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Chinese Chemical Letters 2024年第5期35卷 207-212页

作者： Xiaoyao Ma Jinling Zhang ge fang he Gao Jie Gao Li fu Yuanyuan Hou Gang Bai State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300000China College of Life health Dalian UniversityDalian 116622China Dalian fusheng pharmaceutical Co. Ltd.Dalian 116000China

The clinical benefit of combination therapy is significant,but it is not easy to define the mechanism of complexity and *** studies illustrate that phillygenin(phi)binds in the allosteric inhibit pocket of protein kinase B(AKT),and swertiamarin(Swe)acts on the pleckstrin homology(pH)domain of ***,the combined synergistic effect of relieving the inflammatory response has yet to be *** on high sensitivity,specificity and fast-responsibility fluorescent sensors,the förster resonance energy transfer(fRET)technique offers a route to provide clear insights into physiological and pathological *** the study,molecular docking,the fluorescent probes of phi and Swe for fRET were designed and *** analysis shown that Swe and phi concurrently acted on the pH domain and allosterically inhibited pocket of AKT,*** combination of Swe and phi significantly increased the heat stability of AKT and decreased protease-induced *** lipopolysaccharides(LpS)-induced mice and cells,the combination arrested AKT activation,nuclear factor kappa-B(Nf-κB)phosphorylation,and the expression of tumor necrosis factor-α(TNf-α),interleukin(IL)-6 and *** conclusion,fRET revealed phi and Swe concurrently targeted AKT on different domains and the combination of phi and Swe enhanced the anti-inflammatory effect.

关键词： fRET Swertiamarin phillygenin AKT Anti-inflammation Combinatorial drug

f?rster resonance energy transfer reveals phillygenin and swertiamarin concurrently target AKT on different binding domains to increase the anti-inflammatory effect

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Chinese Chemical Letters 2024年第5期 233-238页

作者： Xiaoyao Ma Jinling Zhang ge fang he Gao Jie Gao Li fu Yuanyuan Hou Gang Bai State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University College of Life health Dalian University Dalian fusheng pharmaceutical Co. Ltd.

The clinical benefit of combination therapy is significant, but it is not easy to define the mechanism of complexity and diversity. previous studies illustrate that phillygenin(phi) binds in the allosteric inhibit pocket of protein kinase B(AKT), and swertiamarin(Swe) acts on the pleckstrin homology(pH) domain of AKT. However, the combined synergistic effect of relieving the inflammatory response has yet to be elucidated. Based on high sensitivity, specificity and fast-responsibility fluorescent sensors, the f?rster resonance energy transfer(fRET) technique offers a route to provide clear insights into physiological and pathological processes. In the study, molecular docking, the fluorescent probes of phi and Swe for fRET were designed and synthesized. fRET analysis shown that Swe and phi concurrently acted on the pH domain and allosterically inhibited pocket of AKT, respectively. The combination of Swe and phi significantly increased the heat stability of AKT and decreased protease-induced degeneration. In lipopolysaccharides(LpS)-induced mice and cells, the combination arrested AKT activation, nuclear factor kappa-B(Nf-κB)phosphorylation, and the expression of tumor necrosis factor-α(TNf-α), interleukin(IL)-6 and IL-8. In conclusion, fRET revealed phi and Swe concurrently targeted AKT on different domains and the combination of phi and Swe enhanced the anti-inflammatory effect.

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Can near-to-mid Infrared Spectral Energy Distribution Quantitatively Trace protoplanetary Disk Evolution?

