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上海航天 1989年第5期6卷 61-62页

作者： Brecuk w.henderson 自力

哈里斯微波半导体公司研制了一种先进的GaAs(砷化镓)制造设备,力图成为军用单片微波集成电路(MMIC)的主要生产厂家.哈里斯公司掌握GaAs MMIC从晶体生长(几乎不用铸造工艺)到封装整个电路的每一道生产工序.该公司已对生产厂和设备投资了3... 详细信息

哈里斯微波半导体公司研制了一种先进的GaAs(砷化镓)制造设备,力图成为军用单片微波集成电路(MMIC)的主要生产厂家.哈里斯公司掌握GaAs MMIC从晶体生长(几乎不用铸造工艺)到封装整个电路的每一道生产工序.该公司已对生产厂和设备投资了3000万美元,雇用人员仅70人,年产近 5万个MMIC和多达40万个微波元件(如场效应晶体管).年销售额达1000万美元.哈里斯同通用电气和休斯公司一起参与了DARPA(国防预研项目局)的微波/毫米波MMIC硬件研制计划第一阶段的机载和陆基雷达系统研究工作.

关键词：砷化镓制造设备单片集成电路

担载的Ru-M(M=Co,Fe,Mo,Ni,Rh,Mn,Cr)原子簇催化剂在CO+H_2反应中的催化行为研究

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中国科学（B辑） 1992年第6期B卷 568-574页

作者：肖丰收徐如人市川胜福冈淳 D.F.Shriver w.henderson 郭燮贤辛勤吉林大学化学系长春130023 日本北海道大学触媒化学研究中心美国西北大学化学系大连化学物理研究所国家催化基础研究实验室大连116023

本文描述了一系列SiO_2担载的Ru和Ru-M(M=Co,Fe,Mo,Ni,Rh,Mn,Cr)双金属原子簇催化剂的制备,并发现在CO+H_2反应中,若和担载的Ru原子簇催化剂相比,Ru-Co/SiO_2,Ru-Fe/SiO_2和Ru-Mo/SiO_2催化剂显示了较高的含氧化合物的生成速率和选择性... 详细信息

本文描述了一系列SiO_2担载的Ru和Ru-M(M=Co,Fe,Mo,Ni,Rh,Mn,Cr)双金属原子簇催化剂的制备,并发现在CO+H_2反应中,若和担载的Ru原子簇催化剂相比,Ru-Co/SiO_2,Ru-Fe/SiO_2和Ru-Mo/SiO_2催化剂显示了较高的含氧化合物的生成速率和选择性。原位的红外光谱揭示了1584和1555cm^(-1)物种是生成甲醇和高级含氧化合物(C_2以上)的中间体,并在较高温度下1584cm^(-1)物种可以与表面烷基反应形成1555cm^(-1)新物种。通过表面化学反应和同位素标记的红外研究,提出了1584cm^(-1)和1555cm^(-1)分别归属于表面甲酰基和酰基。

关键词：双金属原子簇加氢一氧化碳催化

Assessing gully erosion and rehabilitation using multi temporal LiDAR DEMs:Case study from the Great Barrier Reef catchments,Australia

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International Soil and water Conservation Research 2024年第1期12卷 184-199页

作者： Sana Khan Rebecca Bartley Anne Kinsey-henderson Aaron Hawdon The Commonwealth Scientific and Industrial Research Organisation(CSIRO) Environment1 James Cook DrDouglas4814Australia The Commonwealth Scientific and Industrial Research Organisation(CSIRO) EnvironmentGPO Box 2583BrisbaneQLD4001Australia

Millions of dollars are being spent on gully rehabilitation to help reduce excess fine sediment delivery to the Great Barrier Reef(GBR).There is an urgent need for(i)prioritisation of active gullies for rehabilitation and(ii)the development of methodologies to inform the effectiveness of *** this study we analyse DEMs of Difference derived from 0.5 m resolution 2-3 year interval multi-temporal LiDAR data collected pre and post rehabilitation at three variable gully morphologies in the Burdekin *** analysis indicates that the highest annual average fine sediment erosion rates for the untreated control gullies occur at the linear gully(53.38 t ha^(-1)y^(-1))followed by linear-alluvial gully(34.24 t ha^(-1)y^(-1))and least at the alluvial gully(14.41 t ha^(-1)y^(-1)).The proportional loss or export of fine sediment from the gullies in their un-treated condition ranges from∼68 to 90%of what is eroded,and when the gullies are treated the proportion of fine sediment that is retained in the gully proportional to what is eroded increases to∼60%at all *** pre-treatment baseline erosion rates,and additional post treatment LiDAR captures,it is difficult to quantify the treatment *** results offer insights in the erosion mechanisms within different geomorphic gully morphologies and rehabilitation effects in these erosional *** study provides crucial knowledge of gully dynamics that can be coupled with other lines of evidence for better prioritisation of rehabilitation in the GBR catchments.

