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剪切波弹性成像对甲状腺滤泡性病变的术前危险分级:诊断的准确性和最佳测量层面

国际医学放射学杂志 2016年第1期 72-73页

作者： A.E.Samir M.Dhyani A.Anvari J.Prescott E.F.Halpern w.c.faquin 陈文萍 Department of Radiology Massachusetts General Hospital Harvard Medical School

摘要目的评估剪切波弹性成像对甲状腺滤泡性病变恶性度的诊断准确性,并确定最佳的剪切波弹性成像测量平面。材料与方法本研究经伦理委员会批准,符合HIPAA。受试者为术前细针抽吸活检报告诊断为"意义不明的细胞非典型病变"、"可疑滤泡性... 详细信息

摘要目的评估剪切波弹性成像对甲状腺滤泡性病变恶性度的诊断准确性,并确定最佳的剪切波弹性成像测量平面。材料与方法本研究经伦理委员会批准,符合HIPAA。受试者为术前细针抽吸活检报告诊断为"意义不明的细胞非典型病变"、"可疑滤泡性病变"、"可疑滤泡性肿瘤"或"可疑嗜酸细胞瘤",受试者均签署知情同意书并接受常规超声检查、多普勒评价和剪切波弹性成像。甲状腺恶性肿瘤的预测值参考手术病理结果。结果 35例(男12例,女23例)经细针抽

关键词：剪切波弹性成像滤泡性病变甲状腺滤泡甲状腺泡术前性病性传播疾病传染病

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Marigold(Tagetes erecta): The Potential Value in the Phytoremediation of chromium

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Pedosphere 2017年第3期27卷 559-568页

作者： Lívia c.cOELHO Ana Rosa R.BASTOS Paulo J.PINHO Guilherme A.SOUZA Janice G.cARVALHO Viviane A.T.cOELHO Luiz carlos A.OLIVEIRA Rimena R.DOMINGUES Valdemar faquin Soil Science Department Federal University of Lavras chemistry Department Federal University of Minas Gerais

Environmental pollution with chromium （cr） is harmful to humans, animals and plants, while in plants it causes diminished growth, anatomical alterations and death. In the present study, the potential value of marigold （Tagetes erecta） in the phytoremediation of cr has been investigated. The randomized experimental design involved the exposure of plants to nutrient solutions containing 0.00, 0.04, 0.08, 0.12, 0.16 or 0.24 mmol L-1 cr（III）. chromium toxicity was observed at cr（III） concentrations ≥ 0.12 mmol L-1 as demonstrated by diminished growth of the aerial parts and reduced density of the root system. Increasing cr（III） concentrations in the nutrient solution resulted in a higher bioaccumulation of total cr in the tissues, although translocation from roots to aerial parts was not efficient （maximum value of 25% at 0.12 mmol L-1 cr（III））. The cr bioaccumulation was up to 11-fold greater in roots than in the aerial parts. Tagetes erecta exhibited leaf plasticity when exposed to cr, indicating the existence of a tolerance mechanism to cr in this species. chromium caused a reduction in xilem vases, resulting in a plastic effect in T. erecta leaves that increased the metal tolerance in culture solution. Tagetes spp. are potential cr hyperaccumulators; at cr（III） concentrations up to 0.12 mmol L-1, the plants accumulated levels above that proposed for hyperaccumulators and still maintained a considerable growth and even flourished. However, this study was conducted in nutrient solution, and studies on species confirmation as cr hyperaccumulator should be conducted in soils for further clarification.

关键词： anatomical alterations heavy metal hyperaccumulor leaf anatomy toxicity

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活化型NOcTcH1弥漫着色与NOcTcH1基因突变状态相关且与腺样囊性癌预后差密切相关

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临床与实验病理学杂志 2018年第10期34卷 1137-1137页

作者： Sajed D P faquin w c carey c 王婷余英豪解放军福州总医院病理科福州350025

腺样囊性癌是一种罕见的唾液腺来源的癌,多发生于头颈部、上呼吸道及乳腺。肿瘤虽生长缓慢,但多侵犯神经并远处转移致预后差。由于腺样囊性癌中常存在NOTcH1基因突变,为进一步证实免疫组化NOTcH1染色能检测腺样囊性癌伴NOTcH1突变,作者... 详细信息

腺样囊性癌是一种罕见的唾液腺来源的癌,多发生于头颈部、上呼吸道及乳腺。肿瘤虽生长缓慢,但多侵犯神经并远处转移致预后差。由于腺样囊性癌中常存在NOTcH1基因突变,为进一步证实免疫组化NOTcH1染色能检测腺样囊性癌伴NOTcH1突变,作者将173例患者的197次活检确诊为腺样囊性癌病例行活化型NOTcH1(NIcD1)免疫组化染色并分析。

关键词：腺样囊性癌基因突变预后差活化 NOTcH1 免疫组化染色状态着色

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滤泡性甲状腺癌皮肤转移:4例病例报道及文献回顾

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 26-27页

作者： Quinn T.R. Duncan L.M. Zembowicz A. faquin w.c. 李政霄 Dr. Pathology Services Inc. 640 Memorial Drive Cambridge MA 02139 United States

cutaneous metastasis of follicular carcinoma of the thyroid is very rare, and when it occurs, can exhibit a variety of histologic appearances. The 4 cases presented here were identified from the surgical pathology files of the James Homer wright Laboratories of Pathology at the Massachusetts General Hospital (MGH). The cases consisted of 4 patients, 3 men and 1 woman, aged 52 to 75 years, with cutaneousmetastasis of follicular thyroid carcinoma. The tumors include a conventional follicular carcinoma, a follicular carcinoma with anaplastic transformation following initial metastasis, the first reported cutaneous metastases of a follicular carcinoma with oncocytic features (Hü rthle cell carcinoma), and a follicular carcinoma with a prominent insular carcinoma component. All 4 tumors were widely invasive within the thyroid gland. Sites of dermal metastases included a post- thyroidectomy scar, scalp, and sacral skin. Three metastases retained the morphologic and immunocytochemical features of the primary thyroid tumors. However, in one case there was high- grade transformation to anaplastic carcinoma following treatment of a sacral metastasis with accompanying loss of the characteristic immunophenotype of follicular thyroid carcinoma. Awareness of the varied morphologies of metastatic follicular thyroid carcinoma to the skin may prompt immunohistochemical analysis and the request for a complete clinical history, ultimately preventing misdiagnosis.

关键词：滤泡性甲状腺癌滤泡性癌文献回顾甲状腺肿瘤首例报道甲状腺切除术后瘢痕瘤细胞免疫细胞化学麻萨诸塞

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