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准静态地震力学

力学进展 1981年第2期 176-181页

作者： w.d.stuart 殷有泉

从连续体力学边值问题的角度来看,地震力学的课题可归结为研究:(1)断层带和围岩的本构特性(应力-应变规律)和几何性质, (2)在远处作用的边界冬件。在这里介绍的纯准静态表述中,还需要给出一个导致动态破裂的明确的失稳准则。现今比较一... 详细信息

从连续体力学边值问题的角度来看,地震力学的课题可归结为研究:(1)断层带和围岩的本构特性(应力-应变规律)和几何性质, (2)在远处作用的边界冬件。在这里介绍的纯准静态表述中,还需要给出一个导致动态破裂的明确的失稳准则。现今比较一致的意见是支持地震循环的概念,它大致包括下面几个阶段:(1)由于远处加载,

关键词：断层长度本构地震活动性孔隙流体断层带准静态

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帕克菲尔德断层模型的压磁场

世界地震译丛 1998年第3期29卷 62-71页

作者： w.d.stuart P.O.Banks Y.Sasai 刘述旺平建军河北省地震局

对适用于加州帕克菲尔德附近的圣安德烈斯断层上中强地震(M～6)的地震不稳定模型,计算了作为时间和地面位置函数的理论压磁场。不稳定模型对一个32a地震轮回的所有时段模拟断层滑动和应力,其中包括失稳(主震)滑动。当该断层的一个近乎... 详细信息

对适用于加州帕克菲尔德附近的圣安德烈斯断层上中强地震(M～6)的地震不稳定模型,计算了作为时间和地面位置函数的理论压磁场。不稳定模型对一个32a地震轮回的所有时段模拟断层滑动和应力,其中包括失稳(主震)滑动。当该断层的一个近乎闭锁的断块受周围非地震滑动的作用变得充分承载以致于达到快速破裂的条件时,就会发生主震滑动。使用基于类似于应变核的压磁核的解析法,直接由断层滑动计算了压磁场。在地震间隔期间,闭锁断块上应力集中的增强将伴随着磁异常场的缓慢演变,在临近震中地区导致约±2nT的最大积累变化。主震滑动大约消除地震间隔期间所积累变化的一半,快速震后松驰消除剩余的大部分。地震间隔期间在闭锁断层附近一些测点上,场的变化速率逐渐增加,而另一些测点则逐渐减小。这种效应在主震前最后3～4a最显著,并且在适当选取的一些成对测点上,造成差值场时序趋势反向。如果这样的反向可与其他源所引起的地磁变化相区别的话,那么这种反向将构成临近破裂的前兆指标。

关键词：地震断层模型压磁场帕克菲尔德

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse w.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead department of Surgery University of TorontoTorontoONCanada donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Theoretical study and optimization of a high power mid-infrared erbium-doped ZBLAN fibre laser

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Chinese Physics B 2011年第3期20卷 239-246页

作者：李剑峰 stuart d.Jackson School of Optoelectronic Information University of Electronic Science and Technology of China Institute of Photonics and Optical Science School of PhysicsUniversity of Sydney

Based on the rate equations describing the erbium-doped fluoride glass （ZBLAN） fibre lasers with different pumping configurations being taken into account, this paper presents theoretical calculations related to the dynamic population density and the operation performance of a high power mid-infrared all-fibre erbium-doped ZBLAN fibre laser. It shows that the ground-state absorption, excited-state absorption and energy-transfer-upconversion processes co-exist and produce a population balance, causing the laser to operate stably at a continuous wave state. A good agreement between the theoretical results and recent experimental measurement is obtained. Furthermore, the laser structure parameters including fibre length, reflectance of output fibre Bragg grating and pumping configurations are quantitatively optimised to achieve the best performance. The results show, as expected, that the slope efficiency of the fibre laser can be improved significantly through optimisation, which then provides an important guide for the design of high-performance mid-infrared erbium-doped ZBLAN fibre lasers.

关键词： Lerbium-doped fibre laser mid-infrared fibre laser ZBLAN fibre rate equations