关键词： Digital elevation models (dis)connectivity Restoration Geomorphic change detection Geomorphic effectiveness GIS

Seismic attribute and well-log analysis for channel characterization in the upper San Andres and Grayburg formations of the Midland Basin,Texas

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Energy Geoscience 2024年第2期5卷 263-278页

作者： Sumit Verma Esra Yalçın Yılmaz Laura Ortiz Sanguino Justin Yandell Miles A.henderson Robert C.Trentham Department of Geosciences The University of Texas Permian BasinOdessaTXUSA School of Geosciences The University of OklahomaNormanOKUSA

The Permian Basin is one of the most prolific,and currently one of the most active,oil and gas basins in the *** Lower Permian strata in the Permian Basin have produced more than 14 billion barrels of oil(BBO),making it the largest volume of hydrocarbon in the *** in the Midland Basin during late Leonardian through early Guadalupian(ca.272-269 Ma)resulted in progradation of shelf edge and ultimately closure of the basin by Middle Permian *** analyzed a merged seismic survey covering parts of the Permian Basin(i.e.,Central Basin Platform and Midland Basin)in Andrews,Ector,and Midland Counties,*** seismic survey and well logs show the presence of gently dipping(ca.1°)clinoforms in the Upper San Andres and Grayburg Formations on the eastern edge of the Central Basin Platform and western Midland *** seismic attributes,curvature,and spectral decomposition identify low sinuosity slope channels oriented north-south,but such channels do not appear beyond the *** shelf edge shifts from north to south during deposition of the Upper San Andres and Grayburg *** identify five basinward shifts noted by the migration of the shelf edge toward the basin center and the presence of channel features along the depositional *** petrophysical analysis indicates that channels cut into carbonate rocks and are filled by siliciclastic sediments;this interpretation is supported by the most negative curvature anomalies along the channel axes caused by the differential compaction between the carbonate and siliciclastic *** are a few channels with a northwest-southeast strike,which matches the direction of the Concho Lineament observed by satellite *** observations are consistent with previous interpretations of the northern Midland Basin closure during Middle-Late Permian time.

关键词： Permian shelf carbonate

Remodeling Tumor Immune Microenvironment by Using Polymer-Lipid-Manganese Dioxide Nanoparticles with Radiation Therapy to Boost Immune Response of Castration-Resistant Prostate Cancer

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Research 2024年第3期2023卷 83-96页

作者： Abdulmottaleb E.Zetrini HoYin Lip Azhar Z.Abbasi Ibrahim Alradwan Taksim Ahmed Chunsheng He Jeffrey T.henderson Andrew M.Rauth Xiao Yu wu Advanced Pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoM5S 3M2TorontoONCanada. Departments of Medical Biophysics and Radiation Oncology University of TorontoM5G 1L7TorontoONCanada.

Despite substantial progress in the treatment of castration-resistant prostate cancer (CRPC), including radiation therapy and immunotherapy alone or in combination, the response to treatment remains poor due to the hypoxic and immunosuppressive nature of the tumor microenvironment. Herein, we exploited the bioreactivity of novel polymer–lipid manganese dioxide nanoparticles (PLMDs) to remodel the tumor immune microenvironment (TIME) by increasing the local oxygen levels and extracellular pH and enhancing radiation-induced immunogenic cell death. This study demonstrated that PLMD treatment sensitized hypoxic human and murine CRPC cells to radiation, significantly increasing radiation-induced DNA double-strand breaks and ultimately cell death, which enhanced the secretion of damage-associated molecular patterns, attributable to the induction of autophagy and endoplasmic reticulum stress. Reoxygenation via PLMDs also polarized hypoxic murine RAw264.7 macrophages toward the M1 phenotype, enhancing tumor necrosis factor alpha release, and thus reducing the viability of murine CRPC TRAMP-C2 cells. In a syngeneic TRAMP-C2 tumor model, intravenous injection of PLMDs suppressed, while radiation alone enhanced recruitment of regulatory T cells and myeloid-derived suppressor cells. Pretreatment with PLMDs followed by radiation down-regulated programmed death-ligand 1 and promoted the infiltration of antitumor CD8+ T cells and M1 macrophages to tumor sites. Taken together, TIME modulation by PLMDs plus radiation profoundly delayed tumor growth and prolonged median survival compared with radiation alone. These results suggest that PLMDs plus radiation is a promising treatment modality for improving therapeutic efficacy in radioresistant and immunosuppressive solid tumors.

