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A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 123-138页

作者： Chentong GAO Huiyu SUN Jianping GU w.M.HUANG College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics School of Mechanical and Aerospace Engineering Nanyang Technological University Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology

Currently, there are a limited number of dynamic models available for braided composite plates with large overall motions, despite the incorporation of three-dimensional(3D) braided composites into rotating blade components. In this paper, a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established. Based on Kirchhoff's plate assumptions, the displacement variables of the plate are expressed. By incorporating the braiding directions into the constitutive equation of the braided composites, the dynamic model of the plate considering braiding directions is obtained. The effects of the speeds, braiding directions, and braided angles on the responses of the plate with fixed-axis rotation and translational motion, respectively, are investigated. This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions. It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.

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Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan Ma Nolan fullenkamp Giles w.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

Role of membrane and compound properties in affecting the rejection of pharmaceuticals by different RO/Nf membranes

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frontiers of Environmental Science & Engineering 2017年第6期11卷 193-205页

作者： Yang-ying Zhao fan-xin Kong Zhi wang Hong-wei Yang Xiao-mao wang Yuefeng f. Xie T. David waite State Key Joint Laboratory of Environment Simulation and Pollution Control School of Environment Tsinghua University Beijing 100084 China School of Chemical Engineering China University of Petroleum Beijing 102249 China Environmental Engineering Programs The Pennsylvania State University Middletown PA 17057 USA School of Civil and Environmental Engineering The University of New South Wales Sydney NSW 2052 Australia

This study was conducted to assess the merits and limitations of various high-pressure membranes, tight nanofiltration （Nf） membranes in particular, for the removal of trace organic compounds （TrOCs）. The performance of a low-pressure reverse osmosis （LPRO） membrane （ESPA1）, a tight Nf membrane （Nf90） and two loose Nf membranes （HL and Nf270） was compared for the rejection of 23 different pharmaceuticals （PhACs）. Efforts were also devoted to understand the effect of adsorption on the rejection performance of each membrane. Difference in hydrogen bond formation potential （HfP） was taken into consideration. Results showed that Nf90 performed similarly to ESPA1 with mean rejection higher than 95%. Nf270 outperformed HL in terms of both water permeability and PhAC rejection higher than 90%. Electrostatic effects were more significant in PhAC rejection by loose Nf membranes than tight Nf and LPRO membranes. The adverse effect of adsorption on rejection by HL and ESPA1 was more substantial than Nf270 and Nf90, which could not be simply explained by the difference in membrane surface hydrophobicity, selective layer thickness or pore size. The HL membrane had a lower rejection of PhACs of higher hydrophobicity （log D〉0） and higher HfP （〉0.02）. Nevertheless, the effects of PhAC hydrophobicity and HfP on rejection by ESPA1 could not be discerned. Poor rejection of certain PhACs could generally be explained by aspects of steric hindrance, electrostatic interactions and adsorption. High-pressure membranes like Nf90 and Nf270 have a high promise in TrOC removal from contaminated water.

关键词： Trace organic compounds (TrOCs) Nanofiltration (Nf) Adsorption Membrane properties water treatment

New Development of Acid Regeneration in Steel Pickling Plants

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Journal of Iron and Steel Research International 2008年第4期15卷 1-6页

作者： w f Kladnig ICC Chemical Consulting Vienna A-1193 Austria

for acid pickling heat treated mild steel and steel products, up to the middle of the last century, sulfuric acid was primarily in use, which has been replaced stepwise by hydrochloric acid since the sixties. During this time, the pickling of high alloyed steel with hydrofluoric acid or mixtures for hydrofluoric acid together with nitric acid has also been applied on industrial scale. The technologies used by several plant contractors hereby show considerable differences in their engineering. The study provides a survey of the progress in the state of art of regeneration technology as well as the use of different *** media in the form of a review on existing technologies as well as improvements done within the recent years in the area.