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Research in Astronomy and Astrophysics 2024年第7期24卷 34-46页

作者： Mingchao Liu Jinhua he Zhen Guo Jixing ge Yuping Tang Yunnan Observatories Chinese Academy of SciencesKunming 650216China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Departamento de Astronomía Universidad de ChileLas Condes7591245 SantiagoChile Instituto de física y Astronomía Universidad de Valparaísoave.Gran Bretaña1111Casilla 5030ValparaísoChile Centre for Astrophysics Research University of HertfordshireHatfield AL109ABUK Millennium Institute of Astrophysics Nuncio Monseñor Sotero Sanz 100Of.104ProvidenciaSantiagoChile Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Xinjiang Key Laboratory of Radio Astrophysics Urumqi 830011China Shanghai Key Lab for Astrophysics Shanghai Normal UniversityShanghai 200234China

Infrared(IR)spectral energy distribution(SED)is the major tracer of protoplanetary *** was recently proposed to use the near-to-mid IR(or K-24)SED slopeαdefined between 2 and 24μm as a potential quantitative tracer of disk *** critically examine the viability of this idea and confront it with additional statistics of IR luminosities and SED *** point out that,because the statistical properties of most of the complicated physical factors involved in disk evolution are still poorly understood in a quantitative sense,the only viable way is to assume them to be random so that an idealized“average disk”can be defined,which allows theαhistogram to trace its *** confirm that the statistics of the zeroth order(luminosity),first order(slopeα),and second order characteristics(concavity)of the observed K-24 SEDs indeed carry useful information upon the evolutionary processes of the“average disk”.we also stress that intrinsic diversities in K-24 SED shapes and luminosities are always large at the level of individual stars so that the application of the evolutionary path of the“average disk”to individual stars must be done with *** data of most curves in plots are provided on GitHub(Disk-age package https://***/starage/disk-age/).

关键词： stars formation-stars pre-main sequence-stars protostars-infrared stars-protoplanetary disks

Lifetime-tunable circularly polarized luminescent system based on triplet-to-singlet förster resonance energy transfer

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Science China Chemistry 2024年第9期67卷 2918-2922页

作者： Zhenyi he Zizhao Huang Xiang Ma Key Laboratory for Advanced Materials and feringa Nobel prize Scientist Joint Research Center Institute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

Circularly polarized luminescence(CpL)materials have received widespread attention due to their remarkable performance and broad ***,current CpL material research primarily focuses on tunable color,intensity,and *** CpL with adjustable lifetime remains a significant ***,a series of CpL polymeric materials with tunable lifetime were obtained by employing phosphorescent terephthalic acid and chiral organic small molecule R/S-BNAf(a luminescent binaphthol derivative)to copolymerize with acrylamide in different *** was verified that this performance results from the different energy transfer efficiency between luminophores with varying ratios of the monomers for *** strategy to realize CpL with tunable lifetime by modulating the energy transfer efficiency will provide a new perspective to broaden the applications of CpL materials.

关键词： circularly polarized luminescence tunable lifetime förster resonance energy transfer room temperature phosphorescence

Copper-mediated assembly of SO_(2)f group via radical fluorine-atom transfer strategy

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Chinese Chemical Letters 2024年第9期35卷 4-5页

作者： Yu-Yu Tan Lin-heng he wei-Min he School of Electrical Engineering University of South ChinaHengyang 421001China

Because of the unique reactivity of sulfonyl fluoride(SO_(2)f)group,such compound has found increasing applications in the areas of organic synthesis,new drug development,pesticide,material science and click chemistry,*** is of current interest to develop novel strategies and methods for the facile preparation of sulfonyl fluorides in a green and highly efficient manner[1,2].Although the traditional approach for the synthesis of sulfonyl fluorides relies on the nucleophilic substitution of fluoride atom with sulfonyl chlorides.

关键词： fluoride synthesis fluorine

Establishment of a three-dimensional particle library for graded crushed stone based on a new aggregate morphology characterization method

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 117-130页

作者： Haitao ge Aimin Sha Zhenqiang Han School of future Transportation Chang'an UniversityXi'an 710064China University of Strasbourg INSA StrasbourgCNRSICubeUMR 7357Strasbourg F-67000France School of Highway Chang'an UniversityXi'an 710064China Key Laboratory for Special Area Highway Engineering of Ministry of Education Chang'an UniversityXi'an 710064China

