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DeHP exposure destroys blood-testis barrier (BTB) integrity of immature testes through excessive ROS-mediated autophagy

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Genes & Diseases 2018年第3期5卷 263-274页

作者： w.e.i.Yi Tang Xiang-Liang Zhou Yu Liu Bin Shen Lian-Ju Long Chun-lan L.i.N.Tao H.e.Da-wei w.U.Sheng-de w.e.i.guang-hui Department of Urology Children’s Hospital of Chongqing Medical UniversityZhongshan 2RDYuzhong DistrictChongqing400014China Chongqing Key Laboratory of Children Urogenital Development and Tissue engineering China Ministry of education Key Laboratory of Child Development and Disorders China China international Science and Technology Cooperation Base of Child Development and Critical Disorders China Chongqing Key Laboratory of Pediatrics Chongqing China

Di-(2-ethylhexyl)phthalate(DeHP),is known to impair testicular functions and ***,its effects on immature testis Blood-testis barrier(BTB)and the underlying mechanisms remain *** constructed a rat model to investigate the roles of autophagy in BTB toxicity induced by *** rats were developmentally exposed to 0,250 and 500 mg/kg DeHP via intragastric administration from postnatal day(PND)1 to PND *** morphology,expressions of BTB junction proteins and autophagy related proteins were *** addition,expressions of oxidative stress markers were also *** results demonstrated that developmental DeHP exposure induced decreasing organ coefficients of immature testes and severe testicular damage in *** expressions of junctional proteins were down-regulated significantly after DeHP ***,DeHP simultaneously increased the number of autophagosomes and the levels of autophagy marker LC3-ii and p62,suggesting that the accumulated autophagosomes resulted from impaired autophagy ***,the expressions of HO-1 and SOD levels remarkably decreased after DeHP *** e and C could alleviate the DeHP-induced oxidative stress,reverse the autophagy defect and restore the BTB *** together,DeHP exposure destroys immature testis blood-testis barrier(BTB)integrity through excessive ROSmediated autophagy.

关键词： Autophagy BTB DeHP immature testis Oxidative stress

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Unraveling brain aging through the lens of oral microbiota

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Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si wang weiqi Zhang Jing Qu guang-hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-hui Zhang Zhi-Lai Zhan guang-Lu Chang Yan Gao Xia Li wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:in this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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Achromatic super-oscillatory lenses with subwavelength focusing

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Light(Science & Applications) 2017年第1期6卷 615-622页

作者： guang hui Yuan edward TF Rogers Nikolay i Zheludev Centre for Disruptive Photonic Technologies The Photonic InstituteSchool of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore Optoelectronics Research Centre and Centre for Photonic Metamaterials University of SouthamptonHighfieldSouthampton SO171BJUK institute for Life Sciences University of SouthamptonHighfieldSouthampton SO171BJUK

Lenses are crucial to light-enabled *** lenses have been perfected to achieve near-diffraction-limited resolution and minimal chromatic ***,such lenses are bulky and cannot focus light into a hotspot smaller than a half-wavelength of *** filters,initially suggested by Toraldo di Francia,can overcome the resolution constraints of conventional lenses but are not intrinsically chromatically *** we report single-element planar lenses that not only deliver sub-wavelength focusing,thus beating the diffraction limit of conventional refractive lenses,but also focus light of different colors into the same *** the principle of super-oscillations,we designed and fabricated a range of binary dielectric and metallic lenses for visible and infrared parts of the spectrum that are manufactured on silicon wafers,silica substrates and optical fiber *** low-cost,compact lenses could be useful in mobile devices,data storage,surveillance,robotics,space applications,imaging,manufacturing with light and spatially resolved nonlinear microscopies.

关键词： achromatic super-oscillation super-resolution

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An efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying wang Kai Zhang Liping Ding Liyun wu Songfeng e Qian He Nanyang wang hui Zuo Zhengyang Zhou Feng Ding Yue Hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of electronic information and Artificial intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.in addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

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The Berry-esseen bound for identically distributed random variables by Stein method

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Applied Mathematics(A Journal of Chinese Universities) 2012年第4期27卷 455-461页

作者： CAi guang-hui Department of Mathematics Zhejiang Gongshang UniversityHangzhou 310018China

in this paper, we obtain the Berry-esseen bound for identically distributed random variables by Stein method. The results obtained generalize the results of Shao and Su （2006） and Stein （1986）.

关键词： Berry-esseen bound Stein method exchangeable pair.

