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Large-vessel thrombosis in intestinal Behet's disease complicated with myelodysplastic syndrome and trisomy 8

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world Journal of Gastroenterology 2012年第10期18卷 1137-1140页

作者： Huang-Chi Chen Ying-Ming chiu Division of Critical Care Medicine Department of Internal Medicine Changhua Christian Hospital 500 Changhua Taiwan China Division of Allergy Immunology and Rheumatology Department of Internal Medicine Changhua Christian Hospital 500 Changhua Taiwan China

Behet's disease is characterized by recurrent oral ulcers, genital ulcers, uveitis and skin lesions. Myelodysplastic syndrome (MDS) is characterized by problems due to ineffective hematopoiesis. Several studies have identified a relationship between MDS and Behet's disease, especially intestinal Behet's disease. Trisomy 8 seems to play an important role in these disorders as well. The present case was a 24-year-old woman who had a huge tonsil ulcer with initial symptoms of odynophagia and intermittent fever. we also noted folliculitis on her upper back. Five days later, she began to experience diarrhea and abdominal pain. Abdominal computed tomography and subsequent surgery revealed ileum perforation and enterocolitis with multiple ulcers. Later, she was admitted again for a vulvar suppurative ulcer and suspicious Bartholin's cyst infection. The patient's clinical presentations met the criteria for Behet's disease. Six months after the bowel perforation event, we noted the development of pancytopenia in a routine laboratory examination. All the examinations led to the diagnosis of MDS with trisomy 8. The most unusual finding was that multiple large vessel thrombi developed during follow-up. Previous studies have suggested that trisomy 8 in MDS leads to concurrent intestinal Behet's disease. Moreover, the inflammatory and immune genes related to thrombus formation are overexpressed in cases of MDS with trisomy 8. Trisomy 8 must play a role in thrombosis. Further studies are needed to help clarify the pathophysiology and pathogenesis of these disorders.

关键词： Behcet's disease Myelodysplastic syndrome Trisomy 8 Intestinal ulcers Thrombosis

Monkeypox virus:a re-emergent threat to humans

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Virologica Sinica 2022年第4期37卷 477-482页

作者： Qizan Gong Changle wang Xia Chuai Sandra chiu Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei230026China Department of Pathogenic Biology Hebei Medical UniversityShijiazhuangHebei050017China

Human monkeypox(MPX)is a rare zoonotic infection characterized by smallpox-like signs and *** is caused by monkeypox virus(MPXV),a double stranded DNA virus belonging to the genus *** was first identified in 1970 and mostly prevailed in the rural rainforests of Central and west Africa in the *** Africa,MPX was reported in the United kingdom,the USA,Israel,and *** 2022,the resurgence of MPX in Europe and elsewhere posed a potential threat to *** was transmitted by the animals-human or human-human pathway,and the symptoms of MPXV infection are similar to that of smallpox,but in a milder form and with lower mortality(1%–10%).Although the smallpox vaccination has been shown to provide 85%protection against MPXV infection,and two anti-smallpox virus drugs have been approved to treat MPXV,there are still no specific vaccines and drugs against MPXV *** it is urgent to take active measures including the adoption of novel anti-MPXV strategies to control the spread of MPXV and prevent MPX *** this review,we summarize the biological features,epidemiology,pathogenicity,laboratory diagnosis,and prevention and treatment strategies on *** review provides the basic knowledge for prevention and control of future outbreaks of this emerging infection.

关键词： Monkeypox virus(MPXV) Orthopoxvirus Smallpox vaccine Antiviral drugs

Bioleaching of zinc from gold ores using Acidithiobacillus ferrooxidans

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International Journal of Minerals,Metallurgy and Materials 2009年第4期16卷 368-374页

作者： Pakawadee kaewkannetra Francisco Jose Garcia-Garcia Tze Yen chiu Department of Biotechnology Faculty of TechnologyKhon Kaen University Corrosion and Protection Centre School of MaterialsThe University of Manchester Centre of water Science Cranfield University

The present work investigated microbial leaching of zinc from ore using Acidithiobacillus ferrooxidans （ATCC 14859）. The ore samples, consisted of 13wt% zinc, were obtained from a gold mine in north-eastern Thailand. A shake flask study was performed on the ore samples using a rotary shaker under the following fixed conditions （250 r·min^-1, 30℃ for 16 d）. The influence of various conditions, namely medium type （with and without iron）, particle ore size （〈20, 20-40, 40-60, 60-100, and 〉100 mesh）, ore density （20 kg·m^-3, 50 kg·m^-3, and 100 kg·m^-3）, and pH of the medium （2, 2.5, 2.8, and 3）, were investigated. The microbial leaching was assessed by determining the concentration of zinc in the medium and compared with the initial sample concentration. The results show that Acidithiobacillus ferrooxidans can successfully leach zinc by as much as 6 times compared with the control experiment （without Acidithiobacillus ferrooxidans ferrooxidans）. The maximum efficiency （92.3%） for microbial leaching is obtained in iron-containing medium, 20-40 mesh ore sizes, 20 kg·m^-3 ore density at pH 2.8, and the zinc content is found in the medium at about 120 mg·m^-1.