The morphology of graded crushed stone(GCS)particles has an essential influence on the performance of aggregate *** impact of particle shape is a comprehensive effect that cannot be considered separately,leading to difficulties in establishing the relationship between the mixture properties and the aggregate morphology by using laboratory *** discrete element method(DEM)is an effective way widely adopted to reconstruct the morphology of particles and simulate performance tests of granular ***,selecting limited particles characterizing a real particle-assembly for simulation is still a challenge in current research due to the inherent rich variability of particle *** this study,based on the acquisition of three-dimensional(3D)aggregate shapes by using laser scanning,ellipsoid index(EDI)translating the particle shape as a function of surface area,volume,and contour length is proposed to comprehensively evaluate aggregate ***,a particle library capable of characterizing aggregate morphology distribution is established based on the statistics of the corresponding morphological characteristics of particle *** model reliability is validated by carrying out a series of experimental and numerical penetration tests with nine different *** established particle library can be used to model aggregate mixtures and the proposed simulation framework is promising for optimizing the mixture gradation design numerically.

关键词： particle library Discrete element method 3D laser scanning Coarse aggregate Morphology characterization Gradation design

Molecular packing tuning via chlorinated end group enables efficient binary organic solar cells over 18.5%

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Carbon Energy 2024年第3期6卷 196-203页

作者： Yafeng Li Zhenyu Chen Xingzheng Yan Ziyi ge Zhejiang Business Technology Institute NingboZhejiangChina Zhejiang Engineering Research Center for Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboZhejiangChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina

Designing novel nonfullerene acceptors(NfAs)is of vital importance for the development of organic solar cells(OSC).Modification on the side chain and end group are two powerful tools to construct efficient ***,based on the high-performance L8BO,we selected 3-ethylheptyl to substitute the inner chain of 2-ethylhexyl,obtaining the backbone of *** we introduced different halogen atoms of fluorine and chlorine on 2-(3-oxo-2,3-dihydro-1Hinden-1-ylidene)malononitrile end group(EG)to construct efficient NfAs named BON3-f and BON3-Cl,*** donor D18 was chosen to combine with two novel NfAs to construct OSC ***,D18:BON3-Cl-based device shows a remarkable power conversion efficiency(pCE)of 18.57%,with a high open-circuit voltage(V_(OC))of 0.907 V and an excellent fill factor(ff)of 80.44%,which is one of the highest binary pCE of devices based on D18 as the ***,BON3-f-based device shows a relatively lower pCE of 17.79%with a decreased ff of 79.05%.The better photovoltaic performance is mainly attributed to the red-shifted absorption,higher electron and hole mobilities,reduced charge recombination,and enhanced molecular packing in the D18:BON3-Cl ***,we performed stability tests on two binary systems;the D18:BON3-Cl and D18:BON3-f devices maintain 88.1%and 85.5%of their initial efficiencies after 169 h of storage at 85°C in an N2-filled glove box,*** work demonstrates the importance of selecting halogen atoms on EG and provides an efficient binary system of D18:BON3-Cl for further improvement of pCE.

关键词： binary organic solar cell chlorinated end group molecular packing

End-group modulation of phenazine based non-fullerene acceptors for efficient organic solar cells with high open-circuit voltage

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Journal of Energy Chemistry 2024年第1期88卷 461-468,I0011页

作者： Yahui Zhang Yafeng Li Ruixiang peng Yi Qiu Jingyu Shi Zhenyu Chen Jinfeng ge Cuifen Zhang Zheng Tang Ziyi ge School of Materials Science and Engineering Shanghai UniversityShanghai 200444China Zhejiang Business Technology Institute Ningbo 315012ZhejiangChina Zhejiang provincial Engineering Research Center of Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201ZhejiangChina Center for Advanced Low-dimension Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China

phenazine-based non-fullerene acceptors(NfAs)have demonstrated great potential in improving the power conversion efficiency(pCE)of organic solar cells(OSCs).Halogenation is known to be an effective strategy for increasing optical absorption,refining energy levels,and improving molecular packing in organic ***,a series of NfAs(pz IC-4H,pz IC-4f,pz IC-4Cl,pz IC-2Br)with phenazine as the central core and with/without halogen-substituted(dicyanomethylidene)-indan-1-one(IC)as the electron-accepting end group were synthesized,and the effect of end group matched phenazine central unit on the photovoltaic performance was systematically *** photophysical and morphological analyses revealed that the pM6:pz IC-4f blend involves efficient exciton dissociation,higher charge collection and transfer rates,better crystallinity,and optimal phase ***,OSCs based on pM6:pz IC-4f as the active layer exhibited a pCE of 16.48%with an open circuit voltage(Voc)and energy loss of 0.880 V and 0.53 e V,***,this work demonstrated a promising approach by designing phenazine-based NfAs for achieving high-performance OSCs.

