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Chinese journal of Chemistry 2023年第12期41卷 1450-1464页

作者： Bingbing Sheng Ping Lan jolynn Kiong Zeinab G. Khalil Robert j. Capon martin G.Banwell Institute for Advanced and Applied Chemical Synthesis College of Pharmacy Jinan University Guangzhou Guangdong 510632 China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research Jinan University Guangzhou Guangdong 510632 China Institute for Molecular Bioscience The University of Queensland St Lucia QLD 4072 Australia Guangdong Key Laboratory for Research and the Development of Natural Drugs The Marine Biomedical Research Institute Guangdong Medical University Zhanjiang Guangdong 524023 China

The structures assigned to all four members,1-4,of the recently reported favolasin class of natural product have been prepared for the first time by chemical ***-Miyaura cross-coupling chemistry was used to establish the associated biaryl *** key step used in preparing the 1,5-benzodioxepin ring system associated with compounds 3 and 4 was the acid-catalyzed 7-exo-tet cyclization of an appropriately substituted 2-(oxiran-2-ylmethoxy)phenol while a base-promoted 6-exo-tet cyclization of the same substrate was used to construct the 2,3-dihydrobenzo[b][1,4]dioxine core of target *** spectral data derived from the four synthetically-produced favolasins matched those reported for the corresponding natural *** biological screening of compounds 1-3 as well as a suite of fourteen precursors reveal that they display no notable anti-bacterial,anti-fungal or anti-tumor activities but congener K(4)is active,in the mM range,against Plasmodium falciparum.

关键词： Total syntheses Favolasins Suzuki-Miyaura cross-coupling Acetalization Anti-malarial

Adaptive optical microscopy: the ongoing quest for a perfect image

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Light(Science & Applications) 2014年第1期3卷 243-249页

作者： martin j Booth Department of Engineering Science University of OxfordOxford OX13PJUK Centre for Neural Circuits and Behaviour University of OxfordOxford OX13SRUnited Kingdom School in Advanced Optical Technologies Friedrich-Alexander Universita¨t Erlangen-Nu¨rnberg91052 ErlangenGermany

Adaptive optics is becoming a valuable tool for high resolution microscopy,providing correction for aberrations introduced by the refractive index structure of *** is proving particularly promising for applications that require images from deep within biological tissue *** review recent developments in adaptive microscopy,including methods and applications.A range of advances in different microscope modalities is covered and prospects for the future are discussed.

关键词： aberrations adaptive optics microscopy

SIRK1-QSK1 as a novel receptor complex perceiving endogenous PEP7 peptides

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Molecular Plant 2023年第2期16卷 298-300页

作者： jakub Rzemieniewski martin Stegmann hytopathology School of Life SciencesTechnical University of MunichFreisingGermany

Endogenous peptides are important signaling molecules facilitating short-and long-distance signaling in plant growth,development,and immunity(Rzemieniewski and Stegmann,2022).Multiple plant peptides emerged to have dual regulatory functions in both growth and defense and are thus classified as phytocytokines(Rzemieniewski and Stegmann,2022).

关键词： n,2 endogenous immunity

Heart rate response and recovery during exercise predict future delirium risk——A prospective cohort study in middle-to older-aged adults

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journal of Sport and Health Science 2023年第3期12卷 312-323页

作者： Lei Gao Aden Gaba Peng Li Richa Saxena Frank A.j.LScheer Oluwaseun Akeju martin K.Rutter Kun Hu Department of Anesthesia Critical Care and Pain MedicineMassachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Medical Biodynamics Program Brigham and Women's HospitalBostonMA 02115USA Division of Sleep Medicine Harvard Medical SchoolBostonMA 02115USA Broad Institute of Massachusetts Institute of Technology and Harvard CambridgeMA 02142USA Center for Genomic Medicine Massachusetts General HospitalBostonMA 02114USA Division of Diabetes Endocrinology and GastroenterologySchool of Medical SciencesFaculty of BiologyMedicine and HealthManchester Academic Health Science CentreUniversity of ManchesterManchester M139PLUK Diabetes Endocrinology and Metabolism CentreManchester University National Health Service Foundation TrustManchester M139WLUK

