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3层呼气相cT:不足以评估囊性纤维化病人的空气潴留?

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国际医学放射学杂志 2012年第3期 275-275页

作者： M.Loeve M.de Bruijne I.c.j.Hartmann M.van Straten w.c.j.hop H.A.w.M.Tiddens 郝彩仙 Department of Pediatric Pulmonology & Allergology Erasmus Medical Center-Sophia Children's HospitalDr Molewaterplein 603015 GJ Rotterdamthe Netherlands

目的应用现有的评分系统和一个新的量化评分系统评估cT层数对囊性纤维化(cF)病人空气潴留(TA)的评价作用,并通过横向和纵向研究,比较cT和肺功能测试(PFT)对TA的评估作用。材料与方法本次初步研究获机构审查委员会批准,20例受试病人,年龄... 详细信息

目的应用现有的评分系统和一个新的量化评分系统评估cT层数对囊性纤维化(cF)病人空气潴留(TA)的评价作用,并通过横向和纵向研究,比较cT和肺功能测试(PFT)对TA的评估作用。材料与方法本次初步研究获机构审查委员会批准,20例受试病人,年龄6～20岁(女12例,男

关键词：呼气相 PFT 病人 TA cT 空气潴留

儿童颅缝早闭综合征脑白质微结构完整性的评估:扩散张量成像研究

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国际医学放射学杂志 2012年第1期 75-75页

作者： j.M.G.Florisson j.Dudink I.V.Koning w.c.j.hop M.L.c.van Veelen I.M.j.Mathijssen 管宇 Department of Plastic Reconstructiveand Hand SurgeryCraniofacial CenterErasmus Medical CenterSophia Children's HospitalPO Box 2040Room Ee 913000 CA Rotterdamthe Netherlands

目的评估复杂性颅缝早闭综合征病人是否存在脑白质微结构的改变。材料与方法本项研究获医学伦理委员会批准。病人的父母或监护人在成像前均签署知情同意

关键词：扩散张量颅缝早闭脑白质综合征综合病症儿童

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn j.w.So Konstantin Feinberg Marina Manoraj jenny cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Status and prospects for symmetric organic redox flow batteries

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journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

A sand production prediction model for weak sandstone reservoir in Kazakhstan

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journal of Rock Mechanics and Geotechnical Engineering 2019年第4期11卷 760-769页

作者： Ainash Shabdirova Nguyen hop Minh Yong Zhao School of Engineering Nazarbayev UniversityAstanaKazakhstan Fulbright University Vietnam Ho Chi Minh CityViet Nam

weakly consolidated reservoirs are prone to sand production problem,which can lead to equipment damages and environmental *** conditions for sand production depend on stresses and properties of rock and *** sand volume estimation is,however,still a challenging issue,especially for reservoirs in weak *** weak reservoirs containing viscous or heavy oil are mainly discovered in shallow depths in Kazakhstan,with moderate temperature and *** prediction models developed for open-hole completions where the reservoir materials usually possess certain strength are not applicable for the local reservoirs where the materials are significantly weaker even if casing is used to support the wellbore with oil produced through the perforation *** this context,a prediction model was proposed where the volume of the produced sand was estimated as the volume of the plastic zone of the failed materials surrounding the perforation *** model assumes an evolving truncated conical shape for the damage zone and takes into account stress distributions and shear failure in this ***,the proposed model was used to estimate sand volumes in 20 wells during oil production with sequential increase of flow *** predictions match well with the measured sand volumes in a local oil ***,a sensitivity analysis was conducted on the model *** shows that the permeability of the plastic zone was the most significant controlling factor in the prediction results.

关键词： Sand production Shear failure Perforation tunnel Plastic zone weak sandstone

Role of plastic zone porosity and permeability in sand production in weak sandstone reservoirs

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Underground Space 2022年第6期7卷 1003-1020页

作者： Ainash Shabdirova Nguyen hop Minh Yong Zhao School of Engineering and Digital Sciences Nazarbayev UniversityNur-SultanKazakhstan Fulbright University Vietnam Ho Chi Minh CityViet Nam

Sand production is often characterized as a two-stage process,in which material failure occurs near the cavity,leading to the formation of a plastic zone,from which particles are detached and transported out because of continuous hydrodynamic erosion under the effects of the produced fluid *** plastic zone porosity is affected by coupled processes,while the plastic zone permeability has a significant impact on the performance of sand production prediction,especially in weak sandstone ***-scale sand production experiments were conducted using a customized high-pressure consolidation *** results show that specific stress-fluid pressure conditions may create a plastic zone around a hole,which has lower permeability than the intact *** plastic zone comprises two subzones:a high-permeability shear band zone and a low-permeability compaction *** sand production,sand migrates from the compaction zone through the shear band zone to the perforation ***,sand production is associated with the increased permeability and porosity in the compaction *** sand prediction models were modified according to the new findings,resulting in a modified model with improved *** modified model was validated using the sanding data from a weak sandstone reservoir in Kazakhstan.

