检索结果-南通市图书馆

A quinolinyl analog of resveratrol improves neuronal damage after ischemic stroke by promoting Parkin-mediated mitophagy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2025年第2期23卷 214-224页

作者： Qingqi Meng Yan Mi Libin Xu Yeshu Liu Dong Liang Yongping wang Yan wang Yueyang Liu Guoliang Chen Yue Hou Key Laboratory of bioresource Research and Development of Liaoning Province College of Life and Health Sciences National Frontiers Science Center for Industrial Intelligence and Systems Optimization Key Laboratory of Data Analytics and Optimization for Smart Industry Ministry of Education Northeastern University State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences Guangxi Normal University Shenyang Key Laboratory of Vascular biology Science and Research Center Department of Pharmacology Shenyang Medical College Key Laboratory of Structure-based Drug Design & Discovery of Ministry of Education School of Pharmaceutical Engineering Shenyang Pharmaceutical University

Ischemic stroke(IS) is a prevalent neurological disorder often resulting in significant disability or mortality. Resveratrol, extracted from Polygonum cuspidatum Sieb. et Zucc.(commonly known as Japanese knotweed), has been recognized for its potent neuroprotective ***, the neuroprotective efficacy of its derivative,(E)-4-(3,5-dimethoxystyryl) quinoline(RV02), against ischemic stroke remains inadequately explored. This study aimed to evaluate the protective effects of RV02 on neuronal ischemia-reperfusion injury both in vitro and in vivo. The research utilized an animal model of middle cerebral artery occlusion/reperfusion and SH-SY5Y cells subjected to oxygen-glucose deprivation and reperfusion to simulate ischemic conditions. The findings demonstrate that RV02 attenuates neuronal mitochondrial damage and scavenges reactive oxygen species(ROS) through mitophagy activation. Furthermore, Parkin knockdown was found to abolish RV02's ability to activate mitophagy and neuroprotection in vitro. These results suggest that RV02 shows promise as a neuroprotective agent, with the activation of Parkin-mediated mitophagy potentially serving as the primary mechanism underlying its neuroprotective effects.

关键词： (E)-4-(3,5-dimethoxystyryl) quinoline Ischemic stroke Mitophagy Parkin Resveratrol

Searching Radio Signals from Two Magnetars and a High-magnetic Field Pulsar and the Serendipitous Discovery of a New Radio Pulsar PSR J1935+2200

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2025年第1期25卷 110-115页

作者： Lang Xie J.L.Han Z.L.Yang w.C.Jing D.J.Zhou w.Q.Su Yi Yan Tao wang Nan-Nan Cai P.F.wang Chen wang National Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences National Key Laboratory for Radio Astronomy Chinese Academy of Sciences

Magnetars are slowly rotating, highly magnetized young neutron stars that can show transient radio phenomena for radio pulses and fast radio bursts. we conducted radio observations from two magnetars SGR J1935+2154 and3XMM J185246.6+003317 and a high-magnetic field pulsar PSR J1846–0258 using the Five-hundred-meter Aperture Spherical radio Telescope（FAST）. we performed single pulse and periodicity searches and did not detect radio signals from them. From the piggyback data recorded by other FAST telescope beams when we observed the magnetar SGR 1935+2154, we serendipitously discovered a new radio pulsar, PSR J1935+2200. we carried out the follow-up observations and obtained the timing solution based on these new observations and the archive FAST data. PSR J1935+2200 is an isolated old pulsar, with a spin period of 0.91 s, a spin-period derivative of9.19 × 10-15s s-1, and a characteristic age of 1.57 Myr. It is a weak pulsar with a flux density of 9.8 μJy at1.25 GHz. Discovery of a new pulsar from the long FAST observations of 30 minutes implies that there may be more weak older pulsars in the Galactic disk to be discovered.