Background:Delirium is a neurocognitive disorder characterized by an abrupt decline in attention,awareness,and cognition after surgical/illness-induced stressors on the *** is now an increasing focus on how cardiovascular health interacts with neurocognitive disorders given their overlapping risk factors and links to subsequent dementia and *** common indicator for cardiovascular health is the heart rate response/recovery(HRR)to exercise,but how this relates to future delirium is ***:Electrocardiogram data were examined in 38,740 middle-to older-aged UK Biobank participants(mean age=58.1 years,range:40-72 years;47.3%males)who completed a standardized submaximal exercise stress test(15-s baseline,6-min exercise,and 1-min recovery)and required hospitalization during *** HRR index was derived as the product of the heart rate(HR)responses during exercise(peak/resting HRs)and recovery(peak/recovery HRs)and categorized into low/average/high groups as the bottom quartile/middle 2 quartiles/top quartile,*** between 3 HRR groups and new-onset delirium were investigated using Cox proportional hazards models and a2-year landmark analysis to minimize reverse *** factors,lifestyle factors/physical activity,cardiovascular risk,comorbidities,cognition,and maximal workload achieved were included as ***:During a median follow-up period of 11 years,348 participants(9/1000)newly developed *** with the high HRR group(16/1000),the risk for delirium was almost doubled in those with low HRR(hazard ratio=1.90,95%)confidence interval(95%CI):1.30-2.79,p=0.001)and average HRR(hazard ratio=1.54,95%CI:1.07-2.22,p=0.020)).Low HRR was equivalent to being 6 years older,a current smoker,or>3 additional cardiovascular disease *** were robust in sensitivity analysis,but the risk appeared larger in those with better cognition and when only postoperative delirium was considered(n=1

关键词： Brain health Delirium Exercise stress test UK Biobank

A global synthesis of the effectiveness and ecological impacts of management interventions for Spartina species

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Frontiers of Environmental Science & Engineering 2023年第11期17卷 263-272页

作者： Shengyu wang Philip A.martin Yan Hao william j.Sutherland Gorm E.Shackelford jihua wu Ruiting ju wenneng Zhou Bo Li Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering National Observations and Research Station of Wetland Ecosystems of the Yangtze EstuaryInstitute of Biodiversity Science and Institute of Eco-ChongmingSchool of Life SciencesFudan UniversityShanghai 200438China Biosecurity Research Initiative at St Catharine’s(BioRISC) St Catharine’s CollegeUniversity of CambridgeCambridgeCB21RLUK Conservation Science Group Department of ZoologyUniversity of CambridgeCambridgeCB23QZUK State Key Laboratory of Grassland Agro-Ecosystems and College of Ecology Lanzhou UniversityLanzhou 730000China Guangdong Provincial Key Laboratory of water Quality Improvement and Ecological Restoration for watersheds School of EcologyEnvironment and ResourcesGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory for Transboundary Ecosecurity of Southwest China Yunnan Key Laboratory of Plant Reproductive AdaptationEvolutionary Ecology and Centre for Invasion BiologyInstitute of BiodiversitySchool of Ecology and Environmental ScienceYunnan UniversityKunming 650504China

Invasions by Spartina species pose serious threats to global coastal *** many studies have examined the effectiveness and ecological impacts of invasive Spartina management,no comprehensive global synthesis has been conducted to assess the effects of management on Spartina per se and on wider ***,we conducted a global meta-analysis of 3,459 observations from 102 studies to quantify the effects of different management interventions(physical,chemical,biological,and integrated control)on Spartina per se and native biodiversity and *** found that physical measures quickly suppressed Spartina but that their effectiveness declined over *** contrast,chemical measures decreased the abundance and growth of Spartina to a lesser degree in the early stage,but the effectiveness increased over *** management measures did not significantly decrease the diversity of native biota on the whole,but native-plant diversity significantly decreased with time after physical *** management measures did not affect abiotic factors *** results support the use of chemical measures to control invasive Spartina,although their effectiveness would depend on the time since the management *** the problem of Spartina regrowth following physical control requires improved *** hold that initial states of invaders and subsequent environmental changes after management interventions should be weighed in evaluating control efficacy.

