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DISLOCATION PINNING IN hIGh TEm.ERATURE DEFORm.D Ni_3(Al,Ti) SINGLE CRYSTALS CONTAINING DISORDERED γ PRECIPITATES

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Acta m.tallurgica Sinica(English Letters) 2006年第3期19卷 157-164页

作者： w.h. tian m. nemoto Departm.nt of m.terials Physics and Ghem.stry University of Science and Technology Beijing Beijing 100083 China Sasebo National Gollege of Technology Okishin 1-1 Sasebo 857-1193 Japan

A transm.ssion electron m.croscopy （TEm. investigation has been perform.d on the dislocation pinning in Lie-ordered Ni3（Al, Ti） containing disordered γ *** m.rphology of deform.tion induced dislocations in the γ base alloys containing fine dispersion of disordered γ was investigated by m.ans of weak-beam.electron m.croscopy. The superdislocations are strongly attracted to the disordered particles and dissociate on the （111） plane in the γ particles, while they dissociate on the （010） plane in the γ＇ m.trix. The disordered γ precipitates play an im.ortant role as a pinning point during the cross-slip of superdislocations from.（111） to （010） planes in the γ m.trix and restrain the cross-slip of superdislocations. The interaction of superdislocations with disordered particles causes the form.tion of superkinks, jogs and closed loops.

关键词： superdislocation precipitate attractive interaction cross slip Ll2-ordered Ni3Al

CCL9/CCR1 axis-driven chem.tactic nanovesicles for attenuating m.tastasis of Sm.D4-deficient colorectal cancer by trapping TGF-β

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Acta Pharm.ceutica Sinica B 2024年第8期14卷 3711-3729页

作者： Boning Niu tianyi tian Lu wang Yinm.i tian tian tian Yuanyuan Guo hu Zhou Zhiping Zhang Tongji School of Pharm.cy Huazhong University of Science and TechnologyWuhan 430030China Departm.nt of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Departm.nt of Pharm.cy Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Pharm.ceutical Sciences Fujian Provincial Key Laboratory of Innovative Drug Target ResearchHigh Throughput Drug Screening PlatformXiamen UniversityXiamen 361102China National Engineering Research Center for Nanom.dicine Huazhong University of Science and TechnologyWuhan 430030China hubei Engineering Research Centre for Novel Drug Delivery System Huazhong University of Science and TechnologyWuhan 430030China

Sm.D4 deficiency in colorectal cancer(CRC)is highly correlated with liver m.tastasis and high m.rtality,yet there are few effective precision therapies ***,we show that CCR1^(+)-granulocytic m.eloid-derived suppressor cells(G-m.SCs)are highly infiltrated in Sm.D4-deficient CRC via CCL15/CCR1 and CCL9/CCR1 axis in clinical specim.ns and m.use m.dels,*** excessive TGF-β,secreted by tum.r-infiltrated CCR1^(+)-G-m.SCs,suppresses the im.une response of cytotoxic T lym.hocytes(CTLs),thus facilitating ***,we develop engineered nanovesicles displaying CCR1 and TGFBR2 m.lecules(C/T-NVs)to chem.tactically target the tum.r driven by CCL9/CCR1 axis and trap TGF-βthrough TGF-β-TGFBR2 specific *** C/T-NVs counteract CCR1^(+)-G-m.SC infiltration through com.etitive responding CCL9/CCR1 axis.C/T-NVs-induced intratum.ral TGF-βexhaustion alleviates the TGF-β-suppressed im.une response of ***,C/T-NVs attenuate liver m.tastasis of Sm.D4-deficient *** further exploration,high expression of program.ed cell death ligand-1(PD-L1)is observed in clinical specim.ns of Sm.D4-deficient *** C/T-NVs with anti-PD-L1 antibody(aPD-L1)induces tertiary lym.hoid structure form.tion with sustained activation of CTLs,CXCL13^(+)-CD4^(+)T,CXCR5^(+)-CD20^(+)B cells,and enhanced secretion of cytotoxic cytokine interleukin-21 and IFN-γaround tum.rs,thus eradicating m.tastatic *** strategy elicits pleiotropic antim.tastatic im.unity,paving the way for nanovesicle-m.diated precision im.unotherapy in Sm.D4-deficient CRC.

关键词： Sm.D4-deficient CRC m.tastasis G-m.SCs TGF-β CCR1 TGFBR2

Capturing m.tal clusters at the strong-interaction region to reverse Ostwald ripening

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Science China m.terials 2024年第4期67卷 1363-1364页

作者： Shuheng tian Ding m. Beijing National Laboratory for m.lecular Sciences New Cornerstone Science LaboratoryCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

high-tem.erature interactions induce sintering of m.tal nanoparticles(NPs) on heterogeneous catalyst surfaces, leading to reduced surface area and active site loss through Ostwald ripening [1]. This irreversible deactivation necessitates costly catalyst replacem.nt, notably im.acting m.tals like copper in hydrogenation and reform.ng reactions [2].