关键词： (stars:) pulsars: individual (PSR J1935+2200) stars: neutron

Construction of eco-friendly dual carbon dots ratiometric fluorescence probe for highly selective and efficient sensing mercury ion

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2025年第2期148卷 1-12页

作者： Yongli Liu Xiaoyan Su Huanjia Liu Guifen Zhu Guobei Ge Yuxin wang Penghui Zhou Qingxiang Zhou School of Environment Henan Key Laboratory for Environmental Pollution ControlKey Laboratory for Yellow River and Huai River Water Environmental and Pollution ControlMinistry of EducationHenan Normal UniversityXinxiang 453007China College of Chemical Engineering and Environment China University of Petroleum-BeijingBeijing 102249China

In present work,blue carbon dots(b-CDs)were derived from ammonium citrate and guanidine hydrochloride,and red carbon dots(r-CDs)were stemmed from malonate,ethylenediamine and meso-tetra(4-carboxyphenyl)porphin based on facile hydrothermal ***-friendly ratiometric fluorescence probe was innovatively constructed to effectively measure Hg2+utilizing b-CDs and *** developed probe displayed two typical emission peaks at 450 nm from b-CDs and 650 nm from r-CDs under the excitation at 360 *** ion has strong quenching effect on the fluorescence intensity at 450 nm due to the electron transfer process and the fluorescence change at 450 nm was used as the response signal,whereas the fluorescence intensity at 650 nm kept unchangeable which resulted from the chemical inertness between Hg^(2+)and r-CDs,serving as the reference signal in the sensing *** optimal circumstances,this probe exhibited an excellent linearity between the fluorescence response values of F450/F650 and Hg^(2+)concentrations over range of 0.01-10μmol/L,and the limit of detectionwas down to 5.3 nmol/***,this probe was successfully employed for sensing Hg^(2+)in practical environmental water samples with satisfied recoveries of 98.5%-105.0%.The constructed ratiometric fluorescent probe provided a rapid,environmental-friendly,reliable,and efficient platform for measuring trace Hg^(2+)in environmental field.

关键词： blue carbon dots Red carbon dots Electron transfer Hg^(2+) Eco-friendliness

Characterization and genomic analysis of Pseudoalteromonas phage v b_Pal P_Y7,representing a novel viral genus,Miuvirus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2025年第1期43卷 299-312页

作者： Miaolan wU Hongmin wang Ye MI Yantao LIANG Kaiyang ZHENG Yundan LIU Yue DONG Linyi REN Yue SU Hongbing SHAO Yeong Yik SUNG wen Jye MOK Li Lian wONG Min wang College of Marine Life Sciences Institute of Evolution and Marine BiodiversityMoE Laboratory of Evolution and Marine BiodiversityFrontiers Science Center for Deep Ocean Multispheres and Earth SystemCenter for Ocean Carbon NeutralityOcean University of ChinaQingdao 266100China Qingdao City Center for Disease Control and Prevention Qingdao Institute of Prevention MedicineQingdao 266033China UMT-OUC Joint Centre for Marine Studies Qingdao 266100China Institute of Marine biotechnology Universiti Malaysia TerengganuKuala Terengganu 21030Malaysia Haide College Ocean University of ChinaQingdao 266100China The Affiliated Hospital of Qingdao University Qingdao 266000China

Pseudoalteromonas is a group of marine bacteria widespread in diverse marine sediments,producing a wide range of bioactive ***,only a limited number of Pseudoalteromonas phages have been isolated and *** this study,a novel lytic Pseudoalteromonas phage,denoted as vb_PalP_Y7,was isolated from sewage samples collected at the Seafood Market in Qingdao,***_PalP_Y7 remained stable across a wide range of temperatures(-20–50℃)and a wide pH range(3–12).The vb_PalP_Y7 phage harbors a linear double-stranded DNA molecule of 57699 base pairs(bp)with a G+C content of 45.90%.Furthermore,it is predicted to contain 58 open reading frames(ORFs).Phylogenetic analysis and protein network relationship analysis revealed low similarity between vb_PalP_Y7 and viruses in the ICTV and IMG/VR4 database,suggesting that vb_PalP_Y7 may be a potential new genus,*** study contributed valuable insights to comprehend the relationship between Pseudoalteromonas phages and their host organisms.

关键词： Pseudoalteromonas phage genomic analysis phylogenetic analysis viral cluster

维普期刊数据库

Crop root system architecture in drought response

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2025年第1期52卷 4-13页

作者： Yanjun Zhang Xi wu Xingrong wang Mingqiu Dai Yunling Peng College of Agronomy Gansu Agricultural UniversityLanzhouGansu 730070China State Key Laboratory of Aridland Crop Science Gansu Agricultural UniversityLanzhouGansu 730070China Crop Research Institute Gansu Academy of Agricultural SciencesLanzhouGansu 730070China Key Laboratory of Crop Gene Resources and Germplasm Innovation in Northwest Cold and Arid Regions Ministry of Agriculture and Rural AffairsLanzhouGansu 730070China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhanHubei 430070China Hubei Hongshan Laboratory WuhanHubei 430070China