关键词： bioleaching Acidithiobacillusferrooxidans gold ores gold mine

Lu Xun＇s View of the Awakening of the Chinese People--was There Really an ＂Epistemological Break＂？

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2012年第3期6卷 410-425页

作者： chiu-yee Cheung Division of Chinese School of Humanities and Social Science Nanyang Technological University Singapore 639798 Singapore

It has been argued that, starting in the late 1920s, Lu Xun＇s intellectual development underwent a significant transformation constituting what the French Marxist philosopher Louis Althusser has termed an ＂epistemological break.＂ Some of the explicitly more positive comments about the masses that Lu Xun made in his later years have been used to demonstrate this point. However, the existence of such a ＂break＂ is still debatable, and a detailed examination of Lu Xun＇s apparently optimistic comments reveals that Lu Xun possessed a more sophisticated understanding of the masses and the Chinese people. His understanding was informed by the concept of ＂national character.＂ This paper attempts to demonstrate the consistency of Lu Xun＇s view of the masses and the Chinese people and to resolve an apparent self-contradiction in Lu Xun＇s arguments.

关键词： Lu Xun Chinese "national character" epistemological break

Distribution and contamination status of chromium in surface sediments of northern kaohsiung Harbor, Taiwan

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Journal of Environmental Sciences 2013年第7期25卷 1450-1457页

作者： Cheng-Di Dong chiu-wen Chen Chih-Feng Chen Department of Marine Environmental Engineering "National" Kaohsiung Marine University

Thedistribution, enrichment, accumulation, and potential ecological risk of chromium （Cr） in the surface sediments of northern kaohsiung Harbor, Taiwan, Chinawere investigated. Sediment samples from ten locations located between the river mouths and harbor entrance of northern kaohsiung Harborwere collected quarterly in 2011 and characterized for Cr, aluminum,water content, organic matter, total nitrogen, total phosphorous, total grease, and grain size. Results showed that the Cr concentrations varied from 27.0 to361.9 mg/kgwith an average of （113.5 ± 87.0） mg/kg. High Cr concentrationwas observed near the Jen-Gen River mouth. The mean Cr concentrationwas high at 255.5 mg/kg,whichwas at least 2 to 7 times than that of other sites. This might imply significant Cr contribution from upstream receiving tannerieswastewater into the Jen-Gen River. The spatialdistribution of Cr reveals relatively high in the river mouth region, especially in Jen-Gen River, and graduallydiminishes toward the harbor entrance region. This indicates that the major sources of Cr pollution from upstream industrial and municipalwastewatersdischarged along the river bank; and Cr maydriftwith sea current and bedispersed into open sea. Moreover, Cr concentrations correlated closely to the physical-chemical properties of the sediments,which suggested the influence of industrial and municipalwastewatersdischarged from the neighboring industrial parks and river basins. Results from the enrichment factor andgeo-accumulation index analyses imply that the Jen-Gen River sediments can be characterized as moderate enrichment and none to medium accumulation of Cr, respectively. However, results of potential ecological risk index indicate that the sediment has low ecological potential risk. The results can provide valuable information todeveloping future strategies for the management of river mouth and harbor.

关键词： accumulation chromium ecological risk enrichment sediment

Laparoscopic nephroureterectomy for upper tract urothelial carcinoma-Update

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Asian Journal of Urology 2016年第3期3卷 115-119页

作者： Victor C.Lin Chung-hsien Chen Allen w.chiu Department of Urology E-Da HospitalKaohsiung School of Medicine for International Students I-Shou UniversityKaohsiung Department of Urology School of MedicineNational Yang-Ming UniversityTaipei

Upper urinary tract urothelial carcinomas(UTUCs)are uncommon and account for only 5%e10%of urothelial *** tumors are about twice as common as ureteral *** percent of UTUCs are invasive at *** nephroureterectomy,including the excision of the distal ureter and bladder cuff is standard of care for treatment of localized UTUCs,because of the high potential for recurrence,multifocality,and *** first laparoscopic nephroureterectomy(LNU)was introduced by Clayman et *** 1991 and improvement of laparoscopic technique and equipment,LNU has been reported to be equivalent to conventional open *** reviewed the current literature of patients with UTUCs treated by LNU focusing on technical aspects,peri-operative and oncological *** radical nephroureterectomy offers the advantages of minimally invasive surgery without deteriorating the oncological outcome for treatment of *** tend to increase as operator skills *** for laparoscopic or open nephroureterectomy are in principle the *** basic requirement for laparoscopic surgery in UTUCs is to achieve benefits of minimal invasive surgery and maintain oncologic principles.

