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南加州人应对地震

世界地震译丛 2002年第4期33卷 82-85页

作者： K.w.hudnut J.J.Mori w.h.prescott P.h.Stauffer 杨一飞中国地震局地球物理研究所

几十年来,南加州人一直在努力减小在地震面前的脆弱性。1994年北岭地震时虽然损失很大,但也显示了这种努力的价值。然而尚需要继续努力。科学家正在编制一种新的南加州地震震害危险图。通过集中力量加固现有的建筑物和指导建筑新的建筑... 详细信息

几十年来,南加州人一直在努力减小在地震面前的脆弱性。1994年北岭地震时虽然损失很大,但也显示了这种努力的价值。然而尚需要继续努力。科学家正在编制一种新的南加州地震震害危险图。通过集中力量加固现有的建筑物和指导建筑新的建筑物,这些图帮助人们生活在此更安全。

关键词：南加州人地震地震震害危险图建筑防震减灾

洛杉矶连续的全球定位系统台阵有助于地震灾害评估吗?

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世界地震译丛 1997年第1期28卷 82-82页

作者： w.h.prescott 吕春来国家地震局地球物理研究所

景色美丽气候宜人的南加州是2000多万人口的家园,而且对国民经济非常重要。遗憾的是,该地区也纵横分布着许多可产生强烈地震的活断层。来自一些科研院所的科学家正在探索一种研究高危险性大都市地区地震灾害的新方法。

关键词： GPS 地震灾害洛杉矶活断层

New perspectives and progress in vertebrate pest management:The 6th European Vertebrate Pest Management Conference

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Integrative Zoology 2010年第1期5卷 1-1页

作者： Colin prescott Chris FEARE School of Biological Sciences University of ReadingReadingRG66ASUK wildwings Bird Management 2 North View CottagesHaslemereSurrey GU272DNUK

The 6th European Vertebrate Pest Management Con-ference was held at the University of Reading in September *** was one of a series of international symposia that bring together scientists in the field of vertebrate pest management from Europe and beyond,to exchange information on problems,research and solutions;to provide opportunities for collaboration in research;and to ensure that management techniques employed are effective,humane,environmentally safe and conform to current legislation.

关键词： Vertebrate management European

Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy

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world Journal of Gastroenterology 2016年第41期22卷 9104-9116页

作者： Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L prescott Ian C Lawrance Meri K Tulic Faculty of Medicine and Dentistry School of Medicine and Pharmacology University of Western Australia Perth WA 6009 Australia Department of Immunology Fremantle Hospital Royal Brisbane and Women’s Hospital Perth WA 6160 Australia Royal Brisbane Queensland 4006 Australia University of Nice Sophia-Antipolis EA6302 06202 Nice France Department of Gastroenterology and Nutrition l’Archet Hospital 2 06202 Nice France School of Paediatrics and Child health University of Western Australia Subiaco WA 6008 Australia International Inflammation network (in-FLAME) of the world Universities Network University of Western Australia Subiaco WA 6008 Australia Centre for Inflammatory Bowel Diseases St John of God Subiaco Hospital Perth WA 6009 Australia Mediterranean Center for Molecular Medicine (C3M)-INSERM U1065 Team 12 06204 Nice France

AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) *** Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC "responders"(n = 12) and "non-responders"(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with *** Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P wing TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P hed TNF(P his innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy

关键词： Ulcerative colitis Innate immunity Antitumor necrosis factor therapy Toll-like receptor IRAK4 Inflammatory bowel disease

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从远处看地震

地震地质译丛 1994年第5期16卷 52-53页

作者： w.prescott 沈

雷达影象的新用途是它可以恢复奇迹的方向。Massonnet(1903)等人利用合成口径雷达恢复了地表运动的迹象。其详细程度足以看出形变场,他们绘制去年加州兰德斯地震引起的位移图。这幅图呈现出一些读者很熟悉的景象。我们看过一些类似的理... 详细信息

雷达影象的新用途是它可以恢复奇迹的方向。Massonnet(1903)等人利用合成口径雷达恢复了地表运动的迹象。其详细程度足以看出形变场,他们绘制去年加州兰德斯地震引起的位移图。这幅图呈现出一些读者很熟悉的景象。我们看过一些类似的理论的地震位移场图。但是别的技术没能绘制出这么详细的真实位移场图。这个影象图包括约3亿个点的地震产生的运动的信息。