Drought is a natural disaster that profoundly impacts on global agricultural production,significantly reduces crop yields,and thereby poses a severe threat to worldwide food *** the challenge of effectively improving crop drought resistance(DR)to mitigate yield loss under drought conditions is a global *** optimal root system architecture(RSA)plays a pivotal role in enhancing the capacity of crops to efficiently uptake water and nutrients,which consequently strengthens their resilience against environmental *** this review,we discuss the compositions and roles of crop RSA and summarize the most recent developments in augmenting drought tolerance in crops by manipulating RSA-related *** on the current research,we propose the potential optimal RSA configuration that could be helpful in enhancing crop ***,we discuss the existing challenges and future directions for breeding crops with enhanced DR capabilities through genetic improvements targeting RSA.

关键词： Crop Drought resistance Root system architecture Genetic improvement

Adjusting *CO adsorption configuration over tandem trimetallic AuAgCu heterojunction boosts CO_(2) electroreduction to ethanol via asymmetric C–C coupling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Materials 2025年第1期68卷 173-179页

作者： Yongxia Shi Junjun Li Zhiwen Min Xinyi wang Man Hou Hao Ma Zechao Zhuang Yuchen Qin Yuanmiao Sun Dingsheng wang Zhicheng Zhang Key Laboratory of Organic Integrated Circuit Ministry of Education&Tianjin Key Laboratory of Molecular Optoelectronic SciencesDepartment of ChemistrySchool of ScienceTianjin UniversityTianjin 300072China Faculty of Materials Science and Energy Engineering/Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Chemistry Tsinghua UniversityBeijing 100084China College of Sciences Henan Agricultural UniversityZhengzhou 450000China

Rationally modulating the adsorption configuration of the key*CO intermediate could facilitate carbon±carbon(C±C)coupling to generate multi-carbon products in the electrochemical CO_(2) reduction *** this work,theoretical calculations reveal that C±C coupling via atopadsorbed*CHO and hollow-adsorbed*CO over Cu sites is an energetically favorable *** a proof of concept,a tandem trimetallic AuAgCu heterojunction(Au@Ag/Cu)was prepared,where the atop-adsorbed*CO over Au@Ag sites could migrate to Cu sites with hollow adsorption configuration,and then the asymmetric C±C coupling via transferred hollow-adsorbed*CO and existed atop-adsorbed*CHO over Cu sites facilitates the formation of the ethanol product,exhibiting a maximum Faraday efficiency of 65.9%at a low potential of−0.3 V *** hydrogen *** work provides new insights into the intrinsic understanding of tandem catalysis by regulating adsorption configuration of the intermediate products.

关键词： CO_(2)electroreduction C–C coupling tandem catalysis adsorption configuration ethanol

Thickness-dependent magnetic property of FeNi thin film grown on flexible graphene substrate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics b 2025年第2期34卷 448-452页

作者： Suixin Zhan Shaokang Yuan Yuming bai Fu Liu bohan Zhang weijia Han Tao wang Shengxiang wang Cai Zhou State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200China School of Mathematical and Physical Sciences Wuhan Textile UniversityWuhan 430200China School of Integrated Circuits Huazhong University of Science and TechnologyWuhan 430074China Key Laboratory for Magnetism and Magnetic Materials Ministry of EducationLanzhou UniversityLanzhou 730000China

Electronics over flexible substrates offer advantages of flexibility, portability and low cost, and promising applications in the areas of energy, information, defense science and medical service. In recent years, tremendous progress has been witnessed in the development of flexible wearable devices that can be potentially massively deployed. Of particular interest are intelligent wearable devices, such as sensors and storage cells, which can be integrated by flexible magnetoelectronic devices based on magnetic thin films. To examine this further, the magnetic properties of FeNi thin films with different thicknesses grown on flexible graphene substrate are investigated at room temperature. The coercivity increases with increasing thicknesses of FeNi thin film, which can be attributed to the increase of grain size and decrease of surface roughness. Moreover, the thickness modulated magnetic property shows a magnetic anisotropy shift increase with varying thicknesses of FeNi thin film by using measurements based on ferromagnetic resonance, which further enhances the resonance frequency. In addition, the resonance peak is quite stable after bending it for ten cycles. The result is promising for the future design of flexible magnetoelectronic devices.

