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Novel high- with low specific on-resistance high voltage lateral double-diffused mOSFET

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Chinese Physics B 2017年第2期26卷 382-386页

作者： Li-Juan wu Zhong-Jie Zhang Yue Song Hang Yang Li-min Hu Na Yuan School of Physics ＆ Electronic Science Changsha University of Science ＆ Technology Changsha 410114 China

A novel voltage-withstand substrate with high-K（HK, k 〉 3.9, k is the relative permittivity） dielectric and low specific on-resistance（Ron,sp） bulk-silicon, high-voltage LDmOS（HKLR LDmOS）is proposed in this paper. The high-K dielectric and highly doped interface N＋-layer are made in bulk silicon to reduce the surface field drift region. The high-K dielectric can fully assist in depleting the drift region to increase the drift doping concentration（Nd） and reshape the electric field distribution. The highly doped N＋-layer under the high-K dielectric acts as a low resistance path to reduce the Ron,sp. The new device with the high breakdown voltage（BV）, the low Ron,sp, and the excellent figure of merit（FOm = BV^2/Ron,sp） is obtained. The BV of HKLR LDmOS is 534 V, Ron,sp is 70.6 m？·cm^2, and FOm is 4.039 mw·cm^（-2）.

关键词： LDmOS high-K dielectric highly doped N+-layer high voltage specific on-resistance

Structure and Expression of Several Putative Cdc42-Interacting Proteins in magnaporthe grisea

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Agricultural Sciences in China 2006年第10期5卷 780-786页

作者： ZHENG wu CHEN Ji-sheng ZHENG Shi-qin LU Guo-dong wANG Zong-hua Key Laboratory of Bio-pesticide and Chemistry Biology Ministry of Education/Functional Genomics Center Fujian Agriculture and Forestry University Fuzhou 350002 P.R.China

mgCdc42 （Cdc42 in magnaporthe grisea）, with high homology to ScCdc42 （Cdc42 in Saccharomyces cerevisiae）, has been demonstrated to involve in the morphogenesis and infection process. To further understand the signaling network, the putative mgCdc42-interacting proteins were analyzed. ScCdc42-interacting protein sequences were first used to BLAST against the m. grisea genome database to retrieve their corresponding analogs. Subsequently, conserved domains of these proteins were compared and expression patterns of their encoding genes in different mgCdc42 mutation states were analyzed by semiquantitative RT-PCR. All retrieved analogs of ScCdc42-interacting proteins from the m. grisea database have conserved domains as those in S. cerevisiae. Expression of their encoding genes increased in mgCdc42CA mutant and decreased in mgCdc42KO mutant. However, mgBeml, Chin1, and mgGicl in mgCdc42DN mutant had the same expression level as that in the wild type, although mgBem4, mgBoi2, mgCdc24, mgGic2, mgRgal, and mst20 had decreased expression level, as expected. Overall, it is concluded that there may exist a similar Cdc42 signal pathway in m. grisea as in S. cerevisiae and mgCdc42 plays a key role in the pathway.

关键词： Cdc42 magnaporthe grisea guanine nucleotide exchange factor GTPase-activating protein

Intensive blood pressure control on arterial stiffness among older patients with hypertension

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Chinese medical Journal 2024年第9期137卷 1078-1087页

作者： Shuyuan Zhang Yixuan Zhong Shouling wu Hailei wu Jun Cai weili Zhang On behalf of the STEP Study Group National Clinical Research Center of Cardiovascular Diseases Fuwai HospitalNational Center for Cardiovascular DiseasesPeking Union Medical College&Chinese Academy of Medical SciencesBeijing 100037China Department of Cardiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesPeking Union Medical College&Chinese Academy of Medical SciencesBeijing 100037China Department of Cardiology Kailuan General HospitalTangshanHebei 063000China Central China Subcenter of National Center for Cardiovascular Diseases Henan Cardiovascular Disease CenterFuwai Central-China Cardiovascular HospitalCentral China Fuwai Hospital of Zhengzhou UniversityZhengzhouHenan 450046China 不详

