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Effects of alkaline-electrolyzed and hydrogen-rich water,in a high-fat-diet nonalcoholic fatty liver disease mouse model

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world Journal of Gastroenterology 2018年第45期24卷 5095-5108页

作者： Karen Jackson Noa Dressler Rotem S Ben-Shushan Ari Meerson Tyler w LeBaron Snait Tamir Laboratory of Human Health and Nutrition Sciences MIGAL-Galilee Research InstituteKyriat Shmona 11016Israel Tel Hai College Upper Galilee 12110Israel Center of Experimental Medicine Institute for Heart ResearchSlovak Academy of SciencesBratislava 84005Slovakia Molecular Hydrogen Institute UT 48101United States

AIM To identify the effect of hydrogen-rich water(HRw) and electrolyzed-alkaline water(EAw) on high-fat-induced non-alcoholic fatty acid disease in *** Mice were divided into four groups:(1) Regular diet(RD)/regular water(Rw);(2) high-fat diet(HFD)/Rw;(3) RD/EAw; and(4) HFD/EAw. weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers were processed for histology and reverse-transcriptase polymerase chain reaction. A similar experiment was performed using HRw to determine the influence and importance of molecular hydrogen(H2) in EAw. Finally, we compared the response of hepatocytes isolated from mice drinking HRw or Rw to palmitate *** EAw had several properties important to the study:(1) pH = 11;(2) oxidation-reduction potential of-495 mV; and(3) H2 = 0.2 mg/L. However, in contrast to other studies, there were no differences between the groups drinking EAw or Rw in either the RD or HFD groups. we hypothesized that the null result was due to low H2 concentrations. Therefore, we evaluated the effects of Rw and low and high HRw concentrations(L-HRw = 0.3 mg H2/L and H-HRw = 0.8 mg H2/L, respectively) in mice fed an HFD. Compared to Rw and L-HRw, H-HRw resulted in a lower increase in fat mass(46% vs 61%), an increase in lean body mass(42% vs 28%), and a decrease in hepatic lipid accumulation(P w to palmitate overload demonstrated a protective effect from H2 by reducing hepatocyte lipid accumulation in comparison to mice drinking regular *** H2 is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice.

关键词： Hydrogen-rich-water Nonalcoholic fatty liver disease Alkaline water Metabolic syndrome Molecular hydrogen High-fat diet

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Element selection for functional materials discovery by integrated machine learning of elemental contributions to properties

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npj Computational Materials 2023年第1期9卷 639-648页

作者： Andrij Vasylenko Dmytro Antypov Vladimir V.Gusev Michael w.Gaultois Matthew S.Dyer Matthew J.Rosseinsky Department of Chemistry University of LiverpoolCrown StreetLiverpool L697ZDUnited Kingdom Department of Computer Science University of LiverpoolAshton StreetLiverpool L693BXUnited Kingdom

The unique nature of constituent chemical elements gives rise to fundamental differences in *** materials based on their phase fields,defined as sets of constituent elements,before specific differences emerge due to composition and structure can reduce combinatorial complexity and accelerate screening,exploiting the distinction from composition-level *** and evaluation of novelty of materials classes align with the experimental challenge of identifying new areas of *** address this,we present PhaseSelect,an end-to-end machine learning model that combines representation,classification,regression and novelty ranking of phase *** leverages elemental characteristics derived from computational and experimental materials data and employs attention mechanisms to reflect the individual element contributions when evaluating functional performance of phase *** demonstrate this approach for high-temperature superconductivity,high-temperature magnetism,and targeted bandgap energy applications,showcasing its versatility and potential for accelerating materials exploration.

关键词： materials phase elements

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交易成本、治理成本与边界选择:制度变迁中煤电交易的博弈问题

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华东经济管理 2015年第1期29卷 73-80页

作者：谭忠富刘平阔华北电力大学能源环境经济研究所北京102206

文章定义了交易—治理总成本,利用制度变迁演化博弈分析和交易成本离散结构分析,对中国煤电交易的经济行为及边界选择的问题进行研究。研究结果表明:理论层面,煤炭企业和火力发电企业进行策略选择时,交易成本和治理成本是双方做出有效... 详细信息

文章定义了交易—治理总成本,利用制度变迁演化博弈分析和交易成本离散结构分析,对中国煤电交易的经济行为及边界选择的问题进行研究。研究结果表明:理论层面,煤炭企业和火力发电企业进行策略选择时,交易成本和治理成本是双方做出有效选择的基础;技术层面,煤、电企业在选择"购买"或"生产"的问题时,不仅要根据概率和成本等信息做出交易决策,还要根据企业的专用性资产现状,分析长期交易的成本节约问题;现实层面,当煤炭企业和火力发电企业的专用性资产发生变化时,随着制度变迁,策略选择会体现三种趋势,即市场制、混合制和层级制。并据此提出了相关的政策建议。

关键词：演化博弈分析离散结构分析边界选择煤电交易

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Antimicrobial Activity of Ulva reticulata and Its Endophytes

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Journal of Ocean University of China 2016年第2期15卷 363-369页