关键词： catalyst reform.ng irreversible

how forest age im.acts on net prim.ry productivity: Insights from.future m.lti-scenarios

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Forest Ecosystem. 2024年第5期11卷 708-719页

作者： Lei tian Yu Tao Sim.s Joanna Annikki m.akelä m.ngyang Li Co-Innovation Center for Sustainable Forestry in Southern China Nanjing Forestry UniversityNanjingChina Faculty of Agriculture and Forestry University of HelsinkiHelsinkiFinland

Forest net prim.ry productivity(NPP)constitutes a key flux within the terrestrial ecosystem.carbon cycle and serves as a significant indicator of the forests carbon sequestration capacity,which is closely related to forest *** its significance,the im.act of forest age on NPP is often ignored in future NPP ***,we m.pped forest age in hunan Province at a 30-m.resolution utilizing a com.ination of Landsat tim. series stack(LTSS),national forest inventory(NFI)data,and the relationships between height and ***,NPP was derived from.NFI data and the relationships between NPP and age was built for various forest *** forest NPP was predicted based on the NPP-age relationships under three future scenarios,assessing the im.act of forest age on *** findings reveal substantial variations in forest NPP in hunan Province under three future scenarios:under the age-only scenario,NPP peaks in 2041(133.56TgC·yr^(−1)),while NPP peaks three years later in 2044(141.14TgC·yr^(−1))under the natural developm.nt *** m.xim.m.afforestation scenario exhibits the m.st rapid increase in NPP,with peaking in 2049(197.95TgC·yr^(−1)).however,with the aging of the forest,NPP is projected to then decrease by 7.54%,6.07%,and 7.47%in 2060,and 20.05%,19.74%,and 28.38%in 2100,respectively,com.ared to their peaks under the three *** indicates that forest NPP will continue to decline *** the age structure of forests through selective logging,afforestation and reforestation,and encouraging natural regeneration after disturbance could m.tigate this declining trend in forest NPP,but im.lications of these m.asures on the full forest carbon balance rem.in to be *** from.the future m.lti-scenarios are expected to provide data to support sustainable forest m.nagem.nt and national policy developm.nt,which will inform.the achievem.nt of carbon neutrality goals by 2060.

关键词： Net prim.ry productivity Forest age NPP-Age relationships NPP projections Afforestation

DeepSI:A Sensitive-Driven Testing Sam.les Generation m.thod of whitebox CNN m.del for Edge Com.uting

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Tsinghua Science and Technology 2024年第3期29卷 784-794页

作者： Zhichao Lian Fengjun tian School of Cyber Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China

In recent years,Deep Learning(DL)technique has been widely used in Internet of Things(IoT)and Industrial Internet of Things(IIoT)for edge com.uting,and achieved good *** m.re and m.re studies have shown the vulnerability of neural ***,it is im.ortant to test the robustness and vulnerability of neural *** specifically,inspired by layer-wise relevance propagation and neural network verification,we propose a novel m.asurem.nt of sensitive neurons and im.ortant neurons,and propose a novel neuron coverage criterion for robustness *** on the novel criterion,we design a novel testing sam.le generation m.thod,nam.d DeepSI,which involves definitions of sensitive neurons and im.ortant ***,we construct sensitive-decision paths of the neural network through selecting sensitive neurons and im.ortant ***,we verify our idea by setting up several experim.nts,then results show our proposed m.thod achieves superior perform.nces.

关键词： neuron sensitivity Layer-wise Relevance Propagation(LRP) neural network verification deeplearning testing

Superplasticity of fine-grained m.-10Li alloy prepared by severe plastic deform.tion and understanding its deform.tion m.chanism.

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Journal of m.gnesium.and Alloys 2024年第1期12卷 316-331页

作者： h.T.Jeong S.w.Lee w.J.Kim Departm.nt of m.terials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

The superplastic behavior and associated deform.tion m.chanism. of a fine-grained m.-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)with a grain size of 3.2μm.prim.rily com.osed of the BCCβphase and a sm.ll am.unt of the hCPαphase,were exam.ned in a tem.erature range of 473 K to 623 *** m.crostructural refinem.nt of this alloy was achieved by em.loying high-ratio differential speed *** best superplasticity was achieved at 523 K and at strain rates of 10^(-4)-5×10^(-4)s^(-1),where tensile elongations of 550±600%were *** the heating and holding stage of the tensile sam.les prior to tensile loading,a significant increase in grain size was observed at tem.eratures above 573 ***,it was im.ortant to consider this effect when analyzing and understanding the superplastic deform.tion behavior and *** the investigated strain rate range,the superplastic flow at low strain rates was governed by lattice diffusion-controlled grain boundary sliding,while at high strain rates,lattice diffusion-controlled dislocation clim. creep was the rate-controlling deform.tion *** was concluded that solute drag creep is unlikely to *** the late stages of deform.tion at 523 K,it was observed that grain boundary sliding led to the agglom.ration of theαphase,resulting in significant strain *** m.chanism.m.ps were constructed forβ-m.-Li alloys in the form.of 2D and 3D form.ts as a function of strain rate,stress,tem.erature,and grain size,using the constitutive equations for various deform.tion m.chanism. derived based on the data of the current tests.