关键词： RAw264.7 alone treatment

住院患者认知障碍识别和信息管理的整合性综述

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International Journal of Nursing Sciences 2024年第1期11卷 120-132页

作者：熊蓓蓓 Daniel X.Bailey Paul Prudon Elaine M.Pascoe Leonard C.Gray Frederick Graham Amanda henderson Melinda Martin-Khan Centre for Health Services Research Faculty of MedicineThe University of QueenslandBrisbaneAustralia Centre for Clinical Research Faculty of MedicineThe University of QueenslandRoyal Brisbane&Women’s HospitalBrisbaneAustralia Dementia and Delirium Division of MedicinePrincess Alexandra HospitalBrisbaneAustralia School of Nursing Faculty of HealthQueensland University of TechnologyBrisbaneAustralia Nursing Practice Development Unit Princess Alexandra HospitalBrisbaneAustralia School of Nursing Midwifery and Social SciencesCentral Queensland UniversityBrisbaneAustralia Griffith Health Griffith UniversityBrisbaneAustralia School of Nursing Midwifery and ParamedicineThe University of the Sunshine CoastBrisbaneAustralia Department of Health and Life Sciences University of ExeterExeterUnited Kingdom School of Nursing University of Northern British ColumbiaPrince GeorgeCanada

目的旨在对目前提供急性照护的医院识别认知障碍患者以及在病历中记录和管理认知相关信息的实际情况及政策要求和推荐方法进行综述。方法采用whittemore和Knaf1的五步法,系统检索Medline,CINAHL和Scopus数据库,并检索了灰色文献来源。... 详细信息

目的旨在对目前提供急性照护的医院识别认知障碍患者以及在病历中记录和管理认知相关信息的实际情况及政策要求和推荐方法进行综述。方法采用whittemore和Knaf1的五步法,系统检索Medline,CINAHL和Scopus数据库,并检索了灰色文献来源。纳人了提供急性照护的医院已实施的患者认知障碍识别和认知信息管理相关的文献。采用混合方法评价工具和灰色文献质量评估清单对文章质量进行评价。采用主题分析法呈现和整合结果。该综述已在PROSPERO预注册(CRD42022343577)。结果共22篇原始研究文献和10篇政府/行业文件被纳人分析。结果显示,实践和政策之间存在差距。尽管在政策层面上高度重视认知障碍的识别、认知相关信息的透明度,以及与患者、家属和照顾者(如适用)之间的互动,但有时在临床实践中,认知评估是非正式的,患者的认知相关信息未作记录,与患者、家属和照顾者的互动也存在不足。结论.通过整合认知评估,利用信息技术开发信息管理综合系统,建立相关法律法规,提供教育与和培训,并采用国家层面的策略,有可能显著改善对认知障碍患者的识别和护理。

关键词：急性照护认知功能障碍数据透明度谵妄痴呆健康信息管理与患者互动.

High-resolution precipitation variations in the Northeast Tibetan Plateau over the last 800 years documented by sediment cores of Qinghai Lake

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Chinese Science Bulletin 2003年第14期48卷 1451-1456页

作者： ZHANGJiawu JINMing CHENFahu R.w.Battarbee A.CoG.henderson CenterforAddEnvironmentandPaleoclimateResearch NationalLab.ofWesternChina'sEnvironmentalSystemLanzhouUniversityLanzhou730000China DesertandDesertificationLab. ColdandAridRegionsEnviron-mentalandEngineeringResearchInstituteChineseAcademyofSci-encesLanzhou730000China EnvironmentalChangeResearchCenter DepartmentofGeographyUniversityCollegeLondon26BedfordWayWC1H0APUK