关键词： resonance frequency FeNi thin film flexible graphene substrate magnetic property

A Novel Composite of Aptamer-based Ti3C2Tx and Molecularly Imprinted Polymer with Double Recognition Property for Sensitive Electrochemical Detection of Ofloxacin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Analysis and Testing 2025年第01期 109-117页

作者： Hanxing Yang wenting wang Yanbo Zeng Rong Tang Huixiang Yan Yiwen Yang Hailong wang Jianbo wang Longhua Guo Jianguo Xu Lei Li Jiaxing Key Laboratory of Molecular Recognition and Sensing College of BiologicalChemical Sciences and EngineeringJiaxing University School of Petrochemical Engineering Changzhou University College of Advanced Materials Engineering Jiaxing Nanhu University

A novel composite of aptamer-based Ti3C2Txand molecularly imprinted polymer（Apt-Ti3C2Tx-MIP） with double recognition property was prepared for sensitive electrochemical detection of ofloxacin（OFL）. First, Ti3C2Tx@SiO2was synthesized using multi-layer Ti3C2Txand tetraethyl orthosilicate（TEOS） in alkaline conditions. Amino Ti3C2Tx@SiO2was then prepared through Ti3C2Tx@SiO2in the presence of（3-aminopropyl）triethoxysilane. Carboxyl OFL aptamers were then grafted onto amino Ti3C2Tx@SiO2to prepare aptamer-modified Ti3C2Tx@SiO2. A novel composite of Apt-Ti3C2Tx-MIP was prepared with sol–gel method in the presence of Ti3C2Tx@SiO2-Apt-OFL and TEOS. The Apt-Ti3C2Tx-MIP sensor exhibited double recognition for OFL because of aptamer specificity and imprinted binding sites. The electrochemical response of Apt-Ti3C2Tx-MIP sensor for OFL was 2.29 and 2.75 times that of Apt-Ti3C2Tx-NIP and Ti3C2Tx-MIP sensors, respectively,demonstrating the double recognition of Apt-Ti3C2Tx-MIP for OFL. The Apt-Ti3C2Tx-MIP sensor with double recognition displayed a linear peak current to OFL centration from 0.025 to 10 μM with a detection limit of 10 nM. The Apt-Ti3C2Tx-MIP sensor had excellent selectivity for OFL and has been successfully applied to the detection of OFL in a wastewater sample.

关键词：

Multifunctional Graphdiyne Enables Efficient Perovskite Solar Cells via Anti-Solvent Additive Engineering

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第5期17卷 492-507页

作者： Cong Shao Jingyi He Jiaxin Ma Yirong wang Guosheng Niu Pengfei Zhang Kaiyi Yang Yao Zhao Fuyi wang Yongjun Li Jizheng wang CAS Key Laboratory of Organic Solids Institute of ChemistryBeijing National Laboratory for Molecular SciencesChinese Academy of SciencesBeijing 100049People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China CAS Key Laboratory of Engineering Plastics Institute of ChemistryChinese Academy of SciencesBeijing 100049People’s Republic of China CAS Key Laboratory of Photochemistry Institute of ChemistryChinese Academy of SciencesBeijing 100049People’s Republic of China National Centre for Mass Spectrometry in beijing CAS Key Laboratory of Analytical Chemistry for Living BiosystemsBeijing National Laboratory for Molecular SciencesChinese Academy of SciencesBeijing 100049People’s Republic of China

Finding ways to produce dense and smooth perovskite films with negligible defects is vital for achieving high-efficiency perovskite solar cells(PSCs).Herein,we aim to enhance the quality of the perovskite films through the utilization of a multifunctional additive in the perovskite anti-solvent,a strategy referred to as anti-solvent additive ***,we introduce ortho-substituted-4′-(4,4″-di-tertbutyl-1,1′:3′,1″-terphenyl)-graphdiyne(o-Tb-GDY)as an AAE additive,characterized by its sp/sp^2-cohybridized and highlyπ-conjugated structure,into the anti-solvent.o-Tb-GDY not only significantly passivates undercoordinated lead defects(through potent coordination originating from specific highπ–electron conjugation),but also serves as nucleation seeds to effectively enhance the nucleation and growth of perovskite *** markedly reduces defects and non-radiative recombination,thereby increasing the power conversion efficiency(PCE)to 25.62%(certified as 25.01%).Meanwhile,the PSCs exhibit largely enhanced stability,maintaining 92.6%of their initial PCEs after 500 h continuous 1-sun illumination at~23°C in a nitrogen-filled glove box.

关键词： Perovskite solar cells Graphdiyne Anti-solvent additive engineering Crystallization Defect passivation