关键词： Organic solar cells Non-fullerene acceptor phenazine Central core End group

Target Controllability of Multi-Layer Networks with High-Dimensional Nodes

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1999-2010页

作者： Lifu wang Zhaofei Li ge Guo Zhi Kong School of Control Engineering Northeastern University at QinhuangdaoQinhuangdao 066004China

This paper studies the target controllability of multilayer complex networked systems,in which the nodes are highdimensional linear time invariant(LTI)dynamical systems,and the network topology is directed and *** influence of inter-layer couplings on the target controllability of multi-layer networks is *** is found that even if there exists a layer which is not target controllable,the entire multi-layer network can still be target controllable due to the inter-layer *** the multi-layer networks with general structure,a necessary and sufficient condition for target controllability is given by establishing the relationship between uncontrollable subspace and output *** the derived condition,it can be found that the system may be target controllable even if it is not state *** this basis,two corollaries are derived,which clarify the relationship between target controllability,state controllability and output *** the multi-layer networks where the inter-layer couplings are directed chains and directed stars,sufficient conditions for target controllability of networked systems are given,*** conditions are easier to verify than the classic criterion.

关键词： High-dimensional nodes inter-layer couplings multi-layer networks target controllability

A seismic elastic moduli module for the measurements of low-frequency wave dispersion and attenuation of fluid-saturated rocks under different pressures

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petroleum Science 2024年第1期21卷 162-181页

作者： Yan-Xiao he Shang-Xu wang gen-Yang Tang Chao Sun Hong-Bing Li San-Yi Yuan Xian wei Li-Deng Gan Xiao-feng Dai Qiang ge peng-peng wei Hui-Qing Zhang National Key Laboratory of petroleum Resources and Engineering CNPC Key Lab of Geophysical ExplorationCollege of GeophysicsChina University of Petroleum(Beijing)Beijing102249China School of Resources and geosciences China University of Mining and TechnologyXuzhou221116JiangsuChina Research Institute of petroleum Exploration and Development CNPCBeijing100083China Beijing Vocational College of Labour and Social Security Beijing100029China petroChina Dagang Oilfield Exploration and Development Research Institute CNPCTianjin300280China

Knowledge about the seismic elastic modulus dispersion,and associated attenuation,in fluid-saturated rocks is essential for better interpretation of seismic observations taken as part of hydrocarbon identification and time-lapse seismic surveillance of both conventional and unconventional reservoir and overburden performances.A Seismic Elastic Moduli Module has been developed,based on the forced-oscillations method,to experimentally investigate the frequency dependence of Young's modulus and poisson's ratio,as well as the inferred attenuation,of cylindrical samples under different confining pressure *** with three standard samples showed that the measured elastic moduli were consistent with the published data,indicating that the new apparatus can operate reliably over a wide frequency range of f∈[1-2000,10^(6)]*** Young's modulus and poisson's ratio of the shale and the tight sandstone samples were measured under axial stress oscillations to assess the frequency-and pressure-dependent *** dry condition,both samples appear to be nearly frequency independent,with weak pressure dependence for the shale and significant pressure dependence for the *** particular,it was found that the tight sandstone with complex pore microstructure exhibited apparent dispersion and attenuation under brine or glycerin saturation conditions,the levels of which were strongly influenced by the increased effective *** addition,the measured Young's moduli results were compared with the theoretical predictions from a scaled poroelastic model with a reasonably good agreement,revealing that the combined fluid flow mechanisms at both mesoscopic and microscopic scales possibly responsible for the measured dispersion.

关键词： Low-frequency measurements Dispersion and attenuation Rock physics fluid flow