Background:Arterial stiffening increases with age and blood pressure and is associated with cardiovascular disease(CVD),but the relationship between blood pressure lowering and arterial stiffening is still uncertain,especially in older *** study aimed to evaluate the effect of intensive blood pressure treatment on the progression of arterial stiffness and risk of CVD in older patients with ***:The Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients(STEP)trial was a multicenter,randomized,controlled trial performed at 42 clinical centers throughout China,and 8511 patients aged 60-80 years with essential hypertension were enrolled and randomly assigned to systolic blood pressure(SBP)target of 110 mmHg tommHg(intensive treatment)or 130 mmHg tommHg(standard treatment).Patients underwent repeated examinations of the brachial-ankle pulse wave velocity(baPwV)and ankle-brachial index(ABI)at baseline,and the arterial stiffness was evaluated at the 3-year follow-up.A total of 5339 patients who had twice repeated measurements were included in this *** in arterial stiffness between the intensive and standard treatment groups were analyzed using a multivariate linear regression *** Cox proportional hazard regression model was used to evaluate the effect of intensive treatment on primary CVD ***:The changes in baPwV were 61.5 cm/s(95%confidence interval[CI]:49.8-73.2 cm/s)in the intensive treatment group and 98.4 cm/s(95%CI:86.7-110.1 cm/s)in the standard treatment group(Pment significantly delayed the progression of arterial stiffness,with an annual change of 23.1 cm·s^(-1)·year-1 vs.36.7 cm·s^(-1)·year^(-1)of baPwV in the intensive and standard treatment groups,*** a median follow-up period of 3.36 years,primary CVD outcomes occurred in 77(2.9%)patients in the intensive treatment group compared with 93(3.5%)in the standard treatment *** tre

关键词： Hypertension Arterial stiffness Cardiovascular disease Older people Blood pressure Pulse wave velocity

A&zeta;x- and Open CD*-Filters Process of Compactifications and Any Hausdorff Compactification

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Advances in Pure mathematics 2012年第4期2卷 296-300页

作者： Hueytzen J. wu wan-Hong wu Department of mathematics Texas A & M University—Kingsville Kingsville USA University of Texas at San Antonio One UTSA Circle San Antonio USA

By means of a characterization of compact spaces in terms of open CD*-filters induced by a , a - and open CD*-filters process of compactifications of an arbitrary topological space Y is obtained in Sec. 3 by embedding Y as a dense subspace of , YS = {ε |ε is an open CD*-filter that does not converge in Y}, YT = {A|A is a basic open CD*-filter that does not converge in Y}, is the topology induced by the base B = {U*|U is open in Y, U ≠φ} and U* = {F∈Ysw (or YTw)|U∈F}. Furthermore, an arbitrary Hausdorff compactification (Z, h) of a Tychonoff space X?can be obtained from a by the?similar process in Sec.3.

关键词： Net Open Filter Open CD*-Filter Base Basic Open CD*-Filter Open CD*-Filter -Filter x-Filter Tychonoff Space Normal T1-Space Compact Space Compactifications Stone-Cech Compactification wallman Compactification

Clinical and molecular heterogeneity associated with tumor sidedness in colorectal liver metastasis: a multicenter propensity cohort study

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Hepatobiliary Surgery and Nutrition 2024年第2期13卷 214-228,I0004-I0008页

作者： Yibin wu Jiamin Zhou Huipeng wang Guojiu Fang weiping Zhu Sanjun Cai Lu wang Department of Hepatic Surgery Fudan University Shanghai Cancer CenterShanghai Medical CollegeFudan UniversityShanghaiChina Department of Oncology Shanghai Medical College of Fudan UniversityFudan UniversityShanghaiChina Department of General Surgery Fifth People’s Hospital of Shanghai Fudan UniversityShanghaiChina Department of General Surgery Shanghai Fengxian Central HospitalShanghaiChina Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai Medical CollegeFudan UniversityShanghaiChina