关键词： Urothelial carcinoma Upper urinary tract Laparoscopic nephroureterectomy

Two New Compounds from Hemsleya penxianensis var. gulinensis

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Chinese Chemical Letters 2003年第2期14卷 169-172页

作者： Yu Ping LIN Ming Hua chiu 等 StatekeyLaboratoryofPhytochemistryandPlantResourcesinwestChina.kunmingInstituteofBotany TheChineseAcademyofSciencesKunming650204 StatekeyLaboratoryofPhytochemistryandPlantRe

Two new compounds, oleanolic acid 28-O--D-glucopyranosyl-3-O--L-arabinopyrano- syl-(13)-(6-butyl ester)--D-glucuropyranoside 1, oleanolic acid 28-O--D-glucopyranosyl- (16)--D-glucopyranoside 2 have been isolated from the roots of Hemsleya penxianensis var. gulinensis. Their structures were determined on the bases of the spectral and chemical evidences.

关键词： Hemsleya penxianensis var. gulinensis cucurbitaceae oleanolic acid 28-O--D-glucop -yranosyl-3-O--L-arabinopyranosyl-(13)-(6-butyl ester)--D-glucuropyranoside oleanolic acid 28-O--D-glucopyranosyl-(16)--D-glucopyranoside.

3D vena contracta area in degenerative mitral regurgitation:cross-platform comparison in a single patient

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Journal of Geriatric Cardiology 2022年第4期19卷 322-324页

作者： Shing Ching chiu Sun Yue Division of Cardiology Department of Medicine and GeriatricsUnited Christian HospitalHong KongChina

Quantification of degenerative mitral reg-urgitation(MR)by two-dimensional(2D)transthoracic echocardiography(TTE)and transesophageal echocardiography(TEE)is ***,obliquely oriented regurgitant jets limit inter-observer and intra-observer *** recent years,with increasingly sophisticated three-dimensional(3D)TTE and TEE systems that enable single-beat 3D color acquisition,3D vena contracta area(VCA)has emerged as an attractive indicator of MR *** overcomes geometric assumptions in 2D techniques and can be acquired in a single car-diac cycle,which is a major benefit in atrial ***,most studies of 3D VCA were perfo-rmed on the Philips TEE platform.[1-3]The perform-ance of the technique on GE systems and on 3D TTE is *** report 3D VCA measurements in a case of severe degenerative MR on 3D TTE(4V-D transducer,Vivid E95,GE Vingmed Ultrasound,Horten,Norway),and 3D TEE performed on GE(6VT-D transducer,Vivid E95,GE Vingmed Ultraso-und,Horten,Norway)and Philips(X7-2t transdu-cer,EPIC 7C,Philips Medical Systems,Andover,MA,USA).

关键词： degenerative overcome attractive

The potential of plant proteins as antifungal agents for agricultural applications

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Synthetic and Systems Biotechnology 2022年第4期7卷 1075-1083页

作者： Tiffany chiu Theo Poucet Yanran Li Graduate Program in Genetics GenomicsAnd Bioinformatics1140 Batchelor HallUniversity of California RiversideCalifornia92521USA Department of Chemical and Environmental Engineering University of CaliforniaRiversideCA92521USA

Fungal pathogens induce a variety of diseases in both plants and post-harvest food crops,resulting in significant crop losses for the agricultural *** the usage of chemical-based fungicides is the most common way to control these diseases,they damage the environment,have the potential to harm human and animal life,and may lead to resistant fungal ***,there is an urgent need for diverse and effective agricultural fungicides that are environmentally-and *** have evolved various mechanisms in their innate immune system to defend against fungal pathogens,including soluble proteins secreted from plants with antifungal *** proteins can inhibit fungal growth and infection through a variety of mechanisms while exhibiting diverse functionality in addition to antifungal *** this mini review,we summarize and discuss the potential of using plant antifungal proteins for future agricultural applications from the perspective of bioengineering and biotechnology.

关键词： antifungal potential crops