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A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

An approach for automatic sleep stage scoring and apnea-hypopnea detection

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Frontiers of Computer Science 2012年第2期6卷 230-241页

作者： TimSCHLǔter StefanCONRAD InstituteofComputerScience HeinrichHeineUniversity40225DtisseldorfGermany

In this article we present an application of data mining to the medical domain sleep research, an approach for automatic sleep stage scoring and apnea-hypopnea detec- tion. By several combined techniques （Fourier and wavelet transform, derivative dynamic time warping, and waveform recognition）, our approach extracts meaningful features （fre- quencies and special patterns like k-complexes and sleep spindles） from physiological recordings containing EEG, ECG, EOG and EMG data. based on these pieces of in- formation, an ensemble of decision trees is constructed us- ing the principle of bagging, which classifies sleep epochs in their sleep stages according to the rules by Rechtschaf- fen and Kales and annotates occurrences of apnea-hypopnea （total or partial cessation of respiration）. After that, case- based reasoning is applied in order to improve quality. we tested and evaluated our approach on several large public databases from Physiobank, which showed an overall accu- racy of 95.2% for sleep stage scoring and 94.5% for classify- ing minutes as apneic or non-apneic.

关键词： time series data processing signal processing,feature extraction pattern classification biomedical signalprocessing sleep

Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

An L-band emitter with quantum memory in silicon

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npj Computational Materials 2022年第1期8卷 2498-2503页

作者： Péter Udvarhelyi Anton Pershin Péter Deák Adam Gali wigner Research Centre for Physics P.O.Box 49H-1525BudapestHungary Budapest University of Technology and Economics Institute of PhysicsDepartment of Atomic PhysicsMűegyetem rakpart 3.1111BudapestHungary

Fluorescent centres in silicon have recently attracted great interest,owing to their remarkable properties for quantum ***,we demonstrate that the C-centre in silicon can realise an optically readable quantum register in the L-band wavelength region where the transmission losses in commercial optical fibres are *** in-depth theoretical characterisation confirms the assignment of the C-centre to the carbon-oxygen interstitial pair *** further explore its magneto-optical properties,such as hyperfine and spin-orbit coupling constants from first principles calculations,which are crucial for tight control of the quantum states of the triplet electron *** on this data,we set up quantum optics protocols to initialise and read out the quantum states of the electron spin,and realise a quantum memory by transferring quantum information from the electron spin to proximate ^(29)Si nuclear *** findings establish an optically readable long-living quantum memory in silicon where the scalability of qubits may be achieved by CMOS-compatible technology.

关键词： quantum centre optics

Effects of diabetes type 2 and metformin treatment in Swedish patients with colorectal cancer

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world Journal of Gastroenterology 2022年第19期28卷 2148-2151页

作者： Jan Dimberg Levar Shamoun Kalle Landerholm Dick wågsäter Department of Natural Science and Biomedicine School of Health and WelfareJönköping UniversityJönköping 55111Sweden Department of Laboratory Medicine and Pathology Region Jönköping CountyJönköping 55305Sweden Department of Medical Cell Biology Uppsala UniversityUppsala 75123Sweden Department of Surgery Region Jönköping CountyJönköping 55305Sweden Department of Biomedical and Clinical Sciences Linköping UniversityLinköping 58185Sweden

The association between type 2 diabetes mellitus(DM)and colorectal cancer(CRC)has been thoroughly investigated and reports have demonstrated that the risk of CRC is increased in DM *** association between DM and the survival of patients with CRC is *** suggests that metformin with its anti-inflammatory effects is a protective factor against the development of CRC among DM patients and that metformin therapy is associated with a better prognosis in patients with *** our cohort,we did not find any associations between the presence of DM or metformin and cancer specific survival or any relation to plasma levels of a panel of 40 inflammatory factors and *** the other hand,we identified that the insulin-like growth factor binding protein 7 single nucleotide polymorphism rs2041437 was associated with DM in CRC *** dominance of the T bearing genotypes in patients with DM was statistically significant(P=0.038),with an odds ratio of 1.66(95%confidence interval:1.03-2.69).

关键词： Diabetes Metformin Cytokines Survival Colorectal cancer Polymorphism

Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles w.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

Fine-tuning of mechanical properties in a Zn-Ag-Mg alloy via cold plastic deformation process and post-deformation annealing

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Bioactive Materials 2021年第10期6卷 3424-3436页

作者： Maria wątroba wiktor Bednarczyk Jakub Kawałko Piotr bała AGH University of Science and Technology Faculty of Metals Engineering and Industrial Computer ScienceAl.A.Mickiewicza 3030-059 KrakowPoland AGH University of Science and Technology Academic Centre for Materials and NanotechnologyAl.A.Mickiewicza 3030-059 KrakowPoland

In recent years,Zn-based materials have been extensively investigated as potential candidates for biodegradable implant *** introduction of alloying elements providing solid-solution strengthening and second phase strengthening seems crucial to provide a suitable platform for the thermo-mechanical strengthening of Zn *** this study,a systematic investigation of the microstructure,crystallographic texture,phase composition,and mechanical properties of a Zn-3Ag-0.5Mg(wt%)alloy processed through combined hot extrusion(HE)and cold rolling(CR),followed by short-time heat treatment(CR+HT)at 200◦C was ***,the influence of different annealing temperatures on the microstructure and mechanical properties was *** adequate combination of processing conditions during CR and HT successfully addressed brittleness obtained in the high-strength HE Zn-3Ag-0.5Mg *** controlling the microstructure,the most promising results were obtained in the sample subjected to 50%CR reduction and 5-min annealing,which were:ultimate tensile strength of 432 MPa,yield strength of 385 MPa,total elongation to failure of 34%,and Vickers microhardness of 125 *** obtained properties clearly exceed the mechanical benchmarks for biodegradable implant *** on the conducted investigation,brittle multi-phase Zn alloys’mechanical performance can be substantially enhanced to provide sufficient plasticity by grain refinement through cold deformation process,followed by short-time annealing to restore proper strength.

关键词： Zinc alloys Cold rolling Heat treatment Mechanical properties Grain refinement

Large eddy simulations of a turbulent mixing layer periodically excited with fundamental and third harmonic frequency

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Chinese Journal of Aeronautics 2023年第5期36卷 33-40页

作者： Jörg SCHLÜter Dan ZHAO Abhishek SARKAR School of Engineering Deakin UniversityWaurn Ponds 3216Australia College of Engineering University of CanterburyChristchurch 8041New Zealand School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore

A better understanding of the mixing behavior of excited turbulent mixing layers is critical to a number of aerospace *** studies of excited turbulent mixing layers focused on single frequency excitation or the excitation with fundamental and its second harmonic *** is a lack of detailed studies on applying low and higher frequency *** this study,we have performed large-eddy simulations of periodically excited turbulent mixing *** excitation consists of a fundamental frequency and its third *** have used phase-averaging to identify the vortex structure and strength in the mixing layer,and we have studied the vortex *** different vortex paring mechanisms are observed depending on the phase shift between the two excitation *** influence of these two mechanisms on the mixing of a passive scalar is also *** is found that exciting the mixing layer with these low and high frequencies has initially an adverse influence on the mixing process;however,it improves the mixing further downstream of the splitter plate with the excitation using a phase shift ofΔφ=πshowing the best mixing *** present works shed lights on the fundamental vortex dynamics,and has great potential for aeronautical,automotive and combustion engineering applications.

关键词： Flow control Flow excitation Large eddy simulations Turbulent mixing layer Vortex dynamics