Background:Colorectal liver metastasis(CRLm)exhibits highly heterogeneity,with clinically and molecularly defined subgroups that differ in their *** aim of this study is to explore whether left-sided tumors is clinically and gnomically distinct from right-sided tumors in ***:This retrospective study included 1,307 patients who underwent primary tumor and metastases resection at three academic centers in China from January 1,2012,to December 31,*** score matching with 1:1 ratio matching was *** prognostic impact of tumor sidedness was determined after stratifying by the KRAS mutational ***,whole-exome sequencing(wES)of 200 liver tumor tissues were performed to describe the heterogeneity across the analysis of somatic and germline ***:The median follow-up was 68 *** yielded 481 pairs of *** to right-sided CRLm,left-sided patients experienced with better 5-year overall survival(OS)in surgery responsiveness,with a 14.6 lower risk of death[hazard ratio(HR),1.36,95%confidence interval(CI),1.10-1.69,P=0.004].Interaction between tumor sidedness and KRAS status was statistically significant:left-sidedness was associated with better prognosis among KRAS wild-type patients(HR 1.71;95%CI:1.20-2.45;P=0.003),but not among KRAS mutated-type *** molecular analyses showed that right-sided tumors more frequently harbored TP53,APC,KRAS,and BRAF alterations,and identified a critical role of KRAS mutation in correlation with their survival *** pathogenic germline variants were identified in the right-sided tumors compared with left-sided tumors(29.3%vs.15.5%,P=0.03).Conclusions:we demonstrated that the prognostic impacts of tumor sidedness in CRLm is restricted patients with KRAS wild-type *** sidedness displays considerable clinical and molecular heterogeneity that may associate with their therapy benefits and prognosis.

关键词： Colorectal liver metastasis(CRLm) tumor sidedness KRAS mutational status somatic mutation germline mutation germline mutation

model Predictive Current Control with Adaptive-adjusting Timescales for PmSms

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CES Transactions on Electrical machines and Systems 2021年第2期5卷 108-117页

作者： Feng Niu Xi Chen Shaopo Huang Xiaoyan Huang Lijian wu Kui Li Youtong Fang School of Electrical Engineering Hebei University of Technology College of Electrical Engineering Zhejiang University

A model predictive current control(mPCC)with adaptive-adjusting method of timescales for permanent magnet synchronous motors(PmSms)is proposed in this paper to improve the dynamic response and prediction accuracy in transient-state,while lessening the computational burden and improving the control performance in *** timescale characteristics of different parts of mPCC,such as signal sampling,prediction calculation,control output,model error correction,are analyzed,and the algorithm architecture of mPCC with multi-timescale is *** difference between reference and actual speed,and the change rate of actual speed are utilized to discriminate the transient state of speed change and load change,***-adjusting method of control period and prediction stepsize are illustrated in detail after operation condition *** results of a PmSm are presented to validate the effectiveness of proposed *** addition,comparative evaluation of single-step mPCC with fixed timescale and proposed mPCC is conducted,which demonstrates the superiority of proposed control strategy.

关键词： model predictive current control(mPCC) permanent magnet synchronous motor(PmSm) multi-timescale adaptive-adjusting method

ZBP1 mediates interferon-induced necroptosis

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Cellular & molecular Immunology 2020年第4期17卷 356-368页

作者： Daowei Yang Yaoji Liang Shubo Zhao Yan Ding Qiuyu Zhuang Qilin Shi Tingting Ai Su-Qin wu Jiahuai Han State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen 361005 FujianChina Department of Cancer Prevention Diagnosis and Treatment Cancer HospitalThe First Affiliated Hospital of Xiamen UniversityTeaching Hospital of Fujian Medical UniversityXiamenChina School of Pharmaceutical Sciences Xiamen UniversityXiamen 361102 FujianChina XmU School of Pharmaceutical Sciences-Amogene Joint R&D Center for Genetic Diagnostics Amogene BiotechXiamen 361102 FujianChina

Interferons(IFNs)play an important role in immunomodulatory and antiviral ***-induced necroptosis has been reported in cells deficient in receptor-interacting protein kinase 1(RIPK1),Fas-associated protein with death domain(FADD),or caspase-8,but the mechanism is largely ***,we report that the DNA-dependent activator of IFN regulatory factors(ZBP1,also known as DAI)is required for both type Ⅰ(β)and type Ⅱ(γ)IFN-induced *** show that L929 fibroblast cells became susceptible to IFN-induced necroptosis when RIPK1,FADD,or Caspase-8 was genetically deleted,confirming the antinecroptotic role of these proteins in IFN *** found that the pronecroptotic signal from IFN stimulation depends on new protein synthesis and identified ZBP1,an IFN-stimulated gene(ISG)product,as the de novo synthesized protein that triggers necroptosis in IFN-stimulated *** N-terminal domain(ND)of ZBP1 is important for ZBP1–ZBP1 homointeraction,and its RHIm domain in the C-terminal region interacts with RIPK3 to initiate RIPK3-dependent *** antinecroptotic function of RIPK1,FADD,and caspase-8 in IFN-treated cells is most likely executed by caspase-8-mediated cleavage of RIPK3,since the inhibitory effect on necroptosis was eliminated when the caspase-8 cleavage site in RIPK3 was ***1-mediated necroptosis in IFN-treated cells is likely physiologically relevant,as ZBP1 KO mice were significantly protected against acute systemic inflammatory response syndrome(SIRS)induced by TNF+IFN-γ.

