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Positive health:An integrated quantitative approach in patients with chronic gastrointestinal and hepato-pancreatico-biliary disorders

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world Journal of Gastroenterology 2024年第28期30卷 3418-3427页

作者： Anja H w m Lemlijn-Slenter Karolina AP wijnands Gijs van der Hamsvoort Luuk P van Iperen Nico wolter Angelique E de Rijk Ad Am masclee Department of Social medicine Faculty of HealthMedicine and Life sciencesCare and Public Health Research Institute Maastricht UniversityMaastricht 6200 MDLimburgNetherlands Division of Gastroenterology and Hepatology Department of Internal MedicineSchool of Nutrition and Translational Research in MetabolismMaastricht 6200 MDLimburgNetherlands Social medical Affairs Employee Insurance Agency(UWV)Heerlen 6400 ACLimburgNetherlands Department of Research Academic Knowledge Center Work and Health South-East Netherlands(AKAG-ZON)Heerlen 6400 ACLimburgNetherlands

BACKGROUND The concept of positive health(PH)supports an integrated approach for patients by taking into account six dimensions of *** approach is especially relevant for patients with chronic *** gastrointestinal and hepatopancreatico-biliary(GI-HPB)disorders are among the top-6 of the most prevalent chronically affected organ *** impact of chronic GI-HPB disorders on individuals may be disproportionally high because:(1)The affected organ system frequently contributes to a malnourished state;and(2)persons with chronic GIHPB disorders are often younger than persons with chronic diseases in other organ *** To describe and quantify the dimensions of PH in patients with chronic GI-HPB *** Prospective,observational questionnaire study performed between 2019 and 2021 in 235 patients with a chronic GIHPB disorder attending the Outpatient Department of the maastricht University medical *** questionnaires and data from patient files were used to quantify the six dimensions of *** consistency was tested with mcDonald’s ***-order Pearson correlations and t-tests were used to assess associations and differences.A P valuewas considered *** The GI-HPB patients scored significantly worse in all dimensions of PH compared to control data or norm scores from the general *** quality of life,participation and daily functioning,GI-HPB patients scored in the same range as patients with chronic disorders in other organ systems,but depressive symptoms(in 35%)and malnutrition(in 45%)were more frequent in patients with chronic GI-HPB *** scores between the six dimensions were only very weak to weak,forcing us to quantify each domain *** All six dimensions of PH are impaired in the GI-HPB *** and depressive symptoms are more prevalent compared to patients with chronic disorders in other organ systems.

关键词： Positive health Chronic gut disorders Gastrointestinal disorders Hepato-pancreatico-biliary disorders Integrated care

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New insights into protein–polysaccharide complex coacervation:Dynamics,molecular parameters,and applications

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Aggregate 2024年第1期5卷 148-166页

作者： Jiabao Zheng Paul van der meeren weizheng Sun School of Food Science and Engineering South China University of TechnologyGuangzhouChina Department of Green Chemistry and Technology Faculty of Bioscience EngineeringGhent UniversityGhentBelgium Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health(111 Center) GuangzhouChina

For more than a decade,the discovery of liquid–liquid phase separation within living organisms has prompted colloid scientists to understand the connection between coacervate functionality,phase behavior,and dynamics at a multidisciplinary *** the protein–polysaccharide was the first system in which the coacervation phenomenon was discovered and is widely used in food systems,the phase state and relaxation dynamics of protein–polysaccharide complex coacervates(PPCC)have rarely been discussed ***,this review aims to unravel the relationship between PPCC dynamics,thermodynamics,molecular architecture,applications,and phase states in past *** ahead,solving the way molecular architecture spreads to macro-functionality,that is,establishing the relationship between molecular architecture–dynamics–application,will catalyze novel advancements in PPCC research within the field of foods and biomaterials.

关键词： dynamics encapsulation liquid coacervate protein-polysaccharide complex coacervation solid precipitate

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Clinical-based phenotypes in children with pediatric post-COVID-19 condition

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world Journal of Pediatrics 2024年第7期20卷 682-691页