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Nanozyme-mediated elemental biogeochemical cycling and environmental effects

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Science China earth Sciences 2021年第7期64卷 1015-1025页

作者： Zhi-Lai CHi guang-hui YU institute of Surface-earth System Science School of Earth System ScienceTianjin Key Laboratory of Earth Critical Zone Science and Sustainable Development in Bohai RimBohai Coastal Critical Zone National Observation and Research StationTianjin UniversityTianjin 300072China College of Resources&environmental Sciences Nanjing Agricultural UniversityNanjing 210095China

in earth systems,thousands of terragrams(Tg)(1 Tg=10^(12) g)of mineral nanoparticles move around *** mineral nanoparticles have exhibited unexpected intrinsic enzyme-like characteristics(so called“mineral nanozymes”),and are ubiquitously distributed in natural ecosystems such as the atmosphere,oceans,waters,and *** with natural enzymes,these mineral nanozymes have several advantages such as tunable catalytic efficiency and robustness to harsh conditions,e.g.,heat,acid,and alkaline *** mineral nanozymes are new products of multidisciplinary cross-cutting,they have been widely applied in various *** review,for the first time,systematically introduces the species and properties of mineral nanozymes in earth systems,discusses the critical roles played by nanozymes in environmental biogeochemical cycles,compiles the interfacial processes and mechanisms of mineral nanozymes,and provides an overview of the future prospects of mineral nanozymes.

关键词： Nanozymes Peroxidase Nanominerals Reactive oxygen species Biogeochemical cycles

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A new algorithm for computing the convex hull of a planar point set

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Journal of Zhejiang University-Science A(Applied Physics & engineering) 2007年第8期8卷 1210-1217页

作者： LiU guang-hui CHeN Chuan-bo College of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

when the edges of a convex polygon are traversed along one direction,the interior of the convex polygon is always on the same side of the edges. Based on this characteristic of convex polygons,a new algorithm for computing the convex hull of a simple polygon is proposed in this paper,which is then extended to a new algorithm for computing the convex hull of a planar point set. First,the extreme points of the planar point set are found,and the subsets of point candidate for vertex of the convex hull between extreme points are obtained. Then,the ordered convex hull point sequences between extreme points are constructed separately and concatenated by removing redundant extreme points to get the convex hull. The time complexity of the new planar convex hull algorithm is O(nlogh) ,which is equal to the time complexity of the best output-sensitive planar convex hull algorithms. Compared with the algorithm having the same complexity,the new algorithm is much faster.

关键词： Computational geometry Convex hull extreme points Ordered convex hull point sequence

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A Middle Triassic stem-neopterygian fish from China sheds new light on the peltopleuriform phylogeny and internal fertilization

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Science Bulletin 2016年第22期61卷 1766-1774页

作者： guang-hui Xu Xin-Ying Ma Key Laboratory of Vertebrate evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences

internal fertilization and viviparity are easily observed and well studied in living neopterygian fishes(14teleostean families), but they are difficult to identify in extinct taxa due to the limitation of the fossil record. The Peltopleuriformes from the Middle to Late Triassic of europe and South China are a stem group of Neopterygii that may have first evolved internal fertilization and viviparity in this clade because they show a highly modified anal fin in presumed males resembling the intromittent organ in living viviparous teleosts. Until recently, Peltopleurus lissocephalus and P. rugosus from the Ladinian/Anisian boundary(*242 Ma) of Monte San Giorgio area in Switzerland and italy represent the oldest record of Peltopleuriformes, and the phylogenetic interrelationships of this group remain controversial. Here, we report the discovery of a new peltopleuriform, Peltopleurus nitidus sp. nov., based on eleven well-preserved specimens from the early Middle Triassic(Pelsonian, Anisian, *244 Ma)of Luoping, eastern Yunnan, China. The discovery documents the oldest convincing peltopleuriform, extending the geological range of this clade by proximately two million years. Results of the phylogenetic analysis recover *** at the base of Peltopleuridae, and provide robust support for the sister-group relationships of Peltopleuridae with Thoracopteridae within the Peltopleuriformes. The male anal fin of P. nitidus shows a primitive condition unknown in other peltopleuriforms. Comparative studies of the male anal fin in P. nitidus and other peltopleuriforms shed new light on the internal fertilization in this group.

关键词： Sexual dimorphism Viviparity Peltopleuridae Thoracopteridae Triassic

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Modulation of Self-healing of Polyion Complex Hydrogel by ion-specific effects

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Chinese Journal of Chemical Physics 2016年第6期29卷 725-728,I0002页

作者： hui-li Liu guang-ming Liu guang-zhao Zhang DepartmentofChemicalPhysics HefeiNationalLaboratoryforPhysicalSciencesattheMicroscaleUniversityofScienceandTechnologyofChinaHefei230026China FacultyofMaterialsScienceandengineering SouthChinaUniversityofTechnologyGuangzhou510640China

we have prepared polyion complex （PiC） hydrogel consisting of poly（3-（methacryloylami no）propyl-trimethylamonium chloride） and poly（sodium p-styrenesulfonate） polyelectrolytes via a two-step polymerization procedure and have investigated specific ion effects on the self- healing of the PiC hydrogel. Our study demonstrates that the mechanical properties of the PiC hydrogel are strongly dependent on the type of the ions doped in the hydrogel. The ion-specific effects can be used to modulate the self-healing efficiency of the PiC hydrogel. As the doped anions change from kosmotrops to chaotropes, the self-healing efficiency of the PiC hydrogel increases. A more chaotropic anion has a stronger ability to break the ionic bonds formed within the hydrogel, leading to a higher efficiency during the healing.

关键词： Polyelectrolyte hydrogel Self-healing ion-specific effects Mechanical property Counterions

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