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Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying wang Xiang Zhang Henrik Biverstål Nicolas GBazan Shuai Tan Nailin li Makiko Ohshima Marianne Schultzberg Xiaofei li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. with this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. we pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

EFFECT OF MnO_(2) ADDITIVE ON PERFORMANCES OF NiFe_(2)O_(4) SPINEl BASED INERT ANODE

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Acta Metallurgica Sinica(English letters) 2005年第5期18卷 603-608页

作者： w.l. Jiao l. Zhang G. C. Yao School of Material Science and Engineering Shandong University of TechnologyZibo 255049 China School of Material and Metallurgy Northeastern University Shenyang 110004 China

The NiFe2O4 inert anode is synthesized by high-temperature solid-state reaction method using NiO and Fe2O3 as main raw materials and adding MnO2 powder as additive. Archimedes method using water immersion technique is used to measure the sintering performances of sampies. The static thermal corrosion rates of samples are measured by weight loss. SEM is employed for the observation of material microstructure, and phase structure of the sample surface after corrosion is determined by XRD. The experimental results indicate that a suitable MnO2 additive content is 2%, while the sintering performance is the best, and the static thermal corrosion rate is the lowest. Because of MnO2 dopant enriching at crystal boundary, the corrosion reaction of molten salt to crystal grain creates Mn2AlO4 phase, which is denser than NiFe2O4 phase, and prevents the cryolite molten salt to penetrate into the inert anode, thus reducing the corrosion.

关键词： nickel ferrite spinel inert anode corrosion resistance,aluminum electrolysis

Critics, coteries, and Pre-Raphaelite celebrity

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Understanding the management of brachial plexus birth palsy and the roles of nerve transfers

作者： wendy Graham.

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Plastic and Aesthetic Research 2023年第1期10卷 451-462页

作者： wendy Chen Ryan Keyho Idris Gharboui Department of Plastic and Reconstructive Surgery UT Houston McGovern Medical SchoolHoustonTX 77030USA

Early recognition and management of neonatal brachial plexus injury(NBPP)is key to optimizing outcomes and surgical *** up to a third of patients with birth palsy may require surgical intervention,the multidisciplinary team must follow up on the function and recovery of the entire upper extremity,from shoulder to fingertips,within the first few months of *** include neuroma resection and primary nerve grafting and/or nerve transfers,which can be intra-or extra-plexal,as adjunctive or standalone *** limited proximal nerve roots are available for nerve grafting,or when too many nerve roots are involved,exceeding the supply of nerve graft,extra-plexal nerve transfers are then *** early intervention is preferred(between 3 and 6 months for most authors),older children presenting late(>1 year since birth)with partial nerve recovery may still potentially benefit from nerve transfers,which can be offered to late-presenting *** we discuss the anatomy,indications,work-up,options,complications,and outcomes for such nerve transfers for upper,lower,and global plexus palsy in *** transfers are a common procedure done for the treatment of various types of birth plexus ***,while there is an abundance of clinical reports and evidence,there is still a lack of clarity regarding best practices or in terms of the type of procedure and technique for the treatment of birth plexus *** hope is that this chapter provides a concise source after an extensive cumulative review of the evidence of best practices for nerve transfers in the case of birth plexus palsy.

关键词： Neonatal birth plexus palsy brachial plexus nerve transfer birth palsy

Hydrogeochemical modelling of corrosive environment contributing to premature failure of anchor bolts in underground coal mines

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Journal of Central South University 2020年第5期27卷 1599-1610页

作者： PENG Ya wendy TIMMS School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China School of Minerals and Energy Resources Engineering UNSW SydneySydney 2052Australia Faculty of Science Engineering&Built Environment Deakin UniversityGeelong 3216Australia

Anchor bolts are commonly used throughout underground mining and tunnelling operations to improve roof ***,premature failures of anchor bolts are significant safety risks in underground excavations around the world due to susceptible bolt materials,a moist and corrosive environment and tensile *** this paper,laboratory experiments and hydrogeochemical models were combined to investigate anchor bolt corrosion and failure associated with aqueous environments in underground coal *** data and collated mine water chemistry data were used to simulate bolt corrosion reactions with groundwater and rock materials with the PHREEQC code.A series of models quantified reactions involving iron and carbon under aerobic and anaerobic conditions in comparison with ion,pH and pE trends in experimental *** models showed that corrosion processes are inhibited by some natural environmental factors,because dissolved oxygen would cause more iron from the bolts to oxidize into *** interdisciplinary insights into corrosion failure of underground anchor bolts confirm that environmental factors are important contributors to stress corrosion cracking.