作者： Lieke C.E.Noij Jelle m.Blankestijn Coen R.Lap marlies A.van Houten Giske Biesbroek Anke-Hilse maitland-van der Zee mahmoud I.Abdel-Aziz Johannes B.van Goudoever mattijs w.Alsem Caroline L.H.Brackel Kim J.Oostrom Simone Hashimoto Suzanne w.J.Terheggen-Lagro Department of Pediatric Pulmonology and Allergy Amsterdam UMCLocation AMCEmma Children’s HospitalAmsterdam University Medical CenterRoom G2-222Meibergdreef 91105AZAmsterdamThe Netherlands Department of Pulmonary medicine Amsterdam UMCAmsterdamThe Netherlands Department of Pediatrics Spaarne GasthuisHoofddorpThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterAmsterdamThe Netherlands Department of Rehabilitation medicine Amsterdam Movement SciencesMeibergdreef 9AmsterdamThe Netherlands Department of Paediatric Pulmonology Department of PaediatricsTergooi MCHilversumThe Netherlands Department of Child and Adolescent Psychiatry and Psychosocial Care Amsterdam UMCAmsterdam Reproduction and DevelopmentAmsterdamThe Netherlands

Background Pediatric post coronavirus disease 2019(COVID-19)condition(PPCC)is a heterogeneous syndrome,which can significantly affect the daily lives of *** study aimed to identify clinically meaningful phenotypes in children with PPCC,to better characterize and treat this *** Participants were children with physician-diagnosed PPCC,referred to the academic hospital Amsterdam UmC in the Netherlands between November 2021 and march *** factors and information on post-COVID symptoms,comorbidities,and impact on daily life were *** clusters were identified using an unsupervised and unbiased approach for mixed data *** Analysis of 111 patients(aged 3–18 years)revealed three distinct clusters within *** 1(n=62,median age=15 years)predominantly consisted of girls(74.2%).These patients suffered relatively more from exercise intolerance,dyspnea,and smell *** 2(n=33,median age=13 years)contained patients with an even gender distribution(51.5%girls).They suffered from relatively more sleep problems,memory loss,gastrointestinal symptoms,and *** 3(n=16,median age=11 years)had a higher proportion of boys(75.0%),suffered relatively more from fever,had significantly fewer symptoms(median of 5 symptoms compared to 8 and 10 for clusters 1 and 2 respectively),and experienced a lower impact on daily *** This study identified three distinct clinical PPCC phenotypes,with variations in sex,age,symptom patterns,and impact on daily *** findings highlight the need for further research to understand the potentially diverse underlying mechanisms contributing to post-COVID symptoms in children.

关键词： Adolescents Clusters Long COVID Pediatric Phenotypes Post-COVID syndrome

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mycorrhizal fungi mitigate nitrogen losses of an experimental grassland by facilitating plant uptake and soil microbial immobilization

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Pedosphere 2024年第2期34卷 399-410页

作者： Yangyang JIA marcel G.A.van der HEIJDEN Alain Y.VALZANO-HELD markus JOCHER Florian wALder Postdoctoral mobile Station of Ecology College of Ecology and EnvironmentXinjiang UniversityÜrümqi 830046China Research Group Plant-Soil Interactions AgroscopeZürich 8046Switzerland Research Group Climate and Agriculture AgroscopeZürich 8046Switzerland Department of Plant and microbial Biology University of ZürichZürich 8008Switzerland Research Group Soil Quality and Soil Use AgroscopeZürich 8046Switzerland

Nitrogen(N)is one of the most limited nutrients of terrestrial ecosystems,whose losses are prevented in tightly coupled cycles in finely tuned *** change-induced N enrichment through atmospheric deposition and application of vast amounts of fertilizer are now challenging the terrestrial N *** mycorrhizal fungi(AmF)are known drivers of plant-soil nutrient fluxes,but a comprehensive assessment of AmF involvement in N cycling under global change is still ***,we simulated N enrichment by fertilization(low/high)in experimental grassland microcosms under greenhouse conditions in the presence or absence of AmF and continuously monitored different N pathways over nine *** found that high N enrichment by fertilization decreased the relative abundance of legumes and the plant species dominating the plant community changed from grasses to forbs in the presence of AmF,based on aboveground *** presence of AmF always maintained plant N:phosphorus(P)ratios between 14 and 16,no matter how the soil N availability *** in plant N:P ratios due to the increased plant N and P uptake might thus be a primary pathway of AmF altering plant community ***,we constructed a comprehensive picture of AmF’s role in N cycling,highlighting that AmF reduced N losses primarily by mitigating N leaching,while N_(2)O emissions played a marginal *** mycorrhizal fungi reduced N_(2)O emissions directly through the promotion of N_(2)O-consuming *** underlying mechanism for reducing N leaching is mainly the AmF-mediated improved nutrient uptake and AmF-associated microbial *** results indicate that synergies between AmF and other soil microorganisms cannot be ignored in N cycling and that the integral role of AmF in N cycling terrestrial ecosystems can buffer the upcoming global changes.

