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The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing

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Asian Journal of Andrology 2013年第3期15卷 301-308页

作者： Alexander w wyatt Fan Mo Yuzhuo wang Colin C Collins vancouver Prostate Centre & Department of Urologic Sciences University of British Columbia Vancouver BC V6H 3Z6 Canada Department of experimental Therapeutics BC Cancer Agency Vancouver BC VSZ 1L3 Canada

Prostate cancer is a leading cause of global cancer-related death but attempts to improve diagnoses and develop novel therapies have been confounded by significant patient heterogeneity. In recent years, the application of next-generation sequencing to hundreds of prostate tumours has defined novel molecular subtypes and characterized extensive genomic aberration underlying disease initiation and progression. It is now clear that the heterogeneity observed in the clinic is underpinned by a molecular landscape rife with complexity, where genomic rearrangements and rare mutations combine to amplify transcriptomic diversity. This review dissects our current understanding of prostate cancer ＇omics＇, including the sentinel role of copy number variation, the growing spectrum of oncogenic fusion genes, the potential influence of chromothripsis, and breakthroughs in defining mutation-associated subtypes. Increasing evidence suggests that genomic lesions frequently converge on specific cellular functions and signalling pathways, yet recurrent gene aberration appears rare. Therefore, it is critical that we continue to define individual tumour genomes, especially in the context of their expressed transcriptome. Only through improved characterisation of tumour to tumour variability can we advance to an age of precision therapy and personalized oncology.

关键词： cancer sequencing copy number fusion gene genome genome rearrangement personalized oncology prostate cancer transcriptome

exergy analysis of R1234ze（Z） as high temperature heat pump working fluid with multi-stage compression

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Frontiers in energy 2017年第4期11卷 493-502页

作者： Bin HU Di wU L.w. wANG R.Z. wANG Institute of Refrigeration and Cryogenics Shanghai Jiao Tong University Shanghai 200240 China

In this paper, the simulation approach and exergy analysis of multi-stage compression high tempera- ture heat pump （HTHP） systems with R1234ze（Z） working fluid are conducted. Both the single-stage and multi-stage compression cycles are analyzed to compare the system performance with 120℃ pressurized hot water supply based upon waste heat recovery. The exergy destruction ratios of each component for different stage compression systems are compared. The results show that the exergy loss ratios of the compressor are bigger than that of the evaporator and the condenser for the single-stage compres- sion system. The multi-stage compression system has better energy and exergy etticiencies with the increase of compression stage number. Compared with the single- stage compression system, the coefficient of performance （COP） improvements of the two-stage and three-stage compression system are 9.1% and 14.6%, respectively. when the waste heat source temperature is 60℃, the exergy efficiencies increase about 6.9% and 11.8% for the two-stage and three-stage compression system respec- tively.

关键词： multi-stage compression high temperatureheat pump heat recovery exergy destruction,R1234ze(Z) working fluid

Stellar X-ray Sources in the Rosette Nebula

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Chinese Journal of Astronomy and Astrophysics 2004年第2期4卷 153-165页

作者： w.P.Chen P.S.Chiang J.Z.Li Institute of Astronomy National Central UniversityChung-Li 32054Taiwan National Astronomical Observatories Chinese Academy of SciencesBeijing 100012

we present optical photometric and spectroscopic studies of ROSAT X-ray stellar sources in the Rosette Nebula star-forming region. The brightest X-ray sources are either massive stars or active T Tauri stars associated with the open cluster NGC 2244, or are foreground stars. Some of the spectra of the young stars newly identified in the region are presented.

关键词： stars: early-type stars: pre-main sequence stars: formation HII regions

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Optical emission Analysis of Molecular Nitrogen by Using a Self-Resonating Dielectric Barrier Plasma Reactor

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Chinese Physics Letters 2012年第5期29卷 177-180页

作者： A.M.A.Amry V.J.Law I.w.Boyd Physics Department Faculty of ScienceTaif UniversityTaif 21974Kingdom of Saudi Arabia Department of electronic and electrical engineering University College London WC1E 7JEUnited Kingdom Melbourne Centre for Nanofabrication 151 Wellington RoadClaytonVic 3168Australia

we present a spectroscopic investigation of molecular nitrogen using a self-resonating co-axial dielectric barrier plasma *** properties of the nitrogen plasma generated were recorded as functions of radio frequency (27.12MHz),power (20-50 w) and gas pressure (0.1 60mbar). The intensity distribution of the transitional structure of the electronic bands C^(3)∏_(u) → B^(3)∏_(g),B^(2)Σ_(u)^(+) → X^(2)Σ_(g)^(+) and D^(2) ∏_(g) → A^(2)∏_(7u) was measured as a fimction of gas *** energy efficiency (total emitted intensity from the plasma It divided by total electric power to the discharge P),as high as 14% can be obtained at a dissipated electrical power level of 20 w and a pressure of 10mbar.

