Technology

In recent years the occurrence of civilisation related diseases such as diabetes and obesity is increasing at a dramatic rate. This results in a growing consumer awareness of relationships between diet and health. Industry is respond ing to this trend by introducing products with a healthy image, including products with dietary fibre. Every year about 500 products are being launched globally with statements regarding their fibre content. Dietary fibre is usually defined as "the edible parts of plants or analogous carbohydrates that are resistant to digestion and absorption in the human small intestine with complete or partial fermentation in the large intestine. Dietary fibre includes polysaccharides, oligosaccharides, lignin, and associated substances. Dietary fibres promote beneficial physiological effects including laxation, and/or blood cholesterol attenuation, and/or blood glucose attenuation" (AACC, 2001).

关键词：食物纤维谷类产品保健营养

Emission from quantum-dot high-β microcavities: transition from spontaneous emission to lasing and the effects of superradiant emitter coupling

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Light(Science & Applications) 2017年第1期6卷 638-645页

作者： Sören Kreinberg weng w Chow Janik wolters Christian Schneider Christopher Gies Frank Jahnke Sven Höfling Martin kamp Stephan Reitzenstein 无 Institut für Festkörperphysik Technische Universität BerlinBerlin 10623Germany Sandia National Laboratories AlbuquerqueNM 87185-1086USA Lehrstuhl für Technische physik Universität WürzburgWürzburg 97074Germany School of physics and Astronomy University of St AndrewsSt Andrews KY169SSUK Institute for Theoretical physics University of BremenBremen 28334Germany

Measured and calculated results are presented for the emission properties of a new class of emitters operating in the cavity quantum electrodynamics *** structures are based on high-finesse GaAs/AlAs micropillar cavities,each with an active medium consisting of a layer of InGaAs quantum dots(QDs)and the distinguishing feature of having a substantial fraction of spontaneous emission channeled into one cavity mode(highβ-factor).This paper demonstrates that the usual criterion for lasing with a conventional(lowβ-factor)cavity,that is,a sharp non-linearity in the input–output curve accompanied by noticeable linewidth narrowing,has to be reinforced by the equal-time second-order photon autocorrelation function to confirm *** paper also shows that the equal-time second-order photon autocorrelation function is useful for recognizing superradiance,a manifestation of the correlations possible in high-βmicrocavities operating with *** terms of consolidating the collected data and identifying the physics underlying laser action,both theory and experiment suggest a sole dependence on intracavity photon *** for this assertion comes from all our measured and calculated data on emission coherence and fluctuation,for devices ranging from light-emitting diodes(LEDs)and cavity-enhanced LEDs to lasers,lying on the same two curves:one for linewidth narrowing versus intracavity photon number and the other for g(2)(0)versus intracavity photon number.

关键词： coherence laser physics microlasers nanolasers optoelectronics photon statistics quantum dots quantum optics

Glacier Fluctuations between 1975 and 2008 in the Greater Himalaya Range of Zanskar,Southern Ladakh

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Journal of Mountain Science 2011年第3期8卷 374-389页

作者： Ulrich kamp Martin BYRNE Tobias BOLCH Department of Geography The University of Montana Geographisches Institut Universitt Zürich

Glaciers in the Himalaya are often heavily covered with supraglacial debris,making them difficult to study with remotely-sensed imagery *** methods such as band ratios can be used effectively to map clean-ice glaciers;however,a thicker layer of debris often makes it impossible to distinguish between supraglacial debris and the surrounding ***,a morphometric mapping approach employing an ASTER-derived digital elevation model has been used to map glaciers in the Khumbu Himal and the Tien *** study on glaciers in the Greater Himalaya Range in Zanskar,southern Ladakh,aims (i) to use the morphometric approach to map large debris-covered glaciers;and (ii) to use Landsat and ASTER data and GpS and field measurements to document glacier change over the past four *** work was carried out in the summers of *** clean ice,band ratios from the ASTER dataset were used to distinguish glacial *** debris-covered glaciers,topographic features such as slope were combined with thermal imagery and supervised classifiers to map glacial *** method is promising for large glaciers,although problems occurred in the distal and lateral parts and in the fore field of the glaciers.A multi-temporal analysis of glaciers in Zanskar showed that in general they have receded since at least the mid-to ***,some few glaciers that advanced or oscillated - probably because of specific local environmental conditions - do exist.