关键词： N cycling N enrichment N uptake N:P ratio plant community structure symbiotic soil fungi

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Enabling low-cost decentralized power reserves adopting carbon dioxide for green methane exchange in stabilized clathrate adsorbent

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Journal of Energy Chemistry 2024年第10期97卷 438-443页

作者： Lucas Hanssens maarten Houlleberghs C.Vinod Chandran Geert watson Sambhu Radhakrishnan Pascal van der Voort Joeri F.m.Denayer Christine E.A.Kirschhock Johan A.martens Eric Breynaert Centre for Surface Chemistry and Catalysis-Characterization and Application Team (COK-KAT) NmR/X-Ray Platform for Convergence Research (NmRCoRe) Centre for Ordered materials Organometallics and Catalysis (COMOC) Department of Chemistry Ghent University Department of Chemical Engineering Vrije Universiteit Brussel

*** circular methane energy systems In recent decades,methane-based energy systems have rapidly gained traction across the globe because of the increasing availability of low-cost methane production ***,fossil methane... 详细信息

关键词： Long duration energy storage Green methane Carbon neutrality Confined clathrate hydrates CH4 /CO2 exchange Direct gas exchange ENERGY-STORAGE CONFINED NANOSPACE TO-mETHANE GAS mECHANISmS ADSORPTION HYDROGEN

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应用3D准连续性动脉自旋标记mR成像对阿尔茨海默病和轻度认知障碍病人的脑血流量测量:疾病严重程度的一种标志

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国际医学放射学杂志 2013年第3期 279-280页

作者： m.A.Binnewijzend J.P.A.Kuijer m.R.Benedictus w.m.van der flier A.m.wink m.P.wattjes 林江南 Departments of Radiology Alzheimercenter AmsterdamVU University Medical Center

目的在3.0T技术下通过使用全脑三维(3D)准连续性动脉自旋标记(ASL)技术比较阿尔茨海默病(AD)病人、轻度认知障碍(mCI)病人和有主观主诉受试者的脑血流量(CBF)值。材料与方法该研究获得伦理委员会批准。所有受试者均已签署知情同意书。... 详细信息

目的在3.0T技术下通过使用全脑三维(3D)准连续性动脉自旋标记(ASL)技术比较阿尔茨海默病(AD)病人、轻度认知障碍(mCI)病人和有主观主诉受试者的脑血流量(CBF)值。材料与方法该研究获得伦理委员会批准。所有受试者均已签署知情同意书。对71例AD病人[平均年龄为(65±7)岁,55%为女性],35例mCI病人[平均年龄(65±8)岁,42%为女性]和73例曾在门诊就诊有主观主诉的受试者[平均年龄(60±9)岁,39%为女性]在3.0T场强下进行了3D全脑快速自旋回波准连续性ASL的图像采集。使用未进行校正的图像和已进行部分容积效应校正的图像进行分析。通过使用方差分析比较区域脑血流量;用体素方式比较作排列检验。通过线性回归分析认知状态(简易精神状态检查)。所有分析均校正年龄和性别。结果 AD病人未校正的CBF相对于有主观主诉受试者有所减少[(27±5)mL/(100g·min)与(33±5)mL/(100g·min);PmL/(100g·min)与(30±5)mL/(100g·min);指标误差(ie),减少27%]。校正的皮质CBF显示出相似结果。与有主观主诉受试者相比较,mCI病人的CBF在楔前叶、顶叶和枕叶有所下降。体素方式比较证实了感兴趣区的发现,显示出楔前叶和双侧顶叶皮质的CBF最大差异。未校正和校正过的皮质CBF与认知在组间相关(β=0.46和β=0.42,PmR成像脑血流量测量有助于发现AD病人在患病初期和更晚期的功能改变,是病情严重程度的一个标志。

关键词：阿尔茨海默病 mR 认知障碍脑血流量自旋标记病人连续性动脉

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基于皮质萎缩自动识别对阿尔茨海默病和行为异常型额颞叶痴呆的个体化诊断

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国际医学放射学杂志 2016年第4期 440-441页

作者： C.mller Y.A.L.Pijnenburg w.m.van der flier A.Versteeg B.Tijms J.C.de munck 王玉亮 Alzheimer Center and Department of Neurology Neuro-science Campus Amsterdam VU University Medical Center

摘要目的探讨用一种基于图像的分类器来个体化区分阿尔茨海默病(AD)和行为异常型额颞叶痴呆(bv FTD)的诊断准确性,这种分类器是用多个成像系统获得标准的T1加权结构图来计算灰质(Gm)密度图并有独立的训练数据和预测数据。材料与方法该... 详细信息