关键词： Plant invasion Biodiversity Meta-analysis Restoration Salt marshes Treatment timing

Kilowatt-class high-energy frequency conversion to 95 j at 10 Hz at 515 nm

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High Power Laser Science and Engineering 2023年第5期11卷 153-156页

作者： martin Divoky jonathan Phillips jan Pilar martin Hanus Petr Navratil Ondrej Denk Tomas Paliesek Patricie Severova Danielle Clarke martin Smrz Thomas Butcher Chris Edwards john Collier Tomas Mocek HiLASE Centre Institute of Physics of the Czech Academy of SciencesDolni BrezanyCzech Republic Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK

we report on frequency doubling of high-energy,high repetition rate ns pulses from a cryogenically gas cooled multi-slab ytterbium-doped yttrium aluminum garnet laser system,Bivoj/DiPOLE,using a type-I phase matched lithium triborate *** achieved conversion to 515 nm with energy of 95 j at repetition rate of 10 Hz and conversion efficiency of 79%.High conversion efficiency was achieved due to successful depolarization compensation of the fundamental input beam.

关键词： diode pumped solid state laser frequency conversion high energy high average power

Precise Orientational Control of Electroactive Units Using a Tripodal Triptycene Scaffold to Direct Noncovalent Pairing at the Single Molecular Level

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Precision Chemistry 2023年第6期1卷 388-394页

作者： Colin j.martin Tomoya Fukui Ryosuke Takehara Shintaro Fujii Takanori Fukushima Laboratory for Chemistry and Life Science Institute of Innovative ResearchTokyo Institute of TechnologyYokohama 226-8503Japan Department of Chemistry School of ScienceTokyo Institute of TechnologyTokyo 152-8551Japan

A break junction technique has been established to explore conductive behavior at the single molecular level,and recent interest has shifted toward the evaluation of bimolecular systems interacting through noncovalent intermolecular *** requires precise control over the orientation of the two molecules so that they can adapt an appropriate face-to-face arrangement between two ***,we present an approach using a tripodal triptycene scaffold that allows for accurate positioning of electroactive subunits with an upright configuration on substrate *** incorporated electron-donating tetrathiafulvalene or electron-accepting anthraquinone into the molecular scaffold and confirmed that the resulting molecules retain the electronic properties particular to their attached ***-assembled monolayers(SAMs)of these molecules were prepared on Au(111)and characterized by XPS and *** break junction techniques were applied to the SAMs,revealing two electrical conduction regimes;one arises from single-molecules sandwiched between two electrodes,and the second from intermolecularly interacting homodimers that bridge between *** observation demonstrates the validity of the approach of using tripodal triptycene scaffolds to precisely direct electroactive subunits to undergo intermolecular *** believe that the present work will provide a new avenue for evaluating the heterodimers at the single molecular level.

关键词： STM break junction self-assembled monolayers supramolecular scaffold noncovalent interactions triptycene

Spontaneous liver rupture following SARS-CoV-2 infection in late pregnancy:A case report

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world journal of Clinical Cases 2022年第15期10卷 5042-5050页

作者： Radek Ambroz martin Stasek ján Molnár Petr Spicka Dusan Klos jozef Hambálek Daniela Skanderová Department of Surgery I University Hospital Olomouc and Faculty of Medicine and DentistryPalacky UniversityOlomouc 77900Czech Republic Department of Obstetrics and Gynecology University Hospital Olomouc and Faculty of Medicine and DentistryPalacky UniversityOlomouc 77900Czech Republic Department of Pathology University Hospital Olomouc and Faculty of Medicine and DentistryPalackýUniversityOlomouc 77900Czech Republic

BACKGROUND Coronavirus disease-2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is characterized by systemic inflammatory response syndrome and ***-CoV-2 associated mortality ranges from 2%to 6%.Liver dysfunction was observed in 14%-53%of COVID-19 cases,especially in moderate severe ***,no cases of spontaneous hepatic rupture in pregnant women with SARS-CoV-2 have been *** SUMMARY A 32-year-old pregnant patient(gestational age:32 wk+4 d)without any remarkable medical history or long-term medication presented with ***,non-infectious,and pregnancy-related hepatopathies were *** onset of right subcostal pain with D-dimer and liver enzyme elevation was followed by shock with *** performing an emergency cesarean section,hemoperitoneum was observed,and the patient delivered a stillbirth.A 6-cm liver rupture at the edges of segments V and VI had occurred,which was sutured and ***-CoV-2 positivity on reverse transcriptionpolymerase chain reaction was *** revisions for intrahepatic hematoma with hemorrhagic shock and abdominal compartment syndrome were ***,the patient developed hemoptysis,which was treated using bronchoscopic therapy and non-invasive *** tissue biopsy revealed hemorrhagic foci and necrosis with an irregular centrilobular *** syndrome and autoimmune hepatitis were also ruled *** death was caused by acute intrauterine *** This case reveals that pregnant women with SARS-CoV-2 infection may be predisposed to liver parenchyma disease with liver rupture.