关键词： Sand production Plastic zone weak sandstone Porosity Permeability

An integrated laboratory experiment of realistic diagenesis,perforation and sand production using a large artificial sandstone specimen

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journal of Rock Mechanics and Geotechnical Engineering 2021年第1期13卷 154-166页

作者： Ashirgul Kozhagulova Ainash Shabdirova Nguyen hop Minh Yong Zhao School of Engineering and Digital Sciences Nazarbayev University53 Kabanbay Batyr AvenueNur-SultanKazakhstan Fulbright University Vietnam 105 Ton Dat TienHo Chi Minh CityViet Nam

Sand production is,a challenging issue in petroleum industry,mainly associated with weak unconsolidated formations.A novel testing procedure and a new apparatus were developed to conduct an integrated experiment of diagenesis,perforation and sand production on a single large cylindrical artificial sandstone specimen,where solid and fluid pressures can be independently controlled such that realistic reservoir historical conditions can be well simulated in the *** injection can be performed in both radial and vertical directions,where both single-and two-phase flows can be implemented for study of sand production behaviors at different reservoir’s maturity *** equipment consists of an intensive instrumentation system to monitor pressures,displacements and material states *** produced sand particles were filtered and monitored in real-time for the study of time-dependent *** experimental results showed similar patterns to that observed in the field and provided valuable insight for the development of prediction methods for sand production of similar materials.

关键词： Sand production Equipment development Geotechnical testing weak sandstone formations New testing procedure

Laser additive manufacturing of biodegradable Mg-based alloys for biomedical applications: A review

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journal of Magnesium and Alloys 2022年第4期10卷 915-937页

作者： c.L.wu w.j.Xie H.c.Man Department of Industrial and Systems Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Metallic implants are widely used in internal fixation of bone fracture in surgical *** are mainly used for providing mechanical support and stability during bone reunion,which usually takes a few months to *** implants made of stainless steels,Ti-based alloys and cocrMo alloys have been widely used for orthopedic reconstruction due to their high strength and high corrosion *** metallic implants will remain permanently inside the body after implantation,and a second surgery after bone healing is needed because the long-term presence of implant will lead to various *** implant removal surgery not only incurs expenditure,but also risk and psychological *** a consequence,studies on the development of biodegradable implants,which would degrade and disappear in vivo after bone reunion is completed,have drawn researchers’*** this connection,Mg-based alloys have shown great potentials as promising implant materials mainly due to their low density,inherent biocompatibility,biodegradability and mechanical properties close to those of ***,the high degradation rate of Mg-based implants in vivo is the biggest hurdle to *** from materials selection,a fixation implant is ideally tailor-made in size and shape for an individual case,for best surgical ***,laser additive manufacturing(LAM),with the advent of sophisticated laser systems and software,is an ideal process to solve these *** this paper,we reviewed the progress in LAM of biodegradable Mg-based alloys for biomedical *** effect of powder properties and laser processing parameter on the formability and quality was thoroughly *** microstructure,phase constituents and metallurgical defects formed in the LAMed samples were *** mechanical properties,corrosion resistance,biocompatibility and antibacterial properties of the LAMed samples were summarized and compared with samples fabricated by

关键词： Laser additive manufacturing Magnesium alloys Implant Biomedical applications Mechanical properties Biodegradability

One-step multi-compositional oxidation of YSi alloy:Experiments and ab initio computation

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journal of Materials Science & Technology 2023年第27期158卷 253-262页

作者： w.j.wang j.c.Luo L.chen G.j.Yang State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China Xi’an jiaotong University Suzhou Institute Suzhou 215123China

YSi alloy is a promising candidate as oxidation resistant coatings for both the bond coat of environmental barrier coatings(EBcs)and anti-ablation coatings at a high temperature of∼1300℃.In this study,a one-step multi-compositional oxidation by rapid heating oxidation mode is proposed to reduce the oxidation rate by 3.6 times compared to conventional slow heating oxidation *** show that preferentially formed Y_(2)O_(3) oxide initiates a multi-step oxidation,produces a cracking and porous oxides,and thereby resulting in a fast oxidation with *** one-step multi-compositional oxidation with a compact and dense Y_(2)Si_(2)O_(7)scale contributes to the much better oxidation resistance for rapid heating oxidation mode of YSi *** stable formation of Y_(2)Si_(2)O_(7)scale is comprehensively understood by the energy barrier,charge density and electronic level based on density functional *** study demonstrates a promising application of YSi alloy by rapid heating oxidation mode.

关键词： YSi alloy One-step oxidation Multi-compositional scale Y_(2)Si_(2)O_(7) Energy barrier