作者： Dhanya K.I. Swati V.I. Vanka Kanth Swaroop Osborne w.J. School of Biosciences and Technology lilT UniversityVellore-632014lndia

Seaweeds are known to exhibit various antimicrobial properties, since it harbours an enormous range of indigenous bioactive compounds. The emergence of drug resistant strains has directed to the identification of prospective metabolites from seaweed and its endophytes, thereby exploiting the properties in resisting bacterial diseases. The current study was aimed to assess the antimicrobial activity of extracts obtained from Ulva reticulate, for which metabolites of Ulva reticulata and its endophytes were extracted and assessed against human pathogens like Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, and Bacillus subtilis. It was observed that the hexane extract of isolate VITDSJ2 was effective against all the tested pathogens but a significant inhibition was observed for Staphylococcus aureus and Escherichia coli. Further, Gas chromatography coupled with Mass spectroscopy （GC-MS） revealed the existence of phenol, 3, 5-bis （1, 1-dimethylethyl） in the crude hexane extract which is well-known to possess antibacterial activity. The effective isolate VITDSJ2 was identified to be the closest neighbour of Pseudomonas smtzeri by phenotypic and genotypic methods. The crude extracts of the seaweed Ulva reticulata was also screened for antibacterial activity and the hexane extract was effective in showing inhibition against all the tested pathogens. The compound in the crude extract of Ulva reticulata was identified as hentriacontane using GC-MS. The extracts obtained from dichloromethane did not show significant activity in comparison with the hexane extracts. Hence the metabolites of Ulva reticulata and the bacterial secondary metabolites of the endophytes could be used in the treatment of bacterial infections.

关键词： endophytic bacteria anti-microbial macroalgae bioactive compounds GC-MS

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Juvenile polyposis syndrome

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world Journal of Gastroenterology 2011年第44期17卷 4839-4844页

作者： Lodewijk AA Brosens Danielle Langeveld w Arnout van Hattem Francis M Giardiello G Johan A Offerhaus Department of Pathology University Medical Centre Utrecht Department of Pathology Academic Medical Centre Division of Gastroenterology Department of Medicine The Johns Hopkins University School of Medicine

Juvenile polyposis syndrome is a rare autosomal dominant syndrome characterized by multiple distinct juvenile polyps in the gastrointestinal tract and an increased risk of colorectal *** cumulative life-time risk of colorectal cancer is 39% and the relative risk is *** polyps have a distinctive histology characterized by an abundance of edematous lamina propria with inflammatory cells and cystically dilated glands lined by cuboidal to columnar epithelium with reactive ***,juvenile polyposis syndrome is defined by the presence of 5 or more juvenile polyps in the colorectum,juvenile polyps throughout the gastrointestinal tract or any number of juvenile polyps and a positive family history of juvenile *** about 50%-60% of patients diagnosed with juvenile polyposis syndrome a germline mutation in the SMAD4 or BMPR1A gene is *** genes play a role in the BMP/TGF-beta signalling *** has been suggested that cancer in juvenile polyposis may develop through the socalled "landscaper mechanism" where an abnormal stromal environment leads to neoplastic transformation of the adjacent epithelium and in the end invasive *** of this rare disorder is important for patients and their families with regard to treatment,follow-up and screening of at risk *** clinician confronted with the diagnosis of a juvenile polyp should therefore consider the possibility of juvenile polyposis *** addition,juvenile polyposis syndrome provides a unique model to study colorectal cancer pathogenesis in general and gives insight in the molecular genetic basis of *** review discusses clinical manifestations,genetics,pathogenesis and management of juvenile polyposis syndrome.

关键词： Juvenile polyposis syndrome Hamartoma Colorectal cancer SMAD4 BMPR1A

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Controlled release and biocompatibility of polymer/titania nanotube array system on titanium implants

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Bioactive Materials 2017年第1期2卷 44-50页

作者： Tingting wang Zhengyang weng Xiangmei Liu Kelvin w.K.Yeung Haobo Pan Shuilin wu Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional MaterialsHubei Key Laboratory of Polymer MaterialsSchool of Materials Science&EngineeringHubei UniversityWuhanChina Division of Spine Surgery Department of Orthopaedics&TraumatologyLi Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong KongChina Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055China

Bacterial infection and tissue inflammation are the major causes of early failure of titanium-based orthopedic implants;thus,surgical implants with tunable drug releasing properties represent an appealing way to address some of these problems of bacterial infection and tissue inflammation in early age of orthopedic *** this work,a hybrid surface system composed of biodegradable poly(lactic-coglycolic acid)(PLGA)and titania nanotubes(TNTs)has been successfully constructed on Ti implants with the aim of preventing bacterial infection via long-term drug *** varying the size of the TNTs and the thickness of the polymer film,the drug release profile can be tuned to achieve the optimal therapeutic action throughout the treatment *** size of TNTs plays a dominant role in the drug loading dose of TNTs/PLGA hybrid *** this work,TNTs with an average size of 80 nm can achieve the largest loading *** on the polymer thickness,significant improvement in the drug release characteristics is attained,for instance,reduced burst release(from 84%to 27%)and overall release time extended from 5 to over 40 *** addition,the PLGA layers may favor the proliferation and osteogenesis of MC3T3-E1 mouse cells at an earlier ***,this TNT/PLGA hybrid surface system can be employed as an effective bioplatform for improving both self-antibacterial performance and biocompatibility of Ti-based biomaterials.