关键词： Glacier Mapping Himalaya Ladakh Monitoring Zanskar

Refined and dynamic susceptibility assessment of landslides using InSAR and machine learning models

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Geoscience Frontiers 2024年第6期15卷 105-120页

作者： Yingdong wei Haijun Qiu Zijing Liu wenchao Huangfu Yaru Zhu Ya Liu Dongdong Yang Ulrich kamp Shaanxi Key Laboratory of Earth Surface and Environmental Carrying Capacity College of Urban and Environmental SciencesNorthwest UniversityXi’an 710127China Insitute of Earth Surface System and Hazards College of Urban and Environmental SciencesNorthwest UniversityXi’an 710127China Earth and Environmental Sciences Discipline Department of Natural SciencesUniversity of Michigan-DearbornDearbornMI 48104USA

Landslide susceptibility assessment is crucial in predicting landslide occurrence and potential ***,traditional methods usually emphasize on larger regions of landsliding and rely on relatively static environmental conditions,which exposes the hysteresis of landslide susceptibility assessment in refined-scale and temporal dynamic *** study presents an improved landslide susceptibility assessment approach by integrating machine learning models based on random forest(RF),logical regression(LR),and gradient boosting decision tree(GBDT)with interferometric synthetic aperture radar(InSAR)technology and comparing them to their respective original *** results demonstrated that the combined approach improves prediction accuracy and reduces the false negative and false positive *** LR-InSAR model showed the best performance in dynamic landslide susceptibility assessment at both regional and smaller scale,particularly when identifying areas of high and very high *** results were verified using data from field investigations including unmanned aerial vehicle(UAV)*** study is of great significance to accurately assess dynamic landslide susceptibility and to help reduce and prevent landslide risk.

关键词： Landslide susceptibility Machine learning models InSAR Dynamic assessment

Tackling Addiction with Integrated Care

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Open Journal of Therapy and Rehabilitation 2023年第3期11卷 122-147页

作者： Jacobien kamp psychologist & MBA Graduate University of Cumbria Lancaster UK

Addiction is recognised as one of the chronic illnesses, often leading to medical, psychological, economic, and social problems, making multi-dimensional care for these people within the existing system a challenge. This loads an already loaded primary and secondary care system. The Verslavingskoepel Kempen (VKK) is an initiative to answer this challenge as it aims to integrate the care provided by the zeroth to third-line care around addiction treatment. Zeroth refers to the care and support provided by the human context of the patients, such as family and peers. This extends the integrated care model that is suggested by the wHO. The aim of the dissertation is firstly, to identify the organizational aspects crucial for the success of the network. The Findings show that success is confirmed by participating local communities when highlighting the importance of the intramural connection between their community social services and professionals, hospitals, and experience holders. All interviewees recognize collateral and process leadership with resources emerging from different partners and without hierarchical management. The second aim considers whether success must be attributed to the instrumental organizational aspects of the collaboration or the values of the different caregivers. The Findings show that in this network the organizational aspects and the caregivers’ values are complementary. The third aim is to develop conclusions on the transferability of the network model. This is confirmed;however, the governmental policy is not accompanied by a funding system within the institutionalized remuneration and reimbursement structure. It makes the initiative dependent on the motivation of partner organizations to participate financially, raises doubt about the sustainability of the initiative, and sets conditions for as well as limitations on transferability.

关键词： Integrated Care people with Addiction Efficacy Transferability