关键词： Liver rupture SARS-CoV-2 Pregnancy Abortion HELLP Case report

A culture model to analyze the acute biomaterial-dependent reaction of human primary neutrophils in vitro

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生物活性材料(英文) 2023年第2期20卷 627-637页

作者： Marinus A.wesdorp Andrea Schwab Ezgi Irem Bektas Roberto Narcisi David Eglin martin j.Stoddart Gerjo j.V.M.Van Osch Matteo D’Este AO Research Institute Davos AO FoundationDavos PlatzSwitzerland Department of Orthopaedics and Sports Medicine Erasmus MCUniversity Medical Center Rotterdamthe Netherlands Mines Saint-Étienne Univ LyonUniv Jean MonnetINSERMU1059 SainbioseSaint-ÉtienneFrance Department of Biomaterials Science and Technology University of TwenteEnschedethe Netherlands Department of Otorhinolaryngology Erasmus MCUniversity Medical Center Rotterdamthe Netherlands Department of Biomechanical Engineering Faculty of MechanicalMaritimeand Materials EngineeringDelft University of Technologythe Netherlands Department of Oral and Maxillofacial Surgery Erasmus MCUniversity Medical Center Rotterdamthe Netherlands

Neutrophils play a pivotal role in orchestrating the immune system response to biomaterials,the onset and resolution of chronic inflammation,and macrophage ***,the neutrophil response to biomaterials and the consequent impact on tissue engineering approaches is still scarcely ***,we report an in vitro culture model that comprehensively describes the most important neutrophil functions in the light of tissue *** isolated human primary neutrophils from peripheral blood and exposed them to a panel of hard,soft,naturally-and synthetically-derived *** overall trend showed increased neutrophil survival on naturally derived constructs,together with higher oxidative burst,decreased myeloperoxidase and neutrophil elastase and decreased cytokine secretion compared to neutrophils on synthetic *** culture model is a step to better understand the immune modulation elicited by *** studies are needed to correlate the neutrophil response to tissue healing and to elucidate the mechanism triggering the cell response and their consequences in determining inflammation onset and resolution.

关键词： inflammation healing culture

Erratum to:Influence of structural defects on charge density waves in 1T-TaS_(2)

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Nano Research 2024年第3期17卷 2204-2204页

作者： Iaroslav Lutsyk Karol Szalowski Pawel Krukowski Pawel Dabrowski Maciej Rogala witold Kozlowski Maxime Le Ster Michal Piskorski Dorota A.Kowalczyk wojciech Rys Rafal Dunal Aleksandra Nadolska Klaudia Toczek Przemyslaw Przybysz Ewa Lacinska johannes Binder Andrzej wysmolek Natalia Olszowska jacek j.Kolodziej martin Gmitra Takuma Hattori Yuji Kuwahara Guang Bian Tai-Chang Chiang Pawel j.Kowalczyk Faculty of Physics and Applied Informatics University of LodzPomorska 149/15390-236 LodzPoland Faculty of Physics University of WarsawPasteura 502-093 WarsawPoland Faculty of Physics Astronomyand Applied Computer ScienceJagiellonian UniversityLojasiewicza 1130-348 KrakowPoland National Synchrotron Radiation Centre SOLARIS Jagiellonian UniversityCzerwone Maki 9830-392 KrakówPoland Institute of Physics Faculty of SciencePavol JozefŠafárik University in KošicePark Angelinum 904001 KošiceSlovakia Institute of Experimental Physics Slovak Academy of SciencesWatsonova 4704001 KošiceSlovakia Department of Precision Engineering Graduate School of EngineeringOsaka University2-1 Yamada-okaSuita 565-0871Japan Department of Physics and Astronomy University of MissouriColumbiaMissouri 65211USA Department of Physics and Frederick Seitz Materials Research Laboratory University of Illinois at Urbana-ChampaignUrbanaIllinois 61801-3080USA

The name of the second author in original paper was unfortunately *** should be“Karol Szalowski”,instead of“Karoli Szalowski”.

关键词： structural charge defects