关键词： ZBP1 interferon necroptosis

microbial aerosol characteristics in highly polluted and nearpristine environments featuring different climatic conditions

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Science Bulletin 2015年第16期60卷 1439-1447页

作者： Kai wei Yunhao Zheng Jing Li Fangxia Shen Zhuanglei Zou Hanqing Fan Xinyue Li Chang-yu wu maosheng Yao State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering Peking University max-Plank Institute for Chemistry School of water Resources and Environment China University of Geosciences Department of Environmental Engineering Sciences Engineering School of Sustainable Infrastructure and Environment University of Florida

There is an increasing interest in understanding ambient bioaerosols due to their roles both in health and in climate. Here, we deployed an Ultraviolet Aerodynamic Particle Sizer to monitor viable （fluorescent） bioaerosol concentration levels at city centers （highly polluted） and their corresponding suburbs （near pristine）（total 40 locations） in 11 provinces featuring different climate zones in China between July 16 and 28, 2013. The concentration levels of viable bioaerosol particles （BioPm） of 〉0.5 μm were measured, and corresponding percentages of BioPm% （biological fraction of total Pm） and BioPm2.5% （biological fraction of Pm2.5） in particulate matter （Pm） and BioPm, respectively, were determined. For some key cities, indoor viable bioaerosol levels were also obtained. In addition, bacterial structures of the air samples collected across these monitoring locations were studied using pyrosequencing. BioPm concentration levels ranged from 2.1 ×10^4 to 2.4 × 10^5/m3 for city centers [BioPm% = 6.4 % （4-6.3 %）] and 0.5 × 10^4 to 4.7 × 10^5/m3 for suburbs [BioPm% = 10 % （4-8.7 %）]. Distinctive bioaerosol size distribution patterns were observed for different climate zones, e.g., some had fluorescence peaks at 3 μm, while the majority had peaks at 1 μm. Ambient bacterial aerosol community structures were also found different for different geophysical locations. Results suggest that there was a poor overall relationship between Pm and BioPm across 40 monitoring locations （R2= 0.081, two-tailed P value = 0.07435）. Generally, city centers had higher Pm concentrations than suburbs, but not BioPm and BioPm%. Indoor bioaerosol levels were found at least tenfold higher than those corresponding outdoors. Bacillus was observed to dominate the bacterial aerosol community in the air sample.

关键词： Viable bioaerosol Bacteria Airpollution - Climate China

Non-layered InSe nanocrystalline bulk materials with ultra-low thermal conductivity

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Journal of materiomics 2024年第2期10卷 448-455页

作者： Yifei Liu Tian-Ran wei Jiangtao wu Hexige wuliji Haoran Huang Zhengyang Zhou Kunpeng Zhao Jie ma Xun Shi State Key Laboratory of metal matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Artificial Structures and Quantum Control School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of High Performance Ceramics and Superfine microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China

Exploring new prototypes for a given chemical composition is of great importance and interest to several *** a famous semiconducting binary compound,InSe usually exhibits a two-dimensional layered structure with decent physical and mechanical ***,it is less noticed that InSe can also adopt a monoclinic structure,denoted as *** synthesis of such a phase usually re-quires high-pressure conditions,and the knowledge is quite scarce on its chemical bonding,lattice dynamics,and thermal *** in this work,by developing a facile method combining me-chanical alloying and spark plasma sintering,we successfully synthesize mcl-InSe bulks with well-crystallized *** chemical bonding of mcl-InSe is understood as compared with layered InSe via charge *** cut-off frequencies of acoustic phonons and several low-lying optical modes are ***,mcl-InSe exhibits a low room-temperature thermal conductivity of 0.6 w·m^(-1)·K^(-1),which is smaller than that of other materials in the IneSe system and many other ***-temperature thermal analyses corroborate the role of nanograin boundaries and low-frequency optical phonons in scattering acoustic *** work provides new insights into the non-common prototype of the InSe binary compound with potential applications in thermoelectrics or thermal insulation.

关键词： monoclinic InSe Chemical bond Nano grains Thermal transport