关键词： pickling mild steel high alloyed steel acid recycling technology global emission standard treatment of stack gas

Ligand-mediated contaminant degradation by bare and carboxymethyl cellulose-coated bimetallic palladium-zero valent iron nanoparticles in high salinity environments

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Journal of Environmental Sciences 2019年第3期31卷 303-311页

作者： Xiaoming Ma Di He Adele M.Jones T.David waite Taicheng An Institute of Environmental Health and Pollution Control Guangdong University of Technology Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control School of Environmental Science and Engineering Guangzhou University of Technology School of Civil and Environmental Engineering University of New South Wales

The application of nanoscale zero-valent iron(nZVI) for the degradation of contaminants has been extensively investigated, however, few studies have focused on degradation in high salinity environments. In this study, the ability of bare and carboxymethyl cellulose(CMC)-coated bimetallic Pd-nZVI particles to degrade 33′44′-tetrachlorobiphenyl in high saline water(Sw) is examined with particular attention given to the effects of ethylenediaminetetraacetic acid(EDTA) on the rate of degradation. EDTA enhances the reactivity of Pd-nZVI in Sw, with evidence provided to link this to the removal of the passivating layer. Additionally, a conceptual model is proposed which provides a quantitative description of the removal of these iron oxide layers in the presence of EDTA. An optimum EDTA to bare Pd-nZVI molar ratio of 0.1 exists, with insufficient EDTA unable to remove the passivating layer whilst excess EDTA results in fe loss and enhanced agglomeration due to magnetic attraction of the bare fe(0) particles. In contrast, CMCcoating of Pd-nZVI assemblages actually impedes degradation, despite the coated particles displaying a smaller average size compared to uncoated particles, with even the presence of EDTA in this case not significantly improving degradation. The reduced reactivity in the presence of CMC is primarily attributed to the effect of CMC on the association of Pd with nZVI particles. In particular, the presence of CMC reduced the total amount of Pd incorporated with the stabilized particles compared to the non-stabilized ***, the presence of CMC results in less Pd present in its reactive zero-valent oxidation state.

关键词： Bimetallic zero valent iron ligand-mediated depassivation polychlorinated biphenyls high salinity water

High-throughput quantification of microbial birth and death dynamics using fluorescence microscopy

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frontiers of Electrical and Electronic Engineering in China 2019年第1期7卷 69-81页

作者： Samuel f. M. Hart David Skelding Adam J. waite Justin C. Burton wenying Shou fred Hutchinson Cancer Research Center SeattleWA 98109USA

Background: Microbes live in dynamic environments where nutrient concentrations fluctuate. Quantifying fitness in terms of birth rate and death rate in a wide range of environments is critical for understanding microbial evolution and ecology. Methods^ Here, using high-throughput time-lapse microscopy, we have quantified how Saccharomyces cerevisiae mutants incapable of synthesizing an essential metabolite (auxotrophs) grow or die in various concentrations of the required metabolite. we establish that cells normally expressing fluorescent proteins lose fluorescence upon death and that the total fluorescence in an imaging frame is proportional to the number of live cells even when cells form multiple layers. we validate our microscopy approach of measuring birth and death rates using flow cytometry, cell counting, and chemostat culturing. Results: for lysine-requiring cells, very low concentrations of lysine are not detectably consumed and do not support cell birth, but delay the onset of death phase and reduce the death rate compared to no lysine. In contrast, in low hypoxanthine, hypoxanthine-requiring cells can produce new cells, yet also die faster than in the absence of hypoxanthine. for both strains, birth rates under various metabolite concentrations are better described by the sigmoidal-shaped Moser model than the well-known Monod model, while death rates can vary with metabolite concentration and time. Conclusions: Our work reveals how time-lapse microscopy can be used to discover non-intuitive microbial birth and death dynamics and to quantify growth rates in many environments.

关键词： Saccharomyces cerevisiae fluorescence microscopy microbial growth birth rate death rate