Short cores of about 80-cm retrieved from three main basins of the deepwater areas in Qinghai Lake, the largest inland enclosed lake in China, were studied. Stable isotopes of authigenic carbonates, grain-size, carbonate and organic matter content at 5-year resolution are used to reconstruct the climatic history over the last 800 years in the Northeastern Tibetan Plateau. Chronology was established according to 210Pb dating and 137Cs methods and the core correlation. It is found that cores from different deep basins of the lake can be well correlated. The sedimentary rate is highest in the western basin of the lake and lowest in the east. In the southern basin of the lake where the short core Qing-6 is located, the recent average sedimentation rate is 0.1004 cm/yr. Variations in effective precipitation recorded by the oxygen isotopes and grain size data during the last 800 years are consistent with the glacial accumulation record form the Dunde and Guliya ice cores. A dry climate lasted for 300 years from 1200 AD to 1500 AD, followed by a wet period from 1500 to 1560 AD. The two dry periods, 1560 to 1650 AD and 1780 to 1850 AD, were the results of southwest monsoon weakening. The effective precipitation generally increased since 1650 AD due to the strengthening of the Asian Southwest Monsoon, resulting in a wet period until the 1950s. Except the early stage, the Little Ice Age on the Plateau is characterized by increased effective moisture. Organic mat- ter content, with nearly 200-year cycles, shows similar trend with the atmospheric delta carbon-14 before the 1850s, indicating that the bioproductivity responds to solar activity.

关键词：中国西藏东北部青海湖沉积岩心古气候碳酸盐氧同位素有效降水量

Practical application of the neuroregenerative properties of ketamine: real world treatment experience

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Neural Regeneration Research 2016年第2期11卷 195-200页

作者： Theodore A.henderson Neuro-Luminance The Synaptic Space Neuro-Laser Foundation

while controversial, ketamine has emerged as an effective treatment for refractory depression. Serial infusions have been performed 3 times per week, but our practical experience has challenged this precept concerning infusion frequency. Depression is associated with neuron loss, reduced synapse numbers, and dearborization of dendrites. Ketamine appears to potently induce mechanisms which reverse these neurodegenerative processes. Ketamine not only blocks the glutamate receptor, it activates eukaroyotic elongation factor 2（e EF2）. This, in turn, activates brain-derived neurotrophic factor（BDNF） protein synthesis. This is thought to underlie ketamine＇s enduring benefits. In addition, ketamine alters glycogen synthase kinase-3（GSK-3） phosphorylation, probably responsible for its rapid antidepressant effect. Notably, inhibition of the BDNF receptor does not block the immediate benefits of ketamine, but does prevent the enduring effects. Neuro-Luminance Ketamine Infusion Centers have been treating patients with serial ketamine infusions for over three years. Our methods differ from what is often reported, as we perform infusions only once per week and generally do not perform more than five infusions. Data from 100 patients showed that 80% of the patients responded. The baseline Quick Inventory of Depressive Symptomatology-Self Report（QIDS-SR） score was 17.8 ± 2.8. Responders to ketamine showed a drop in QIDS-SR score of 10.8 ± 3.5, while non-responders showed a 0.8 ± 1.8 change. Moreover, they often had persistent benefits over several months. Recently, it was proposed that psychotomimetic effects are necessary during a ketamine infusion to yield effective antidepressant benefits. Yet, only one patient in our clinic has experienced hallucinations in three years. Nevertheless, 80% of our patients show clinical improvement. Further studies of clinical methods for ketamine infusion therapy are encouraged.

关键词： Ketamine brain-derived neurotrophic factor infusion therapy depression safety

Multi-watt near-infrared light therapy as a neuroregenerative treatment for traumatic brain injury

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Neural Regeneration Research 2016年第4期11卷 563-565页

作者： Theodore A.henderson Neuro-Laser Foundation The Synaptic SpaceNeuro-LuminanceCentennialCO

Infrared light represents a broad spectrum of light with wavelengths from 700 nm to 1 million nm（1,000 microns）.At its shortest wavelengths（referred to as near-infrared）,it merges with the red spectrum of visible ... 详细信息

关键词： TBI Multi-watt near-infrared light therapy as a neuroregenerative treatment for traumatic brain injury NIR