关键词： bands dielectric spectroscopic

State-feedback set stabilization of logical control networks with state-dependent delay

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Science China(Information Sciences) 2021年第6期64卷 233-235页

作者： Yating ZHeNG Haitao LI Jun-e FeNG School of Mathematics Shandong University School of Mathematics and Statistics Shandong Normal University

Dear editor,As an important mathematical model for the elucidation,analysis, and control of gene regulatory networks(GRNs),logical networks have attracted considerable attention from scientists in numerous fields of study. From a mathematical point of view, a logical network is parameter-free; thus, it can be utilized to reconstruct relatively large-scale *** studying logical networks, stabilization is highly critical as it has been widely used in maintaining human health and treating diseases [1, 2].

关键词： State-feedback set stabilization of logical control networks with state-dependent delay

western Sources of the China Trade from the 18^th and early 19^th Century

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Fudan Journal of the Humanities and Social Sciences 2011年第2期4卷 45-60页

作者： Paul A. van Dyke

Merchants from many countries went to China to trade in the eighteenth and early nineteenth century, including Portuguese, Spanish, english, French, Flemish, Armenians, Muslims, Parsees, Dutch, Danish, Austrians, Italians, and Americans. Many of these travelers kept detailed records of their encounters with China. Their documents can be very helpful in unraveling parts of the history that are silent in Chinese sources. These records can be divided into three basic groups, those of： east India companies, private traders, and private travelers. east India companies kept massive volumes of records and tended to be very systematic in the type of information they recorded from one year to the next. Private trade records were much less sophisticated than those of the companies, and often consisted of miscellaneous bundles of receipts, reports, letters, contracts, and journals. Private travel records were written by persons who sailed on merchant ships but were not necessarily merchants themselves. They recorded what they saw and heard along the way, which is information that often does appear in other records. Taken as a whole, company records, private trade records and private travel journals add much detail to the history of China that cannot be found in Chinese language sources.

关键词： China trade travel voyage eurpope United States

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BOOK ReVIew

International Journal of Digital earth 2008年第1期1卷 165-167,I0012页

作者： van Genderen, John

Geo-information science and digital earth,by Chen Shupeng,Science Press USA,Inc.,Monmouth Junction,New Jersey,2004,740 pp.,ISBN 1-880132-86-9 To my knowledge,this is the first book published which is specifically dedicated to the concept of‘Digital earth’.Geo-information science and digital earth is a compendium of the work carried out by the author over a ten-year period,from 1993 to 2003 and is a follow-up of the author’s previous book,The starting of remote sensing and GIS in China published in 1993(also published by Science Press).Together the two books form an almost complete history and overview of developments in earth observation and geo-information science in ***,this book on digital earth is much more global in its perspective and not limited to Chinese *** consists of a Preface,five main parts,a series of appendices,and more than 50 pages of color illustrations.

关键词： illustration Together starting

Orientation dependence of deformation twinning in Cu single crystals

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Journal of Materials Science & Technology 2018年第8期34卷 1364-1370页

作者： S.S.Cai X.w.Li N.R.Tao Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Department of Materials Physics and Chemistry School of Materials Science and Engineeringand Key LaboratoryforAnisotropy and Texture of Materials(Ministry of Education)Northeastern UniversityShenyang 110819China

Cu single crystals were subjected to dynamic compression plastic deformation to investigate orientation- dependent twinning. The experimental results showed that twinning is closely related to the ratio of the maximum Schmid factor for twinning partial （mt） to the maximum Schmid factor for perfect dislocation （ms）, i.e., mT/ms, rather than roT. The twin volume fraction VT increases with the rot/ms value and the most favorable orientation for twinning has the maximum roT/ms value （1.15）. The relationships of roT/ms with both effective stacking fault energy γeff and threshold stress for twinning TT were established for under- standing orientation-dependent twinning. Further insights into the orientation-dependent twinning and guidance for developing bulk high density nanotwinned materials are provided.

关键词： Orientation Twinning Cu Single crystal

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Teleportation of entangled States through Divorce of entangled Pair Mediated by a weak Coherent Field in a High-Q Cavity

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Chinese Physics Letters 2008年第7期25卷 2488-2491页

作者： w. B. Cardoso N. G. de Almeida Instituto de Ffsica Universidade Federal de Goiaes 74.001-970 Goiaenia (GO) Brazil Nucleo de Pesquisas em Fisica Universidade Catoelica de Goids 74.605-080 Goiania (GO) Brazil

we propose a scheme to partially teleport an unknown entangled atomic state. A high-Q cavity, supporting one mode of a weak coherent state, is needed to accomplish this process. By partial teleportation we mean that teleportation will occur by changing one of the partners of the entangled state to be teleported. The entangled state to be teleported is composed by one pair of particles, we called this surprising characteristic of maintaining the entanglement, even when one of the particle of the entangled pair being teleported is changed, of divorce of entangled states.

关键词： UNKNOwN ATOMIC STATe DeTeRMINISTIC QUANTUM TeLePORTATION PODOLSKY-ROSeN CHANNeLS SCHeMe SUPeRPOSITION OPeRATIONS LIGHT