摘要目的探讨用一种基于图像的分类器来个体化区分阿尔茨海默病(AD)和行为异常型额颞叶痴呆(bv FTD)的诊断准确性,这种分类器是用多个成像系统获得标准的T1加权结构图来计算灰质(Gm)密度图并有独立的训练数据和预测数据。材料与方法该研究经当地机构伦理委员会批准。

关键词：额颞叶痴呆阿尔茨海默病行为异常行为问题个体化

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Drug repurposing screen identifies vidofludimus calcium and pyrazofurin as novel chemical entities for the development of hepatitis E interventions

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Virologica Sinica 2024年第1期39卷 123-133页

作者： Hongbo Guo Dan Liu Kuan Liu Yao Hou Chunyang Li Qiudi Li Xiaohui Ding monique m.A.Verstegen Jikai Zhang Lingli wang Yibo Ding Renxian Tang Xiucheng Pan Kuiyang Zheng Luc J.wvan der Laan Qiuwei Pan wenshi wang Department of Pathogen Biology and Immunology Jiangsu Key Laboratory of Immunity and MetabolismJiangsu International Laboratory of Immunity and MetabolismXuzhou Medical UniversityXuzhou221004China Department of Gastroenterology and Hepatology Erasmus MC-University Medical CenterRotterdamNL-3015 CNthe Netherlands Department of Surgery Erasmus MC Transplant InstituteUniversity Medical CenterRotterdam3015CENL-3015 CNthe Netherlands Department of Infectious Diseases The Affiliated Hospital of Xuzhou Medical UniversityXuzhou221002China

Hepatitis E virus(HEV)infection can cause severe complications and high mortality,particularly in pregnant women,organ transplant recipients,individuals with pre-existing liver disease and immunosuppressed ***,there are still unmet needs for treating chronic HEV ***,we screened a best-in-class drug repurposing library consisting of 262 drugs/*** screening,we identified vidofludimus calcium and pyrazofurin as novel anti-HEV *** calcium is the next-generation dihydroorotate dehydrogenase(DHODH)inhibitor in the phase 3 pipeline to treat autoimmune diseases or SARS-CoV-2 *** selectively targets uridine monophosphate synthetase(UmPS).Their anti-HEV effects were further investigated in a range of cell culture models and human liver organoids models with wild type HEV strains and ribavirin treatment failure-associated HEV ***,both drugs exhibited a sizeable therapeutic window against *** instance,the IC50 value of vidofludimus calcium is 4.6–7.6-fold lower than the current therapeutic doses in ***,their anti-HEV mode of action depends on the blockage of pyrimidine ***,two drugs robustly inhibited ribavirin treatment failure-associated HEV mutants(Y1320H,G1634R).Their combination with IFN-αresulted in synergistic antiviral *** conclusion,we identified vidofludimus calcium and pyrazofurin as potent candidates for the treatment of HEV *** on their antiviral potency,and also the favorable safety profile identified in clinical studies,our study supports the initiation of clinical studies to repurpose these drugs for treating chronic hepatitis E.

关键词： Hepatitis Evirus(HEV) Drug repurposing Vidofludimus calcium Pyrazofurin Pyrimidine biosynthesis

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mRI等级评定表对后部皮质萎缩的视觉评估

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国际医学放射学杂志 2012年第1期 101-101页

作者： E.L.Koedam m.Lehmann w.m.van der flier P.Scheltens Y.A.Pijnenburg N.Fox 管宇 Department of Neurology and Alzheimer Centre VU University Medical CentrePO Box 70571007MBAmsterdamThe Netherlands

目的制定评估后部皮质萎缩(PA)的视觉等级评定表,并分析此评价表能否鉴别阿尔茨海默病(AD)和其他痴呆。材料与方法由不同评价者对118例临床记忆障碍病人的mR影像进行分析,PA(范围0～3)、内侧颞叶萎缩

关键词：阿尔茨海默病痴呆 mRI 后部萎缩

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后皮质萎缩视觉等级评分的量化验证

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国际医学放射学杂志 2014年第2期 198-198页

作者： C.mller w.m.van der flier A.Versteeg m.R.Benedictus m.P.wattjes E,L.G.m.Koedam 张倩 Department of Neurology VU University Medical Center Neuroscience Campus AmsterdamP.OBox 7057 1007 MB Amsterdam The Netherlands

目的通过mRI灰质(Gm)体积定量和基于体素的形态学测量(VBm)来验证四分视觉等级评分评估后皮质萎缩(PCA)的临床实用性。方法229例可疑阿尔茨海默病的病

关键词：视觉等级评分 mRI 后皮质萎缩验证基于体素形态学测量

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