关键词：地震位移图雷达测量

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特发性面神经麻痹类固醇治疗的效果

国外医学（耳鼻咽喉科学分册） 1989年第3期13卷 146-147页

作者： prescott CAJ 徐心田

本文报告1016例特发性面神经麻痹的类固醇治疗效果,认为其预后取决于病变的程度,而与应用类固醇剂量无明显关系。

关键词：类固醇面神经麻痹疗效面瘫

A key role for PTP1B in dendritic cell maturation, migration, and T cell activation

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分子细胞生物学报:英文版 2015年第6期7卷 517-528页

作者： Cristina Martin-Granados Alan R.prescott Samantha Le Sommer Izabela P.Klaska Tian Yu Elizabeth Muckersie Claudiu V.Giuraniuc Louise Grant Mirela Delibegovic John V.Forrester Institute of Medical Sciences University of AberdeenCollege of Life Sciences and MedicineAberdeen AB252ZDUK Department of Pharmacology University of CambridgeCambridge CB21PDUK Division of Cell Biology and Immunology College of Life SciencesUniversity of DundeeDundee DD15EHUK Centre for Ophthalmology and Visual Science The University of Western AustraliaPerthAustralia Centre for Experimental Immunology Lions Eye InstituteNedlandsWA 6009Australia

Dendritic cells(DC)are the major antigen-presenting cells bridging innate and adaptive immunity,a function they perform by converting quiescent DC to active,mature DC with the capacity to activate naı¨ve T *** do this by migrating from the tissues to the T cell area of the secondary lymphoid ***,wedemonstrate thatmyeloid cell-specific genetic deletion of PTP1B(LysM PTP1B)leads to defects in lipopolysaccharide-driven bone marrow-derivedDC(BMDC)activation associated with increased levels of phosphorylated *** showthatmyeloid cell-specific PTP1Bdeletion also causes decreased migratory capacity of epidermal DC,aswell as reduced CCR7 expression and chemotaxis to CCL19 by ***1B deficiency in BMDC also impairs their migration in ***,immature LysM PTP1B BMDC display fewer podosomes,increased levels of phosphorylated Src at tyrosine 527,and loss of Src localization to podosome *** co-culture with T cells,LysM PTP1B BMDC establish fewer and shorter contacts than control ***,LysMPTP1BBMDCfail to present antigen to T cells as efficiently as *** data provide first evidence for a key regulatory role for PTP1B in mediating a central DC function of initiating adaptive immune responses in response to innate immune cell activation.

关键词： dendritic cell maturation podosomes T cell activation adaptive immune response protein tyrosine phosphatase 1B

Edmund Spenser's poetry

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北京延庆断层崩积物记录的古地震事件释光测年研究

作者： selected and edited by Andrew D. hadfield University Of Sussex Anne Lake prescott Barnard College Emerita Columbia University.

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中国地震 2001年第2期17卷 176-186页

作者：赵华 prescott J.R. 卢演俦陈杰尹功明中国科学院地质与地球物理研究所中国西安710054.中国科学院地球环境研究所黄土与第四纪地质国家重点实验室中国地震局地质研究所 Physics/Mathematical Physics University of Adelaide Australia 5005

对北京延庆西羊房古地震探槽西壁采集的 10个崩积物和坡面沉积物样品进行了细颗粒 (4～ 11μm)多测片的红外释光 (IRSL)和绿光释光 (GLSL)测年。其中 4个样品既在中国地震局地质研究所用Daybreak仪器作了测量 ,也在澳大利亚Adelaide大... 详细信息

对北京延庆西羊房古地震探槽西壁采集的 10个崩积物和坡面沉积物样品进行了细颗粒 (4～ 11μm)多测片的红外释光 (IRSL)和绿光释光 (GLSL)测年。其中 4个样品既在中国地震局地质研究所用Daybreak仪器作了测量 ,也在澳大利亚Adelaide大学物理系用Ris 仪器作测量 ,其结果基本一致。该探槽剖面见 4个断层崩积楔 ,可视为 4次古地震事件的记录。释光测年表明 ,最新一个崩积楔有可能是公元 2 94年延庆东居庸村 6级地震的地质记录 ,大约在 1 7～2 0kaBP或 1 7～ 2 4kaBP期间至少有两次强烈地震事件。本文还对比了细颗粒GLSL与IRSL的测年结果。

关键词：释光测年断层崩积楔延庆古地震事件断层活动性