关键词： anchor bolts hydrogeochemical modelling rock bolts and cable bolts stress corrosion cracking water chemistry analysis

Enhanced Heat Transfer with Full Circumferential Ribs in Helical Pipe

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Journal of Thermal Science 2002年第3期11卷 241-248页

作者： S.w.Chang l.M.Su T.l.Yang Department of Marine Engineering National Kaohsiung Institute of Marine Technology Kaohsiung Taiwan China Associate Professor Department of Electrical Engineering Tong Fang College of Technology and Commerce Taiwan China Associate Professor and Head of Department Department of Electrical Engineering Fortune Institute of Technology Taiwan China

This paper describes an experimental study of heat transfers in the smooth-walled and rib-roughened helical pipes with reference to the design of enhanced cooling passages in the cylinder head and liner of a marine propulsive diesel engine. The manner in which the repeated ribs modify the forced heat convection in the helical pipe is considered for the case where the flow is turbulent upon entering the coil but laminar in further downstream. A selection of experimental results illustrates the individual and interactive effects of Dean vortices and rib-flows on heat transfer along the inner and outer helixes of coils. The experimental-based observations reveal that the centrifugal force modifies the heat transfer in a manner to generate circumferential heat transfer variation with better cooling performance on the outer edge relative to its inner counterpart even with the agitated flow field caused by the repeated ribs. Heat transfer augmentation factor in the range of 1.3 ~ 3 times of the smooth-walled

关键词： helical pipe heat transfer enhancement.

The notorious Mrs. Clem

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Shear-accelerated crystallization of glass-forming metallic liquids in high-pressure die casting

作者： (1958-)Gamber wendy

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Journal of Materials Science & Technology 2022年第22期117卷 146-157页

作者： l.H.liu w.J.Gao X.S.Huang T.Zhang Z.Y.liu C.Yang w.w.Zhang w.R.li l.li P.J.li National Engineering Research Center of Near-net-shape Forming for Metallic Materials South China University of TechnologyGuangzhou510640China Department of Mechanical Engineering Tsinghua UniversityBeijing100084China Institute of Eontech New Materials Co. Ltd.Dongguan523662China Guangdong Provincial Key laboratory of Micro/Nano Optomechatronics Engineering College of Mechatronics and Control EngineeringShenzhen UniversityShenzhen518060China

As one of the most important forming technologies for industrial bulk metallic glass (BMG) parts withcomplex shapes, high-pressure die casting (HPDC) can fill a die cavity with a glass-forming metallic liquidin milliseconds. However, to our knowledge, the correlation between flow and crystallization behavior inthe HPDC process has never been established. In this study, we report on the solidification behavior ofZr_(55)Cu_(30)Ni_(5)Al_(10) glass forming liquid under various flow rates. Surprisingly, the resulting alloys display adecreasing content of amorphous phase with increase of flow rate, i.e. increase of cooling rate, suggestingthat crystallization kinetics of glass-forming metallic liquids in the HPDC process is strongly dependenton the flow field. Analysis reveals that the accelerated crystallization behavior is mainly ascribed to therapid increase in viscosity with a decreasing temperature as well as to the huge shear effect in the glassforming liquid at the end stage of the filling process when the temperature is close to the glass-transitionpoint;this results in a transition from diffusion- to advection-dominated transport. The current investigation suggests that flow-related crystallization must be considered to assess the intrinsic glass-formingability of BMGs produced via HPDC. The obtained results will not only improve the understanding ofcrystallization dynamics but also promote the high-quality production and large-scale application of BMGparts.

关键词： Crystallization Shear Supercooled liquid High pressure die casting

Equine-assisted interventions for veterans with servicerelated health conditions: a systematic mapping review

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Military Medical Research 2020年第2期7卷 174-189页

作者： Adam R.Kinney Aaron M.Eakman Rebecca lassell wendy woo Department of Occupational Therapy Colorado State UniversityFort CollinsCO 80523USA Temple Grandin Equine Center Department of Animal SciencesColorado State UniversityFort CollinsCO 80523USA

Background:Evidence-based treatments for service-related health conditions such as posttraumatic stress disorder(PTSD),depression,and traumatic brain injury(TBI)are not effective for all ***-assisted interventions are emerging as an additional treatment modality,but little is known regarding the safe and effective delivery of these *** study aimed to describe the following features of the body of literature concerning equineassisted interventions among veterans:1)veterans who have participated in equine-assisted interventions;2)specific characteristics of equine-assisted interventions in veterans;and 3)the specific characteristics of research on equineassisted interventions in ***:we conducted a systematic mapping review of peer-reviewed literature reporting on equine-assisted interventions among veterans between 1980 and *** of nine databases yielded 3336 unique records,six of which met the inclusion criteria and were *** relevant to the study aims were extracted and ***:Equine-assisted interventions among veterans disproportionately targeted psychosocial outcomes and yielded promising *** detailed methods of EAI varied in the reported studies,ranging from communicating with the horse to mounted *** was also great diversity in outcome *** state of theoretical development regarding the mechanisms by which equine-assisted interventions benefit the veteran population is currently *** provided insufficient detail with respect to the description of the intervention,reasons for attrition,and the dose-response ***:Scientific development of equine-assisted interventions targeting psychosocial outcomes among veterans is warranted to establish their *** outcomes should be expanded,including outcomes more closely aligned with the nature of polytraumatic *** research must also emphasize the theoretical develo

关键词： Veterans Service-related injuries Equine-assisted interventions Posttraumatic stress disorder Systematic mapping review