关键词： Antibacterial Biocompatibility Coating Drug delivery Implants

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Boundary Conditions for Sturm-Liouville Equation with Transition Regions and Barriers or wells

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Advances in Pure Mathematics 2021年第4期11卷 254-295页

作者： Alfred wünsche Institut für Physik Humboldt-Universit&#228 t Nonclassical Radiation Berlin Germany

By means of expansions of rapidly in infinity decreasing functions in delta functions and their derivatives, we derive generalized boundary conditions of the Sturm-Liouville equation for transitions and barriers or wells between two asymptotic potentials for which the solutions are supposed as known. we call such expansions “moment series” because the coefficients are determined by moments of the function. An infinite system of boundary conditions is obtained and it is shown how by truncation it can be reduced to approximations of a different order (explicitly made up to third order). Reflection and refraction problems are considered with such approximations and also discrete bound states possible in nonsymmetric and symmetric potential wells are dealt with. This is applicable for large wavelengths compared with characteristic lengths of potential changes. In Appendices we represent the corresponding foundations of Generalized functions and apply them to barriers and wells and to transition functions. The Sturm-Liouville equation is not only interesting because some important second-order differential equations can be reduced to it but also because it is easier to demonstrates some details of the derivations for this one-dimensional equation than for the full three-dimensional vectorial equations of electrodynamics of media. The article continues a paper that was made long ago.

关键词： Schrödinger Equation Drude Approximation Transition Layer Potential Barrier Potential well Reflection Refraction Moment Series Generalized Functions Delta Function and Its Derivatives Discrete or Bound Eigenstates

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A Two-Parameter Continuation Method for Rotating Two-Component Bose-Einstein Condensates in Optical Lattices

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Communications in Computational Physics 2013年第2期13卷 442-460页

作者： Y.-S.wang B.-w.Jeng C.-S.Chien Department of Applied Mathematics National Chung Hsing UniversityTaichung 402Taiwan Department of Mathematics Education National Taichung University of EducationTaichung 403Taiwan Department of Computer Science and Information Engineering Ching Yun UniversityJungli 320Taiwan

we study efficient spectral-collocation and continuation methods(SCCM)for rotating two-component Bose-Einstein condensates(BECs)and rotating two-component BECs in optical lattices,where the second kind Chebyshev polynomials are used as the basis functions for the trial function space.A novel two-parameter continuation algorithm is proposed for computing the ground state and first excited state solutions of the governing Gross-Pitaevskii equations(GPEs),where the classical tangent vector is split into two constraint conditions for the bordered linear *** results on rotating two-component BECs and rotating two-component BECs in optical lattices are *** results on the former are consistent with the published numerical results.

关键词： Spectral collocation method second kind Chebyshev polynomials periodic potential bifurcation

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The limitations of DNA-based approaches to species delimitation cannot be overcome by expanded sampling

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Zoological Systematics 2022年第2期47卷 165-167页

作者： Tom wells Tom Carruthers Robert w.Scotland Department of Plant Sciences University of OxfordOxfordUK Royal Botanic Gardens KewRichmondUK

Luo and Zhu(2022)write that“DNA-based integrative taxonomy”requires researchers to ensure they have sufficient sampling to justify the delimitation of a *** we agree that sample size is an undeniably important aspect of species delimitation,this is neither unique to DNA-based approaches,nor sufficient on its own to address their *** the authors also note,increasing sample size is not always *** would add that nor is it always necessary–many species are rare or narrow endemics(willis&Undy Yule,1922)and the majority of new species are adequately described from only a few specimens(Goodwin et al.,2020).

关键词： limitations expanded overcome

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客观知识体系中的多级语义传递规律研究——以wordnet为例

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情报学报 2016年第3期35卷 301-309页

作者：裘江南王光源张阔大连理工大学管理科学与工程学院大连116024

客观知识体系是人类共识的序化知识体系,其中存在着大量的语义传递现象,然而其中的多级语义传递规律却一直未引起学者的关注。本文依据知识体系的语义网络的多路径特性,针对多级语义传递现象及其元素进行了定义及分析,同时引入语义域来... 详细信息

客观知识体系是人类共识的序化知识体系,其中存在着大量的语义传递现象,然而其中的多级语义传递规律却一直未引起学者的关注。本文依据知识体系的语义网络的多路径特性,针对多级语义传递现象及其元素进行了定义及分析,同时引入语义域来泛化语义概念,以wordNet为例,对其进行了多级语义传递规律挖掘,发现了其中的语义传递规律。该研究丰富了语义传递规律的研究,为基于OwL2的语义推理提供了理论依据。

关键词：客观知识体系多级语义传递语义传递规律

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