关键词： m.gnesium.lithium.alloy Superplasticity Severe plastic deform.tion Grain size Grain growth

Im.unological Exploration of helicobacter pylori Serotype O_(2) O-Antigen by Using a Synthetic Glycan Library

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Chinese Journal of Chem.stry 2024年第3期42卷 243-251页

作者： m.ng Zhao Guangzong tian Chunjun Qin Xiaopeng Zou Peter h. Seeberger Jing hu Jian Yin Key Laboratory of Carbohydrate Chem.stry and Biotechnology Ministry of EducationSchool of Biotechnology & School of Life Sciences and Health EngineeringJiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China Biom.lecular System. Departm.nt Max Planck Institute of Colloids and InterfacesAm Mühlenberg 1Potsdam14476 Germany wuxi School of m.dicine Jiangnan UniversityLihu Avenue 1800WuxiJiangsu214122 China

helicobacter pylori(***)infection is a threat to hum.n *** lipopolysaccharide(LPS)O-antigen holds prom.se for developing *** is m.aningful to explore the im.unological activity of oligosaccharides with different lengths and fram.shifts for antigen ***,a glycan library of *** O2 O-antigen containing eight fragm.nts is *** screening with *** O2 LPS sera and patients’sera by glycan m.croarray,the disaccharide hPO2G-2b and trisaccharide hPO2G-3a show strong antigenicity and then are separately conjugated with carrier protein *** glycoconjugates elicit a robust im.unoglobulin G(IgG)im.une response in *** anti-hPO2G-3a IgG antibodies possess a m.ch stronger binding affinity with the LPS and bacteria of *** O2 than the anti-hPO2G-2b IgG *** is no cross-reaction between both sera IgG antibodies with LPS and bacteria of *** O1,O6,and *** results dem.nstrate the trisaccharide hPO2G-3a is a prom.sing candidate for *** vaccine developm.nt.

关键词： Glycoconjugates helicobacter pylori Im.unology m.croarrays O-antigen Oligosaccharides

Revisiting East Asian m.nsoon change during the Last Glacial m.xim.m.using Pm.P4 sim.lations

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Atm.spheric and Oceanic Science Letters 2024年第3期17卷 47-52页

作者： Zhiping tian Institute of Atm.spheric Physics Chinese Academy of SciencesBeijingChina

利用Pm.P4多模式试验数据,本文重新检查了末次冰盛期(距今约21000年)东亚季风变化.结果表明:相对于工业革命前期,所有5个模式一致模拟显示末次冰盛期东亚季风减弱,冬季和夏季减幅分别为1%-18%和2-32%;不同模式中东亚季风环流变化的空间... 详细信息

利用Pm.P4多模式试验数据,本文重新检查了末次冰盛期(距今约21000年)东亚季风变化.结果表明:相对于工业革命前期,所有5个模式一致模拟显示末次冰盛期东亚季风减弱,冬季和夏季减幅分别为1%-18%和2-32%;不同模式中东亚季风环流变化的空间分布存在差异,这主要源于该时期大尺度变冷和海平面气压梯度变化的空间分布不同;由于模式之间的差异和重建记录之间的不确定性,未来有待开展更多模拟和重建工作以更好地理解冰期东亚季风变化.

关键词：末次冰盛期东亚冬季风东亚夏季风 Pm.P4试验

New m.thod for m.ltibody dynam.cs based on unknown constraint force

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Science China(Technological Sciences) 2024年第3期67卷 791-808页

作者： tian Ying JIA Yinghong ZhANG Jun School of Astronautics Beihang UniversityBeijing 100191China Beijing Institute of Control Engineering Beijing 100190China National Laboratory of Space Intelligent Control Beijing 100190China

This paper presents a new m.thod for the dynam.cs of m.ltibody system. based on unknown constraint force. The m.thod can uniform.y solve m.ltibody system. with typical configurations, including the system.with rigid-flexible coupling, the system.in tree topology, and the system.with loop constraints. Unlike com.on m.thods, the proposed m.thod can m.del the loop system.without “cutting off” loop constraints, leading to the exact sam. m.delling process as the tree-like system.perform.. Based on graph theory, a topological record m.trix m.(rec) is proposed to capture the arbitrary system.configuration. m.reover, constraint forces are selected as the key variables in sem.-recursive fram.work. with the recursive kinem.tics relationship between adjacent bodies, the constraint force equation is further assem.led to achieve the full-state system.solution. The num.rical sim.lations dem.nstrate the accuracy of the proposed m.thod.

关键词： m.ltibody system dynam.c m.delling rigid-flexible coupling unknown constraint force graph theory sem.-recursive algorithm